TB-Profiler result

Run: SRR21690574
Summary

Run ID: SRR21690574

Sample name:

Date: 2024-04-30T22:57:28.770497

Number of reads: 4303363

Percentage reads mapped: 99.51

Median coverage: 64.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.99
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 1.0
La1.2.BCG M.bovis None 0.06
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.98 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620682 c.792G>A synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.14 capreomycin
amikacin
kanamycin
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
hadA 732321 p.Glu131Ala missense_variant 0.12 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.13 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.14 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.18 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.17 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.18 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.15 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.15 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.15 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.15 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.92 rifampicin Not assoc w R
rpoB 760328 c.522G>C synonymous_variant 0.14 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.14 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.17 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.15 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.15 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.18 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.18 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.14 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.14 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.14 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.16 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.13 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.12 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.14 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.15 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.17 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.19 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.2 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.21 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.17 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.13 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.12 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.13 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.17 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.13 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.14 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.15 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.16 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.15 rifampicin
rpoB 762926 c.3120C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.14 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.2 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.21 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.18 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.16 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.18 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.16 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.15 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.13 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.12 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.16 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.22 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.2 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.2 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.2 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.2 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 764827 c.1458G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.18 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765292 c.1923G>C synonymous_variant 0.14 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.14 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.14 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.15 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.15 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.19 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.22 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.24 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.21 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.23 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.22 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.17 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.16 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.12 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.22 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.17 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.13 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.13 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.16 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.12 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.14 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.14 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.14 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.17 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.19 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.21 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.2 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.17 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.13 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.18 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.18 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.16 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.2 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767181 p.Ala1271Glu missense_variant 0.12 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777133 p.Val450Ile missense_variant 0.12 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.13 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.12 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.13 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.13 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.12 clofazimine
bedaquiline
mmpL5 777492 p.Pro330Leu missense_variant 0.98 clofazimine
bedaquiline
rpsL 781276 c.-284A>C upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.13 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.16 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.13 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.16 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.18 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.18 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.17 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.17 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.19 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.17 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.17 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.15 streptomycin
rplC 800612 c.-197A>G upstream_gene_variant 0.13 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.13 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.15 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.15 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.18 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.21 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.19 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.2 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.18 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.13 linezolid
rplC 800817 c.9A>T synonymous_variant 0.11 linezolid
fbiC 1304526 c.1596T>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.12 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.12 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.12 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.12 clofazimine
pretomanid
delamanid
atpE 1461170 c.126A>G synonymous_variant 0.13 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.14 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.12 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.12 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.14 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.13 capreomycin
linezolid Uncertain significance
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833532 c.-10A>C upstream_gene_variant 0.12 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.2 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.12 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.12 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.12 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.17 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.17 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.14 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101939 c.1104A>G synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.14 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.14 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.13 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.13 ethionamide
delamanid
isoniazid
PPE35 2170408 p.Ala69Thr missense_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.14 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.14 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.14 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.13 isoniazid
Rv2477c 2782927 p.Thr372Glu missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.13 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.2 capreomycin Uncertain significance
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.23 capreomycin Uncertain significance
thyX 3067661 c.285C>G synonymous_variant 0.12 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.12 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.12 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.12 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.12 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.13 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3627068 c.282T>C synonymous_variant 0.12 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.12 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.12 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.12 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.12 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.15 bedaquiline
rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.14 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.13 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.13 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.14 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.21 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.2 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.17 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.17 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.14 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.13 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.12 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.13 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.14 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3878292 c.216T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.13 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878376 c.132G>C synonymous_variant 0.14 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.14 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.15 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.15 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.12 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.14 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.14 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.14 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.14 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.16 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.18 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.15 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.13 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.12 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.13 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.13 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.12 rifampicin
clpC1 4038596 c.2109A>G synonymous_variant 0.13 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.29 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.28 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.28 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.12 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.2 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.14 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.14 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.14 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.15 pyrazinamide
glpK 4138718 c.1038T>C synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.12 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.13 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.14 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.13 ethambutol
embC 4242803 p.Val981Leu missense_variant 0.87 ethambutol Not assoc w R
embB 4247512 c.999T>C synonymous_variant 0.15 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.14 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.13 ethambutol
embB 4247974 c.1461C>G synonymous_variant 0.12 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.18 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.18 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.18 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.19 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.19 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.19 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.2 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.23 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.2 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin