TB-Profiler result

Run: ERR4817584
Summary

Run ID: ERR4817584

Sample name:

Date: 01-04-2023 15:04:44

Number of reads: 326831

Percentage reads mapped: 26.66

Strain: lineage3

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.5 rifampicin
rpoB 761196 p.Leu464Met missense_variant 0.29 rifampicin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.69 streptomycin
katG 2155964 c.146_147dupAC frameshift_variant 0.5 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 761037 c.1231T>C synonymous_variant 0.4
rpoB 761051 c.1245G>C synonymous_variant 0.33
rpoB 761054 c.1248G>C synonymous_variant 0.33
rpoB 761057 c.1251G>C synonymous_variant 0.33
rpoB 761060 c.1254C>G synonymous_variant 0.33
rpoB 761084 c.1278C>A synonymous_variant 0.5
rpoB 761132 c.1326G>T synonymous_variant 0.5
rpoB 761133 c.1327T>C synonymous_variant 0.6
rpoB 761147 c.1341C>T synonymous_variant 0.29
rpoB 761150 c.1344A>T synonymous_variant 0.5
rpoB 761156 c.1350G>C synonymous_variant 0.25
rpoB 761159 c.1353G>A synonymous_variant 0.5
rpoB 761165 c.1359G>T synonymous_variant 0.43
rpoB 761168 c.1362C>G synonymous_variant 0.25
rpoB 761180 c.1374A>C synonymous_variant 0.43
rpoB 761186 p.Glu460Asp missense_variant 0.33
rpoB 761189 c.1383T>C synonymous_variant 0.33
rpoB 761195 c.1389G>C synonymous_variant 0.29
rpoB 761201 c.1395G>A synonymous_variant 0.25
rpoB 761207 c.1401C>A synonymous_variant 0.22
rpoB 761213 c.1407G>C synonymous_variant 0.22
rpoB 761219 c.1413G>C synonymous_variant 0.22
rpoB 762024 p.Val740Ile missense_variant 0.5
rpoB 762051 p.His749Tyr missense_variant 0.4
rpoB 762057 p.Ile751Val missense_variant 0.5
rpoB 762062 c.2256T>C synonymous_variant 0.5
rpoB 762065 c.2259T>C synonymous_variant 0.67
rpoB 762071 p.Asp755Glu missense_variant 0.67
rpoB 762080 c.2274G>C synonymous_variant 0.67
rpoB 762085 p.Ala760Glu missense_variant 0.5
rpoB 762089 c.2283G>A synonymous_variant 0.5
rpoB 762110 c.2304G>C synonymous_variant 0.4
rpoB 762114 p.Ile770Val missense_variant 0.4
rpoB 762143 c.2337T>C synonymous_variant 0.25
rpoB 762149 c.2343G>C synonymous_variant 0.25
rpoB 762156 p.Val784Ile missense_variant 0.25
rpoB 762173 c.2367G>A synonymous_variant 0.25
rpoB 762176 c.2370T>C synonymous_variant 0.25
rpoB 762177 p.Arg791Thr missense_variant 0.29
rpoB 762181 p.Asp792Ala missense_variant 0.25
rpoB 762185 c.2379G>C synonymous_variant 0.29
rpoB 762191 c.2385C>T synonymous_variant 0.29
rpoB 762194 c.2388G>C synonymous_variant 0.25
rpoB 762200 c.2394C>T synonymous_variant 0.22
rpoB 762218 c.2412T>C synonymous_variant 0.29
rpoB 762221 c.2415G>A synonymous_variant 0.29
rpoB 762233 c.2427G>C synonymous_variant 0.6
rpoB 762239 c.2433G>A synonymous_variant 0.5
rpoB 762245 c.2439G>C synonymous_variant 0.67
rpoB 762254 c.2448T>C synonymous_variant 0.67
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoB 762858 p.Thr1018Ser missense_variant 0.38
rpoC 762863 c.-507T>C upstream_gene_variant 0.22
rpoB 762879 p.Met1025Leu missense_variant 0.38
rpoC 762887 c.-483G>C upstream_gene_variant 0.38
rpoC 762893 c.-477C>T upstream_gene_variant 0.2
rpoC 762896 c.-474G>C upstream_gene_variant 0.3
rpoC 762899 c.-471G>C upstream_gene_variant 0.18
rpoC 762902 c.-468C>T upstream_gene_variant 0.2
rpoC 762911 c.-459C>T upstream_gene_variant 0.2
rpoC 762917 c.-453C>T upstream_gene_variant 0.18
rpoC 762920 c.-450C>T upstream_gene_variant 0.2
rpoC 762926 c.-444C>G upstream_gene_variant 0.14
rpoC 762929 c.-441G>T upstream_gene_variant 0.57
rpoC 762938 c.-432G>C upstream_gene_variant 0.41
rpoC 762944 c.-426C>T upstream_gene_variant 0.19
rpoC 762956 c.-414G>T upstream_gene_variant 0.17
rpoC 762962 c.-408C>T upstream_gene_variant 0.41
rpoC 762971 c.-399G>C upstream_gene_variant 0.29
rpoC 762980 c.-390T>C upstream_gene_variant 0.15
rpoC 762983 c.-387C>T upstream_gene_variant 0.46
rpoC 762989 c.-381G>C upstream_gene_variant 0.62
rpoC 762995 c.-375G>T upstream_gene_variant 0.4
rpoB 763005 p.Cys1067Val missense_variant 0.45
rpoB 763017 p.Gln1071Glu missense_variant 0.56
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoB 763038 p.Thr1078Ala missense_variant 0.4
rpoC 763043 c.-327G>C upstream_gene_variant 0.4
rpoC 763049 c.-321G>A upstream_gene_variant 0.4
rpoC 763053 c.-317T>C upstream_gene_variant 0.5
rpoC 763070 c.-300T>C upstream_gene_variant 0.42
rpoB 763077 p.Val1091Thr missense_variant 0.42
rpoC 763082 c.-288C>T upstream_gene_variant 0.17
rpoC 763103 c.-267G>C upstream_gene_variant 0.42
rpoC 763115 c.-255T>C upstream_gene_variant 0.27
rpoB 763119 p.Asn1105Asp missense_variant 0.27
rpoC 763127 c.-243G>C upstream_gene_variant 0.2
rpoC 763133 c.-237G>C upstream_gene_variant 0.2
rpoC 763486 c.117T>C synonymous_variant 0.33
rpoC 763492 c.123G>C synonymous_variant 0.44
rpoC 763507 c.138G>C synonymous_variant 0.22
rpoC 763528 c.159G>C synonymous_variant 0.57
rpoC 763531 c.162G>C synonymous_variant 0.57
rpoC 763534 c.165T>C synonymous_variant 0.57
rpoC 763537 c.168C>G synonymous_variant 0.5
rpoC 763546 c.177A>G synonymous_variant 0.5
rpoC 763550 p.Tyr61Ala missense_variant 0.5
rpoC 763570 c.201G>C synonymous_variant 0.43
rpoC 763578 p.Phe70Tyr missense_variant 0.4
rpoC 763585 c.216C>G synonymous_variant 0.4
