Run ID: 0f20eaa6-cd70-4570-9a47-2fffdb176852
Sample name:
Date: 18-06-2023 16:19:40
Number of reads: 2017872
Percentage reads mapped: 74.32
Median coverage: 51
Strain: lineage4.5
Spoligotype:
Drug-resistance: Other
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 1.0 |
| lineage4.5 | Euro-American | RD122 | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| moxifloxacin | ||||
| levofloxacin | ||||
| bedaquiline | ||||
| delamanid | ||||
| pretomanid | ||||
| linezolid | ||||
| streptomycin | rrs | n.799C>T | Uncertain significance | |
| amikacin | rrs | n.1402C>A | Uncertain significance | |
| kanamycin | rrs | n.1402C>A | Uncertain significance | |
| capreomycin | rrs | n.1402C>A | Uncertain significance | |
| clofazimine | ||||
| ethionamide | ||||
| para-aminosalicylic_acid | ||||
| cycloserine |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| rrs | 1472644 | n.799C>T | non_coding_transcript_exon_variant | 0.21 | streptomycin | Uncertain significance | |
| rrs | 1473247 | n.1402C>A | non_coding_transcript_exon_variant | 0.13 | kanamycin | Uncertain significance | |
| capreomycin | Uncertain significance | ||||||
| aminoglycosides | Uncertain significance | ||||||
| amikacin | Uncertain significance |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 6071 | p.Phe278Leu | missense_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7892 | c.591G>A | synonymous_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| ccsA | 620029 | c.139C>T | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| rpoB | 759620 | c.-187A>C | upstream_gene_variant | 0.23 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| Rv1258c | 1406101 | p.Pro414Ser | missense_variant | 1.0 | streptomycin | Uncertain significance |
| pyrazinamide | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| embR | 1417416 | c.-69G>A | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472172 | n.327T>C | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472400 | n.555C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472422 | n.577T>C | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472435 | n.590T>C | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472437 | n.592T>G | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472438 | n.593T>C | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472448 | n.603T>C | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1472449 | n.604C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472450 | n.605A>G | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472452 | n.607G>C | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472460 | n.615T>G | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472464 | n.619A>G | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472473 | n.628G>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472489 | n.644A>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472494 | n.649A>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472496 | n.651T>G | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472498 | n.653C>T | non_coding_transcript_exon_variant | 0.23 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1472530 | n.685G>A | non_coding_transcript_exon_variant | 0.2 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472581 | n.736A>C | non_coding_transcript_exon_variant | 0.24 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472583 | n.738T>A | non_coding_transcript_exon_variant | 0.22 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472584 | n.739A>T | non_coding_transcript_exon_variant | 0.21 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472655 | n.810G>T | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1472953 | n.1108G>A | non_coding_transcript_exon_variant | 0.26 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1472956 | n.1111T>C | non_coding_transcript_exon_variant | 0.35 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472957 | n.1112C>T | non_coding_transcript_exon_variant | 0.35 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1472958 | n.1113A>G | non_coding_transcript_exon_variant | 0.26 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1472973 | n.1128A>G | non_coding_transcript_exon_variant | 0.32 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472974 | n.1129A>G | non_coding_transcript_exon_variant | 0.29 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472988 | n.1143T>C | non_coding_transcript_exon_variant | 0.33 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472989 | n.1144G>A | non_coding_transcript_exon_variant | 0.33 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472990 | n.1145A>G | non_coding_transcript_exon_variant | 0.44 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472992 | n.1147A>G | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473035 | n.1190G>A | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473053 | n.1208T>C | non_coding_transcript_exon_variant | 0.33 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1473055 | n.1210C>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473056 | n.1211A>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473081 | n.1236C>T | non_coding_transcript_exon_variant | 0.28 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1473088 | n.1243A>G | non_coding_transcript_exon_variant | 0.29 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473093 | n.1248C>T | non_coding_transcript_exon_variant | 0.28 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473094 | n.1249T>G | non_coding_transcript_exon_variant | 0.22 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473100 | n.1255G>A | non_coding_transcript_exon_variant | 0.24 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.22 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473110 | n.1265T>G | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473111 | n.1266A>G | non_coding_transcript_exon_variant | 0.2 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473123 | n.1278A>G | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1473165 | n.1320C>T | non_coding_transcript_exon_variant | 0.29 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473201 | n.1356A>G | non_coding_transcript_exon_variant | 0.26 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473202 | n.1357C>T | non_coding_transcript_exon_variant | 0.21 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473252 | n.1407T>C | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473259 | n.1414C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473270 | n.1425G>A | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473276 | n.1431A>C | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473277 | n.1432G>A | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473283 | n.1438T>C | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473291 | n.1446G>C | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473294 | n.1449A>G | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | Uncertain significance | |||||
| rrs | 1473300 | n.1455C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473301 | n.1456T>G | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473315 | n.1470T>C | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1473316 | n.1471C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrl | 1473395 | n.-263G>A | upstream_gene_variant | 0.11 | linezolid | |
| rrl | 1473760 | n.103A>G | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1473997 | n.340T>G | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| rrl | 1474133 | n.478delG | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1474823 | n.1166C>G | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1474824 | n.1167A>G | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1474825 | n.1168G>A | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1474827 | n.1170C>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1474830 | n.1173A>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1474864 | n.1207C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1474874 | n.1217A>C | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1475027 | n.1370G>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1475031 | n.1374G>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1475056 | n.1399A>C | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475059 | n.1404_1406delCAA | non_coding_transcript_exon_variant | 0.21 | linezolid | |
| rrl | 1475064 | n.1407_1408insT | non_coding_transcript_exon_variant | 0.23 | linezolid | |
| rrl | 1475067 | n.1410_1411insG | non_coding_transcript_exon_variant | 0.25 | linezolid | |
| rrl | 1475076 | n.1419C>T | non_coding_transcript_exon_variant | 0.25 | linezolid | |
| rrl | 1475079 | n.1422T>C | non_coding_transcript_exon_variant | 0.25 | linezolid | |
| rrl | 1475080 | n.1423G>T | non_coding_transcript_exon_variant | 0.25 | linezolid | |
| rrl | 1475081 | n.1424C>G | non_coding_transcript_exon_variant | 0.25 | linezolid | |
| rrl | 1475089 | n.1432A>G | non_coding_transcript_exon_variant | 0.23 | linezolid | |
| rrl | 1475090 | n.1433A>T | non_coding_transcript_exon_variant | 0.23 | linezolid | |
| rrl | 1475108 | n.1451C>G | non_coding_transcript_exon_variant | 0.27 | linezolid | |
| rrl | 1475113 | n.1456C>T | non_coding_transcript_exon_variant | 0.27 | linezolid | |
| rrl | 1475114 | n.1457C>T | non_coding_transcript_exon_variant | 0.27 | linezolid | Uncertain significance |
| rrl | 1475115 | n.1458A>C | non_coding_transcript_exon_variant | 0.27 | linezolid | |
| rrl | 1475137 | n.1480A>G | non_coding_transcript_exon_variant | 0.2 | linezolid | |
| rrl | 1475193 | n.1536C>A | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475208 | n.1551C>A | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| rrl | 1475225 | n.1568A>G | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1475518 | n.1861A>G | non_coding_transcript_exon_variant | 0.11 | linezolid | Uncertain significance |
| rrl | 1475722 | n.2065G>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1475726 | n.2069G>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1475783 | n.2126T>G | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1475803 | n.2146T>C | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1475883 | n.2226A>C | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475884 | n.2227A>G | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475892 | n.2235A>G | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| rrl | 1475902 | n.2245T>C | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1475906 | n.2249C>T | non_coding_transcript_exon_variant | 0.1 | linezolid | Uncertain significance |
| rrl | 1475916 | n.2259C>A | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1475937 | n.2280A>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1476110 | n.2453G>T | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1476131 | n.2474C>T | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| rrl | 1476164 | n.2507A>G | non_coding_transcript_exon_variant | 0.29 | linezolid | |
| rrl | 1476165 | n.2508T>G | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rrl | 1476194 | n.2537A>G | non_coding_transcript_exon_variant | 0.26 | linezolid | Uncertain significance |
| rrl | 1476196 | n.2539C>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1476200 | n.2543A>T | non_coding_transcript_exon_variant | 0.24 | linezolid | |
| rrl | 1476201 | n.2544C>T | non_coding_transcript_exon_variant | 0.25 | linezolid | |
| rrl | 1476204 | n.2547C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1476205 | n.2548A>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.45 | linezolid | |
| rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.4 | linezolid | |
| rrl | 1476228 | n.2571A>T | non_coding_transcript_exon_variant | 0.35 | linezolid | |
| rrl | 1476245 | n.2588C>T | non_coding_transcript_exon_variant | 0.38 | linezolid | |
| rrl | 1476252 | n.2595T>G | non_coding_transcript_exon_variant | 0.35 | linezolid | |
| rrl | 1476255 | n.2598A>G | non_coding_transcript_exon_variant | 0.3 | linezolid | |
| rrl | 1476256 | n.2599A>G | non_coding_transcript_exon_variant | 0.35 | linezolid | |
| rrl | 1476260 | n.2603A>G | non_coding_transcript_exon_variant | 0.43 | linezolid | Uncertain significance |
| rrl | 1476267 | n.2610G>T | non_coding_transcript_exon_variant | 0.3 | linezolid | |
| rrl | 1476268 | n.2611A>G | non_coding_transcript_exon_variant | 0.3 | linezolid | |
| rrl | 1476275 | n.2618T>C | non_coding_transcript_exon_variant | 0.3 | linezolid | |
| rrl | 1476276 | n.2619C>A | non_coding_transcript_exon_variant | 0.3 | linezolid | |
| rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.32 | linezolid | |
| rrl | 1476296 | n.2639C>T | non_coding_transcript_exon_variant | 0.35 | linezolid | |
| rrl | 1476297 | n.2640C>G | non_coding_transcript_exon_variant | 0.29 | linezolid | |
| rrl | 1476298 | n.2641C>G | non_coding_transcript_exon_variant | 0.27 | linezolid | |
| rrl | 1476300 | n.2643G>T | non_coding_transcript_exon_variant | 0.27 | linezolid | |
| rrl | 1476301 | n.2644A>G | non_coding_transcript_exon_variant | 0.29 | linezolid | |
| rrl | 1476306 | n.2649A>T | non_coding_transcript_exon_variant | 0.27 | linezolid | |
| rrl | 1476309 | n.2652G>T | non_coding_transcript_exon_variant | 0.25 | linezolid | |
| rrl | 1476353 | n.2696G>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1476359 | n.2702C>G | non_coding_transcript_exon_variant | 0.37 | linezolid | |
| rrl | 1476369 | n.2712C>T | non_coding_transcript_exon_variant | 0.33 | linezolid | |
| rrl | 1476381 | n.2724G>C | non_coding_transcript_exon_variant | 0.4 | linezolid | |
| rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 0.41 | linezolid | |
| rrl | 1476429 | n.2772A>T | non_coding_transcript_exon_variant | 0.25 | linezolid | |
| rrl | 1476466 | n.2809C>T | non_coding_transcript_exon_variant | 0.35 | linezolid | Uncertain significance |
| rrl | 1476481 | n.2824T>C | non_coding_transcript_exon_variant | 0.32 | linezolid | |
| rrl | 1476506 | n.2849T>C | non_coding_transcript_exon_variant | 0.33 | linezolid | |
| rrl | 1476514 | n.2857C>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1476515 | n.2858C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1476524 | n.2867C>T | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| rrl | 1476525 | n.2868A>G | non_coding_transcript_exon_variant | 0.24 | linezolid | |
| rrl | 1476530 | n.2873C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1476536 | n.2879G>A | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1476539 | n.2882A>G | non_coding_transcript_exon_variant | 0.19 | linezolid | Uncertain significance |
| rrl | 1476540 | n.2883C>G | non_coding_transcript_exon_variant | 0.22 | linezolid | |
| rrl | 1476547 | n.2890C>T | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| rrl | 1476585 | n.2928A>G | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| rrl | 1476594 | n.2937C>A | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476603 | n.2946G>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1476607 | n.2950C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476614 | n.2957A>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1476616 | n.2959A>G | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476619 | n.2962C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476628 | n.2971T>G | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476629 | n.2972C>A | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476748 | n.3091A>G | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | |
| PPE35 | 2167786 | p.Phe943Val | missense_variant | 0.1 | pyrazinamide | |
| PPE35 | 2168463 | p.Pro717His | missense_variant | 0.1 | pyrazinamide | |
| PPE35 | 2168505 | p.Gly703Asp | missense_variant | 0.12 | pyrazinamide | |
| PPE35 | 2168840 | c.1773T>C | synonymous_variant | 0.12 | pyrazinamide | |
| PPE35 | 2168875 | p.Asn580Asp | missense_variant | 0.13 | pyrazinamide | |
| PPE35 | 2168891 | c.1722A>C | synonymous_variant | 0.14 | pyrazinamide | |
| PPE35 | 2168914 | c.1684_1698delTCGGTGACGGTTCCG | conservative_inframe_deletion | 1.0 | pyrazinamide | |
| PPE35 | 2168987 | c.1626A>G | synonymous_variant | 0.11 | pyrazinamide | |
| PPE35 | 2170568 | p.Ile15Met | missense_variant | 1.0 | pyrazinamide | |
| Rv1979c | 2222051 | p.Leu372Val | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| clpC1 | 4038318 | p.Pro796Leu | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| embC | 4240733 | p.Thr291Ala | missense_variant | 0.11 | ethambutol | |
| embC | 4242419 | p.Ser853Arg | missense_variant | 0.11 | ethambutol | |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4242883 | c.-350C>G | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4245544 | p.Gly771Ala | missense_variant | 0.11 | ethambutol | |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance |
