TB-Profiler result

Run: ERR4814396

Summary

Run ID: ERR4814396

Sample name:

Date: 2024-03-25T23:11:25.910410

Number of reads: 4510221

Percentage reads mapped: 86.83

Median coverage: 80.0

Strain: lineage4.1.1.3

Spoligotype:

Drug-resistance: Sensitive


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 1.0
lineage4.1.1.3 Euro-American (X-type) RD193 1.0
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6673 c.-629A>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.12 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.1 levofloxacin
moxifloxacin
gyrA 6739 c.-563C>T upstream_gene_variant 0.11 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7559 c.258G>C synonymous_variant 0.11 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8330 c.1029C>G synonymous_variant 0.11 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.11 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8846 c.1545C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9437 c.2136G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760571 c.765G>C synonymous_variant 0.12 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.13 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.13 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.13 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.13 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.14 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760910 c.1104C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.11 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.11 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.11 rifampicin
rpoC 763732 c.363C>A synonymous_variant 0.14 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.12 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.12 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.12 rifampicin Uncertain significance
rpoC 765886 c.2517C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765907 c.2538G>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781802 c.243G>C synonymous_variant 0.1 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.12 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.12 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.12 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.2 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.16 streptomycin
rplC 800219 c.-590T>C upstream_gene_variant 1.0 linezolid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rpsA 1833823 c.282G>A synonymous_variant 0.11 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.11 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.11 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.12 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.13 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.14 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155296 c.816C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.1 isoniazid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087225 p.Val136Leu missense_variant 1.0 cycloserine
fbiD 3339178 p.Ala21Thr missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877638 c.870T>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
clpC1 4038838 c.1867C>T synonymous_variant 0.13 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.13 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4038974 c.1731T>C synonymous_variant 0.11 pyrazinamide Not assoc w R - Interim
clpC1 4039121 c.1584T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.21 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.18 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.2 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.12 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.12 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.12 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.11 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.1 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.12 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040546 c.159G>C synonymous_variant 0.11 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.11 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.11 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.12 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.13 pyrazinamide
embC 4239763 c.-100C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embB 4249408 c.2895G>A synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin