Run ID: SRR13861396
Sample name:
Date: 2024-10-04T19:31:00.477966
Number of reads: 2019603
Percentage reads mapped: 67.39
Median coverage: 71.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: HR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | katG | c.1313_1314insT | Assoc w R | High-level resistance |
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
katG | 2154798 | c.1313_1314insT | frameshift_variant | 1.0 | isoniazid | Assoc w R | High-level resistance |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 5906 | p.Val223Leu | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6011 | p.Val258Met | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6678 | p.Pro480Arg | missense_variant | 0.9 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7523 | c.222C>G | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7532 | c.231T>C | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7541 | c.240C>G | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8111 | c.810G>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8168 | c.867A>G | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8174 | c.873C>G | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8177 | c.876A>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8198 | c.897T>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8375 | c.1074G>C | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 8399 | c.1098T>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8516 | c.1215T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8519 | c.1218A>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8537 | c.1236G>A | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8546 | c.1245T>C | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8552 | c.1251C>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8556 | p.Ala419Gln | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8561 | c.1260A>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8562 | c.1261C>T | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8619 | c.1318T>C | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8636 | c.1335A>G | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8642 | c.1341A>G | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8645 | c.1344C>G | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
fgd1 | 490676 | c.-107G>C | upstream_gene_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491244 | c.462T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
mshA | 575649 | p.Val101Glu | missense_variant | 0.14 | isoniazid | |
ethionamide | ||||||
ccsA | 620028 | c.138G>C | synonymous_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
hadA | 732346 | c.417T>C | synonymous_variant | 0.15 | isoniazid | |
nusG | 734442 | c.189G>A | synonymous_variant | 0.13 | rifampicin | |
nusG | 734457 | c.204C>G | synonymous_variant | 0.17 | rifampicin | |
nusG | 734472 | c.219T>C | synonymous_variant | 0.17 | rifampicin | |
nusG | 734475 | c.222T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
nusG | 734481 | c.228C>G | synonymous_variant | 0.17 | rifampicin | |
nusG | 734499 | c.246G>C | synonymous_variant | 0.18 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
nusG | 734541 | c.288A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
nusG | 734559 | c.306T>C | synonymous_variant | 0.17 | rifampicin | |
nusG | 734580 | c.327T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 759638 | c.-169T>A | upstream_gene_variant | 0.97 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760454 | c.650delG | frameshift_variant | 0.95 | rifampicin | |
rpoB | 761150 | c.1344A>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761165 | c.1359G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 761171 | c.1365C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 761222 | c.1416G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761255 | c.1449T>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763158 | c.-212C>T | upstream_gene_variant | 0.15 | rifampicin | |
rpoC | 763858 | c.489A>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763933 | c.564C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764161 | c.792G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764196 | p.Ser276* | stop_gained | 0.14 | rifampicin | |
rpoC | 764560 | c.1191T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764791 | c.1422C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764893 | c.1524T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 765487 | p.Met706Ile | missense_variant | 0.91 | rifampicin | |
rpoC | 765658 | c.2289C>T | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoC | 765700 | c.2331T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765739 | c.2370G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765751 | c.2382C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765753 | p.Asp795Ala | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoC | 765772 | c.2403C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765784 | c.2415C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765928 | c.2559C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765970 | c.2601C>T | synonymous_variant | 0.13 | rifampicin | |
rpoC | 765982 | c.2613C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765985 | c.2616C>T | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766010 | p.Ser881Thr | missense_variant | 0.13 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.15 | rifampicin | |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 767158 | c.3789T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 767167 | c.3798C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767181 | p.Ala1271Glu | missense_variant | 0.15 | rifampicin | |
rpsL | 781409 | c.-151T>A | upstream_gene_variant | 1.0 | streptomycin | |
rpsL | 781841 | c.282C>G | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781859 | c.300T>C | synonymous_variant | 0.14 | streptomycin | Not assoc w R - Interim |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.14 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.18 | streptomycin | Uncertain significance |
rplC | 800567 | c.-242A>G | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800582 | c.-227C>G | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.18 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800648 | c.-161A>C | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800747 | c.-62C>G | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800771 | c.-38C>T | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800794 | c.-15_-9delAGATTGGinsGAGTT | upstream_gene_variant | 0.22 | linezolid | |
