TB-Profiler result

Run: ERR11068570
Summary

Run ID: ERR11068570

Sample name:

Date: 2025-02-11T19:39:23.403697

Number of reads: 2564319

Percentage reads mapped: 93.1

Median coverage: 78.0

Strain: lineage4

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
ccsA 620682 c.792G>A synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.13 kanamycin
capreomycin
amikacin
rpoB 760331 c.525G>C synonymous_variant 0.13 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.14 rifampicin
rpoB 760381 p.Thr192Met missense_variant 0.12 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.14 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.13 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.13 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.15 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.21 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.22 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.19 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.19 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.17 rifampicin
rpoB 761373 p.Val523His missense_variant 0.14 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.13 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.15 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.14 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.14 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.16 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.14 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.19 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.17 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.18 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.14 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Asp missense_variant 0.12 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.16 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.16 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.15 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.15 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.16 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.17 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.16 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.15 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.13 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.13 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.14 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.16 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.14 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.16 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.18 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.2 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.16 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.12 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.14 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.14 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.12 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.16 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.19 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.24 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.29 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.26 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.26 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.26 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.23 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.16 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.16 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.17 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.19 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.18 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.18 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.2 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.21 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.23 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.24 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.25 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.15 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.13 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.13 rifampicin Uncertain significance
rpoC 765811 c.2442T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.13 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.14 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781703 c.144G>T synonymous_variant 0.12 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.13 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.14 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.15 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.15 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.14 streptomycin
rplC 800540 c.-269T>C upstream_gene_variant 0.14 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.16 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.19 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.21 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.2 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.21 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.22 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.24 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.22 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.19 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.18 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.17 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.15 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.16 linezolid
rplC 801309 c.501C>G synonymous_variant 0.14 linezolid
rplC 801312 c.504G>C synonymous_variant 0.14 linezolid
rplC 801321 c.513C>T synonymous_variant 0.14 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.14 linezolid
fbiC 1303797 c.867A>G synonymous_variant 0.13 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.12 pretomanid
delamanid
clofazimine
atpE 1461132 p.Val30Ile missense_variant 0.14 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.14 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.14 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.14 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.14 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.15 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.13 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.14 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.14 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.14 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473637 n.-21A>G upstream_gene_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.14 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rpsA 1833661 c.120A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.15 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.14 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834732 c.1191T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.13 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.13 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.15 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.14 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.12 pyrazinamide
tsnR 1854241 c.636C>G synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064993 c.-265T>C upstream_gene_variant 0.13 kanamycin
capreomycin
streptomycin
amikacin
katG 2154735 p.Lys459Asn missense_variant 1.0 isoniazid
katG 2154915 c.1197A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv2477c 2783422 c.621T>C synonymous_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.12 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3066501 c.-310G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrA 3626759 c.591T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.12 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.12 rifampicin
bedaquiline
fbiA 3640308 c.-235C>T upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
rpoA 3877613 p.Ile299Val missense_variant 0.16 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.24 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.24 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.22 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.16 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.15 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.15 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.15 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.15 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.15 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.15 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.16 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.15 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.16 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878367 c.141C>G synonymous_variant 0.12 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.14 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.13 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.13 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.13 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.13 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.14 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.13 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.13 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.12 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.13 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.12 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.13 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.13 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.16 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.16 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.16 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.13 rifampicin
rpoA 3878838 c.-331A>T upstream_gene_variant 0.12 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.14 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.13 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.14 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.15 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.13 rifampicin
clpC1 4038749 c.1956C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.19 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038956 c.1749T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.14 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.14 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin