TB-Profiler result

Run: ERR11068570
Summary

Run ID: ERR11068570

Sample name:

Date: 06-04-2023 17:45:14

Number of reads: 2564319

Percentage reads mapped: 93.1

Strain: lineage4

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.17 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620682 c.792G>A synonymous_variant 0.15
ccsA 620688 c.798G>C synonymous_variant 0.19
ccsA 620710 p.Val274Ile missense_variant 0.17
ccsA 620718 c.828G>C synonymous_variant 0.14
ccsA 620733 c.843G>C synonymous_variant 0.13
ccsA 620734 c.844C>A synonymous_variant 0.13
ccsA 620739 c.849A>G synonymous_variant 0.13
ccsA 620742 c.852G>C synonymous_variant 0.13
ccsA 620745 c.855G>C synonymous_variant 0.13
ccsA 620748 c.858T>A synonymous_variant 0.13
rpoB 760331 c.525G>C synonymous_variant 0.13
rpoB 760340 c.534G>T synonymous_variant 0.14
rpoB 760361 c.555T>C synonymous_variant 0.13
rpoB 760370 c.564C>G synonymous_variant 0.14
rpoB 760381 p.Thr192Met missense_variant 0.12
rpoB 760406 c.600G>C synonymous_variant 0.14
rpoB 760412 c.606C>G synonymous_variant 0.13
rpoB 760424 c.618C>G synonymous_variant 0.12
rpoB 761189 c.1383T>C synonymous_variant 0.15
rpoB 761195 c.1389G>C synonymous_variant 0.16
rpoB 761207 c.1401C>T synonymous_variant 0.13
rpoB 761213 c.1407G>C synonymous_variant 0.15
rpoB 761219 c.1413G>C synonymous_variant 0.14
rpoB 761249 c.1443A>G synonymous_variant 0.16
rpoB 761255 c.1449T>G synonymous_variant 0.2
rpoB 761261 c.1455G>T synonymous_variant 0.2
rpoB 761306 c.1500C>G synonymous_variant 0.21
rpoB 761312 c.1506G>C synonymous_variant 0.22
rpoB 761327 c.1521A>G synonymous_variant 0.21
rpoB 761330 c.1524G>C synonymous_variant 0.19
rpoB 761354 c.1548C>T synonymous_variant 0.19
rpoB 761360 c.1554T>C synonymous_variant 0.19
rpoB 761362 p.Ser519Thr missense_variant 0.17
rpoB 761373 p.Val523His missense_variant 0.14
rpoB 761948 c.2142G>C synonymous_variant 0.12
rpoB 761954 c.2148C>G synonymous_variant 0.13
rpoB 762185 c.2379G>C synonymous_variant 0.12
rpoB 762206 c.2400C>G synonymous_variant 0.13
rpoB 762233 c.2427G>C synonymous_variant 0.14
rpoB 762246 c.2440C>T synonymous_variant 0.13
rpoB 762254 c.2448T>G synonymous_variant 0.14
rpoB 762257 c.2451C>G synonymous_variant 0.12
rpoB 762284 c.2478G>C synonymous_variant 0.15
rpoB 762293 c.2487T>C synonymous_variant 0.15
rpoB 762317 c.2511A>G synonymous_variant 0.16
rpoB 762329 c.2523G>C synonymous_variant 0.15
rpoB 762338 c.2532T>C synonymous_variant 0.15
rpoB 762347 c.2541T>C synonymous_variant 0.14
rpoB 762362 p.Glu852Asp missense_variant 0.16
rpoB 762369 c.2563T>C synonymous_variant 0.14
rpoC 762398 c.-972T>C upstream_gene_variant 0.16
rpoC 762401 c.-969G>C upstream_gene_variant 0.14
rpoC 762404 c.-966T>C upstream_gene_variant 0.14
rpoC 762410 c.-960T>C upstream_gene_variant 0.19
rpoC 762416 c.-954A>G upstream_gene_variant 0.18
rpoC 762419 c.-951C>G upstream_gene_variant 0.17
rpoC 762434 c.-936T>C upstream_gene_variant 0.18
rpoC 762449 c.-921C>A upstream_gene_variant 0.17
rpoC 762467 c.-903C>T upstream_gene_variant 0.14
rpoC 762488 c.-882G>C upstream_gene_variant 0.13
rpoB 762490 p.Val895Asp missense_variant 0.12
rpoC 763660 c.291T>G synonymous_variant 0.14
rpoC 763675 c.306C>G synonymous_variant 0.13
rpoC 763696 c.327T>C synonymous_variant 0.14
rpoC 763702 c.333C>G synonymous_variant 0.14
rpoC 763717 c.348T>C synonymous_variant 0.15
rpoC 763723 c.354G>C synonymous_variant 0.16
rpoC 763732 c.363C>G synonymous_variant 0.16
rpoC 763741 c.372C>T synonymous_variant 0.15
rpoC 763744 c.375G>C synonymous_variant 0.15
rpoC 763765 c.396T>C synonymous_variant 0.16
rpoC 763774 c.405G>C synonymous_variant 0.17
rpoC 763807 c.438T>C synonymous_variant 0.17
rpoC 763816 c.447C>G synonymous_variant 0.16
rpoC 763835 p.Ala156Met missense_variant 0.15
rpoC 763853 p.Val162Ile missense_variant 0.13
rpoC 763858 c.489A>G synonymous_variant 0.13
rpoC 764098 c.729A>G synonymous_variant 0.14
rpoC 764101 c.732C>G synonymous_variant 0.14
rpoC 764102 p.Val245Ile missense_variant 0.14
rpoC 764112 p.Tyr248Phe missense_variant 0.16
rpoC 764116 c.747C>T synonymous_variant 0.16
rpoC 764131 c.762T>C synonymous_variant 0.14
rpoC 764140 c.771C>T synonymous_variant 0.14
rpoC 764188 c.819A>G synonymous_variant 0.17
rpoC 764195 p.Ser276Ile missense_variant 0.16
rpoC 764203 c.834G>C synonymous_variant 0.18
rpoC 764206 c.837T>C synonymous_variant 0.16
rpoC 764215 c.846A>G synonymous_variant 0.2
rpoC 764236 c.867G>A synonymous_variant 0.19
rpoC 764248 c.879C>G synonymous_variant 0.18
rpoC 764257 c.888G>C synonymous_variant 0.16
rpoC 764266 c.897T>C synonymous_variant 0.12
rpoC 764269 c.900G>C synonymous_variant 0.14
rpoC 764272 c.903G>C synonymous_variant 0.14
rpoC 764278 c.909A>G synonymous_variant 0.13
rpoC 764353 c.984G>C synonymous_variant 0.12
rpoC 764497 c.1128A>G synonymous_variant 0.15
rpoC 764510 c.1141C>T synonymous_variant 0.14
rpoC 764521 c.1152T>C synonymous_variant 0.14
rpoC 764527 c.1158C>T synonymous_variant 0.15
rpoC 764536 c.1167G>C synonymous_variant 0.16
rpoC 764539 c.1170C>G synonymous_variant 0.16
rpoC 764554 c.1185C>T synonymous_variant 0.19
rpoC 764560 c.1191T>C synonymous_variant 0.2
rpoC 764566 c.1197C>G synonymous_variant 0.22
rpoC 764575 c.1206T>G synonymous_variant 0.23
rpoC 764581 c.1212T>C synonymous_variant 0.24
rpoC 764593 c.1224C>T synonymous_variant 0.29
rpoC 764611 c.1242G>T synonymous_variant 0.3
rpoC 764650 c.1281G>C synonymous_variant 0.26
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.26
rpoC 764752 c.1383G>C synonymous_variant 0.2
rpoC 764764 c.1395T>C synonymous_variant 0.19
rpoC 764809 c.1440C>T synonymous_variant 0.22
rpoC 764815 c.1446A>G synonymous_variant 0.24
rpoC 764827 c.1458G>C synonymous_variant 0.2
rpoC 764858 c.1489T>C synonymous_variant 0.21
rpoC 764872 c.1503A>G synonymous_variant 0.23
rpoC 764888 c.1519T>C synonymous_variant 0.23
rpoC 764911 c.1542A>G synonymous_variant 0.26
rpoC 764932 c.1563C>A synonymous_variant 0.23
rpoC 764935 c.1566T>C synonymous_variant 0.23
rpoC 764948 c.1579T>C synonymous_variant 0.2
rpoC 764968 c.1599T>C synonymous_variant 0.21
rpoC 764995 c.1626C>G synonymous_variant 0.19
rpoC 765019 c.1650A>G synonymous_variant 0.17
rpoC 765034 c.1665T>C synonymous_variant 0.16
rpoC 765040 c.1671T>C synonymous_variant 0.14
rpoC 765041 c.1672T>C synonymous_variant 0.14
rpoC 765383 p.Met672Leu missense_variant 0.16
rpoC 765404 p.Leu679Val missense_variant 0.17
rpoC 765409 c.2040T>C synonymous_variant 0.19
rpoC 765421 c.2052C>G synonymous_variant 0.2
rpoC 765478 c.2109T>C synonymous_variant 0.2
rpoC 765499 c.2130C>G synonymous_variant 0.21
rpoC 765529 c.2160C>T synonymous_variant 0.18
rpoC 765541 c.2172C>G synonymous_variant 0.18
