TB-Profiler

Lineage	Family	RDs	Frequency
La1.8	M.bovis	None	1.0
La1.8.1	M.bovis	None	1.0
La1	M.bovis	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472644	n.799C>T	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance	Mutation from literature
pncA	2289073	p.His57Asp	missense_variant	1.0	pyrazinamide	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	467	p.His156Arg	missense_variant	1.0	isoniazid	Not assoc w R
gyrB	5752	c.513G>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	5752	c.513G>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	5951	p.Ala238Pro	missense_variant	0.34	levofloxacin
gyrB	5951	p.Ala238Pro	missense_variant	0.34	moxifloxacin
gyrB	6406	c.1167C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6446	p.Ala403Ser	missense_variant	1.0	levofloxacin	Not assoc w R
gyrB	6446	p.Ala403Ser	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	8285	c.984C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8285	c.984C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9217	p.Asp639Ala	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	9217	p.Asp639Ala	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	9229	p.Asn643Ser	missense_variant	0.21	levofloxacin
gyrA	9229	p.Asn643Ser	missense_variant	0.21	moxifloxacin
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0010c	13197	p.Thr121Ser	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13228	c.330delG	frameshift_variant	1.0	isoniazid	Uncertain significance
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
fgd1	491742	c.960T>C	synonymous_variant	1.0	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
rpoB	763031	c.3225T>C	synonymous_variant	0.89	rifampicin	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	778228	p.Gly85Arg	missense_variant	0.5	bedaquiline
mmpL5	778228	p.Gly85Arg	missense_variant	0.5	clofazimine
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	1.0	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					rifampicin	Not assoc w R
Rv1129c	1254582	c.-48A>G	upstream_gene_variant	1.0	levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					isoniazid	Not assoc w R
					rifampicin	Not assoc w R
fbiC	1302899	c.-32A>G	upstream_gene_variant	1.0	pretomanid
					delamanid	Uncertain significance
					clofazimine	Uncertain significance
Rv1258c	1406492	c.849C>T	synonymous_variant	0.4	streptomycin
					pyrazinamide
					isoniazid
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.13	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472324	n.479G>C	non_coding_transcript_exon_variant	0.12	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472325	n.480G>C	non_coding_transcript_exon_variant	0.12	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472330	n.485G>T	non_coding_transcript_exon_variant	0.12	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	0.13	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472382	n.537G>A	non_coding_transcript_exon_variant	0.17	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472435	n.590T>C	non_coding_transcript_exon_variant	0.17	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472438	n.593T>C	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472439	n.594C>T	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472446	n.601T>G	non_coding_transcript_exon_variant	0.16	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472448	n.603T>C	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472450	n.605A>G	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472451	n.606C>G	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472461	n.616G>C	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472462	n.617T>C	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472464	n.619A>G	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472466	n.621C>T	non_coding_transcript_exon_variant	0.16	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472467	n.622G>C	non_coding_transcript_exon_variant	0.16	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472471	n.626G>A	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472485	n.640delGinsTA	non_coding_transcript_exon_variant	0.17	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472494	n.649A>G	non_coding_transcript_exon_variant	0.19	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472498	n.653C>T	non_coding_transcript_exon_variant	0.19	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.28	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472558	n.713G>A	non_coding_transcript_exon_variant	0.26	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472569	n.724G>A	non_coding_transcript_exon_variant	0.26	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472607	n.762G>A	non_coding_transcript_exon_variant	0.28	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472660	n.815T>C	non_coding_transcript_exon_variant	0.19	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472661	n.816A>G	non_coding_transcript_exon_variant	0.21	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.2	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472674	n.829T>A	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472677	n.832C>T	non_coding_transcript_exon_variant	0.18	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472680	n.836_837delCT	non_coding_transcript_exon_variant	0.19	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472684	n.839G>A	non_coding_transcript_exon_variant	0.19	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472685	n.840G>C	non_coding_transcript_exon_variant	0.19	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472687	n.843_844insTT	non_coding_transcript_exon_variant	0.19	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.23	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472714	n.869A>G	non_coding_transcript_exon_variant	0.22	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	0.25	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472836	n.991G>A	non_coding_transcript_exon_variant	