Run ID: ERR266122
Sample name:
Date: 2024-03-26T15:52:40.780737
Number of reads: 7032812
Percentage reads mapped: 96.64
Median coverage: 141.0
Strain: La3;M.canetti
Spoligotype:
Drug-resistance: Other
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| La3 | M.orygis | None | 0.39 |
| M.canetti | M.canetti | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | mmpR5 | c.442_444delAACinsCA | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | mmpR5 | c.442_444delAACinsCA | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| mmpR5 | 779431 | c.442_444delAACinsCA | frameshift_variant&missense_variant | 1.0 | clofazimine | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| bedaquiline | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| dnaA | 92 | p.Ser31Asn | missense_variant | 1.0 | isoniazid | |
| gyrB | 5452 | c.213G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 5731 | c.492C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6007 | c.768C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6454 | c.1215C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6721 | c.1482C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 7093 | c.1854T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7835 | c.534A>G | synonymous_variant | 0.99 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7988 | c.687G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8714 | c.1413A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9182 | c.1881T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9377 | c.2076A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9716 | c.2415T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9740 | c.2439G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9776 | c.2475T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
| fgd1 | 490666 | c.-117G>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490678 | c.-105_-104insG | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490687 | c.-96T>C | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490734 | c.-49A>T | upstream_gene_variant | 0.23 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491406 | p.Met208Ile | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| mshA | 575060 | c.-288G>C | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 575133 | c.-215C>T | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | Uncertain significance | |||||
| mshA | 575665 | c.318G>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| mshA | 575971 | c.624C>T | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 576285 | p.Val313Ala | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 576757 | c.1410C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| ccsA | 620256 | c.366C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620257 | p.Ile123Ala | missense_variant | 0.99 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620490 | c.600A>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620808 | c.918T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| Rv0565c | 656511 | p.His320Gln | missense_variant | 1.0 | ethionamide | |
| Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv0565c | 657273 | c.198G>A | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | |
| hadA | 731852 | c.-78A>G | upstream_gene_variant | 1.0 | isoniazid | |
| hadA | 732379 | c.450A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| nusG | 733883 | c.-370_-368delGCG | upstream_gene_variant | 1.0 | rifampicin | |
| rpoB | 759741 | c.-66C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
| rpoC | 763660 | c.291T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764152 | c.783C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765478 | c.2109T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766912 | c.3543C>T | synonymous_variant | 1.0 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 778057 | p.Ser142Gly | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778573 | c.-93C>G | upstream_gene_variant | 0.99 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779283 | c.-803G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779295 | c.-815A>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779472 | c.-992G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779523 | c.-618T>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779538 | c.-633A>C | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779539 | c.-634C>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
| rpsL | 781456 | c.-104A>G | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| rplC | 800111 | c.-698C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800155 | c.-654_-653insG | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800970 | c.162T>C | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| rplC | 801003 | c.195G>A | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| Rv1129c | 1253092 | c.1441_1443delTCGinsGT | frameshift_variant&missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253095 | c.1440G>C | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253101 | c.1434T>C | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253170 | c.1365C>T | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253173 | c.1362G>A | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1253178 | p.Thr453Pro | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253179 | c.1356A>C | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1253216 | p.Glu440Ala | missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253222 | p.Ser438Thr | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253233 | c.1302G>C | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1253263 | c.1272T>C | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253299 | c.1236C>T | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253311 | c.1224G>A | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1253329 | c.1206G>A | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253338 | c.1197T>C | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253365 | c.1170G>A | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253368 | c.1165_1167delAGGinsCA | frameshift_variant&missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253371 | c.1164C>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253377 | c.1158C>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253408 | p.Glu376Gly | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253410 | c.1125A>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253569 | c.966C>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253653 | c.882T>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253704 | c.831G>A | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253787 | p.Gly250Cys | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253790 | p.Val249Leu | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253824 | c.711G>A | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253888 | p.Ala216Val | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254110 | p.Thr142Ile | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254121 | c.414A>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254124 | c.411C>T | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1254128 | p.Gly136Ala | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254133 | c.402A>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254214 | c.321A>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254313 | c.222G>A | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254346 | c.189T>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254403 | c.132A>G | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1254434 | p.Val34Ala | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| Rv1129c | 1254572 | c.-38T>A | upstream_gene_variant | 0.98 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1254576 | c.-42C>T | upstream_gene_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1254602 | c.-68C>T | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254610 | c.-76A>C | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254654 | c.-120A>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254678 | c.-144A>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254690 | c.-156T>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| fbiC | 1302694 | c.-237C>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303857 | c.927C>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| Rv1258c | 1406466 | p.Ser292Leu | missense_variant | 1.0 | streptomycin | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| pyrazinamide | Uncertain significance | |||||
