Run ID: 5b31bfaf-c699-45bd-8fff-d156014201ff
Sample name:
Date: 15-09-2023 03:56:41
Number of reads: 388240
Percentage reads mapped: 74.21
Median coverage: 18
Strain: lineage2.2.1
Spoligotype:
Drug-resistance: Pre-XDR-TB
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage2 | East-Asian | RD105 | 0.95 |
| lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 1.0 |
| lineage2.2.1 | East-Asian (Beijing) | RD105;RD207;RD181 | 0.98 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | rpoB | p.Ser450Leu | Assoc w R | |
| rpoC | p.Asp485Asn | Uncertain significance | ||
| isoniazid | katG | p.Ile335Val | Uncertain significance | |
| p.Ser315Thr | Assoc w R | |||
| ethambutol | embB | p.Gln497Arg | Assoc w R | |
| pyrazinamide | pncA | c.-11A>G | Assoc w R | |
| moxifloxacin | gyrA | p.Asp94Gly | Assoc w R | |
| levofloxacin | gyrA | p.Asp94Gly | Assoc w R | |
| bedaquiline | ||||
| delamanid | ||||
| pretomanid | ||||
| linezolid | ||||
| streptomycin | rpsL | p.Lys43Arg | Assoc w R | |
| amikacin | ||||
| kanamycin | ||||
| capreomycin | ||||
| clofazimine | ||||
| ethionamide | ||||
| para-aminosalicylic_acid | ||||
| cycloserine |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| gyrA | 7582 | p.Asp94Gly | missense_variant | 1.0 | ofloxacin | Uncertain significance | |
| moxifloxacin | Assoc w R | ||||||
| levofloxacin | Assoc w R | ||||||
| fluoroquinolones | Uncertain significance | ||||||
| ciprofloxacin | Uncertain significance | ||||||
| rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin | Assoc w R | |
| rpoC | 764822 | p.Asp485Asn | missense_variant | 1.0 | rifampicin | Uncertain significance | |
| rpsL | 781687 | p.Lys43Arg | missense_variant | 1.0 | streptomycin | Assoc w R | |
| katG | 2155109 | p.Ile335Val | missense_variant | 1.0 | isoniazid | Uncertain significance | |
| katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid | Assoc w R | |
| pncA | 2289252 | c.-11A>G | upstream_gene_variant | 1.0 | pyrazinamide | Assoc w R | |
| embB | 4248003 | p.Gln497Arg | missense_variant | 1.0 | ethambutol | Assoc w R |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 5293 | c.54C>T | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6727 | c.-575G>T | upstream_gene_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6730 | c.-572A>G | upstream_gene_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6745 | c.-557T>G | upstream_gene_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6760 | c.-542G>C | upstream_gene_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6778 | c.-524C>T | upstream_gene_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6793 | c.-509T>C | upstream_gene_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrB | 6797 | p.Gly520Thr | missense_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6824 | c.-478C>T | upstream_gene_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6841 | c.-461T>C | upstream_gene_variant | 0.16 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6844 | c.-458T>G | upstream_gene_variant | 0.16 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6853 | c.-449A>G | upstream_gene_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6856 | c.-446T>C | upstream_gene_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6859 | c.-443T>C | upstream_gene_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6862 | c.-440C>G | upstream_gene_variant | 0.16 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6878 | c.-424T>C | upstream_gene_variant | 0.16 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6881 | c.-421T>C | upstream_gene_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6904 | c.-398C>G | upstream_gene_variant | 0.15 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6910 | c.-392G>A | upstream_gene_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrB | 6911 | p.Asn558His | missense_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6919 | c.-383T>C | upstream_gene_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6925 | c.-377T>C | upstream_gene_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6931 | c.