rpoC 765553 c.2184C>T synonymous_variant 0.19
rpoC 765556 c.2187G>C synonymous_variant 0.2
rpoC 765559 c.2190G>C synonymous_variant 0.21
rpoC 765580 c.2211G>C synonymous_variant 0.23
rpoC 765613 p.His748Gln missense_variant 0.24
rpoC 765625 c.2256C>G synonymous_variant 0.26
rpoC 765631 p.Asp754Glu missense_variant 0.25
rpoC 765700 c.2331T>C synonymous_variant 0.21
rpoC 765734 c.2365T>C synonymous_variant 0.19
rpoC 765739 c.2370G>T synonymous_variant 0.15
rpoC 765751 c.2382C>G synonymous_variant 0.13
rpoC 765753 p.Asp795Ala missense_variant 0.13
rpoC 765811 c.2442T>C synonymous_variant 0.14
rpoC 765814 c.2445A>G synonymous_variant 0.16
rpoC 765826 c.2457T>C synonymous_variant 0.13
rpoC 765850 c.2481G>C synonymous_variant 0.14
rpoC 765883 c.2514C>G synonymous_variant 0.13
rpoC 765886 c.2517C>G synonymous_variant 0.14
rpoC 765892 c.2523T>C synonymous_variant 0.13
rpoC 767098 c.3729T>C synonymous_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781703 c.144G>T synonymous_variant 0.12
rpsL 781742 c.183C>T synonymous_variant 0.13
rpsL 781748 c.189C>G synonymous_variant 0.14
rpsL 781754 c.195G>C synonymous_variant 0.15
rpsL 781760 c.201T>C synonymous_variant 0.15
rpsL 781772 c.213C>A synonymous_variant 0.14
rplC 800612 c.-197A>G upstream_gene_variant 0.2
rplC 800618 c.-191T>C upstream_gene_variant 0.21
rplC 800627 c.-182C>T upstream_gene_variant 0.22
rplC 800648 c.-161A>T upstream_gene_variant 0.24
rplC 800654 c.-155T>C upstream_gene_variant 0.22
rplC 800693 c.-116A>G upstream_gene_variant 0.19
rplC 800703 c.-106T>C upstream_gene_variant 0.18
rplC 800715 c.-94A>C upstream_gene_variant 0.18
rplC 800720 c.-89T>C upstream_gene_variant 0.18
rplC 800723 c.-86C>G upstream_gene_variant 0.17
rplC 800747 c.-62C>G upstream_gene_variant 0.15
rplC 800771 c.-38C>T upstream_gene_variant 0.16
rplC 801309 c.501C>G synonymous_variant 0.14
rplC 801312 c.504G>C synonymous_variant 0.14
rplC 801321 c.513C>T synonymous_variant 0.14
rplC 801324 c.516T>C synonymous_variant 0.14
fbiC 1303797 c.867A>G synonymous_variant 0.13
fbiC 1303818 c.888C>G synonymous_variant 0.14
fbiC 1303836 c.906G>C synonymous_variant 0.15
fbiC 1303845 c.915C>G synonymous_variant 0.16
fbiC 1303846 p.Phe306Val missense_variant 0.16
fbiC 1303854 c.924T>C synonymous_variant 0.16
fbiC 1303860 c.930A>C synonymous_variant 0.15
fbiC 1303884 c.954T>G synonymous_variant 0.17
fbiC 1303905 c.975G>C synonymous_variant 0.12
atpE 1461132 p.Val30Ile missense_variant 0.14
atpE 1461149 c.105T>G synonymous_variant 0.14
atpE 1461150 p.Ile36Val missense_variant 0.14
atpE 1461158 c.114T>G synonymous_variant 0.14
atpE 1461159 p.Val39Ile missense_variant 0.14
atpE 1461170 c.126A>G synonymous_variant 0.15
atpE 1461185 c.141G>T synonymous_variant 0.13
atpE 1461197 c.153A>G synonymous_variant 0.14
atpE 1461219 c.175T>C synonymous_variant 0.14
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.15
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.15
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.15
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.18
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.16
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.16
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.14
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.16
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.15