| Rv1258c | 1406492 | c.849C>A | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| pyrazinamide | Not assoc w R - Interim | |||||
| Rv1258c | 1407559 | c.-219C>T | upstream_gene_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| embR | 1417294 | c.54A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embR | 1417454 | c.-107C>A | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417554 | c.-207C>G | upstream_gene_variant | 0.99 | ethambutol | |
| embR | 1417925 | c.-578C>T | upstream_gene_variant | 1.0 | ethambutol | |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471850 | n.5_6delGTinsTGG | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrl | 1473658 | n.1T>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1474438 | n.781A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| fabG1 | 1673257 | c.-183C>G | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674816 | c.615T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| rpsA | 1833367 | c.-175G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833370 | c.-172G>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833381 | c.-161T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833435 | c.-107G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833471 | c.-71_-70insC | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833512 | c.-29delC | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833554 | p.Thr5Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1833568 | c.27G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834169 | p.Thr210Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1834912 | c.1371A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
| tlyA | 1917606 | c.-334G>C | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917807 | c.-133T>G | upstream_gene_variant | 0.99 | capreomycin | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
| tlyA | 1918149 | c.210A>C | synonymous_variant | 1.0 | capreomycin | |
| tlyA | 1918150 | p.Val71Leu | missense_variant | 1.0 | capreomycin | |
| tlyA | 1918242 | c.303G>C | synonymous_variant | 1.0 | capreomycin | |
| tlyA | 1918587 | p.Gln216His | missense_variant | 0.99 | capreomycin | |
| tlyA | 1918604 | p.Ser222Thr | missense_variant | 1.0 | capreomycin | |
| bacA | 2061041 | c.1898_*1767del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | streptomycin | Not assoc w R |
| kanamycin | Not assoc w R | |||||
| capreomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| bacA | 2064378 | c.351C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| kanamycin | Not assoc w R - Interim | |||||
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| ndh | 2101777 | c.1266C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| delamanid | ||||||
| isoniazid | Not assoc w R - Interim | |||||
| ndh | 2102353 | p.Gln230His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| delamanid | ||||||
| isoniazid | Uncertain significance | |||||
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
| katG | 2156055 | c.57C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2156658 | c.-547A>G | upstream_gene_variant | 1.0 | isoniazid | |
| PPE35 | 2167777 | p.Leu946Val | missense_variant | 0.99 | pyrazinamide | |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 0.99 | pyrazinamide | Not assoc w R |
| PPE35 | 2168522 | c.2091T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168531 | c.2082G>A | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168564 | c.2049T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168567 | c.2046A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168575 | p.Ala680Pro | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168588 | c.2025G>A | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168621 | c.1992C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168633 | c.1980C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169461 | p.Val384Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169605 | c.1008T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169623 | c.990T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169643 | p.Ala324Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169668 | c.945C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169686 | c.927T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169717 | p.Asn299Ile | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169740 | c.873C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169767 | c.846A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169779 | c.834A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169809 | c.804A>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169819 | p.Asn265Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169839 | c.774C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169857 | c.756A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169887 | c.726C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169932 | c.681C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169940 | p.Gly225Arg | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169948 | p.Asn222Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169956 | c.657T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169959 | c.654C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169974 | c.639T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169977 | c.636C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169989 | c.624C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169992 | c.621C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169996 | p.Ser206Asn | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169998 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170010 | c.603G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170016 | c.597C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170028 | p.Met195Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170035 | p.Val193Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170125 | p.Val163Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170133 | c.480G>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170148 | c.465T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170156 | p.Ala153Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170169 | c.444A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170175 | c.438G>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170232 | c.381T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170246 | p.Ser123Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170247 | p.Ile122Met | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170250 | c.363G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170261 | p.Ile118Val | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170267 | p.Gly116Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170268 | c.345C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170306 | p.Ala103Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170314 | p.Val100Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170319 | c.294G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170330 | p.Ala95Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170334 | p.Met93Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170351 | p.Thr88Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170485 | p.Val43Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170499 | c.114A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170505 | c.108C>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170511 | c.102G>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170553 | c.60C>A | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170585 | p.Ile10Val | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170601 | c.12A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170620 | c.