TB-Profiler result

Run: ERR9786528
Summary

Run ID: ERR9786528

Sample name:

Date: 02-04-2023 12:30:30

Number of reads: 1114197

Percentage reads mapped: 81.46

Strain: lineage4.6.2.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.2 Euro-American T;LAM RD726 1.0
lineage4.6.2.2 Euro-American (Cameroon) LAM10-CAM RD726 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoB 761627 c.1821C>T synonymous_variant 0.12
rpoB 761633 c.1827G>C synonymous_variant 0.14
rpoB 761650 p.Ser615Asn missense_variant 0.13
rpoB 761655 p.Ala617Ser missense_variant 0.13
rpoB 761666 c.1860G>C synonymous_variant 0.12
rpoB 761675 c.1869G>T synonymous_variant 0.13
rpoB 762114 p.Ile770Val missense_variant 0.12
rpoB 762128 c.2322G>C synonymous_variant 0.13
rpoB 762137 c.2331C>T synonymous_variant 0.15
rpoB 762140 c.2334G>C synonymous_variant 0.12
rpoB 762143 c.2337T>C synonymous_variant 0.14
rpoB 762149 c.2343G>C synonymous_variant 0.15
rpoB 762161 c.2355C>T synonymous_variant 0.15
rpoB 762176 c.2370T>C synonymous_variant 0.11
rpoB 762185 c.2379G>C synonymous_variant 0.11
rpoC 764134 c.765C>G synonymous_variant 0.14
rpoC 764143 c.774G>C synonymous_variant 0.16
rpoC 764147 p.Ser260Ala missense_variant 0.16
rpoC 764153 p.Gln262Lys missense_variant 0.17
rpoC 764161 c.792G>C synonymous_variant 0.16
rpoC 764162 p.Ile265Leu missense_variant 0.15
rpoC 764188 c.819A>G synonymous_variant 0.16
rpoC 764197 c.828G>C synonymous_variant 0.17
rpoC 764203 c.834G>C synonymous_variant 0.16
rpoC 764206 p.Asp279Glu missense_variant 0.16
rpoC 764207 p.Val280Thr missense_variant 0.16
rpoC 764215 c.846A>C synonymous_variant 0.16
rpoC 764217 p.Asn283Ser missense_variant 0.16
rpoC 764227 c.858G>A synonymous_variant 0.16
rpoC 764239 c.870T>G synonymous_variant 0.17
rpoC 764242 c.873C>T synonymous_variant 0.17
rpoC 764245 c.876C>G synonymous_variant 0.18
rpoC 764254 c.885G>A synonymous_variant 0.2
rpoC 764263 c.894G>C synonymous_variant 0.2
rpoC 764266 c.897T>C synonymous_variant 0.2
rpoC 764278 c.909A>G synonymous_variant 0.2
rpoC 764284 c.915G>C synonymous_variant 0.2
rpoC 764297 p.Met310Leu missense_variant 0.18
rpoC 764320 c.951C>G synonymous_variant 0.17
rpoC 764341 c.972G>C synonymous_variant 0.15
rpoC 764344 c.975C>T synonymous_variant 0.15
rpoC 764407 p.Arg346Ser missense_variant 0.11
rpoC 764428 c.1059G>C synonymous_variant 0.11
rpoC 764431 c.1062G>C synonymous_variant 0.11
rpoC 764434 c.1065A>G synonymous_variant 0.11
rpoC 764437 c.1068G>A synonymous_variant 0.12
rpoC 764446 c.1077T>C synonymous_variant 0.14
rpoC 764449 c.1080G>C synonymous_variant 0.14
rpoC 764455 c.1086G>A synonymous_variant 0.16
rpoC 764458 c.1089G>C synonymous_variant 0.18
rpoC 764461 c.1092A>G synonymous_variant 0.18
rpoC 764497 c.1128A>G synonymous_variant 0.2
rpoC 764500 c.1131C>G synonymous_variant 0.18
rpoC 764503 c.1134G>C synonymous_variant 0.17
rpoC 764509 c.1140G>T synonymous_variant 0.21
rpoC 764536 c.1167G>T synonymous_variant 0.16
rpoC 764539 c.1170C>G synonymous_variant 0.17
rpoC 764545 c.1176C>G synonymous_variant 0.18
rpoC 764548 c.1179G>A synonymous_variant 0.2
rpoC 764560 c.1191T>C synonymous_variant 0.2
rpoC 764575 c.1206T>G synonymous_variant 0.21
rpoC 764578 c.1209C>G synonymous_variant 0.21
rpoC 764602 c.1233C>T synonymous_variant 0.19
rpoC 764605 c.1236G>T synonymous_variant 0.17
rpoC 764611 c.1242G>T synonymous_variant 0.17
rpoC 764632 c.1263T>C synonymous_variant 0.18
rpoC 764650 c.1281G>T synonymous_variant 0.18
rpoC 764662 c.1293G>C synonymous_variant 0.16
rpoC 764668 c.1299C>T synonymous_variant 0.17
rpoC 764686 c.1317C>T synonymous_variant 0.16
rpoC 764701 c.1332C>G synonymous_variant 0.16
rpoC 764713 c.1344G>A synonymous_variant 0.14
rpoC 764716 c.1347G>C synonymous_variant 0.14
rpoC 764746 c.1377G>T synonymous_variant 0.12
rpoC 764749 c.1380G>C synonymous_variant 0.12
rpoC 764752 c.1383G>C synonymous_variant 0.14
rpoC 764758 c.1389C>G synonymous_variant 0.14
rpoC 764764 p.His465Gln missense_variant 0.16
rpoC 764767 c.1398G>A synonymous_variant 0.18
rpoC 764797 c.1428G>C synonymous_variant 0.18
rpoC 764803 c.1434C>G synonymous_variant 0.17
rpoC 764824 c.1455T>C synonymous_variant 0.15
rpoC 764858 c.1489T>C synonymous_variant 0.14
rpoC 764863 c.1494G>C synonymous_variant 0.15
rpoC 764869 c.1500C>T synonymous_variant 0.14
rpoC 764872 c.1503A>G synonymous_variant 0.12
rpoC 764888 c.1519T>C synonymous_variant 0.12
rpoC 764893 c.1524T>C synonymous_variant 0.12
rpoC 764902 c.1533C>G synonymous_variant 0.11
rpoC 764911 c.1542A>G synonymous_variant 0.12
rpoC 764912 p.Met515Leu missense_variant 0.12
rpoC 764917 c.1548G>C synonymous_variant 0.12
rpoC 764920 c.1551G>C synonymous_variant 0.12
rpoC 764923 c.1554A>G synonymous_variant 0.12
rpoC 764935 c.1566T>C synonymous_variant 0.13
rpoC 764939 c.1570C>T synonymous_variant 0.13
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 778298 c.-692C>T upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.14
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.12
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.12
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.12
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.14
rrs 1472497 n.652G>A non_coding_transcript_exon_variant 0.14
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.14
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.13
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.13
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.13
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.13
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.13
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.15
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.15
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.14
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.13
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.13
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.14
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.14
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.14
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.14
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.15
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.16
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.16
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.16
rrl 1473828 n.171_172insCT non_coding_transcript_exon_variant 0.12
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.12
rrl 1473835 n.179delA non_coding_transcript_exon_variant 0.12
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.12
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.12
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 0.12
rrl 1474722 n.1065T>G non_coding_transcript_exon_variant 0.13
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.12
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.13
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.13
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.12
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.13
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.11
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.13
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.14
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.12
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.16
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.16
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.15
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.13
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.15
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.13
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.13
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.12
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.12
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.14
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.14
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.16
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.18
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.19
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.19
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.2
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.16
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.16
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.16
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.17
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.18
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.16
rpsA 1833838 c.297G>C synonymous_variant 0.12
rpsA 1833847 c.306C>G synonymous_variant 0.13
rpsA 1833856 c.315A>G synonymous_variant 0.13
rpsA 1833862 c.321G>T synonymous_variant 0.12
rpsA 1833894 p.Ala118Glu missense_variant 0.14
rpsA 1833904 c.363G>A synonymous_variant 0.13
rpsA 1833928 c.387G>C synonymous_variant 0.16
rpsA 1833949 c.408T>C synonymous_variant 0.15
rpsA 1833961 c.420C>G synonymous_variant 0.15
rpsA 1833970 c.429G>C synonymous_variant 0.12
rpsA 1833979 c.438T>C synonymous_variant 0.12
rpsA 1833985 c.444G>C synonymous_variant 0.11
rpsA 1833988 c.447C>G synonymous_variant 0.12
rpsA 1833991 c.450C>A synonymous_variant 0.12
rpsA 1833997 c.456G>C synonymous_variant 0.12
rpsA 1834009 c.468C>T synonymous_variant 0.13
rpsA 1834012 c.471G>C synonymous_variant 0.13
rpsA 1834021 c.480C>T synonymous_variant 0.13
rpsA 1834030 c.489C>G synonymous_variant 0.13
rpsA 1834051 c.510G>A synonymous_variant 0.13
rpsA 1834066 c.525G>A synonymous_variant 0.11
rpsA 1834069 c.528G>C synonymous_variant 0.11
rpsA 1834294 c.753G>T synonymous_variant 0.12
rpsA 1834299 p.Gln253Pro missense_variant 0.11
rpsA 1834327 c.786G>C synonymous_variant 0.11
rpsA 1834357 c.816T>G synonymous_variant 0.12
rpsA 1834366 c.825A>G synonymous_variant 0.12
rpsA 1834375 c.834G>A synonymous_variant 0.12
rpsA 1834396 c.855G>T synonymous_variant 0.12
rpsA 1834399 p.His286Gln missense_variant 0.12
rpsA 1834411 c.870T>C synonymous_variant 0.14
rpsA 1834423 c.882G>T synonymous_variant 0.15
rpsA 1834451 c.910T>C synonymous_variant 0.16
rpsA 1834468 c.927A>G synonymous_variant 0.14
rpsA 1834483 p.Glu314Asp missense_variant 0.16
rpsA 1834486 p.Glu315Asp missense_variant 0.15
rpsA 1834489 c.948T>C synonymous_variant 0.16
rpsA 1834498 c.957C>T synonymous_variant 0.18
rpsA 1834540 c.999G>T synonymous_variant 0.19
rpsA 1834543 c.1002C>G synonymous_variant 0.2
rpsA 1834546 c.1005T>C synonymous_variant 0.19
rpsA 1834552 c.1011G>T synonymous_variant 0.2
rpsA 1834555 c.1014T>C synonymous_variant 0.2
rpsA 1834600 c.1059G>C synonymous_variant 0.14
rpsA 1834606 c.1065C>T synonymous_variant 0.14
rpsA 1834612 c.1071G>T synonymous_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2221746 c.1416_1418dupCCG disruptive_inframe_insertion 0.97
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
thyX 3067474 p.Pro158Ala missense_variant 1.0
Rv3083 3448567 p.His22Asp missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612571 c.546C>T synonymous_variant 1.0
rpoA 3877629 c.879C>G synonymous_variant 0.15
rpoA 3877656 c.852T>C synonymous_variant 0.15
rpoA 3877662 c.846C>T synonymous_variant 0.12
rpoA 3877668 c.840A>G synonymous_variant 0.14
rpoA 3877677 c.831G>C synonymous_variant 0.15
rpoA 3877680 c.828G>T synonymous_variant 0.15
rpoA 3877686 c.822A>G synonymous_variant 0.15
rpoA 3877692 c.816G>C synonymous_variant 0.16
rpoA 3877704 c.804G>T synonymous_variant 0.13
rpoA 3877728 c.780C>G synonymous_variant 0.14
rpoA 3877731 c.777G>T synonymous_variant 0.14
rpoA 3877734 c.774G>C synonymous_variant 0.15
rpoA 3877737 c.771G>C synonymous_variant 0.16
rpoA 3877749 c.759C>T synonymous_variant 0.16
rpoA 3877752 p.Asp252Glu missense_variant 0.17
rpoA 3877765 p.Ala248Ser missense_variant 0.16
rpoA 3877770 c.738A>G synonymous_variant 0.16
rpoA 3877776 c.732T>C synonymous_variant 0.15
rpoA 3877782 c.726T>C synonymous_variant 0.17
rpoA 3877785 c.723C>T synonymous_variant 0.17
rpoA 3877791 c.717C>G synonymous_variant 0.17
rpoA 3877794 c.714G>T synonymous_variant 0.17
rpoA 3877815 c.693C>A synonymous_variant 0.17
rpoA 3877818 c.690A>G synonymous_variant 0.17
rpoA 3877842 c.666A>T synonymous_variant 0.14
rpoA 3877848 c.660C>T synonymous_variant 0.14
rpoA 3877887 c.621G>C synonymous_variant 0.12
clpC1 4038953 c.1752A>G synonymous_variant 0.12
clpC1 4038956 c.1749T>C synonymous_variant 0.12
clpC1 4038965 c.1740T>C synonymous_variant 0.14
clpC1 4038971 c.1734T>C synonymous_variant 0.16
clpC1 4038974 c.1731T>C synonymous_variant 0.17
clpC1 4038986 p.Asp573Glu missense_variant 0.17
clpC1 4038997 c.1708T>C synonymous_variant 0.15
clpC1 4039004 c.1701C>G synonymous_variant 0.15
clpC1 4039007 c.1698G>C synonymous_variant 0.16
clpC1 4039022 c.1683A>G synonymous_variant 0.18
clpC1 4039040 c.1665C>G synonymous_variant 0.16
clpC1 4039046 c.1659C>A synonymous_variant 0.16
clpC1 4039070 c.1635G>C synonymous_variant 0.17
clpC1 4039073 c.1632C>T synonymous_variant 0.17
clpC1 4039079 c.1626C>G synonymous_variant 0.16
clpC1 4039085 c.1620A>G synonymous_variant 0.16
clpC1 4039090 c.1615C>T synonymous_variant 0.13
clpC1 4039097 c.1608G>T synonymous_variant 0.13
clpC1 4039100 c.1605C>G synonymous_variant 0.13
clpC1 4039106 c.1599G>C synonymous_variant 0.13
clpC1 4039654 p.Thr351Ser missense_variant 0.17
clpC1 4039661 c.1044T>C synonymous_variant 0.13
clpC1 4039664 c.1041G>C synonymous_variant 0.13
clpC1 4039670 c.1035G>C synonymous_variant 0.12
clpC1 4039682 c.1023C>G synonymous_variant 0.12
embA 4242550 c.-683C>G upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267272 p.Lys522Arg missense_variant 1.0
ethR 4326739 c.-810G>C upstream_gene_variant 1.0
ethA 4328004 c.-531C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0