Run ID: SRR10177260
Sample name:
Date: 2024-04-15T22:06:39.108772
Number of reads: 1391457
Percentage reads mapped: 97.23
Median coverage: 39.0
Strain: M.canetti
Spoligotype:
Drug-resistance: Other
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| M.canetti | M.canetti | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | mmpR5 | c.442_444delAACinsCA | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | mmpR5 | c.442_444delAACinsCA | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| mmpR5 | 779431 | c.442_444delAACinsCA | frameshift_variant&missense_variant | 1.0 | bedaquiline | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| clofazimine | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 5452 | c.213G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6454 | c.1215C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6721 | c.1482C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 7093 | c.1854T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7763 | c.462T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7835 | c.534A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7937 | c.636A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7970 | c.669T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7988 | c.687G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8039 | c.738T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8054 | c.753T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8198 | c.897T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8219 | c.918T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8399 | c.1098T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8756 | c.1455A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8810 | c.1509A>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8813 | p.Asp504Glu | missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 8966 | c.1665C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9089 | c.1788G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9101 | c.1800A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9182 | c.1881T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9200 | c.1899A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9377 | c.2076A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9716 | c.2415T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9740 | c.2439G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9776 | c.2475T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
| fgd1 | 490666 | c.-117G>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490679 | c.-104delAinsGT | upstream_gene_variant | 0.63 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490679 | c.-105_-104insG | upstream_gene_variant | 0.37 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490679 | c.-104delAinsGT | upstream_gene_variant | 0.63 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490679 | c.-105_-104insG | upstream_gene_variant | 0.37 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490687 | c.-96T>C | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491181 | c.399T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491191 | p.Gly137Arg | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491196 | c.414A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491212 | p.Ser144Arg | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491310 | c.528C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| mshA | 575216 | c.-132C>A | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| mshA | 575665 | c.318G>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| mshA | 576757 | c.1410C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| ccsA | 620256 | c.366C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620257 | p.Ile123Ala | missense_variant | 1.0 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620490 | c.600A>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620808 | c.918T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | |
| hadA | 731852 | c.-78A>G | upstream_gene_variant | 1.0 | isoniazid | |
| hadA | 732379 | c.450A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| nusG | 733883 | c.-370_-368delGCG | upstream_gene_variant | 1.0 | rifampicin | |
| rpoB | 759741 | c.-66C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
| rpoC | 763660 | c.291T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764152 | c.783C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765478 | c.2109T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 779283 | c.-803G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779295 | c.-815A>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779472 | c.-992G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779523 | c.-618T>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779538 | c.-633A>C | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779539 | c.-634C>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
| rpsL | 781456 | c.-104A>G | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| rplC | 800111 | c.-698C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800155 | c.-654_-653insG | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800970 | c.162T>C | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| rplC | 801003 | c.195G>A | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| rplC | 801267 | c.459A>G | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| Rv1129c | 1253216 | p.Glu440Ala | missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253323 | c.1212G>T | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1253904 | p.Asn211Asp | missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| Rv1129c | 1254602 | c.-68C>T | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254654 | c.-120A>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254678 | c.-144A>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| fbiC | 1302694 | c.-237C>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302810 | c.-121C>T | upstream_gene_variant | 0.98 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302860 | c.-71G>A | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303695 | c.765T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304598 | c.1668C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| sigE | 1364547 | c.135G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv1258c | 1406466 | p.Ser292Leu | missense_variant | 1.0 | streptomycin | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| pyrazinamide | Uncertain significance | |||||
| Rv1258c | 1406492 | c.849C>A | synonymous_variant | 0.97 | streptomycin | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| pyrazinamide | Not assoc w R - Interim | |||||
| Rv1258c | 1407449 | c.-109G>T | upstream_gene_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| embR | 1417294 | c.54A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embR | 1417454 | c.-107C>A | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417748 | c.-401T>C | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1418025 | c.-678G>A | upstream_gene_variant | 1.0 | ethambutol | |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471850 | n.5_6delGTinsTGG | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrl | 1474438 | n.781A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| fabG1 | 1673257 | c.-183C>G | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674816 | c.615T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| rpsA | 1833381 | c.-161T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833554 | p.Thr5Ala | missense_variant | 0.97 | pyrazinamide | Uncertain significance |
| rpsA | 1833568 | c.27G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834169 | p.Thr210Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1834912 | c.1371A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
| tlyA | 1917606 | c.-334G>C | upstream_gene_variant | 0.98 | capreomycin | |
| tlyA | 1917812 | c.-128G>A | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
| bacA | 2061037 | c.1898_*1771del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | streptomycin | Not assoc w R |
| kanamycin | Not assoc w R | |||||
| capreomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| bacA | 2064378 | c.351C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| kanamycin | Not assoc w R - Interim | |||||
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| ndh | 2101777 | c.1266C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| delamanid | ||||||
| isoniazid | Not assoc w R - Interim | |||||