0.23	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472840	n.995A>C	non_coding_transcript_exon_variant	0.17	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472843	n.998_999insTCGG	non_coding_transcript_exon_variant	0.17	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472846	n.1002_1005delGTCT	non_coding_transcript_exon_variant	0.17	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472856	n.1012_1013delAG	non_coding_transcript_exon_variant	0.18	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472861	n.1017_1018insCT	non_coding_transcript_exon_variant	0.18	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472874	n.1029C>T	non_coding_transcript_exon_variant	0.2	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472875	n.1030T>G	non_coding_transcript_exon_variant	0.23	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472880	n.1035G>A	non_coding_transcript_exon_variant	0.2	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	0.25	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	0.23	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472958	n.1113A>G	non_coding_transcript_exon_variant	0.23	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472988	n.1143T>C	non_coding_transcript_exon_variant	0.24	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473005	n.1160C>T	non_coding_transcript_exon_variant	0.26	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.24	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473080	n.1235C>T	non_coding_transcript_exon_variant	0.22	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473083	n.1238G>A	non_coding_transcript_exon_variant	0.21	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.2	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473089	n.1244A>T	non_coding_transcript_exon_variant	0.2	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>T	non_coding_transcript_exon_variant	0.19	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>A	non_coding_transcript_exon_variant	0.2	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.2	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.19	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473115	n.1270G>T	non_coding_transcript_exon_variant	0.19	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473123	n.1278A>T	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473128	n.1283C>T	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473132	n.1287T>C	non_coding_transcript_exon_variant	0.18	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473148	n.1303G>A	non_coding_transcript_exon_variant	0.17	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473163	n.1318C>T	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.17	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.14	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.14	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.11	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.11	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.11	linezolid	Uncertain significance
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.18	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.18	linezolid
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1475884	n.2227A>G	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1475884	n.2227A>G	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1475897	n.2240T>C	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1475897	n.2240T>C	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1475900	n.2243A>G	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1475900	n.2243A>G	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1475902	n.2245T>C	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1475902	n.2245T>C	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1475916	n.2259C>G	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1475916	n.2259C>G	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.31	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1475993	n.2336C>T	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1475993	n.2336C>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1475997	n.2340A>T	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1475997	n.2340A>T	non_coding_transcript_exon_variant	0.29	linezolid	Uncertain significance
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1476032	n.2375C>T	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1476032	n.2375C>T	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1476033	n.2376T>A	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1476033	n.2376T>A	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1476034	n.2377C>T	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1476034	n.2377C>T	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1476035	n.2378G>C	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1476035	n.2378G>C	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1476040	n.2383C>T	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1476040	n.2383C>T	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1476046	n.2389G>T	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1476046	n.2389G>T	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476080	n.2423T>A	non_coding_transcript_exon_variant	0.33	capreomycin
rrl	1476080	n.2423T>A	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1476085	n.2428G>A	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476085	n.2428G>A	non_coding_transcript_exon_variant	0.32	linezolid
rrl	1476091	n.2434_2435insC	non_coding_transcript_exon_variant	0.32	capreomycin
rrl	1476091	n.2434_2435insC	non_coding_transcript_exon_variant	0.32	linezolid
rrl	1476099	n.2442A>G	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1476099	n.2442A>G	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476100	n.2443A>C	non_coding_transcript_exon_variant	0.29	capreomycin
