TB-Profiler result

Run: ERR3597006
Summary

Run ID: ERR3597006

Sample name:

Date: 2025-07-24T05:22:54.334425

Number of reads: 3824361

Percentage reads mapped: 99.05

Median coverage: 125.0

Strain: M.canetti

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
M.canetti M.canetti None 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 72 c.72T>C synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 264 c.264C>G synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 362 p.Thr121Ile missense_variant 1.0 isoniazid Uncertain significance
dnaA 400 p.Asp134Asn missense_variant 1.0 isoniazid Uncertain significance
dnaA 481 p.Ala161Thr missense_variant 1.0 isoniazid Uncertain significance
dnaA 549 c.549C>T synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 708 c.708T>C synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 747 c.747G>A synonymous_variant 1.0 isoniazid Uncertain significance
gyrB 5025 c.-215T>A upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5207 c.-33A>C upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5440 c.201A>G synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5452 c.213G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5770 c.531C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6001 c.762G>A synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6004 c.765T>C synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6286 c.1047T>C synonymous_variant 0.99 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6433 c.-869C>T upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6436 c.-866C>T upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 7256 c.2017C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7523 c.222C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8288 c.987T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8654 c.1353C>T synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9074 c.1773G>A synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9218 c.1917C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9377 c.2076A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9716 c.2415T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9740 c.2439G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9776 c.2475T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9817 c.2517_*52delATCAGGCTCGCCCGACGACGATGCGGATCGCGTAGCGATCTGAGGAGGAATCG frameshift_variant&stop_lost&splice_region_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 490666 c.-117G>T upstream_gene_variant 0.97 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490679 c.-104delAinsGT upstream_gene_variant 0.42 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490679 c.-105_-104insG upstream_gene_variant 0.58 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490687 c.-96T>C upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491406 p.Met208Ile missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
mshA 575060 c.-288G>C upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575123 c.-225A>T upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575133 c.-215C>T upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575665 c.318G>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575971 c.624C>T synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 576285 p.Val313Ala missense_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 576757 c.1410C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ccsA 620256 c.366C>G synonymous_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620257 p.Ile123Ala missense_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620415 c.525T>C synonymous_variant 1.0 amikacin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620490 c.600A>C synonymous_variant 1.0 amikacin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620808 c.918T>C synonymous_variant 1.0 amikacin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
Rv0565c 656511 p.His320Gln missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657273 c.198G>A synonymous_variant 1.0 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide Uncertain significance
hadA 731852 c.-78A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
hadA 732379 c.450A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
nusG 733883 c.-370_-368delGCG upstream_gene_variant 1.0 rifampicin Uncertain significance
mmaA3 737397 c.753G>C synonymous_variant 1.0 isoniazid Uncertain significance
mmaA3 738177 c.-28G>T upstream_gene_variant 1.0 isoniazid Uncertain significance
rpoB 759741 c.-66C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763660 c.291T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764152 c.783C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766912 c.3543C>T synonymous_variant 1.0 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.99 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 778057 p.Ser142Gly missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 778573 c.-93C>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 779283 c.-803G>A upstream_gene_variant 0.99 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 779295 c.-815A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpR5 779431 p.Asn148Gln missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 779472 c.-992G>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpS5 779523 c.-618T>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpS5 779538 c.-633A>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpS5 779539 c.-634C>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781456 c.-104A>G upstream_gene_variant 1.0 streptomycin Uncertain significance
Rv1129c 1253093 p.Ser481Leu missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253216 p.Glu440Ala missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253408 p.Glu376Gly missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253653 c.882T>G synonymous_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253692 c.843C>T synonymous_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253904 p.Asn211Asp missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254316 c.219G>A synonymous_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254434 p.Val34Ala missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254576 c.-42C>T upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254602 c.-68C>T upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254610 c.-76A>C upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254654 c.-120A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254678 c.-144A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254690 c.-156T>G upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
