TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472733	n.888G>A	non_coding_transcript_exon_variant	0.38	streptomycin	Uncertain significance	Mutation from literature
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.68	amikacin	Uncertain significance	Mutation from literature
capreomycin	Uncertain significance	Mutation from literature
kanamycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.59	amikacin	Assoc w R
capreomycin	Assoc w R
kanamycin	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472113	n.268T>C	non_coding_transcript_exon_variant	0.64	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472127	n.282C>T	non_coding_transcript_exon_variant	0.69	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472128	n.283G>C	non_coding_transcript_exon_variant	0.61	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472129	n.284G>A	non_coding_transcript_exon_variant	0.35	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472151	n.306C>A	non_coding_transcript_exon_variant	0.34	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.78	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.69	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472223	n.378C>G	non_coding_transcript_exon_variant	0.5	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>A	non_coding_transcript_exon_variant	0.62	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472228	n.383G>C	non_coding_transcript_exon_variant	0.5	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472251	n.406G>A	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472256	n.411T>A	non_coding_transcript_exon_variant	0.39	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472259	n.414C>A	non_coding_transcript_exon_variant	0.46	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.67	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472537	n.692C>T	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472544	n.699C>T	non_coding_transcript_exon_variant	0.44	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.85	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>C	non_coding_transcript_exon_variant	0.69	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472573	n.728C>T	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472579	n.734G>A	non_coding_transcript_exon_variant	0.45	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.85	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472598	n.753A>C	non_coding_transcript_exon_variant	0.59	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472599	n.754G>T	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472655	n.810G>A	non_coding_transcript_exon_variant	0.62	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472658	n.813G>A	non_coding_transcript_exon_variant	0.53	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472659	n.814G>A	non_coding_transcript_exon_variant	0.5	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472661	n.816A>G	non_coding_transcript_exon_variant	0.76	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472664	n.819A>G	non_coding_transcript_exon_variant	0.34	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472666	n.821G>A	non_coding_transcript_exon_variant	0.35	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472673	n.828_830delTTTinsGCC	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472677	n.832C>G	non_coding_transcript_exon_variant	0.45	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472678	n.833T>G	non_coding_transcript_exon_variant	0.41	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472679	n.834T>C	non_coding_transcript_exon_variant	0.39	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472682	n.837_842delTTGGGAinsACGGGT	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472690	n.845C>A	non_coding_transcript_exon_variant	0.41	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472694	n.849C>T	non_coding_transcript_exon_variant	0.42	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472695	n.850C>T	non_coding_transcript_exon_variant	0.33	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472697	n.852T>G	non_coding_transcript_exon_variant	0.83	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472701	n.856T>A	non_coding_transcript_exon_variant	0.33	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472707	n.862A>G	non_coding_transcript_exon_variant	0.42	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.88	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472715	n.870C>T	non_coding_transcript_exon_variant	0.55	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472716	n.871C>T	non_coding_transcript_exon_variant	0.44	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472742	n.897C>T	non_coding_transcript_exon_variant	0.44	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472744	n.899A>G	non_coding_transcript_exon_variant	0.4	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472755	n.910G>A	non_coding_transcript_exon_variant	0.44	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472936	n.1091C>T	non_coding_transcript_exon_variant	0.46	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472954	n.1109T>C	non_coding_transcript_exon_variant	0.33	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472956	n.1111T>C	non_coding_transcript_exon_variant	0.89	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	0.84	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472958	n.1113A>T	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472959	n.1114T>A	non_coding_transcript_exon_variant	0.59	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472963	n.1118G>A	non_coding_transcript_exon_variant	0.56	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472973	n.1128A>C	non_coding_transcript_exon_variant	0.35	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472982	n.1137G>C	non_coding_transcript_exon_variant	0.9	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472987	n.1142G>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472988	n.1143T>A	non_coding_transcript_exon_variant	0.89	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472989	n.1144G>A	non_coding_transcript_exon_variant	0.51	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472990	n.1145A>G	non_coding_transcript_exon_variant	0.9	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473002	n.1157G>T	non_coding_transcript_exon_variant	0.57	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473004	n.1159T>A	non_coding_transcript_exon_variant	0.68	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473008	n.1163C>A	non_coding_transcript_exon_variant	0.57	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473009	n.1164T>C	non_coding_transcript_exon_variant	0.68	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.51	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473044	n.1199C>G	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473051	n.1206T>C	non_coding_transcript_exon_variant	0.82	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473053	n.1208T>G	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473062	n.1217T>A	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.52	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473068	n.1223A>G	non_coding_transcript_exon_variant	0.48	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473080	n.1235C>T	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473089	n.1244A>C	non_coding_transcript_exon_variant	0.82	kanamycin