-371A>C | upstream_gene_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6934 | c.-368A>G | upstream_gene_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6937 | c.-365G>A | upstream_gene_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6952 | c.-350C>G | upstream_gene_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6955 | c.-347G>A | upstream_gene_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7000 | c.-302C>G | upstream_gene_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7979 | c.678G>C | synonymous_variant | 0.15 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7992 | p.Ala231Ser | missense_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7997 | c.696A>C | synonymous_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8009 | c.708A>C | synonymous_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8010 | p.Ser237Thr | missense_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8020 | p.Thr240Ile | missense_variant | 0.21 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8024 | c.723T>C | synonymous_variant | 0.21 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8027 | c.726T>C | synonymous_variant | 0.21 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8036 | c.735A>G | synonymous_variant | 0.21 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8039 | c.738T>C | synonymous_variant | 0.21 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8054 | c.753T>C | synonymous_variant | 0.27 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8057 | c.756A>G | synonymous_variant | 0.27 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8069 | c.768T>C | synonymous_variant | 0.27 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8078 | c.777A>G | synonymous_variant | 0.27 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8090 | c.789C>G | synonymous_variant | 0.27 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8096 | c.795T>C | synonymous_variant | 0.25 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8099 | c.798T>C | synonymous_variant | 0.25 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8111 | c.810G>C | synonymous_variant | 0.25 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8156 | c.855T>C | synonymous_variant | 0.23 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8168 | c.867A>G | synonymous_variant | 0.21 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8174 | c.873C>G | synonymous_variant | 0.21 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8177 | c.876A>C | synonymous_variant | 0.21 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8198 | c.897T>C | synonymous_variant | 0.24 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8207 | c.906T>C | synonymous_variant | 0.24 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8219 | c.918T>C | synonymous_variant | 0.24 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8225 | c.924T>C | synonymous_variant | 0.24 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8234 | c.933T>G | synonymous_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8235 | c.934_936delTTAinsCTG | synonymous_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8253 | p.Ile318Leu | missense_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8264 | c.963T>C | synonymous_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8267 | c.966G>C | synonymous_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8270 | c.969G>C | synonymous_variant | 0.19 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8283 | p.Ile328Leu | missense_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8288 | c.987T>C | synonymous_variant | 0.14 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8294 | c.993T>C | synonymous_variant | 0.14 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8324 | c.1023T>C | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8603 | c.1302A>G | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8619 | c.1318T>C | synonymous_variant | 0.13 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8624 | c.1323G>C | synonymous_variant | 0.13 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8627 | c.1326C>G | synonymous_variant | 0.13 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8636 | c.1335A>C | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8642 | c.1341A>G | synonymous_variant | 0.2 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8645 | c.1344C>G | synonymous_variant | 0.2 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8672 | c.1371A>G | synonymous_variant | 0.27 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8693 | c.1392T>C | synonymous_variant | 0.22 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8699 | c.1398A>G | synonymous_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8711 | c.1410A>C | synonymous_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8714 | c.1413A>G | synonymous_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8717 | c.1416C>G | synonymous_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8720 | c.1419G>A | synonymous_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8729 | c.1428T>C | synonymous_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8732 | c.1431G>C | synonymous_variant | 0.18 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8747 | c.1446A>G | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8756 | c.1455A>G | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8762 | c.1461G>C | synonymous_variant | 0.13 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8765 | p.Asp488Glu | missense_variant | 0.13 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8767 | p.Arg489Lys | missense_variant | 0.13 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8779 | p.Asp493Ala | missense_variant | 0.15 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8786 | c.1485T>C | synonymous_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8796 | p.Ile499Val | missense_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8801 | c.1500G>C | synonymous_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8810 | c.1509A>C | synonymous_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9697 | p.Lys799Met | missense_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | delamanid | |
| rpoB | 760223 | c.417T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 760235 | c.429T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 760253 | c.447T>C | synonymous_variant | 0.13 | rifampicin | |
| rpoB | 760283 | c.477G>C | synonymous_variant | 0.2 | rifampicin | |
| rpoB | 760307 | c.501T>C | synonymous_variant | 0.14 | rifampicin | |
| rpoB | 760328 | c.522G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoB | 760331 | c.525G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoB | 760337 | c.531C>G | synonymous_variant | 0.13 | rifampicin | |
| rpoB | 760340 | c.534G>C | synonymous_variant | 0.13 | rifampicin | |
| rpoB | 760361 | c.555T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 760376 | p.Asp190Glu | missense_variant | 0.11 | rifampicin | |
| rpoB | 760430 | c.624T>C | synonymous_variant | 0.1 | rifampicin | |
| rpoB | 760475 | c.669A>G | synonymous_variant | 0.17 | rifampicin | |
| rpoB | 760481 | c.675G>C | synonymous_variant | 0.17 | rifampicin | |
| rpoB | 760484 | c.678A>G | synonymous_variant | 0.17 | rifampicin | |
| rpoB | 760522 | p.Ser239Asn | missense_variant | 0.14 | rifampicin | |
| rpoB | 760532 | c.726T>C | synonymous_variant | 0.14 | rifampicin | |
| rpoB | 760533 | p.Val243Thr | missense_variant | 0.14 | rifampicin | |
| rpoB | 760547 | c.741G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoB | 760563 | p.Arg253Met | missense_variant | 0.1 | rifampicin | |
| rpoB | 760611 | c.805T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 760634 | c.828T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 760646 | c.840C>G | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 760655 | c.849A>G | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 760661 | c.855A>C | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 763212 | p.Gly1136Cys | missense_variant | 0.18 | rifampicin | |