fbiC 1302694 c.-237C>T upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1302810 c.-121C>T upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1302860 c.-71G>A upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1302870 c.-61G>C upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1302948 c.18T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303288 p.Ser120Gly missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303747 p.Thr273Ala missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303860 c.930A>G synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304064 c.1134G>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304141 p.Ala404Gly missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304330 p.Ala467Asp missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304707 p.Val593Ile missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304907 c.1977C>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
Rv1258c 1406466 p.Ser292Leu missense_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
Rv1258c 1406492 p.Ile283Met missense_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
Rv1258c 1407008 c.333C>A synonymous_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
Rv1258c 1407548 c.-208C>G upstream_gene_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
embR 1416462 p.Ala296Ser missense_variant 1.0 ethambutol Uncertain significance
embR 1417294 c.54A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embR 1417493 c.-146T>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embR 1417829 c.-482C>T upstream_gene_variant 0.99 ethambutol Uncertain significance
embR 1417954 c.-607A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471845 n.4dupT non_coding_transcript_exon_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473420 n.-238A>T upstream_gene_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474615 n.958A>C non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673499 c.-703T>C upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674079 c.-123C>G upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674384 c.183C>T synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674405 c.204G>A synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674471 c.270G>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674480 c.279T>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674483 c.282G>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674486 c.285T>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674603 c.402G>A synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674620 p.Pro140Gln missense_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674780 c.579T>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1833381 c.-161T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833554 p.Thr5Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1833596 c.55_56delAGinsTC synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833790 c.249T>C synonymous_variant 0.99 pyrazinamide Uncertain significance
rpsA 1833907 c.366G>A synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834639 c.1098T>C synonymous_variant 0.99 pyrazinamide Uncertain significance
rpsA 1834648 c.1107C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834912 c.1371A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1853394 c.-212C>G upstream_gene_variant 1.0 linezolid Uncertain significance
tsnR 1853429 c.-177G>A upstream_gene_variant 1.0 linezolid Uncertain significance
tsnR 1853636 p.Thr11Ala missense_variant 1.0 linezolid Uncertain significance
tsnR 1853648 c.43C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1853804 p.Ser67Pro missense_variant 1.0 linezolid Uncertain significance
tsnR 1853902 c.297T>C synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1853926 c.321T>C synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1853954 p.Arg117Gly missense_variant 1.0 linezolid Uncertain significance
tsnR 1853968 c.363C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854028 c.423G>C synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854064 c.459C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854070 c.465C>T synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1854073 c.468C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854076 c.471T>C synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854105 p.Ala167Val missense_variant 1.0 linezolid Uncertain significance
tsnR 1854112 p.Asp169Glu missense_variant 1.0 linezolid Uncertain significance
tsnR 1854114 p.Val170Ala missense_variant 1.0 linezolid Uncertain significance
tsnR 1854116 p.Gly171Pro missense_variant 1.0 linezolid Uncertain significance
tsnR 1854125 p.Ile174Val missense_variant 1.0 linezolid Uncertain significance
tsnR 1854134 c.529C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854289 c.684C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854292 c.687A>G synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tsnR 1854359 p.Glu252Gln missense_variant 1.0 linezolid Uncertain significance
tlyA 1917519 c.-421C>T upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917606 c.-334G>C upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917653 c.-287A>G upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917807 c.-133T>G upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918149 c.210A>C synonymous_variant 1.0 capreomycin Uncertain significance
tlyA 1918150 p.Val71Leu missense_variant 1.0 capreomycin Uncertain significance
tlyA 1918242 c.303G>C synonymous_variant 1.0 capreomycin Uncertain significance
tlyA 1918587 p.Gln216His missense_variant 1.0 capreomycin Uncertain significance
tlyA 1918604 p.Ser222Thr missense_variant 1.0 capreomycin Uncertain significance
bacA 2061037 c.1899_*1771del frameshift_variant&stop_lost&splice_region_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
bacA 2062922 p.Ile603Val missense_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
streptomycin Not assoc w R
bacA 2063040 c.1689C>T synonymous_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
bacA 2063391 c.1338C>G synonymous_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
ndh 2101777 c.1266C>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101876 c.1167C>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2101990 c.1053G>T synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102005 c.1038G>C synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102164 c.879A>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102302 c.741G>C synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102366 p.Ala226Glu missense_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102377 c.666A>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102420 p.Lys208Arg missense_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102443 c.600A>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102482 c.561A>T synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102638 c.405A>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102644 c.399A>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102680 c.363T>C synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102791 c.252A>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2103028 p.Gln5His missense_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2103173 c.-132_-131insG upstream_gene_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2103247 c.-205C>T upstream_gene_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2156055 c.57C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2156658 c.-547A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167934 c.2679G>A synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168269 p.Gly782Ser missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168342 c.2271T>C synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168567 c.2046A>G synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168612 c.2001C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168882 c.1731T>C synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2169263 c.1350C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2169304 p.Met437Leu missense_variant 0.98 pyrazinamide Uncertain significance
