TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.8	Euro-American (mainly T)	RD219	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance	Mutation from literature
amikacin	Uncertain significance	Mutation from literature
kanamycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.92	capreomycin	Assoc w R
amikacin	Assoc w R
kanamycin	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
rpoB	762233	c.2427G>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	762236	c.2430G>T	synonymous_variant	0.44	rifampicin
rpoB	762245	c.2439G>T	synonymous_variant	0.45	rifampicin
rpoB	762254	c.2448T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	762257	c.2451C>G	synonymous_variant	0.27	rifampicin
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472112	n.267C>T	non_coding_transcript_exon_variant	0.9	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472122	n.277G>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472123	n.278A>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472124	n.279C>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>G	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472522	n.677T>G	non_coding_transcript_exon_variant	0.73	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>T	non_coding_transcript_exon_variant	0.73	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472582	n.737G>T	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472585	n.740A>C	non_coding_transcript_exon_variant	0.69	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472623	n.778A>C	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.96	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.95	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472675	n.830T>C	non_coding_transcript_exon_variant	0.95	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472677	n.832C>A	non_coding_transcript_exon_variant	0.95	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472682	n.837T>A	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472683	n.838T>C	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472687	n.842A>T	non_coding_transcript_exon_variant	0.95	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472707	n.862A>T	non_coding_transcript_exon_variant	0.96	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472954	n.1110delC	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472958	n.1113_1114insC	non_coding_transcript_exon_variant	0.92	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472986	n.1141_1142insA	non_coding_transcript_exon_variant	0.78	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472989	n.1145delA	non_coding_transcript_exon_variant	0.78	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472996	n.1151T>C	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473081	n.1236C>T	non_coding_transcript_exon_variant	0.94	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473120	n.1275C>T	non_coding_transcript_exon_variant	0.6	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.6	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473122	n.1277T>G	non_coding_transcript_exon_variant	0.6	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473123	n.1278A>G	non_coding_transcript_exon_variant	0.6	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473226	n.1381C>G	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473288	n.1443C>G	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.82	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473292	n.1447G>T	non_coding_transcript_exon_variant	0.82	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473294	n.1449A>G	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473315	n.1470T>C	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473316	n.1471C>T	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473319	n.1474C>T	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473324	n.1479G>A	non_coding_transcript_exon_variant	0.92	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474488	n.831G>A	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1474488	n.831G>A	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1474496	n.839C>T	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1474516	n.859C>T	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1474516	n.859C>T	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.88	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475978	n.2321C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475978	n.2321C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476153	n.2496T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476153	n.2496T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.88	capreomycin	Not assoc w R
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.93	capreomycin
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.9	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
PPE35	2168728	p.Gly629Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv3083	3448507	c.5_*1408del	frameshift_variant&stop_lost&splice_region_variant	1.0	ethionamide	Uncertain significance
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
amikacin	rrs	n.1484G>T	Assoc w R
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1484G>T	Assoc w R
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1484G>T	Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result