rpoC 763655 p.Glu96Lys missense_variant 0.25
rpoC 763660 c.291T>C synonymous_variant 0.25
rpoC 763669 c.300C>G synonymous_variant 0.25
rpoC 763675 c.306C>G synonymous_variant 0.3
rpoC 763699 c.330G>T synonymous_variant 0.64
rpoC 763708 c.339G>C synonymous_variant 0.69
rpoC 763714 c.345G>C synonymous_variant 0.71
rpoC 763717 c.348T>C synonymous_variant 0.71
rpoC 763718 p.Leu117Val missense_variant 0.69
rpoC 763723 c.354G>C synonymous_variant 0.69
rpoC 763724 p.Asp119Asn missense_variant 0.69
rpoC 763729 c.360G>C synonymous_variant 0.75
rpoC 763732 c.363C>G synonymous_variant 0.82
rpoC 763735 c.366G>C synonymous_variant 0.75
rpoC 763744 c.375G>C synonymous_variant 0.67
rpoC 763751 p.Ile128Val missense_variant 0.82
rpoC 763762 c.393C>T synonymous_variant 0.18
rpoC 763772 p.Val135Met missense_variant 0.8
rpoC 763781 p.Ser138Ala missense_variant 0.75
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.29
rpoC 764410 c.1041G>C synonymous_variant 0.29
rpoC 764424 p.Asn352Thr missense_variant 0.33
rpoC 764428 c.1059G>A synonymous_variant 0.33
rpoC 764431 c.1062G>C synonymous_variant 0.33
rpoC 764434 c.1065A>G synonymous_variant 0.33
rpoC 764435 c.1066_1068delAGGinsCGC synonymous_variant 0.33
rpoC 764441 p.Ile358Leu missense_variant 0.33
rpoC 764446 p.Asp359Glu missense_variant 0.33
rpoC 764455 c.1086G>C synonymous_variant 0.4
rpoC 764458 c.1089G>C synonymous_variant 0.5
rpoC 764461 c.1092A>G synonymous_variant 0.43
rpoC 764485 c.1116G>C synonymous_variant 0.57
rpoC 764491 c.1122G>T synonymous_variant 0.57
rpoC 764497 c.1128A>G synonymous_variant 0.5
rpoC 764503 c.1134G>T synonymous_variant 0.5
rpoC 764509 c.1140G>C synonymous_variant 0.6
rpoC 764512 c.1143G>C synonymous_variant 0.4
rpoC 764521 c.1152T>C synonymous_variant 0.5
rpoC 764536 c.1167G>C synonymous_variant 0.44
rpoC 764539 c.1170C>G synonymous_variant 0.2
rpoC 764542 c.1173C>T synonymous_variant 0.2
rpoC 764543 p.Thr392Ala missense_variant 0.4
rpoC 764548 c.1179G>C synonymous_variant 0.44
rpoC 764549 p.Pro394Val missense_variant 0.2
rpoC 764566 c.1197C>G synonymous_variant 0.43
rpoC 764581 c.1212T>C synonymous_variant 0.33
rpoC 764582 p.Leu405Met missense_variant 0.33
rpoC 764602 c.1233C>T synonymous_variant 0.38
rpoC 764605 c.1236G>T synonymous_variant 0.43
rpoC 764611 c.1242G>T synonymous_variant 0.5
rpoC 764626 c.1257C>T synonymous_variant 0.64
rpoC 764632 c.1263T>C synonymous_variant 0.65
rpoC 764647 c.1278C>T synonymous_variant 0.81
rpoC 764650 c.1281G>T synonymous_variant 0.88
rpoC 764653 c.1284G>C synonymous_variant 0.76
rpoC 764656 c.1287C>G synonymous_variant 0.69
rpoC 764662 c.1293G>C synonymous_variant 0.78
rpoC 764677 c.1308C>G synonymous_variant 0.71
rpoC 764678 p.Lys437Gln missense_variant 0.71
rpoC 764701 c.1332C>G synonymous_variant 0.48
rpoC 764706 p.Leu446Gln missense_variant 0.78
rpoC 764713 c.1344G>C synonymous_variant 0.71
rpoC 764731 c.1362G>C synonymous_variant 0.43
rpoC 764737 c.1368G>C synonymous_variant 0.43
rpoC 765923 p.Asn852Ala missense_variant 0.33
rpoC 765937 c.2568T>C synonymous_variant 0.4
rpoC 765947 c.2578T>C synonymous_variant 0.33
rpoC 765958 c.2589C>G synonymous_variant 0.29
rpoC 765962 c.2593T>C synonymous_variant 0.29
rpoC 765988 c.2619G>C synonymous_variant 0.29
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781796 p.Met79Ile missense_variant 0.5
rpsL 781802 c.243G>C synonymous_variant 0.5
rpsL 781811 c.252C>T synonymous_variant 0.5
rpsL 781814 c.255C>T synonymous_variant 0.5
rpsL 781817 c.258G>T synonymous_variant 0.5
rpsL 781826 c.267C>T synonymous_variant 0.33
rpsL 781832 c.273T>C synonymous_variant 0.36
rpsL 781835 c.276T>C synonymous_variant 0.36
rpsL 781841 c.282C>T synonymous_variant 0.5
rpsL 781845 p.Lys96Arg missense_variant 0.5
rpsL 781851 p.Ile98Val missense_variant 0.5
rpsL 781868 c.309T>C synonymous_variant 0.57
rpsL 781871 c.312G>C synonymous_variant 0.5
Rv1258c 1406601 p.Phe247Ser missense_variant 0.25
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471853 n.8T>C non_coding_transcript_exon_variant 0.5
rrs 1472068 n.223T>G non_coding_transcript_exon_variant 0.88
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.79
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.94
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.22
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.77
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.36
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.15
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.65
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.7
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.72
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.97
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.13
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.7
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.63
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.3
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.29
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.96
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.32
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.45
rrs 1472274 n.429A>G non_coding_transcript_exon_variant 0.14
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.8
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 1.0
rrs 1472330 n.485G>T non_coding_transcript_exon_variant 1.0
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 1.0
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 1.0
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.83
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.33
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.57
rrs 1472412 n.567A>G non_coding_transcript_exon_variant 0.33
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.33
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.33
rrs 1472427 n.582T>G non_coding_transcript_exon_variant 0.33
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.75
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 1.0
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 1.0
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 1.0
rrs 1472447 n.602C>T non_coding_transcript_exon_variant 1.0
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 1.0
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.67
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 1.0
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 1.0
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.75
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 1.0
rrs 1472504 n.659A>T non_coding_transcript_exon_variant 0.15
rrs 1472505 n.660G>A non_coding_transcript_exon_variant 0.14
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.39
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.3
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.52
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.52
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.72
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.71
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.71
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.7
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.14
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.7
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.78
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.62
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.41
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.89
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.97
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.22
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.76
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.77
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.55
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.23
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.92
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.93
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.41
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.55
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.47
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.38
rrs 1472687 n.843dupT non_coding_transcript_exon_variant 1.0
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.7
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.38
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.14
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.65
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.34
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.63
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.68
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.67
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.68
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.36
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.63
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.64
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 1.0
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.31
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.4
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 1.0
rrs 1472840 n.995A>G non_coding_transcript_exon_variant 1.0
rrs 1472875 n.1030T>C non_coding_transcript_exon_variant 0.67
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.95
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.25
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.46
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.27
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.89
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.8
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.16
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 1.0
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 1.0
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.13
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.27
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.13
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.22
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.94
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.51
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.57
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.95
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.93
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.95
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.93