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>A	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473099	n.1254T>C	non_coding_transcript_exon_variant	0.93	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473100	n.1255G>A	non_coding_transcript_exon_variant	0.73	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473116	n.1271A>G	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473127	n.1282G>A	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.72	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473148	n.1303G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473158	n.1313T>C	non_coding_transcript_exon_variant	0.62	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473163	n.1318C>T	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>G	non_coding_transcript_exon_variant	0.33	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.7	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473172	n.1327T>G	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473192	n.1347A>G	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473205	n.1360T>C	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473215	n.1370A>G	non_coding_transcript_exon_variant	0.74	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1473248	n.1403G>A	non_coding_transcript_exon_variant	0.32	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473249	n.1404T>C	non_coding_transcript_exon_variant	0.33	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473259	n.1414C>G	non_coding_transcript_exon_variant	0.72	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473262	n.1417T>C	non_coding_transcript_exon_variant	0.44	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473264	n.1419A>G	non_coding_transcript_exon_variant	0.68	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.72	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473283	n.1438T>C	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473291	n.1446G>A	non_coding_transcript_exon_variant	0.36	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1473295	n.1450G>T	non_coding_transcript_exon_variant	0.34	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.65	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473305	n.1460G>T	non_coding_transcript_exon_variant	0.61	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473315	n.1470T>C	non_coding_transcript_exon_variant	0.8	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473318	n.1473_1474delGCinsT	non_coding_transcript_exon_variant	0.93	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473327	n.1482A>G	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473328	n.1483C>T	non_coding_transcript_exon_variant	0.38	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473352	n.1507C>T	non_coding_transcript_exon_variant	0.41	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrl	1474467	n.810A>G	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474467	n.810A>G	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474468	n.811G>A	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1474468	n.811G>A	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1474476	n.819C>G	non_coding_transcript_exon_variant	0.87	capreomycin
rrl	1474476	n.819C>G	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1474479	n.822A>C	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1474479	n.822A>C	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474483	n.826C>G	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1474483	n.826C>G	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474488	n.831G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474488	n.831G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474516	n.859C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474516	n.859C>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474527	n.870T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474527	n.870T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474529	n.872A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474529	n.872A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474540	n.883T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474540	n.883T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474542	n.885A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474542	n.885A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474551	n.894G>C	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1474551	n.894G>C	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1474555	n.898T>G	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1474555	n.898T>G	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1474558	n.901G>C	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1474558	n.901G>C	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1474581	n.924C>T	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1474581	n.924C>T	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1474732	n.1075A>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1474732	n.1075A>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1474766	n.1109A>G	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1474766	n.1109A>G	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1474777	n.1120T>C	non_coding_transcript_exon_variant	0.6	capreomycin	Not assoc w R
rrl	1474777	n.1120T>C	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1474783	n.1126G>T	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1474783	n.1126G>T	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1474794	n.1137C>G	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474794	n.1137C>G	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474837	n.1180A>G	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1474837	n.1180A>G	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1474852	n.1195T>C	non_coding_transcript_exon_variant	0.86	capreomycin