| rpoC | 765553 | c.2184C>T | synonymous_variant | 0.15 | rifampicin | |
| rpoC | 765556 | c.2187G>C | synonymous_variant | 0.15 | rifampicin | |
| rpoC | 765559 | c.2190G>C | synonymous_variant | 0.17 | rifampicin | |
| rpoC | 765578 | c.2209C>T | synonymous_variant | 0.24 | rifampicin | |
| rpoC | 765583 | c.2214G>T | synonymous_variant | 0.19 | rifampicin | |
| rpoC | 765613 | p.His748Gln | missense_variant | 0.2 | rifampicin | |
| rpoC | 765625 | c.2256C>G | synonymous_variant | 0.2 | rifampicin | |
| rpoC | 765628 | c.2259G>C | synonymous_variant | 0.19 | rifampicin | |
| rpoC | 765631 | p.Asp754Glu | missense_variant | 0.19 | rifampicin | |
| rpoC | 765658 | c.2289C>T | synonymous_variant | 0.18 | rifampicin | |
| rpoC | 765700 | c.2331T>C | synonymous_variant | 0.13 | rifampicin | |
| rpoC | 765734 | c.2365T>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 765739 | c.2370G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 765751 | c.2382C>G | synonymous_variant | 0.17 | rifampicin | |
| rpoC | 765753 | p.Asp795Ala | missense_variant | 0.14 | rifampicin | |
| rpoC | 765772 | c.2403C>G | synonymous_variant | 0.15 | rifampicin | |
| rpoC | 765784 | c.2415C>G | synonymous_variant | 0.17 | rifampicin | |
| rpoC | 765796 | c.2427C>T | synonymous_variant | 0.17 | rifampicin | |
| rpoC | 765883 | c.2514C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 765886 | c.2517C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 765892 | c.2523T>C | synonymous_variant | 0.1 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 778393 | p.Thr30Ala | missense_variant | 0.12 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| rplC | 801427 | p.Met207Val | missense_variant | 0.12 | linezolid | |
| fbiC | 1302917 | c.-14_-13insA | upstream_gene_variant | 1.0 | delamanid | Uncertain significance |
| fbiC | 1304517 | c.1587C>T | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304520 | c.1590A>C | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304523 | c.1593G>T | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304526 | c.1596T>G | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304544 | c.1614T>C | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304545 | p.Val539Thr | missense_variant | 0.11 | delamanid | |
| fbiC | 1304559 | p.Glu543Asp | missense_variant | 0.14 | delamanid | |
| fbiC | 1304565 | c.1635C>G | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1304568 | c.1638T>C | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1304574 | c.1644C>G | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1304580 | c.1650T>C | synonymous_variant | 0.13 | delamanid | |
| fbiC | 1304613 | c.1683T>C | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1304628 | c.1698G>C | synonymous_variant | 0.13 | delamanid | |
| fbiC | 1304634 | c.1704C>G | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1304640 | c.1710A>C | synonymous_variant | 0.15 | delamanid | |
| fbiC | 1304646 | c.1716T>C | synonymous_variant | 0.15 | delamanid | |
| fbiC | 1304658 | c.1728C>G | synonymous_variant | 0.17 | delamanid | |
| fbiC | 1304670 | c.1740G>T | synonymous_variant | 0.17 | delamanid | |
| fbiC | 1304671 | p.Val581Thr | missense_variant | 0.17 | delamanid | |
| fbiC | 1304675 | p.Gly582Glu | missense_variant | 0.17 | delamanid | |
| fbiC | 1304691 | c.1761G>C | synonymous_variant | 0.16 | delamanid | |
| fbiC | 1304694 | c.1764A>C | synonymous_variant | 0.16 | delamanid | |
| fbiC | 1304703 | c.1773C>G | synonymous_variant | 0.21 | delamanid | |
| fbiC | 1304715 | c.1785G>C | synonymous_variant | 0.19 | delamanid | |
| fbiC | 1304724 | c.1794A>G | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1304727 | c.1797A>G | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1304742 | c.1812T>C | synonymous_variant | 0.17 | delamanid | |
| fbiC | 1304748 | c.1818T>C | synonymous_variant | 0.15 | delamanid | |
| fbiC | 1304754 | c.1824G>A | synonymous_variant | 0.15 | delamanid | |
| fbiC | 1304757 | c.1827A>G | synonymous_variant | 0.16 | delamanid | |