| ndh | 2102353 | p.Gln230His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| delamanid | ||||||
| isoniazid | Uncertain significance | |||||
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
| katG | 2156055 | c.57C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2156658 | c.-547A>G | upstream_gene_variant | 1.0 | isoniazid | |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
| PPE35 | 2169686 | c.927T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169717 | p.Asn299Ile | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170232 | c.381T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170394 | c.219G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170485 | p.Val43Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170694 | c.-82T>C | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170720 | c.-108A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170847 | c.-235T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170860 | c.-248A>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2222357 | p.Thr270Ala | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2223318 | c.-154A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| pncA | 2289104 | c.138A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| pncA | 2289700 | c.-459T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289827 | c.-586A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519287 | c.1173T>C | synonymous_variant | 1.0 | isoniazid | |
| eis | 2714714 | p.Ala207Thr | missense_variant | 1.0 | amikacin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| eis | 2714994 | c.339T>C | synonymous_variant | 1.0 | amikacin | Not assoc w R - Interim |
| kanamycin | Not assoc w R - Interim | |||||
| ahpC | 2725905 | c.-288C>A | upstream_gene_variant | 1.0 | isoniazid | |
| folC | 2747204 | p.Ala132Gln | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747572 | c.27T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747575 | c.24G>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747628 | c.-30G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747631 | c.-33C>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747691 | c.-93A>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2477c | 2783425 | c.618C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2784328 | c.-286C>T | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784432 | c.-390A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| pepQ | 2859490 | p.Val310Ala | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| ribD | 2986929 | p.Leu31Phe | missense_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2680 | 2995798 | c.-307T>C | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2680 | 2996440 | c.336G>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2680 | 2996578 | c.474C>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997054 | p.Ser106Gly | missense_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2681 | 2997059 | c.321C>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997122 | c.384A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997293 | c.555G>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2752c | 3064578 | c.1614C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv2752c | 3064971 | c.1221C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv2752c | 3065826 | c.366A>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv2752c | 3066687 | c.-496G>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066905 | c.-714T>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066996 | c.-805T>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3067066 | c.-875T>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| thyX | 3067355 | c.591A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067770 | p.Gly59Ala | missense_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067980 | c.-35T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074160 | c.312A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074238 | c.234C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074247 | c.225C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074529 | c.-58G>C | upstream_gene_variant | 0.97 | para-aminosalicylic_acid | |
| thyA | 3074580 | c.-109T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3087122 | c.303T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087140 | c.321G>A | synonymous_variant | 1.0 | cycloserine | |
| fbiD | 3339049 | c.-69C>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiD | 3339402 | c.285C>T | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| fbiD | 3339568 | c.451C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| Rv3083 | 3448349 | c.-155C>T | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448403 | c.-101G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448453 | c.-51G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448474 | c.-30G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448481 | c.-23G>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448484 | c.-20T>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448487 | c.-17T>G | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448495 | c.-9G>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448545 | c.42A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448588 | p.Asp29Asn | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448606 | c.103C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448611 | c.108A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448869 | p.His122Gln | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448905 | c.402T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448972 | p.His157Asp | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449028 | c.525T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449029 | p.Ser176Ala | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449400 | c.897C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449718 | c.1215C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449868 | c.1365C>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449877 | c.1374T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449885 | p.Arg461Lys | missense_variant | 1.0 | ethionamide | Uncertain significance |
| whiB7 | 3568687 | c.-8A>T | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| Rv3236c | 3611968 | c.1149T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612211 | c.906A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612250 | c.867A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612301 | c.816G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612541 | c.576G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612561 | p.Thr186Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| Rv3236c | 3612577 | c.540G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612580 | c.537C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612709 | c.408G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3613056 | c.61C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3625006 | c.1608A>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3626461 | c.153A>G | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3626999 | c.351G>A | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3627190 | c.160T>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3627715 | c.-366G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | Uncertain significance | |||||
| mtrA | 3627734 | c.-385A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627802 | c.-453T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627831 | c.-482T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627839 | c.-490T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| fbiB | 3641840 | c.306T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642254 | c.720G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642467 | c.933T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642852 | p.Pro440Ser | missense_variant | 1.0 | clofazimine | Uncertain significance |
| pretomanid | ||||||
| delamanid | Uncertain significance | |||||
| fbiB | 3642874 | p.Leu447Arg | missense_variant | 1.0 | clofazimine | Uncertain significance |
| pretomanid | ||||||
| delamanid | Uncertain significance | |||||
| alr | 3840527 | c.894A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840620 | c.801T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840719 | c.702A>G | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840796 | p.Asp209Asn | missense_variant | 1.0 | cycloserine | |