rrl	1476100	n.2443A>C	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1476103	n.2446C>A	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1476103	n.2446C>A	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1476105	n.2450delA	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1476105	n.2450delA	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1476110	n.2453G>T	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1476110	n.2453G>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476113	n.2456T>G	non_coding_transcript_exon_variant	0.32	capreomycin
rrl	1476113	n.2456T>G	non_coding_transcript_exon_variant	0.32	linezolid
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476160	n.2503T>C	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476160	n.2503T>C	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1476165	n.2508T>A	non_coding_transcript_exon_variant	0.36	capreomycin	Uncertain significance
rrl	1476165	n.2508T>A	non_coding_transcript_exon_variant	0.36	linezolid	Uncertain significance
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.3	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.35	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.35	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.4	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.4	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.37	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.37	linezolid	Uncertain significance
rrl	1476267	n.2610G>T	non_coding_transcript_exon_variant	0.36	capreomycin
rrl	1476267	n.2610G>T	non_coding_transcript_exon_variant	0.36	linezolid
rrl	1476276	n.2619C>A	non_coding_transcript_exon_variant	0.35	capreomycin
rrl	1476276	n.2619C>A	non_coding_transcript_exon_variant	0.35	linezolid
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476297	n.2640C>G	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476297	n.2640C>G	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476298	n.2641C>G	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476298	n.2641C>G	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476309	n.2652G>C	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1476309	n.2652G>C	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.3	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.12	capreomycin	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.12	linezolid	Uncertain significance
rpsA	1834859	p.Ala440Thr	missense_variant	1.0	pyrazinamide	Uncertain significance
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2062922	p.Ile603Val	missense_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Not assoc w R
					amikacin	Not assoc w R
ndh	2102193	p.Arg284Trp	missense_variant	0.79	isoniazid	Uncertain significance
					delamanid	Uncertain significance
					ethionamide	Uncertain significance
ndh	2103173	c.-132delG	upstream_gene_variant	1.0	isoniazid
					delamanid
					ethionamide
katG	2154687	c.1425C>T	synonymous_variant	0.31	isoniazid
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
katG	2155503	c.609C>T	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156025	c.87C>A	synonymous_variant	1.0	isoniazid	Not assoc w R
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
PPE35	2168011	p.Ser868Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168319	p.Thr765Ile	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168688	p.Pro642His	missense_variant	0.27	pyrazinamide
PPE35	2168814	c.1798dupA	frameshift_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
kasA	2519161	c.1047G>A	synonymous_variant	0.29	isoniazid
eis	2715125	p.Thr70Ala	missense_variant	1.0	kanamycin	Uncertain significance
eis	2715125	p.Thr70Ala	missense_variant	1.0	amikacin	Uncertain significance
Rv2477c	2782927	c.1116A>G	synonymous_variant	1.0	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2680	2995832	c.-273G>A	upstream_gene_variant	0.13	capreomycin
Rv2681	2997325	p.Ala196Val	missense_variant	1.0	capreomycin	Uncertain significance
ald	3086728	c.-92C>T	upstream_gene_variant	1.0	cycloserine
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
ald	3087084	c.266delA	frameshift_variant	1.0	cycloserine
Rv3083	3448783	p.Val94Ile	missense_variant	1.0	ethionamide	Uncertain significance
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624350	c.561G>T	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624350	c.561G>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624593	c.318G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624593	c.318G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624710	c.201G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624710	c.201G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
clpC1	4038403	c.2302T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
glpK	4138377	p.Val460Ala	missense_variant	1.0	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					streptomycin	Not assoc w R
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
glpK	4138977	p.Gly260Ala	missense_variant	0.9	levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					isoniazid	Uncertain significance
					streptomycin	Uncertain significance
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
glpK	4139183	c.572dupG	frameshift_variant	0.53	levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					isoniazid	Uncertain significance
					streptomycin	Uncertain significance
					rifampicin	Uncertain significance
					ethambutol	Uncertain significance
embC	4240671	p.Thr270Ile	missense_variant	1.0	ethambutol	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embC	4242970	c.3108C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244220	c.988C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4246551	p.Asn13Ser	missense_variant	0.98	ethambutol	Not assoc w R
embB	4246864	c.351C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
aftB	4267858	p.Ile327Val	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269351	c.483C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					amikacin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result