-9_-8insT | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170671 | c.-59G>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170676 | c.-64A>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170677 | c.-65G>A | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170679 | c.-67A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170681 | c.-69G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170690 | c.-78A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170693 | c.-81C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170694 | c.-82T>C | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170695 | c.-83C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170703 | c.-91T>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170717 | c.-105C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170720 | c.-108A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170722 | c.-110G>A | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170723 | c.-111C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170726 | c.-115delT | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170766 | c.-154T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170770 | c.-158T>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170780 | c.-168G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170796 | c.-184C>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170809 | c.-198delA | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170812 | c.-200G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170839 | c.-227C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170848 | c.-236A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170849 | c.-237T>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170858 | c.-246A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170860 | c.-248A>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170868 | c.-256T>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170871 | c.-259A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170890 | c.-278G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170895 | c.-283C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170924 | c.-312T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2222357 | p.Thr270Ala | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2223318 | c.-154A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| pncA | 2288855 | c.387T>C | synonymous_variant | 1.0 | pyrazinamide | |
| pncA | 2289104 | c.138A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| pncA | 2289323 | c.-82G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289664 | c.-423G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289820 | c.-579T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2290120 | c.-879T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| kasA | 2517969 | c.-146C>T | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518265 | p.Val51Ile | missense_variant | 1.0 | isoniazid | |
| kasA | 2518279 | c.165T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518282 | c.168A>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518283 | c.169_171delGCGinsCC | frameshift_variant&missense_variant | 1.0 | isoniazid | |
| kasA | 2518297 | c.183C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518300 | c.186T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519041 | c.927C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519077 | c.963G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519287 | c.1173T>C | synonymous_variant | 1.0 | isoniazid | |
| eis | 2714808 | c.525T>C | synonymous_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2714901 | c.432A>G | synonymous_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2715146 | c.187C>T | synonymous_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2715535 | c.-203T>G | upstream_gene_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2715541 | c.-209A>G | upstream_gene_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2715574 | c.-242T>C | upstream_gene_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| ahpC | 2725905 | c.-288C>A | upstream_gene_variant | 1.0 | isoniazid | |
| ahpC | 2726052 | c.-141C>T | upstream_gene_variant | 0.99 | isoniazid | |
| ahpC | 2726226 | p.Ala12Thr | missense_variant | 1.0 | isoniazid | |
| folC | 2746174 | c.1425A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2746266 | p.Ser445Ala | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2746515 | c.1084C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2746519 | c.1080T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2746771 | c.828A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747425 | c.174C>G | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| folC | 2747549 | p.Val17Ala | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747607 | c.-9T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747628 | c.-30G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747631 | c.-33C>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747675 | c.-77A>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747681 | c.-83G>A | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747691 | c.-93A>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2477c | 2783065 | c.978C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2783086 | p.Asn319Ser | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783092 | c.951A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2783095 | c.948C>A | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784342 | c.-300G>A | upstream_gene_variant | 0.99 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784432 | c.-390A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784569 | c.-527G>T | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| pepQ | 2859490 | p.Val310Ala | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| ribD | 2987505 | c.667C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| ribD | 2987614 | c.766delA | frameshift_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2680 | 2995798 | c.-307T>C | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2680 | 2996009 | c.-96T>C | upstream_gene_variant | 0.88 | capreomycin | Uncertain significance |
| Rv2680 | 2996010 | c.-95C>A | upstream_gene_variant | 0.87 | capreomycin | Uncertain significance |
| Rv2680 | 2996054 | c.-51T>G | upstream_gene_variant | 0.18 | capreomycin | |
| Rv2680 | 2996091 | c.-14A>T | upstream_gene_variant | 0.21 | capreomycin | |
| Rv2680 | 2996105 | p.Leu1? | start_lost | 0.21 | capreomycin | Uncertain significance |