rrl	1474852	n.1195T>C	non_coding_transcript_exon_variant	0.86	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.68	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1474883	n.1226T>C	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1474883	n.1226T>C	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1474896	n.1239A>T	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1474896	n.1239A>T	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1474901	n.1244A>G	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1474901	n.1244A>G	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474913	n.1256T>C	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474913	n.1256T>C	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1475686	n.2029C>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1475686	n.2029C>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1475688	n.2031G>A	non_coding_transcript_exon_variant	0.55	capreomycin
rrl	1475688	n.2031G>A	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1475696	n.2039T>G	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1475696	n.2039T>G	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1475703	n.2046A>C	non_coding_transcript_exon_variant	0.81	capreomycin
rrl	1475703	n.2046A>C	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1475706	n.2049A>C	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475706	n.2049A>C	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475713	n.2056C>T	non_coding_transcript_exon_variant	0.61	capreomycin
rrl	1475713	n.2056C>T	non_coding_transcript_exon_variant	0.61	linezolid
rrl	1475715	n.2058G>C	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1475715	n.2058G>C	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1475735	n.2078T>C	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1475735	n.2078T>C	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1475751	n.2094C>T	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1475751	n.2094C>T	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475756	n.2099T>C	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1475756	n.2099T>C	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1475769	n.2112T>C	non_coding_transcript_exon_variant	0.5	capreomycin
rrl	1475769	n.2112T>C	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1475777	n.2120A>T	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1475783	n.2126T>C	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475783	n.2126T>C	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475791	n.2134A>G	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1475791	n.2134A>G	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475883	n.2226A>C	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1475883	n.2226A>C	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475892	n.2235A>G	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1475892	n.2235A>G	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475897	n.2240T>G	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1475897	n.2240T>G	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475900	n.2243A>G	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1475900	n.2243A>G	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1475916	n.2259C>G	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1475916	n.2259C>G	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1475938	n.2281C>A	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1475938	n.2281C>A	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475945	n.2288C>A	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1475945	n.2288C>A	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.97	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476293	n.2636C>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476293	n.2636C>T	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476313	n.2656G>A	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476313	n.2656G>A	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.58	capreomycin	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.58	linezolid	Uncertain significance
rrl	1476336	n.2679C>T	non_coding_transcript_exon_variant	0.29	capreomycin
rrl	1476336	n.2679C>T	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.44	capreomycin	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.44	linezolid	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476359	n.2702C>T	non_coding_transcript_exon_variant	0.33	capreomycin
rrl	1476359	n.2702C>T	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.52	linezolid	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1476411	n.2754G>A	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1476411	n.2754G>A	non_coding_transcript_exon_variant	0.37	linezolid
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.56	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.52	linezolid	Uncertain significance
rrl	1476443	n.2786G>T	non_coding_transcript_exon_variant	0.38	capreomycin
rrl	1476443	n.2786G>T	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1476455	n.2798C>A	non_coding_transcript_exon_variant	0.36	capreomycin
rrl	1476455	n.2798C>A	non_coding_transcript_exon_variant	0.36	linezolid
rrl	1476463	n.2806C>T	non_coding_transcript_exon_variant	0.31	capreomycin
rrl	1476463	n.2806C>T	non_coding_transcript_exon_variant	0.31	linezolid
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.56	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.82	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.81	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476512	n.2855C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476512	n.2855C>T	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476524	n.2867C>T	non_coding_transcript_exon_variant	0.81	capreomycin
rrl	1476524	n.2867C>T	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476530	n.2873C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476530	n.2873C>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1476547	n.2890C>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1476547	n.2890C>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476567	n.2910C>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1476567	n.2910C>T	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1476572	n.2915G>T	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1476572	n.2915G>T	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476573	n.2916A>T	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1476573	n.2916A>T	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1476577	n.2920T>G	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1476577	n.2920T>G	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.67	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin	rrs	n.888G>A	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
amikacin	rrs	n.1484G>T	Assoc w R
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1484G>T	Assoc w R
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1484G>T	Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result