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.3
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.37
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.96
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.88
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.91
rrs 1473101 n.1256C>T non_coding_transcript_exon_variant 0.19
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.69
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.96
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.96
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.98
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.41
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.97
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.52
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.34
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.91
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.87
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.51
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.63
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.75
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.91
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.94
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 1.0
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.8
rrs 1473293 n.1449delA non_coding_transcript_exon_variant 0.73
rrs 1473293 n.1449A>G non_coding_transcript_exon_variant 0.54
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.72
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 1.0
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 1.0
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.97
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.13
rrs 1473352 n.1507C>T non_coding_transcript_exon_variant 0.22
rrl 1473697 n.40C>G non_coding_transcript_exon_variant 1.0
rrl 1473698 n.41G>C non_coding_transcript_exon_variant 1.0
rrl 1473699 n.42A>T non_coding_transcript_exon_variant 1.0
rrl 1473719 n.62G>A non_coding_transcript_exon_variant 1.0
rrl 1473728 n.71A>T non_coding_transcript_exon_variant 1.0
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 1.0
rrl 1473750 n.93C>T non_coding_transcript_exon_variant 1.0
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 1.0
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 1.0
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 1.0
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.89
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.94
rrl 1474200 n.545delT non_coding_transcript_exon_variant 1.0
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.96
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.11
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.25
rrl 1474271 n.614A>G non_coding_transcript_exon_variant 0.29
rrl 1474272 n.615C>T non_coding_transcript_exon_variant 0.29
rrl 1474275 n.618T>C non_coding_transcript_exon_variant 0.5
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.6
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 1.0
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 1.0
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.83
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.83
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.62
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.62
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.62
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.78
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.6
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.22
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.2
rrl 1474531 n.874G>C non_coding_transcript_exon_variant 0.2
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.9
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.22
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.25
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.56
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.22
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.33
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.4
rrl 1474634 n.977T>G non_coding_transcript_exon_variant 0.43
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 0.93
rrl 1474637 n.980C>G non_coding_transcript_exon_variant 0.5
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.93
rrl 1474643 n.986A>G non_coding_transcript_exon_variant 0.47
rrl 1474658 n.1001A>G non_coding_transcript_exon_variant 0.27
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.91
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.56
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.33
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.88
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.88
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 1.0
rrl 1474706 n.1049G>A non_coding_transcript_exon_variant 0.57
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 1.0
rrl 1474734 n.1077G>C non_coding_transcript_exon_variant 1.0
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0
rrl 1474774 n.1117A>G non_coding_transcript_exon_variant 0.15
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 1.0
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 1.0