PPE35 2169686 c.927T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2169717 p.Asn299Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170178 c.435T>A synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170232 c.381T>C synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
PPE35 2170394 c.219G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170440 p.Gln58Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170452 p.Gly54Asp missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170485 p.Val43Ala missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170499 c.114A>G synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170764 c.-152C>T upstream_gene_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2221723 p.Arg481His missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2222357 p.Thr270Ala missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2222504 p.Met221Leu missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2222598 c.567C>T synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2222897 p.Ile90Val missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223146 p.Arg7Gly missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223255 c.-91A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223691 c.-527G>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
pncA 2289104 c.138A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
pncA 2289700 c.-459T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
pncA 2289827 c.-586A>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid Uncertain significance
kasA 2519287 c.1173T>C synonymous_variant 1.0 isoniazid Uncertain significance
ahpC 2725905 c.-288C>A upstream_gene_variant 1.0 isoniazid Uncertain significance
folC 2746174 c.1425A>C synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747204 p.Ala132Gln missense_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747572 c.27T>C synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747575 c.24G>C synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747628 c.-30G>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747631 c.-33C>G upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747691 c.-93A>G upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
Rv2477c 2782483 c.1560G>A synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782714 c.1329A>G synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782768 c.1275C>T synonymous_variant 1.0 amikacin Not assoc w R - Interim
ethambutol Uncertain significance
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782774 c.1269G>A synonymous_variant 1.0 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
Rv2477c 2782777 c.1266A>G synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782792 c.1251A>G synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783989 c.54G>A synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783992 c.51T>C synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
Rv2477c 2784342 c.-300G>A upstream_gene_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784432 c.-390A>G upstream_gene_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784569 c.-527G>T upstream_gene_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
pepQ 2859490 p.Val310Ala missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
ribD 2987614 c.766delA frameshift_variant 1.0 para-aminosalicylic_acid Uncertain significance
Rv2680 2995798 c.-307T>C upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2680 2996009 c.-96_-95delTCinsCA upstream_gene_variant 0.91 capreomycin Uncertain significance
Rv2680 2996440 c.336G>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2680 2996578 c.474C>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997054 p.Ser106Gly missense_variant 1.0 capreomycin Uncertain significance
Rv2681 2997059 c.321C>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997122 c.384A>G synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997293 c.555G>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2752c 3064627 p.Asn522Ser missense_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3065573 p.Glu207Gln missense_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
thyX 3067239 p.Ala236Asp missense_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyX 3067355 c.591A>C synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyX 3067439 c.507A>G synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyX 3067980 c.-35T>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyA 3074160 c.312A>G synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyA 3074445 c.27C>T synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyA 3074529 c.-58G>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyA 3074580 c.-109T>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
ald 3086623 c.-197A>G upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086661 c.-159G>A upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086671 c.-149T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086707 c.-113G>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086733 c.-87G>A upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086737 c.-83T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086744 c.-76A>T upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086753 c.-67A>G upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086760 c.-60A>T upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086771 c.-49T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086773 c.-47A>G upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086788 c.-32T>A upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086797 c.-23G>A upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086803 c.-17T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3087020 c.201C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087065 c.246C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087070 p.Arg84Leu missense_variant 1.0 cycloserine Uncertain significance
ald 3087074 c.255G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087077 c.258A>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087079 p.His87Arg missense_variant 1.0 cycloserine Uncertain significance
ald 3087140 c.321G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087149 c.330C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087152 c.333C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087155 c.336C>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087158 c.339G>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087164 c.345T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087316 p.Val166Ala missense_variant 1.0 cycloserine Uncertain significance
ald 3087344 c.525C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087380 c.561C>G synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087381 p.Asn188Gly missense_variant 1.0 cycloserine Uncertain significance
ald 3087401 c.582T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087500 c.681T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087512 c.693T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087527 c.708T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087533 c.714C>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087554 c.735G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087560 c.741C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087644 c.825C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087653 c.834A>G synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087743 c.924G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087758 c.939G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087800 p.His327Gln missense_variant 1.0 cycloserine Uncertain significance
ald 3087833 c.1014A>G synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087857 c.1038C>T synonymous_variant 1.0 cycloserine Uncertain significance
fbiD 3339049 c.-69C>T upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiD 3339402 c.285C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
fbiD 3339568 c.451C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
Rv3083 3448474 c.-30G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448611 c.108A>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449305 c.802T>C synonymous_variant 1.0 ethionamide Uncertain significance
Rv3083 3449400 c.897C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449454 c.951G>A synonymous_variant 1.0 ethionamide Uncertain significance
Rv3083 3449868 c.1365C>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449877 c.1374T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449885 p.Arg461Lys missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3611968 c.1149T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612208 c.909G>C synonymous_variant 1.0 pyrazinamide Uncertain significance
Rv3236c 3612250 c.867A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612319 c.798G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612322 c.795G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3613038 c.79C>A synonymous_variant 1.0 pyrazinamide Uncertain significance
Rv3236c 3613056 c.61C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3613799 c.-683G>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
lpqB 3623807 c.1104T>G synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3623900 c.1011C>T synonymous_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624895 c.16T>C synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624901 p.Thr4Ala missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625066 c.-156G>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626362 c.252A>G synonymous_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3626415 p.Asn67Asp missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626443 c.171T>C synonymous_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3626461 c.153A>G synonymous_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrA 3627437 c.-88T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627734 c.-385A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627802 c.-453T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627831 c.-482T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627839 c.-490T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
fbiB 3640899 c.-636G>A upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiB 3640980 c.-555C>T upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiB 3641909 c.375T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiB 3642467 c.933T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiB 3642599 c.1065C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
alr 3840226 p.Thr375Ala missense_variant 1.0 cycloserine Uncertain significance
alr 3840527 c.822A>C synonymous_variant 1.0 cycloserine Uncertain significance
alr 3840719 c.630A>G synonymous_variant 1.0 cycloserine Uncertain significance
alr 3840914 c.435G>C synonymous_variant 1.0 cycloserine Uncertain significance
alr 3840994 p.His119Asp missense_variant 1.0 cycloserine Uncertain significance
alr 3841112 c.237T>C synonymous_variant 1.0 cycloserine Uncertain significance
alr 3841116 p.Ala78Gly missense_variant 1.0 cycloserine Uncertain significance
alr 3841172 c.177A>C synonymous_variant 1.0 cycloserine Uncertain significance
alr 3841199 c.150T>C synonymous_variant 1.0 cycloserine Uncertain significance
rpoA 3877886 c.622C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>T synonymous_variant 1.0 rifampicin Uncertain significance
rpoA 3878124 c.384G>A synonymous_variant 1.0 rifampicin Uncertain significance
rpoA 3878947 c.-440G>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3879193 c.-686G>A upstream_gene_variant 1.0 rifampicin Uncertain significance
ddn 3986805 c.-39G>C upstream_gene_variant 1.0 delamanid Uncertain significance
pretomanid Uncertain significance
ddn 3987050 c.207C>T synonymous_variant 1.0 delamanid Uncertain significance
pretomanid Uncertain significance
ddn 3987287 c.444T>C synonymous_variant 1.0 delamanid Uncertain significance
pretomanid Uncertain significance