rplC | 800814 | c.6A>G | synonymous_variant | 0.21 | linezolid | |
rplC | 800817 | c.9A>T | synonymous_variant | 0.21 | linezolid | |
rplC | 800844 | c.36T>C | synonymous_variant | 0.19 | linezolid | |
rplC | 800865 | c.57A>G | synonymous_variant | 0.15 | linezolid | |
rplC | 800867 | p.Ser20Asn | missense_variant | 0.15 | linezolid | |
rplC | 800874 | c.66A>G | synonymous_variant | 0.15 | linezolid | |
rplC | 800877 | c.69A>C | synonymous_variant | 0.14 | linezolid | |
rplC | 800880 | c.72A>G | synonymous_variant | 0.15 | linezolid | |
rplC | 800889 | c.81C>G | synonymous_variant | 0.18 | linezolid | |
rplC | 800907 | c.99C>G | synonymous_variant | 0.14 | linezolid | |
rplC | 800916 | c.108A>G | synonymous_variant | 0.15 | linezolid | |
rplC | 801301 | c.493C>A | synonymous_variant | 0.14 | linezolid | |
rplC | 801312 | c.504G>C | synonymous_variant | 0.15 | linezolid | |
rplC | 801324 | c.516T>C | synonymous_variant | 0.14 | linezolid | |
Rv1129c | 1254013 | p.Met174Ile | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
Rv1129c | 1254452 | p.Glu28Ala | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
fbiC | 1302873 | c.-58A>T | upstream_gene_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304517 | c.1587C>T | synonymous_variant | 0.13 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304523 | c.1593G>T | synonymous_variant | 0.13 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304565 | c.1635C>G | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304568 | c.1638T>C | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304574 | c.1644C>G | synonymous_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304580 | c.1650T>C | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304628 | c.1698G>C | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304634 | c.1704C>G | synonymous_variant | 0.25 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304640 | c.1710A>C | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304646 | c.1716T>C | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304658 | c.1728C>G | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304670 | c.1740G>T | synonymous_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304671 | p.Val581Thr | missense_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304675 | p.Gly582Glu | missense_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304691 | c.1761G>C | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304694 | c.1764A>C | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304703 | c.1773C>G | synonymous_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304715 | c.1785G>C | synonymous_variant | 0.24 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304724 | c.1794A>G | synonymous_variant | 0.21 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
fbiC | 1304727 | c.1797A>G | synonymous_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304742 | c.1812T>C | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304748 | c.1818T>C | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304754 | c.1824G>A | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304757 | c.1827A>G | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304784 | c.1854T>C | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304787 | c.1857T>C | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304790 | c.1860C>G | synonymous_variant | 0.17 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304808 | c.1878C>G | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304811 | c.1881C>G | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304817 | c.1887T>C | synonymous_variant | 0.17 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
rrs | 1471874 | n.29A>C | non_coding_transcript_exon_variant | 0.93 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472028 | n.183A>T | non_coding_transcript_exon_variant | 0.15 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472030 | n.185G>A | non_coding_transcript_exon_variant | 0.15 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472031 | n.186G>A | non_coding_transcript_exon_variant | 0.16 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472034 | n.189T>C | non_coding_transcript_exon_variant | 0.16 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472044 | n.199G>C | non_coding_transcript_exon_variant | 0.16 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472061 | n.216A>T | non_coding_transcript_exon_variant | 0.16 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.15 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472970 | n.1125C>G | non_coding_transcript_exon_variant | 0.15 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472977 | n.1132G>C | non_coding_transcript_exon_variant | 0.15 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.17 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1474639 | n.982G>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474904 | n.1247G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475599 | n.1942A>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475638 | n.1981C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1475642 | n.1985T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475657 | n.2000A>G | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1475659 | n.2002G>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475763 | n.2106C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476369 | n.2712C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476381 | n.2724G>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476382 | n.2725A>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476383 | n.2726T>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1476384 | n.2727G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1476408 | n.2751G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476411 | n.2754G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1476425 | n.2768G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476429 | n.2772A>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476442 | n.2785T>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1476443 | n.2786G>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1476455 | n.2798C>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1476456 | n.2799A>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1476463 | n.2806C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1476466 | n.2809C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
inhA | 1674582 | c.381T>C | synonymous_variant | 0.14 | isoniazid | |
ethionamide | ||||||
inhA | 1674654 | c.453G>C | synonymous_variant | 0.14 | isoniazid | |
ethionamide | ||||||