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 1.0
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.47
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.94
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.8
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 1.0
rrl 1475059 n.1403_1404insTA non_coding_transcript_exon_variant 1.0
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 1.0
rrl 1475065 n.1409_1411delCAA non_coding_transcript_exon_variant 1.0
rrl 1475080 n.1425_1426delCC non_coding_transcript_exon_variant 1.0
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 1.0
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 1.0
rrl 1475109 n.1452C>T non_coding_transcript_exon_variant 0.5
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 1.0
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 1.0
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 1.0
rrl 1475518 n.1861A>G non_coding_transcript_exon_variant 0.75
rrl 1475521 n.1864T>C non_coding_transcript_exon_variant 0.78
rrl 1475522 n.1865A>T non_coding_transcript_exon_variant 0.22
rrl 1475526 n.1869C>T non_coding_transcript_exon_variant 1.0
rrl 1475529 n.1872A>G non_coding_transcript_exon_variant 0.78
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.22
rrl 1475532 n.1875A>T non_coding_transcript_exon_variant 0.78
rrl 1475538 n.1881T>C non_coding_transcript_exon_variant 0.75
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.25
rrl 1475542 n.1885A>G non_coding_transcript_exon_variant 0.22
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.33
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.33
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.67
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.78
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.33
rrl 1475715 n.2058G>C non_coding_transcript_exon_variant 0.33
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.6
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.25
rrl 1475754 n.2097G>A non_coding_transcript_exon_variant 0.43
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.71
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 1.0
rrl 1475774 n.2117C>T non_coding_transcript_exon_variant 0.33
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.78
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.23
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 1.0
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 1.0
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.6
rrl 1475892 n.2235A>G non_coding_transcript_exon_variant 0.22
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.29
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.29
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.86
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.86
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.29
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.43
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 1.0
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 1.0
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.5
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.75
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.75
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.75
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 1.0
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.57
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.57
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.5
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.25
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.67
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.75
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.5
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.5
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.67
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.67
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.33
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.33
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.33
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.23
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.46
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.73
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.36
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.2
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.5
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.91
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.58
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.42
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.75
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.75
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.75
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 1.0
rrl 1476307 n.2650A>T non_coding_transcript_exon_variant 1.0
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.75
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.14
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.17
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.91
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.92
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.83
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.59
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.71
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.9
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.82
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.79
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.6
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.76
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.35
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.12
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.4
rrl 1476535 n.2878G>A non_coding_transcript_exon_variant 0.27
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.5
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.6
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 1.0
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.71
rrl 1476542 n.2885T>C non_coding_transcript_exon_variant 0.35
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.44
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 1.0
rrl 1476592 n.2935G>A non_coding_transcript_exon_variant 0.2
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.2
rrl 1476600 n.2943A>C non_coding_transcript_exon_variant 0.5
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.22
rrl 1476605 n.2948C>T non_coding_transcript_exon_variant 0.22
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.44
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.78
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.88
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.71
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.88
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.83
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.88
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.29
rrl 1476633 n.2976A>G non_coding_transcript_exon_variant 0.5
rpsA 1833685 c.144G>C synonymous_variant 0.38
rpsA 1833688 c.147C>T synonymous_variant 0.22
rpsA 1833694 c.153G>C synonymous_variant 0.5
rpsA 1833721 c.180A>G synonymous_variant 0.25
rpsA 1833724 c.183C>T synonymous_variant 0.25
rpsA 1833727 c.186G>C synonymous_variant 0.5
rpsA 1833732 p.Pro64Leu missense_variant 0.38
rpsA 1833736 c.195C>T synonymous_variant 0.33
rpsA 1833742 c.201A>G synonymous_variant 0.38
rpsA 1833757 c.216C>T synonymous_variant 0.22
rpsA 1833770 p.Asn77Asp missense_variant 0.33
rpsA 1833776 p.Val79Ile missense_variant 0.22
rpsA 1834189 c.648G>C synonymous_variant 0.33
rpsA 1834195 c.654G>C synonymous_variant 0.5
rpsA 1834207 c.666C>T synonymous_variant 0.36
rpsA 1834210 c.669C>T synonymous_variant 0.14
rpsA 1834213 c.672G>C synonymous_variant 0.45
rpsA 1834219 c.678C>G synonymous_variant 0.13
rpsA 1834222 c.681T>C synonymous_variant 0.13
rpsA 1834225 c.684C>T synonymous_variant 0.31
rpsA 1834228 c.687C>T synonymous_variant 0.4
rpsA 1834231 c.690T>C synonymous_variant 0.12
rpsA 1834234 c.693G>C synonymous_variant 0.59
rpsA 1834240 c.699T>C synonymous_variant 0.55
rpsA 1834241 c.700C>T synonymous_variant 0.25
rpsA 1834246 c.705G>T synonymous_variant 0.76
rpsA 1834249 c.708T>C synonymous_variant 0.78
rpsA 1834261 c.720A>G synonymous_variant 0.76
rpsA 1834264 c.723G>C synonymous_variant 0.74
rpsA 1834285 c.744G>C synonymous_variant 0.12
rpsA 1834294 c.753G>C synonymous_variant 0.7
rpsA 1834298 p.Gln253Glu missense_variant 0.7
rpsA 1834306 c.765T>C synonymous_variant 0.63
rpsA 1834307 p.Asp256Gln missense_variant 0.61
rpsA 1834312 c.771G>A synonymous_variant 0.5
rpsA 1834327 c.786G>T synonymous_variant 0.5
rpsA 1834333 c.792C>T synonymous_variant 0.12
rpsA 1834345 c.804C>T synonymous_variant 0.42
rpsA 1834348 c.807T>C synonymous_variant 0.3
rpsA 1834354 c.813G>C synonymous_variant 0.25
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155604 p.Asn170Asp missense_variant 0.22
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223091 p.Asn25Ser missense_variant 0.4
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
eis 2714503 p.His277Arg missense_variant 0.15
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
folC 2746659 p.Gly314Ser missense_variant 0.15
ribD 2986971 p.Phe45Leu missense_variant 0.22
ribD 2987183 c.345G>A synonymous_variant 0.2
ribD 2987255 c.417A>G synonymous_variant 0.15
thyA 3074006 p.Asp156Asn missense_variant 0.33
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339414 c.297C>T synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3642098 c.564G>A synonymous_variant 1.0
clpC1 4039289 c.1416T>C synonymous_variant 0.2
clpC1 4039804 p.Ala301Ser missense_variant 0.33
clpC1 4039817 c.888A>T synonymous_variant 0.33
clpC1 4039820 c.885T>G synonymous_variant 0.33
clpC1 4039826 c.879C>G synonymous_variant 0.33
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.33
clpC1 4039838 p.Leu289Ile missense_variant 0.43
clpC1 4039865 c.840T>C synonymous_variant 0.38
clpC1 4039871 c.834C>G synonymous_variant 0.38
clpC1 4039875 p.Asn277Arg missense_variant 0.43
embC 4239932 p.Ala24Ser missense_variant 0.13
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246683 p.Asp57Val missense_variant 0.2
whiB6 4338591 c.-70G>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0