| fbiC | 1304784 | c.1854T>C | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304946 | c.2016G>C | synonymous_variant | 0.1 | delamanid | |
| fbiC | 1304958 | c.2028T>G | synonymous_variant | 0.1 | delamanid | |
| fbiC | 1304991 | c.2061G>C | synonymous_variant | 0.13 | delamanid | |
| fbiC | 1304994 | c.2064A>G | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1304995 | c.2065T>C | synonymous_variant | 0.14 | delamanid | |
| fbiC | 1305006 | c.2076A>G | synonymous_variant | 0.17 | delamanid | |
| fbiC | 1305012 | c.2082G>C | synonymous_variant | 0.17 | delamanid | |
| fbiC | 1305015 | c.2085G>C | synonymous_variant | 0.17 | delamanid | |
| Rv1258c | 1406760 | c.580_581insC | frameshift_variant | 1.0 | streptomycin | Uncertain significance |
| pyrazinamide | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| embR | 1417061 | p.Ala96Glu | missense_variant | 0.13 | ethambutol | |
| embR | 1417207 | c.141C>T | synonymous_variant | 0.12 | ethambutol | |
| embR | 1417508 | c.-161C>A | upstream_gene_variant | 0.18 | ethambutol | |
| atpE | 1460856 | c.-189C>T | upstream_gene_variant | 0.15 | bedaquiline | |
| rrs | 1471781 | n.-65G>T | upstream_gene_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472970 | n.1125C>G | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472977 | n.1132G>C | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | Uncertain significance | |||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrl | 1474639 | n.982G>A | non_coding_transcript_exon_variant | 0.18 | linezolid | Uncertain significance |
| rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.2 | linezolid | |
| fabG1 | 1673209 | c.-230delT | upstream_gene_variant | 0.14 | ethionamide | |
| isoniazid | ||||||
| inhA | 1673808 | c.-394A>G | upstream_gene_variant | 0.13 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674296 | p.Gln32Arg | missense_variant | 0.11 | ethionamide | |
| isoniazid | ||||||
| rpsA | 1833403 | c.-139G>T | upstream_gene_variant | 0.1 | pyrazinamide | |
| rpsA | 1834097 | c.556_557delTCinsAG | synonymous_variant | 0.17 | pyrazinamide | |
| rpsA | 1834102 | c.561T>C | synonymous_variant | 0.17 | pyrazinamide | |
| rpsA | 1834150 | c.609G>C | synonymous_variant | 0.17 | pyrazinamide | |
| rpsA | 1834153 | c.612T>C | synonymous_variant | 0.17 | pyrazinamide | |
| rpsA | 1834154 | p.Asn205Gln | missense_variant | 0.17 | pyrazinamide | |
| rpsA | 1834157 | c.616T>C | synonymous_variant | 0.2 | pyrazinamide | |
| rpsA | 1834162 | c.621A>G | synonymous_variant | 0.2 | pyrazinamide | |
| rpsA | 1834165 | c.624A>G | synonymous_variant | 0.17 | pyrazinamide | |
| rpsA | 1834169 | p.Thr210Ala | missense_variant | 0.17 | pyrazinamide | |
| rpsA | 1834177 | c.636A>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834186 | c.645C>G | synonymous_variant | 0.15 | pyrazinamide | |
| rpsA | 1834189 | c.648G>C | synonymous_variant | 0.15 | pyrazinamide | |
| rpsA | 1834195 | c.654G>C | synonymous_variant | 0.15 | pyrazinamide | |
| rpsA | 1834222 | c.681T>C | synonymous_variant | 0.12 | pyrazinamide | |
| rpsA | 1834231 | c.690T>C | synonymous_variant | 0.12 | pyrazinamide | |
| rpsA | 1834240 | c.699T>C | synonymous_variant | 0.14 | pyrazinamide | |
| rpsA | 1834249 | c.708T>C | synonymous_variant | 0.14 | pyrazinamide | |
| rpsA | 1834261 | c.720A>C | synonymous_variant | 0.15 | pyrazinamide | |
| rpsA | 1834264 | c.723G>C | synonymous_variant | 0.15 | pyrazinamide | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | |
| katG | 2154252 | p.Ser620Arg | missense_variant | 0.12 | isoniazid | |
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Uncertain significance |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169801 | p.Asn271Ser | missense_variant | 0.1 | pyrazinamide | |
| PPE35 | 2169810 | p.Gly268Val | missense_variant | 0.11 | pyrazinamide | |
| PPE35 | 2170650 | c.-38T>C | upstream_gene_variant | 0.1 | pyrazinamide | |
| Rv1979c | 2221795 | p.Ile457Asn | missense_variant | 0.12 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2222899 | p.Arg89Gln | missense_variant | 0.17 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| kasA | 2518540 | c.426T>G | synonymous_variant | 0.2 | isoniazid | |
| kasA | 2518561 | c.447T>C | synonymous_variant | 0.18 | isoniazid | |
| kasA | 2518567 | c.453G>C | synonymous_variant | 0.18 | isoniazid | |
| kasA | 2518570 | c.456G>C | synonymous_variant | 0.18 | isoniazid | |
| kasA | 2518574 | p.Ile154Val | missense_variant | 0.2 | isoniazid | |
| kasA | 2518588 | c.474T>C | synonymous_variant | 0.25 | isoniazid | |
| kasA | 2518591 | c.477G>C | synonymous_variant | 0.25 | isoniazid | |
| kasA | 2518609 | p.Met165Ile | missense_variant | 0.2 | isoniazid | |
| kasA | 2518621 | c.507G>A | synonymous_variant | 0.15 | isoniazid | |
| kasA | 2518642 | c.528A>G | synonymous_variant | 0.17 | isoniazid | |
| kasA | 2518663 | c.549T>C | synonymous_variant | 0.14 | isoniazid | |
| kasA | 2518672 | c.558G>C | synonymous_variant | 0.12 | isoniazid | |
| kasA | 2518687 | c.573C>T | synonymous_variant | 0.17 | isoniazid | |
| kasA | 2518696 | c.582C>G | synonymous_variant | 0.15 | isoniazid | |
| kasA | 2518702 | c.588C>T | synonymous_variant | 0.15 | isoniazid | |
| kasA | 2518711 | c.597A>G | synonymous_variant | 0.14 | isoniazid | |
| kasA | 2518714 | c.600A>C | synonymous_variant | 0.14 | isoniazid | |
| kasA | 2518732 | c.618C>G | synonymous_variant | 0.13 | isoniazid | |
| kasA | 2518741 | c.627G>C | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518747 | c.633C>G | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518768 | c.654C>G | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518783 | c.669T>C | synonymous_variant | 0.11 | isoniazid | |
| eis | 2714760 | c.573A>G | synonymous_variant | 0.12 | kanamycin | |
| amikacin | ||||||
| eis | 2714888 | p.Phe149Leu | missense_variant | 0.15 | kanamycin | |
| amikacin | ||||||
| pepQ | 2860513 | c.-95A>G | upstream_gene_variant | 0.15 | clofazimine | |
| bedaquiline | ||||||
| pepQ | 2860575 | c.-157G>A | upstream_gene_variant | 0.11 | clofazimine | |
| bedaquiline | ||||||
| ribD | 2987197 | p.Val120Asp | missense_variant | 0.11 | para-aminosalicylic_acid | |
| ribD | 2987599 | p.Arg254His | missense_variant | 0.11 | para-aminosalicylic_acid | |
| Rv2752c | 3064849 | p.Phe448Tyr | missense_variant | 0.1 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065538 | c.654G>T | synonymous_variant | 0.18 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065883 | c.309C>T | synonymous_variant | 0.14 | rifampicin | |
| isoniazid | ||||||
| thyX | 3067948 | c.-3G>A | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073902 | c.570C>G | synonymous_variant | 0.11 | para-aminosalicylic_acid | |
| thyA | 3073924 | c.534_547delCGCCAGCTATGCGT | frameshift_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074010 | c.462C>G | synonymous_variant | 0.11 | para-aminosalicylic_acid | |
| thyA | 3074100 | c.372T>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
| thyA | 3074128 | p.Ala115Val | missense_variant | 0.17 | para-aminosalicylic_acid | |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| Rv3083 | 3449864 | p.Gln454Leu | missense_variant | 0.15 | ethionamide | |
| fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| fbiB | 3640879 | c.-656C>T | upstream_gene_variant | 1.0 | delamanid | |
| clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.14 | pyrazinamide | |
| clpC1 | 4039524 | p.Phe394Tyr | missense_variant | 0.14 | pyrazinamide | |
| clpC1 | 4039526 | c.1179G>C | synonymous_variant | 0.14 | pyrazinamide | |
| clpC1 | 4039547 | c.1158C>G | synonymous_variant | 0.19 | pyrazinamide | |
| clpC1 | 4039553 | c.1152C>G | synonymous_variant | 0.19 | pyrazinamide | |
| clpC1 | 4039562 | c.1143C>G | synonymous_variant | 0.19 | pyrazinamide | |
| clpC1 | 4039565 | c.1140G>C | synonymous_variant | 0.14 | pyrazinamide | |
| clpC1 | 4039576 | p.Ala377Ser | missense_variant | 0.14 | pyrazinamide | |
| clpC1 | 4039577 | c.1128T>C | synonymous_variant | 0.14 | pyrazinamide | |
| clpC1 | 4039586 | c.1119G>C | synonymous_variant | 0.15 | pyrazinamide | |
| clpC1 | 4039610 | c.1095G>C | synonymous_variant | 0.17 | pyrazinamide | |
| clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.18 | pyrazinamide | |
| clpC1 | 4039622 | c.1083C>G | synonymous_variant | 0.18 | pyrazinamide | |
| clpC1 | 4039682 | c.1023C>G | synonymous_variant | 0.2 | pyrazinamide | |
| clpC1 | 4039685 | c.1020C>T | synonymous_variant | 0.2 | pyrazinamide | |
| clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.17 | pyrazinamide | |
| clpC1 | 4039736 | c.969C>A | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4039748 | c.957G>C | synonymous_variant | 0.17 | pyrazinamide | |
| clpC1 | 4039751 | c.954A>G | synonymous_variant | 0.17 | pyrazinamide | |
| clpC1 | 4039757 | c.948A>G | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4039760 | c.945T>C | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4039769 | c.936C>G | synonymous_variant | 0.14 | pyrazinamide | |
| clpC1 | 4039778 | c.927A>G | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4039781 | c.924G>C | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4039787 | c.916_918delTCGinsAGC | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4039793 | c.912C>G | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4039817 | c.888A>T | synonymous_variant | 0.15 | pyrazinamide | |
| clpC1 | 4039820 | c.885T>G | synonymous_variant | 0.15 | pyrazinamide | |
| clpC1 | 4039831 | c.874T>C | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4039832 | c.873C>G | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4039850 | c.855T>C | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4039865 | c.840T>C | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4040162 | c.543G>C | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040165 | c.540G>C | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040168 | c.537G>C | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040171 | c.534C>G | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040201 | c.504C>G | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040225 | c.480A>C | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4040228 | c.477G>C | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4040234 | c.471C>G | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4040237 | c.468C>T | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4040249 | c.456A>G | synonymous_variant | 0.14 | pyrazinamide | |
| clpC1 | 4040457 | c.247delC | frameshift_variant | 0.15 | pyrazinamide | |
| embC | 4240706 | p.Val282Thr | missense_variant | 0.1 | ethambutol | |
| embC | 4240726 | c.864G>C | synonymous_variant | 0.1 | ethambutol | |
| embC | 4240780 | c.918T>C | synonymous_variant | 0.12 | ethambutol | |
| embC | 4240783 | c.921G>C | synonymous_variant | 0.12 | ethambutol | |
| embC | 4240789 | c.927T>C | synonymous_variant | 0.12 | ethambutol | |
| embC | 4240819 | c.957A>G | synonymous_variant | 0.12 | ethambutol | |
| embC | 4240954 | p.Ile364Met | missense_variant | 0.11 | ethambutol | |
| embC | 4240957 | c.1095C>G | synonymous_variant | 0.11 | ethambutol | |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4243460 | c.228C>T | synonymous_variant | 1.0 | ethambutol | |
| embA | 4243598 | c.366G>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4246286 | c.-228G>C | upstream_gene_variant | 0.12 | ethambutol | |
| embB | 4247419 | c.906C>T | synonymous_variant | 0.12 | ethambutol | |
| embB | 4247872 | c.1359C>T | synonymous_variant | 0.96 | ethambutol | |
| embB | 4248316 | c.1803C>G | synonymous_variant | 0.11 | ethambutol | |
| embB | 4248319 | c.1806A>G | synonymous_variant | 0.11 | ethambutol | |
| embB | 4248322 | c.1809G>C | synonymous_variant | 0.11 | ethambutol | |
| aftB | 4268015 | c.822G>A | synonymous_variant | 0.1 | capreomycin | |
| amikacin | ||||||
| ubiA | 4269244 | p.His197Arg | missense_variant | 0.11 | ethambutol | |
| ethA | 4326474 | p.Pro334Ala | missense_variant | 1.0 | ethionamide | Uncertain significance |
| whiB6 | 4338326 | p.Ala66Thr | missense_variant | 1.0 | streptomycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407927 | p.Glu92Asp | missense_variant | 1.0 | streptomycin | Uncertain significance |