| Rv2681 | 2997054 | p.Ser106Gly | missense_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2681 | 2997059 | c.321C>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997293 | c.555G>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2752c | 3064627 | p.Asn522Ser | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3065573 | p.Glu207Gln | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| thyX | 3067239 | p.Ala236Asp | missense_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067874 | c.72C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067980 | c.-35T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074160 | c.312A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074445 | c.27C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074529 | c.-58G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074580 | c.-109T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074596 | c.-125T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| ald | 3086623 | c.-197A>G | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086661 | c.-159G>A | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086671 | c.-149T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086707 | c.-113G>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086733 | c.-87G>A | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086737 | c.-83T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086744 | c.-76A>T | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086753 | c.-67A>G | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086760 | c.-60A>T | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086771 | c.-49T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086773 | c.-47A>G | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086788 | c.-32T>A | upstream_gene_variant | 0.99 | cycloserine | |
| ald | 3086797 | c.-23G>A | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086803 | c.-17T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3087020 | c.201C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087065 | c.246C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087070 | p.Arg84Leu | missense_variant | 1.0 | cycloserine | |
| ald | 3087074 | c.255G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087077 | c.258A>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087079 | p.His87Arg | missense_variant | 1.0 | cycloserine | |
| ald | 3087140 | c.321G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087149 | c.330C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087152 | c.333C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087155 | c.336C>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087158 | c.339G>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087164 | c.345T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087316 | p.Val166Ala | missense_variant | 1.0 | cycloserine | |
| ald | 3087344 | c.525C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087380 | c.561C>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087381 | p.Asn188Gly | missense_variant | 1.0 | cycloserine | |
| ald | 3087401 | c.582T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087500 | c.681T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087512 | c.693T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087527 | c.708T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087533 | c.714C>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087554 | c.735G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087560 | c.741C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087644 | c.825C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087653 | c.834A>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087743 | c.924G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087758 | c.939G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087800 | p.His327Gln | missense_variant | 1.0 | cycloserine | |
| ald | 3087833 | c.1014A>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087857 | c.1038C>T | synonymous_variant | 1.0 | cycloserine | |
| fbiD | 3339049 | c.-69C>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiD | 3339402 | c.285C>T | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| fbiD | 3339568 | c.451C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| Rv3083 | 3448325 | c.-179G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448403 | c.-101G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448453 | c.-51G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448474 | c.-30G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448495 | c.-9G>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448588 | p.Asp29Asn | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448611 | c.108A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448905 | c.402T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448972 | p.His157Asp | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449028 | c.525T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449029 | p.Ser176Ala | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449237 | p.Arg245Lys | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449305 | c.802T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449400 | c.897C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449421 | c.918T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449622 | c.1119T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449652 | c.1149T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449767 | p.Thr422Val | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449778 | c.1275T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449802 | c.1299T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449820 | c.1317G>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449832 | c.1329T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449835 | c.1332G>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449868 | c.1365C>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449877 | c.1374T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449885 | p.Arg461Lys | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449940 | c.1437T>C | synonymous_variant | 1.0 | ethionamide | |
| lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3625006 | c.1608A>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3626461 | c.153A>G | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3626999 | c.351G>A | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3627190 | c.160T>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3627734 | c.-385A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627802 | c.-453T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627831 | c.-482T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627839 | c.-490T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| fbiB | 3641840 | c.306T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642254 | c.720G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642467 | c.933T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642852 | p.Pro440Ser | missense_variant | 1.0 | clofazimine | Uncertain significance |
| pretomanid | ||||||
| delamanid | Uncertain significance | |||||
| fbiB | 3642874 | p.Leu447Arg | missense_variant | 1.0 | clofazimine | Uncertain significance |
| pretomanid | ||||||
| delamanid | Uncertain significance | |||||
| alr | 3840207 | p.Ala405Asp | missense_variant | 0.99 | cycloserine | |
| alr | 3840527 | c.894A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840719 | c.702A>G | synonymous_variant | 0.99 | cycloserine | |
| alr | 3840914 | c.507G>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840994 | p.His143Asp | missense_variant | 1.0 | cycloserine | |
| alr | 3841112 | c.309T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841116 | p.Ala102Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841172 | c.249A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841199 | c.222T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841419 | p.Val1Ala | missense_variant | 1.0 | cycloserine | |