| alr | 3840914 | c.507G>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840994 | p.His143Asp | missense_variant | 1.0 | cycloserine | |
| alr | 3841112 | c.309T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841116 | p.Ala102Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841172 | c.249A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841365 | c.55_56insA | frameshift_variant | 1.0 | cycloserine | |
| alr | 3841419 | p.Val1Ala | missense_variant | 1.0 | cycloserine | |
| alr | 3841531 | c.-111A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841532 | c.-112A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841539 | c.-119C>T | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841546 | c.-126C>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841568 | c.-148G>A | upstream_gene_variant | 1.0 | cycloserine | |
| rpoA | 3877527 | c.981C>A | synonymous_variant | 0.98 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877740 | c.768G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877886 | c.622C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877887 | c.621G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878001 | c.507A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878049 | c.459G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878722 | c.-215C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878746 | c.-239A>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878848 | c.-341C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878961 | c.-454C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878962 | c.-455G>A | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878968 | c.-461T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3879193 | c.-686G>A | upstream_gene_variant | 1.0 | rifampicin | |
| ddn | 3986910 | c.67C>A | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| ddn | 3987050 | c.207C>T | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| ddn | 3987287 | c.444T>C | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| clpC1 | 4038227 | c.2478G>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038443 | c.2262G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038683 | c.2022T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038746 | c.1959C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038779 | c.1926C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038848 | c.1857C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038860 | c.1845G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038878 | c.1827A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038974 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039046 | c.1659C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039058 | c.1647C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039094 | c.1611C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039100 | c.1605C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039274 | c.1431G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039336 | c.1369C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039352 | c.1353C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039448 | c.1257A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039454 | c.1251A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039502 | c.1203C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039682 | c.1023C>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039700 | c.1005C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039718 | c.987C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039817 | c.888A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039820 | c.885T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039823 | c.882T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040045 | c.660C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040048 | c.657C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040063 | c.642G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040090 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040093 | c.612C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040147 | c.558A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040159 | c.546G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040162 | c.543G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040213 | c.492T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040267 | c.438A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040273 | c.432T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040276 | c.429C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040279 | c.426C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040363 | c.342A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040393 | c.312G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040411 | c.294T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040423 | c.282A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040450 | c.255A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040471 | c.234T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040480 | c.225T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040534 | c.171A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040551 | c.154T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040573 | c.132T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040657 | c.48T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040879 | c.-177_-175delTGGinsCGGT | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4043932 | p.Met117Thr | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| panD | 4044243 | c.39C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| panD | 4044533 | c.-252T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044569 | c.-289_-288delCGinsGC | upstream_gene_variant | 1.0 | pyrazinamide | |
| glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| glpK | 4138883 | c.873C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139321 | c.435T>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139420 | c.336T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139813 | c.-58T>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4139934 | c.-179A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| embC | 4239032 | c.-831T>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239110 | c.-753C>T | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239764 | c.-99G>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4240237 | c.375G>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4243377 | p.Ser49Arg | missense_variant | 0.98 | ethambutol | Uncertain significance |
| embA | 4243690 | p.Met153Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243919 | c.687G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4244154 | p.Thr308Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4244312 | c.1080T>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245023 | c.1791A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245701 | c.2469G>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embB | 4247815 | c.1302C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248195 | p.Lys561Met | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248439 | c.1926C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248664 | c.2151G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248721 | c.2208C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248744 | p.Val744Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248853 | c.2340G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4249069 | c.2556A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| aftB | 4268331 | p.Gln169Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| aftB | 4268810 | c.27G>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269588 | c.246G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269811 | p.Gln8Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| ethA | 4326463 | c.1011C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| ethA | 4326740 | p.Arg245His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| ethR | 4327547 | c.-2_-1insA | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
| amikacin | Not assoc w R | |||||
| kanamycin | Not assoc w R | |||||
| whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338741 | c.-220A>G | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338785 | c.-266_-264delGGCinsAG | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338878 | c.-357C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
| gid | 4408185 | c.18C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