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.14 | pyrazinamide | |
bacA | 2063125 | p.Ala535Asp | missense_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064843 | c.-115C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
katG | 2154654 | p.Ser486Arg | missense_variant | 1.0 | isoniazid | |
katG | 2154882 | c.1230G>A | synonymous_variant | 1.0 | isoniazid | |
katG | 2155857 | c.255C>A | synonymous_variant | 0.98 | isoniazid | |
PPE35 | 2170198 | p.Ala139Ser | missense_variant | 1.0 | pyrazinamide | |
pncA | 2290069 | c.-828C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
kasA | 2518687 | c.573C>T | synonymous_variant | 0.14 | isoniazid | |
kasA | 2518717 | c.603C>T | synonymous_variant | 0.14 | isoniazid | |
kasA | 2518723 | p.Glu203Asp | missense_variant | 0.14 | isoniazid | |
kasA | 2518732 | c.618C>G | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518741 | c.627G>C | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518768 | c.654C>G | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518783 | c.669T>C | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518792 | c.678C>G | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518795 | c.681C>G | synonymous_variant | 0.16 | isoniazid | |
eis | 2714922 | c.411G>A | synonymous_variant | 1.0 | kanamycin | |
amikacin | ||||||
folC | 2747355 | p.Val82Ile | missense_variant | 0.13 | para-aminosalicylic_acid | |
Rv2477c | 2783221 | c.822G>T | synonymous_variant | 0.13 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
thyX | 3067787 | c.159G>A | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067793 | c.153T>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyX | 3067799 | c.147G>A | synonymous_variant | 0.14 | para-aminosalicylic_acid | |
thyX | 3067814 | c.132T>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067826 | c.120C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyA | 3074067 | c.405C>G | synonymous_variant | 0.92 | para-aminosalicylic_acid | |
lpqB | 3624738 | p.Ala58Val | missense_variant | 0.96 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625436 | p.Ile393Asn | missense_variant | 0.99 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625690 | c.-780T>C | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625705 | c.909C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625714 | c.-804C>T | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625720 | c.894G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625729 | c.885A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625735 | c.879C>A | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3626728 | p.Asp208Tyr | missense_variant | 0.93 | rifampicin | |
bedaquiline | ||||||
alr | 3840223 | c.1198A>C | synonymous_variant | 1.0 | cycloserine | |
alr | 3840711 | p.Ser237Leu | missense_variant | 1.0 | cycloserine | |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3877866 | c.642G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3877872 | c.636C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877875 | c.633T>G | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878070 | c.438T>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878082 | c.426T>C | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878094 | c.414C>G | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878100 | c.408C>G | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878103 | c.405A>G | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878106 | c.402G>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878118 | c.390T>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878141 | p.Met123Leu | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoA | 3878142 | p.Gly122Glu | missense_variant | 0.19 | rifampicin | |
rpoA | 3878169 | c.339G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoA | 3878184 | c.324C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3878187 | c.321C>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878193 | c.315T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3878199 | c.309T>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878202 | c.306G>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3878220 | c.288C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878284 | p.Glu75Ala | missense_variant | 0.23 | rifampicin | |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878364 | c.144A>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878370 | c.138T>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878376 | c.132G>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878391 | c.117T>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878396 | c.112C>T | synonymous_variant | 0.16 | rifampicin | |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038748 | p.Arg653Cys | missense_variant | 0.18 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038851 | c.1854G>A | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038923 | c.1782A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038932 | c.1773G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039648 | p.Glu353Gln | missense_variant | 0.85 | pyrazinamide | |
clpC1 | 4039682 | c.1023C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039685 | c.1020C>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039694 | c.1011G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040423 | c.282A>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040426 | c.279T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040431 | c.274T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040465 | c.240T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040471 | c.234T>C | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040477 | c.228G>A | synonymous_variant | 0.14 | pyrazinamide | |
panD | 4045034 | c.-753A>T | upstream_gene_variant | 0.14 | pyrazinamide | |
embC | 4240780 | c.918T>C | synonymous_variant | 0.16 | ethambutol | |
embC | 4240783 | c.921G>C | synonymous_variant | 0.15 | ethambutol | |
embC | 4240789 | c.927T>C | synonymous_variant | 0.15 | ethambutol | |
embC | 4240819 | c.957A>G | synonymous_variant | 0.15 | ethambutol | |
embC | 4241017 | c.1155T>C | synonymous_variant | 0.15 | ethambutol | |
embC | 4241023 | c.1161T>G | synonymous_variant | 0.15 | ethambutol | |
embC | 4241026 | c.1164C>G | synonymous_variant | 0.15 | ethambutol | |
embC | 4241035 | c.1173G>A | synonymous_variant | 0.17 | ethambutol | |
embC | 4241050 | c.1188T>G | synonymous_variant | 0.14 | ethambutol | |
embC | 4242023 | p.Val721Leu | missense_variant | 1.0 | ethambutol | |
embA | 4245071 | c.1839G>A | synonymous_variant | 0.93 | ethambutol | |
ethA | 4327364 | p.Lys37Arg | missense_variant | 1.0 | ethionamide |