| rpoA | 3877527 | c.981C>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877740 | c.768G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877886 | c.622C>T | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877887 | c.621G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878001 | c.507A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878049 | c.459G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878623 | c.-116C>T | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3878637 | c.-130G>A | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3878665 | c.-158A>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878722 | c.-215C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878746 | c.-239A>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878848 | c.-341C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878961 | c.-454C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878962 | c.-455G>A | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878968 | c.-461T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3879193 | c.-686G>A | upstream_gene_variant | 1.0 | rifampicin | |
| ddn | 3986805 | c.-39G>C | upstream_gene_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| ddn | 3987050 | c.207C>T | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| ddn | 3987287 | c.444T>C | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| clpC1 | 4038227 | c.2478G>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038443 | c.2262G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038683 | c.2022T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038746 | c.1959C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038779 | c.1926C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038848 | c.1857C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038860 | c.1845G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038878 | c.1827A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038974 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039046 | c.1659C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039058 | c.1647C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039094 | c.1611C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039100 | c.1605C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039274 | c.1431G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039336 | c.1369C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039352 | c.1353C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039448 | c.1257A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039454 | c.1251A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039502 | c.1203C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039682 | c.1023C>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039700 | c.1005C>T | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039718 | c.987C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039817 | c.888A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039820 | c.885T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039823 | c.882T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040045 | c.660C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040048 | c.657C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040063 | c.642G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040090 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040093 | c.612C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040147 | c.558A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040159 | c.546G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040162 | c.543G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040213 | c.492T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040267 | c.438A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040273 | c.432T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040276 | c.429C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040279 | c.426C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040363 | c.342A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040393 | c.312G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040411 | c.294T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040423 | c.282A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040450 | c.255A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040471 | c.234T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040480 | c.225T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040534 | c.171A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040551 | c.154T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040573 | c.132T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040657 | c.48T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040879 | c.-177_-175delTGGinsCGGT | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4043932 | p.Met117Thr | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| panD | 4044243 | c.39C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| panD | 4044533 | c.-252T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044569 | c.-289_-288delCGinsGC | upstream_gene_variant | 1.0 | pyrazinamide | |
| glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| glpK | 4138736 | c.1020C>T | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138883 | c.873C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139183 | c.572dupG | frameshift_variant | 1.0 | ethambutol | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| glpK | 4139321 | c.435T>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139420 | c.336T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139813 | c.-58T>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4139934 | c.-179A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| embC | 4239032 | c.-831T>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239110 | c.-753C>T | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239764 | c.-99G>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4240237 | c.375G>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4243377 | p.Ser49Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243690 | p.Met153Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243919 | c.687G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4244154 | p.Thr308Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4244312 | c.1080T>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245023 | c.1791A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245701 | c.2469G>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embB | 4247815 | c.1302C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248195 | p.Lys561Met | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248439 | c.1926C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248664 | c.2151G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248721 | c.2208C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248744 | p.Val744Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248853 | c.2340G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4249069 | c.2556A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| aftB | 4268331 | p.Gln169Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| aftB | 4268810 | c.27G>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269588 | c.246G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269811 | p.Gln8Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| ethA | 4326463 | c.1011C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| ethA | 4326740 | p.Arg245His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| ethR | 4327547 | c.-2_-1insA | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
| amikacin | Not assoc w R | |||||
| kanamycin | Not assoc w R | |||||
| whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338741 | c.-220A>G | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338785 | c.-266_-264delGGCinsAG | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338878 | c.-357C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| gid | 4407588 | c.615A>G | synonymous_variant | 0.99 | streptomycin | Not assoc w R |
| gid | 4408185 | c.18C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