rrl 1473637 n.-21A>G upstream_gene_variant 1.0
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.12
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.12
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.13
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.14
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.14
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.15
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.14
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.15
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.16
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.14
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.13
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.13
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.14
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.14
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.13
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.13
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.21
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.12
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.13
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.13
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.2
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.21
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.19
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.12
rpsA 1833661 c.120A>G synonymous_variant 0.15
rpsA 1833667 c.126C>G synonymous_variant 0.16
rpsA 1833721 c.180A>G synonymous_variant 0.18
rpsA 1833724 c.183C>G synonymous_variant 0.18
rpsA 1833727 c.186G>C synonymous_variant 0.19
rpsA 1833742 c.201A>G synonymous_variant 0.21
rpsA 1833745 c.204G>C synonymous_variant 0.19
rpsA 1833748 c.207C>G synonymous_variant 0.19
rpsA 1833787 c.246C>G synonymous_variant 0.18
rpsA 1833790 c.249T>C synonymous_variant 0.15
rpsA 1833802 c.261A>G synonymous_variant 0.16
rpsA 1833811 c.270G>T synonymous_variant 0.15
rpsA 1833838 c.297G>C synonymous_variant 0.2
rpsA 1833841 c.300C>G synonymous_variant 0.2
rpsA 1833847 c.306C>G synonymous_variant 0.23
rpsA 1833856 c.315A>G synonymous_variant 0.21
rpsA 1833874 c.333T>C synonymous_variant 0.21
rpsA 1833886 c.345C>G synonymous_variant 0.22
rpsA 1833928 c.387G>C synonymous_variant 0.21
rpsA 1833940 c.399C>G synonymous_variant 0.24
rpsA 1833971 c.430C>T synonymous_variant 0.23
rpsA 1833979 c.438T>C synonymous_variant 0.22
rpsA 1834000 c.459G>C synonymous_variant 0.2
rpsA 1834021 c.480C>T synonymous_variant 0.18
rpsA 1834030 c.489C>G synonymous_variant 0.15
rpsA 1834249 c.708T>C synonymous_variant 0.13
rpsA 1834261 c.720A>G synonymous_variant 0.14
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.14
rpsA 1834303 c.762T>C synonymous_variant 0.17
rpsA 1834306 c.765T>C synonymous_variant 0.17
rpsA 1834348 c.807T>C synonymous_variant 0.14
rpsA 1834366 c.825A>G synonymous_variant 0.13
rpsA 1834732 c.1191T>C synonymous_variant 0.13
rpsA 1834733 p.Ala398Ser missense_variant 0.13
rpsA 1834738 c.1197A>G synonymous_variant 0.13
rpsA 1834753 c.1212T>C synonymous_variant 0.14
rpsA 1834765 p.Glu408Asp missense_variant 0.15
rpsA 1834775 p.Ala412Thr missense_variant 0.14
rpsA 1834780 c.1239A>G synonymous_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154735 p.Lys459Asn missense_variant 1.0
katG 2154915 c.1197A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3877613 p.Ile299Val missense_variant 0.16
rpoA 3877656 c.852T>G synonymous_variant 0.2
rpoA 3877668 c.840A>G synonymous_variant 0.24
rpoA 3877679 p.Ala277Ser missense_variant 0.24
rpoA 3877686 c.822A>G synonymous_variant 0.19
rpoA 3877692 c.816G>C synonymous_variant 0.19
rpoA 3877704 c.804G>C synonymous_variant 0.22
rpoA 3877743 c.765T>C synonymous_variant 0.19
rpoA 3877764 c.744C>G synonymous_variant 0.16
rpoA 3877770 c.738A>G synonymous_variant 0.15
rpoA 3877776 c.732T>C synonymous_variant 0.15
rpoA 3877782 c.726T>C synonymous_variant 0.13
rpoA 3877962 c.546G>T synonymous_variant 0.14
rpoA 3877986 c.522G>C synonymous_variant 0.16
rpoA 3877989 c.519A>G synonymous_variant 0.16
rpoA 3878001 c.507A>G synonymous_variant 0.16
rpoA 3878022 c.486T>C synonymous_variant 0.15
rpoA 3878028 c.480G>C synonymous_variant 0.15
rpoA 3878031 c.477T>C synonymous_variant 0.15
rpoA 3878040 c.468T>C synonymous_variant 0.16
rpoA 3878043 c.465G>A synonymous_variant 0.15
rpoA 3878055 c.453A>G synonymous_variant 0.15
rpoA 3878058 c.450G>T synonymous_variant 0.15
rpoA 3878061 c.447G>C synonymous_variant 0.16
rpoA 3878067 c.441C>G synonymous_variant 0.15
rpoA 3878070 c.438T>C synonymous_variant 0.15
rpoA 3878076 c.432C>T synonymous_variant 0.16
rpoA 3878082 c.426T>G synonymous_variant 0.15
rpoA 3878367 c.141C>G synonymous_variant 0.12
rpoA 3878376 c.132G>C synonymous_variant 0.14
rpoA 3878385 c.123C>G synonymous_variant 0.13
rpoA 3878415 c.93C>T synonymous_variant 0.13
rpoA 3878424 c.84G>C synonymous_variant 0.13
rpoA 3878442 c.66G>C synonymous_variant 0.13
rpoA 3878454 c.54A>C synonymous_variant 0.14
clpC1 4038749 c.1956C>G synonymous_variant 0.18
clpC1 4038755 c.1950G>T synonymous_variant 0.18
clpC1 4038770 c.1935C>T synonymous_variant 0.19
clpC1 4038773 c.1932T>C synonymous_variant 0.18
clpC1 4038782 c.1923G>C synonymous_variant 0.18
clpC1 4038812 c.1893T>C synonymous_variant 0.2
clpC1 4038821 c.1884G>A synonymous_variant 0.19
clpC1 4038845 c.1860G>C synonymous_variant 0.18
clpC1 4038860 c.1845G>C synonymous_variant 0.19
clpC1 4038878 c.1827A>G synonymous_variant 0.16
clpC1 4038956 c.1749T>C synonymous_variant 0.13
clpC1 4038965 c.1740T>C synonymous_variant 0.13
clpC1 4038989 c.1716T>C synonymous_variant 0.14
clpC1 4038997 c.1708T>C synonymous_variant 0.15
clpC1 4039004 c.1701C>G synonymous_variant 0.16
clpC1 4039022 c.1683A>G synonymous_variant 0.15
clpC1 4039064 c.1641C>T synonymous_variant 0.18
clpC1 4039097 c.1608G>C synonymous_variant 0.13
clpC1 4039103 c.1602T>C synonymous_variant 0.13
clpC1 4039112 c.1593C>G synonymous_variant 0.13
clpC1 4039274 c.1431G>C synonymous_variant 0.14
clpC1 4039286 c.1419T>C synonymous_variant 0.16
clpC1 4039295 c.1410A>C synonymous_variant 0.18
clpC1 4039298 c.1407T>C synonymous_variant 0.17
clpC1 4039319 c.1386T>C synonymous_variant 0.17
clpC1 4039322 c.1383T>C synonymous_variant 0.17
clpC1 4039328 c.1377A>C synonymous_variant 0.18
clpC1 4039331 c.1374C>G synonymous_variant 0.19
clpC1 4039337 p.Thr456Gln missense_variant 0.14
clpC1 4039349 c.1356C>T synonymous_variant 0.15
clpC1 4039352 c.1353C>G synonymous_variant 0.16
clpC1 4039364 c.1341C>G synonymous_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.18
embB 4247024 p.Pro171Ala missense_variant 0.28
whiB6 4338595 c.-75delG upstream_gene_variant 1.0