TB-Profiler result

Run: ERR4814396
Summary

Run ID: ERR4814396

Sample name:

Date: 2025-09-15T14:45:24.213794

Number of reads: 4510221

Percentage reads mapped: 86.83

Median coverage: 80.0

Strain: lineage4.1.1.3

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 100.0
lineage4.1 Euro-American None 100.0
lineage4.1.1 Euro-American (X-type) None 100.0
lineage4.1.1.3 Euro-American (X-type) RD193 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6673 c.-629A>C upstream_gene_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6676 c.-626T>G upstream_gene_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6703 c.-599G>C upstream_gene_variant 0.12 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6712 c.-590G>C upstream_gene_variant 0.1 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6739 c.-563C>T upstream_gene_variant 0.11 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7559 c.258G>C synonymous_variant 0.11 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8330 c.1029C>G synonymous_variant 0.11 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.11 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8837 c.1536C>G synonymous_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8846 c.1545C>T synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8852 c.1551T>C synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8858 c.1557T>C synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8870 c.1569G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9437 c.2136G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760571 c.765G>C synonymous_variant 0.12 rifampicin Uncertain significance
rpoB 760588 p.Thr261Ile missense_variant 0.13 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.13 rifampicin Uncertain significance
rpoB 760595 c.789C>T synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 760596 p.Thr264Pro missense_variant 0.13 rifampicin Uncertain significance
rpoB 760608 c.802C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760668 p.Thr288Ala missense_variant 0.14 rifampicin Uncertain significance
rpoB 760674 c.868T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760910 c.1104C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.11 rifampicin Uncertain significance
rpoC 763711 c.342G>C synonymous_variant 0.11 rifampicin Uncertain significance
rpoC 763714 c.345G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.11 rifampicin Uncertain significance
rpoC 763732 c.363C>A synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 764692 c.1323C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.12 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.12 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.12 rifampicin Uncertain significance
rpoC 765886 c.2517C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765907 c.2538G>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781802 c.243G>C synonymous_variant 0.1 streptomycin Uncertain significance
rpsL 781817 c.258G>T synonymous_variant 0.12 streptomycin Uncertain significance
rpsL 781829 c.270G>C synonymous_variant 0.12 streptomycin Uncertain significance
rpsL 781832 c.273T>C synonymous_variant 0.12 streptomycin Uncertain significance
rpsL 781859 c.300T>C synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.2 streptomycin Uncertain significance
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin Uncertain significance
rpsL 781877 c.318T>A synonymous_variant 0.16 streptomycin Uncertain significance
rplC 800219 c.-590T>C upstream_gene_variant 1.0 linezolid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.13 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473770 n.113T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833823 c.282G>A synonymous_variant 0.11 pyrazinamide Uncertain significance
rpsA 1833838 c.297G>C synonymous_variant 0.11 pyrazinamide Uncertain significance
rpsA 1833841 c.300C>G synonymous_variant 0.11 pyrazinamide Uncertain significance
rpsA 1833847 c.306C>G synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833874 c.333T>G synonymous_variant 0.12 pyrazinamide Uncertain significance
rpsA 1833886 c.345C>G synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833894 p.Ala118Glu missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1833949 c.408T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155296 c.816C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.1 isoniazid Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3087225 p.Val136Leu missense_variant 1.0 cycloserine Uncertain significance
fbiD 3339178 p.Ala21Thr missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877638 c.870T>C synonymous_variant 0.1 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
clpC1 4038838 c.1867C>T synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4038860 c.1845G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4038974 c.1731T>C synonymous_variant 0.11 pyrazinamide Not assoc w R - Interim
clpC1 4039121 c.1584T>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039169 p.Glu512Asp missense_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039172 c.1533A>G synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039178 c.1527G>C synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039183 c.1522T>C synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039190 c.1515C>T synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039196 c.1509G>A synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039199 p.Ala502Glu missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039208 c.1497C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039220 c.1485G>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039454 c.1251A>G synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039469 c.1236T>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039472 c.1233G>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039478 c.1227G>C synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039481 c.1224T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039487 c.1218G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039522 c.1183C>T synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039528 c.1177C>A synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039541 c.1164C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039544 c.1161C>T synonymous_variant 0.12 pyrazinamide Uncertain significance
clpC1 4039622 c.1083C>T synonymous_variant 0.12 pyrazinamide Uncertain significance
clpC1 4039649 c.1056G>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039661 c.1044T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039682 c.1023C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039694 c.1011G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039724 c.981A>G synonymous_variant 0.12 pyrazinamide Uncertain significance
clpC1 4039748 c.957G>C synonymous_variant 0.11 pyrazinamide Uncertain significance
clpC1 4039751 c.954A>G synonymous_variant 0.11 pyrazinamide Uncertain significance
clpC1 4040015 c.690G>C synonymous_variant 0.1 pyrazinamide Uncertain significance
clpC1 4040033 c.672G>C synonymous_variant 0.12 pyrazinamide Uncertain significance
clpC1 4040048 c.657C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040546 c.159G>C synonymous_variant 0.11 pyrazinamide Uncertain significance
clpC1 4040558 c.147G>C synonymous_variant 0.11 pyrazinamide Uncertain significance
clpC1 4040561 c.144A>G synonymous_variant 0.11 pyrazinamide Uncertain significance
clpC1 4040573 c.132T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.12 pyrazinamide Uncertain significance
clpC1 4040582 c.123G>C synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.13 pyrazinamide Uncertain significance
embC 4239763 c.-100C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embB 4249408 c.2895G>A synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance