TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472733	n.888G>A	non_coding_transcript_exon_variant	0.8	streptomycin	Uncertain significance	Mutation from literature
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.72	amikacin	Uncertain significance	Mutation from literature
capreomycin	Uncertain significance	Mutation from literature
kanamycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.72	amikacin	Assoc w R
capreomycin	Assoc w R
kanamycin	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
rrs	1471896	n.51T>C	non_coding_transcript_exon_variant	0.75	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1471900	n.55C>T	non_coding_transcript_exon_variant	0.75	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.97	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472123	n.278A>T	non_coding_transcript_exon_variant	0.96	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472141	n.296G>A	non_coding_transcript_exon_variant	0.9	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472148	n.303T>C	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472251	n.406G>C	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472258	n.413A>G	non_coding_transcript_exon_variant	0.91	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472259	n.414C>A	non_coding_transcript_exon_variant	0.9	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472279	n.434T>G	non_coding_transcript_exon_variant	0.77	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472382	n.537G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472396	n.551A>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472400	n.555C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472507	n.662C>G	non_coding_transcript_exon_variant	0.7	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472517	n.672T>A	non_coding_transcript_exon_variant	0.81	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472518	n.673G>T	non_coding_transcript_exon_variant	0.58	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.6	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472537	n.692C>T	non_coding_transcript_exon_variant	0.77	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472544	n.699C>A	non_coding_transcript_exon_variant	0.65	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472545	n.700A>T	non_coding_transcript_exon_variant	0.75	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472566	n.721G>A	non_coding_transcript_exon_variant	0.63	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>C	non_coding_transcript_exon_variant	0.63	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472579	n.734G>C	non_coding_transcript_exon_variant	0.48	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472580	n.735C>T	non_coding_transcript_exon_variant	0.32	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472598	n.753A>C	non_coding_transcript_exon_variant	0.67	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472599	n.754G>T	non_coding_transcript_exon_variant	0.66	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472655	n.810G>A	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472658	n.813G>A	non_coding_transcript_exon_variant	0.78	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472661	n.816A>G	non_coding_transcript_exon_variant	0.79	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472670	n.825G>T	non_coding_transcript_exon_variant	0.72	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472673	n.828T>A	non_coding_transcript_exon_variant	0.6	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.39	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472675	n.830T>C	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472677	n.832_838delCTTCCTTinsTTTCC	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472687	n.843dupT	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472690	n.845C>A	non_coding_transcript_exon_variant	0.74	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472697	n.852T>C	non_coding_transcript_exon_variant	0.58	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.88	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472716	n.871C>T	non_coding_transcript_exon_variant	0.83	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472742	n.897C>T	non_coding_transcript_exon_variant	0.89	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472744	n.899A>G	non_coding_transcript_exon_variant	0.79	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472781	n.936C>T	non_coding_transcript_exon_variant	0.78	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472790	n.945T>C	non_coding_transcript_exon_variant	0.21	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472793	n.948A>T	non_coding_transcript_exon_variant	0.78	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472803	n.958T>A	non_coding_transcript_exon_variant	0.76	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472824	n.979T>A	non_coding_transcript_exon_variant	0.97	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472951	n.1106T>C	non_coding_transcript_exon_variant	0.3	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472952	n.1107T>C	non_coding_transcript_exon_variant	0.37	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472955	n.1110C>T	non_coding_transcript_exon_variant	0.38	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472956	n.1111T>C	non_coding_transcript_exon_variant	0.67	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	0.68	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472958	n.1113A>G	non_coding_transcript_exon_variant	0.5	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472973	n.1128A>C	non_coding_transcript_exon_variant	0.41	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.52	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472974	n.1129A>G	non_coding_transcript_exon_variant	0.42	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472978	n.1133T>C	non_coding_transcript_exon_variant	0.34	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472987	n.1142G>A	non_coding_transcript_exon_variant	0.85	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472988	n.1143T>C	non_coding_transcript_exon_variant	0.5	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472989	n.1144G>A	non_coding_transcript_exon_variant	0.52	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472990	n.1145A>G	non_coding_transcript_exon_variant	0.66	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473051	n.1206T>C	non_coding_transcript_exon_variant	0.22	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473053	n.1208T>A	non_coding_transcript_exon_variant	0.33	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473055	n.1210C>T	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.7	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473068	n.1223A>G	non_coding_transcript_exon_variant	0.29	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>T	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>A	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473102	n.1257C>T	non_coding_transcript_exon_variant	0.37	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.4	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473109	n.1264T>C	non_coding_transcript_exon_variant	0.58	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473112	n.1267A>G	non_coding_transcript_exon_variant	0.61	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473115	n.1270G>T	non_coding_transcript_exon_variant	0.4	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473123	n.1278A>T	non_coding_transcript_exon_variant	0.53	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.31	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473148	n.1303G>T	non_coding_transcript_exon_variant	0.41	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473150	n.1305T>C	non_coding_transcript_exon_variant	0.3	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473161	n.1316A>G	non_coding_transcript_exon_variant	0.29	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473163	n.1318C>A	non_coding_transcript_exon_variant	0.42	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.3	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.34	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473172	n.1327T>G	non_coding_transcript_exon_variant	0.24	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473192	n.1347A>G	non_coding_transcript_exon_variant	0.48	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473201	n.1356_1357delACinsGT	non_coding_transcript_exon_variant	0.55	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473205	n.1360T>C	non_coding_transcript_exon_variant	0.52	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473215	n.1370A>G	non_coding_transcript_exon_variant	0.32	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1473252	n.1407T>C	non_coding_transcript_exon_variant	0.31	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473259	n.1414C>G	non_coding_transcript_exon_variant	0.5	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.34	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473262	n.1417T>C	non_coding_transcript_exon_variant	0.63	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473264	n.1419A>G	non_coding_transcript_exon_variant	0.51	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473288	n.1443_1446delCTCGinsTTTTT	non_coding_transcript_exon_variant	0.8	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473294	n.1449A>G	non_coding_transcript_exon_variant	0.53	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473305	n.1460G>T	non_coding_transcript_exon_variant	0.73	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473312	n.1467G>A	non_coding_transcript_exon_variant	0.41	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473314	n.1469A>G	non_coding_transcript_exon_variant	0.56	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1473316	n.1471C>T	non_coding_transcript_exon_variant	0.79	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473317	n.1472G>C	non_coding_transcript_exon_variant	0.41	kanamycin
					capreomycin
					streptomycin
					amikacin
rrl	1474542	n.885A>G	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1474542	n.885A>G	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1474582	n.925T>C	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1474582	n.925T>C	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1474584	n.927C>T	non_coding_transcript_exon_variant	0.35	capreomycin
rrl	1474584	n.927C>T	non_coding_transcript_exon_variant	0.35	linezolid
rrl	1474615	n.958A>G	non_coding_transcript_exon_variant	0.32	capreomycin
rrl	1474615	n.958A>G	non_coding_transcript_exon_variant	0.32	linezolid
rrl	1474626	n.969T>C	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1474626	n.969T>C	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1474632	n.975G>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474632	n.975G>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474636	n.979A>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474636	n.979A>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474638	n.981C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474638	n.981C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474732	n.1075A>T	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1474732	n.1075A>T	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474753	n.1096_1097delACinsT	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474753	n.1096_1097delACinsT	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1474783	n.1126G>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1474783	n.1126G>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1474784	n.1127C>T	non_coding_transcript_exon_variant	0.81	capreomycin
rrl	1474784	n.1127C>T	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1474832	n.1175A>G	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1474832	n.1175A>G	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1474837	n.1180A>G	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1474837	n.1180A>G	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1474862	n.1205C>T	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474862	n.1205C>T	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.88	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1474883	n.1226T>C	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1474883	n.1226T>C	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1474896	n.1239A>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474896	n.1239A>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474901	n.1244A>T	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1474901	n.1244A>T	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1474902	n.1245T>C	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474902	n.1245T>C	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474913	n.1256T>C	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1474913	n.1256T>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1475673	n.2016T>C	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475673	n.2016T>C	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1475686	n.2029C>G	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1475686	n.2029C>G	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1475688	n.2031G>A	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1475688	n.2031G>A	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1475692	n.2035G>C	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475692	n.2035G>C	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475696	n.2039T>A	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475696	n.2039T>A	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1475703	n.2046A>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1475703	n.2046A>T	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475706	n.2049A>C	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1475706	n.2049A>C	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1475713	n.2056C>T	non_coding_transcript_exon_variant	0.86	capreomycin
rrl	1475713	n.2056C>T	non_coding_transcript_exon_variant	0.86	linezolid
rrl	1475715	n.2058G>C	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1475715	n.2058G>C	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1475751	n.2094C>T	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1475751	n.2094C>T	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	0.99	linezolid
rrl	1475772	n.2115A>C	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1475772	n.2115A>C	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.99	capreomycin
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.99	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.98	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.98	linezolid
rrl	1475883	n.2226A>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475883	n.2226A>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475892	n.2235A>G	non_coding_transcript_exon_variant	0.97	capreomycin
rrl	1475892	n.2235A>G	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1475897	n.2240T>G	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1475897	n.2240T>G	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.99	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1475900	n.2243A>C	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1475900	n.2243A>C	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1475916	n.2259C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475916	n.2259C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475938	n.2281C>A	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1475938	n.2281C>A	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1475945	n.2288C>A	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1475945	n.2288C>A	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.86	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.97	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.87	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1476530	n.2873C>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1476530	n.2873C>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin	rrs	n.888G>A	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
amikacin	rrs	n.1484G>T	Assoc w R
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1484G>T	Assoc w R
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1484G>T	Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result