clpC1 4038227 c.2478G>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038443 c.2262G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038683 c.2022T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038746 c.1959C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038779 c.1926C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038848 c.1857C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039046 c.1659C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039058 c.1647C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039094 c.1611C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039100 c.1605C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039336 c.1369C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039352 c.1353C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039448 c.1257A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4039502 c.1203C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039682 c.1023C>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039700 c.1005C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039718 c.987C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040045 c.660C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040063 c.642G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.615T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040147 c.558A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040159 c.546G>A synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040213 c.492T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.429C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040363 c.342A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040393 c.312G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040450 c.255A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040471 c.234T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040534 c.171A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040551 c.154T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040573 c.132T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040657 c.48T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040879 c.-177_-175delTGGinsCGGT upstream_gene_variant 1.0 pyrazinamide Uncertain significance
panD 4043932 p.Met117Thr missense_variant 1.0 pyrazinamide Uncertain significance
panD 4044243 c.39C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
panD 4044533 c.-252T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
panD 4044569 c.-289_-288delCGinsGC upstream_gene_variant 1.0 pyrazinamide Uncertain significance
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R
glpK 4139321 c.435T>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
isoniazid Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
glpK 4139420 c.336T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
isoniazid Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
glpK 4139813 c.-58T>G upstream_gene_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139934 c.-179A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
embC 4239575 c.-288C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239600 c.-263A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240060 c.198G>C synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240106 p.Leu82Met missense_variant 0.99 ethambutol Uncertain significance
embC 4240237 c.375G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240499 p.Ser213Arg missense_variant 1.0 ethambutol Uncertain significance
embC 4240533 p.Ser224Thr missense_variant 1.0 ethambutol Uncertain significance
embC 4240559 p.Ala233Thr missense_variant 1.0 ethambutol Uncertain significance
embC 4240587 p.Gly242Ala missense_variant 1.0 ethambutol Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241698 c.1836G>C synonymous_variant 1.0 ethambutol Uncertain significance
embC 4241710 c.1848G>A synonymous_variant 1.0 ethambutol Uncertain significance
embC 4241758 c.1896G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241920 c.2058C>T synonymous_variant 0.99 ethambutol Uncertain significance
embC 4241921 p.Gly687Arg missense_variant 0.99 ethambutol Uncertain significance
embC 4242092 c.2230T>C synonymous_variant 1.0 ethambutol Uncertain significance
embA 4242325 c.-908C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embA 4242460 c.-773G>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242655 c.-578A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embA 4242946 c.-287T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embA 4243628 c.396A>G synonymous_variant 1.0 ethambutol Uncertain significance
embA 4243649 c.417G>C synonymous_variant 1.0 ethambutol Uncertain significance
embA 4243690 p.Met153Thr missense_variant 0.99 ethambutol Uncertain significance
embA 4243961 c.729G>A synonymous_variant 1.0 ethambutol Uncertain significance
embA 4244154 p.Thr308Pro missense_variant 1.0 ethambutol Uncertain significance
embA 4244177 c.945G>C synonymous_variant 1.0 ethambutol Uncertain significance
embA 4244178 p.Ala316Thr missense_variant 1.0 ethambutol Uncertain significance
embA 4244312 c.1080T>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4244846 c.1614C>G synonymous_variant 1.0 ethambutol Uncertain significance
embA 4245023 c.1791A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4245764 c.-750G>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embA 4246193 c.2961C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4246443 p.Asp1071Asn missense_variant 1.0 ethambutol Uncertain significance
embB 4247590 c.1077A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247815 c.1302C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 1.0 ethambutol Uncertain significance
embB 4248206 p.Ser565Gly missense_variant 1.0 ethambutol Uncertain significance
embB 4248226 c.1713G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
aftB 4268331 p.Gln169Pro missense_variant 1.0 ethambutol Uncertain significance
aftB 4268810 c.27G>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269588 c.246G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269811 p.Gln8Arg missense_variant 1.0 ethambutol Uncertain significance
ethA 4326463 c.1011C>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
ethA 4326740 p.Arg245His missense_variant 1.0 ethionamide Uncertain significance
ethR 4327547 c.-2_-1insA upstream_gene_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338741 c.-220A>G upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338785 c.-266_-264delGGCinsAG upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338878 c.-357C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407568 p.Ala212Val missense_variant 1.0 streptomycin Uncertain significance
gid 4407572 p.Ile211Val missense_variant 1.0 streptomycin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407703 p.Ala167Val missense_variant 1.0 streptomycin Uncertain significance
gid 4407705 c.498G>T synonymous_variant 1.0 streptomycin Uncertain significance
gid 4407782 p.Ala141Thr missense_variant 1.0 streptomycin Uncertain significance
gid 4407822 c.381A>G synonymous_variant 0.99 streptomycin Uncertain significance
gid 4407943 p.Gln87Arg missense_variant 1.0 streptomycin Uncertain significance
gid 4407951 c.252G>T synonymous_variant 1.0 streptomycin Uncertain significance
gid 4408008 c.195C>G synonymous_variant 1.0 streptomycin Uncertain significance
gid 4408110 p.Val31Ala missense_variant 1.0 streptomycin Uncertain significance
gid 4408113 c.90T>C synonymous_variant 1.0 streptomycin Uncertain significance
gid 4408153 p.Gly17Asp missense_variant 1.0 streptomycin Uncertain significance
gid 4408176 c.27T>C synonymous_variant 1.0 streptomycin Uncertain significance
gid 4408228 c.-28_-27delCA upstream_gene_variant 0.98 streptomycin Uncertain significance