TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.8	Euro-American (mainly T)	RD219	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.28	kanamycin	Uncertain significance	Mutation from literature
amikacin	Uncertain significance	Mutation from literature
capreomycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.26	kanamycin	Assoc w R
amikacin	Assoc w R
capreomycin	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
fbiC	1303747	p.Thr273Ala	missense_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.31	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.32	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>G	non_coding_transcript_exon_variant	0.15	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472396	n.551A>T	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472400	n.555C>T	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472507	n.662C>A	non_coding_transcript_exon_variant	0.2	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472522	n.677T>G	non_coding_transcript_exon_variant	0.24	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>T	non_coding_transcript_exon_variant	0.31	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472582	n.737G>T	non_coding_transcript_exon_variant	0.25	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472585	n.740A>C	non_coding_transcript_exon_variant	0.27	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472623	n.778A>C	non_coding_transcript_exon_variant	0.55	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.44	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.21	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472675	n.830T>C	non_coding_transcript_exon_variant	0.22	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472677	n.832C>A	non_coding_transcript_exon_variant	0.21	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472682	n.837T>A	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472683	n.838T>C	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472687	n.842A>T	non_coding_transcript_exon_variant	0.21	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472707	n.862A>T	non_coding_transcript_exon_variant	0.24	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472767	n.922G>C	non_coding_transcript_exon_variant	0.22	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472812	n.967A>T	non_coding_transcript_exon_variant	0.16	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472954	n.1110delC	non_coding_transcript_exon_variant	0.19	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472958	n.1113_1114insC	non_coding_transcript_exon_variant	0.2	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.25	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472986	n.1141_1142insA	non_coding_transcript_exon_variant	0.19	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472989	n.1145delA	non_coding_transcript_exon_variant	0.22	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472996	n.1151T>C	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473081	n.1236C>T	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.24	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473226	n.1381C>G	non_coding_transcript_exon_variant	0.23	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.23	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.26	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473324	n.1479G>A	non_coding_transcript_exon_variant	0.21	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin
rrl	1473916	n.259C>A	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1473916	n.259C>A	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1473922	n.265A>G	non_coding_transcript_exon_variant	0.16	capreomycin
rrl	1473922	n.265A>G	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1473923	n.266C>G	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1473923	n.266C>G	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	linezolid	Not assoc w R
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.17	capreomycin
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1474264	n.607T>G	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1474264	n.607T>G	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1474265	n.608G>T	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1474265	n.608G>T	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1474266	n.609T>C	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1474266	n.609T>C	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1474269	n.612C>A	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1474269	n.612C>A	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1474271	n.614A>G	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1474271	n.614A>G	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1474275	n.618T>G	non_coding_transcript_exon_variant	0.16	capreomycin
rrl	1474275	n.618T>G	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.32	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.38	linezolid	Uncertain significance
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1475747	n.2090A>G	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1475747	n.2090A>G	non_coding_transcript_exon_variant	0.21	linezolid	Uncertain significance
rrl	1475751	n.2094C>A	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1475751	n.2094C>A	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1475753	n.2096C>T	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1475756	n.2099_2107delTAACCCGCAinsG	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1475756	n.2099_2107delTAACCCGCAinsG	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1475767	n.2110G>T	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1475767	n.2110G>T	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1475770	n.2113_2114delGAinsATGCGT	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1475770	n.2113_2114delGAinsATGCGT	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.18	capreomycin
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.18	linezolid
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.33	capreomycin
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.21	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.14	linezolid	Uncertain significance
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.16	capreomycin	Not assoc w R
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.19	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.19	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.19	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.19	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.17	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.17	capreomycin
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.12	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.12	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.12	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.12	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.12	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.12	linezolid	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.3	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.28	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.33	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.21	linezolid
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
PPE35	2168728	p.Gly629Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
clpC1	4038501	p.Ile735Thr	missense_variant	1.0	pyrazinamide
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
amikacin	rrs	n.1484G>T	Assoc w R
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1484G>T	Assoc w R
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1484G>T	Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result