TB-Profiler result

Run: ERR266124
Summary

Run ID: ERR266124

Sample name:

Date: 2025-07-24T00:26:26.998284

Number of reads: 20838039

Percentage reads mapped: 99.05

Median coverage: 308.0

Strain: M.canetti

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
M.canetti M.canetti None 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Tyr384Asn Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247663 p.Tyr384Asn missense_variant 1.0 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 72 c.72T>C synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 264 c.264C>G synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 343 p.Pro115Ser missense_variant 1.0 isoniazid Uncertain significance
dnaA 549 c.549C>T synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 708 c.708T>C synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 720 c.720G>A synonymous_variant 1.0 isoniazid Uncertain significance
dnaA 747 c.747G>A synonymous_variant 1.0 isoniazid Uncertain significance
gyrB 5025 c.-215T>G upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5207 c.-33A>C upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5440 c.201A>G synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5452 c.213G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5770 c.531C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6001 c.762G>A synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6004 c.765T>C synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6286 c.1047T>C synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6433 c.-869C>T upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6436 c.-866C>T upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 7256 c.2017C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8288 c.987T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9074 c.1773G>A synonymous_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9218 c.1917C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9377 c.2076A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9716 c.2415T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9740 c.2439G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9776 c.2475T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 490666 c.-117G>T upstream_gene_variant 0.87 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490678 c.-105_-104insG upstream_gene_variant 0.75 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490687 c.-96T>C upstream_gene_variant 0.7 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490720 c.-63T>G upstream_gene_variant 0.27 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491137 p.Glu119Gln missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491310 c.528C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
mshA 575216 c.-132C>A upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575665 c.318G>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 576757 c.1410C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ccsA 620256 c.366C>G synonymous_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620257 p.Ile123Ala missense_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620415 c.525T>C synonymous_variant 1.0 amikacin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620490 c.600A>C synonymous_variant 1.0 amikacin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620808 c.918T>C synonymous_variant 1.0 amikacin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
Rv0565c 656149 p.Gly441Asn missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 656151 c.1320C>G synonymous_variant 1.0 ethionamide Uncertain significance
Rv0565c 656358 c.1113T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 656364 c.1107T>C synonymous_variant 1.0 ethionamide Uncertain significance
Rv0565c 656838 c.633A>G synonymous_variant 1.0 ethionamide Uncertain significance
Rv0565c 656973 c.498A>C synonymous_variant 1.0 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide Uncertain significance
hadA 731852 c.-78A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
hadA 732379 c.450A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
nusG 733883 c.-370_-368delGCG upstream_gene_variant 1.0 rifampicin Uncertain significance
mmaA3 737397 c.753G>C synonymous_variant 1.0 isoniazid Uncertain significance
mmaA3 738177 c.-28G>T upstream_gene_variant 1.0 isoniazid Uncertain significance
rpoB 759741 c.-66C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763660 c.291T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764152 c.783C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766912 c.3543C>T synonymous_variant 1.0 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776132 c.2349A>G synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776432 c.2049G>A synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776807 c.1674G>C synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776818 p.Ile555Val missense_variant 0.99 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776993 c.1488A>G synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777140 c.1341G>A synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777251 c.1230C>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 777254 c.1227G>C synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777284 c.1197C>G synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777296 c.1185C>T synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777431 c.1050A>G synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777497 c.984A>G synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 777512 c.969T>C synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777591 p.Ser297Gln missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777593 c.888G>A synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777596 c.885G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 777755 c.726C>T synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 777800 c.681C>T synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpR5 778136 c.-854T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 778282 p.Asp67Asn missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 778304 p.Ile59Met missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 778470 p.Gln4Arg missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 778510 c.-30T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 778573 c.-93C>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 778654 c.-174A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 779295 c.-815A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 779439 c.-959G>T upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpR5 779468 p.Arg160Gln missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
rpsL 781291 c.-269G>C upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800111 c.-698C>T upstream_gene_variant 1.0 linezolid Uncertain significance
rplC 800155 c.-654_-653insG upstream_gene_variant 1.0 linezolid Uncertain significance
rplC 800321 c.-488T>C upstream_gene_variant 1.0 linezolid Uncertain significance
rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid Uncertain significance
Rv1129c 1253093 p.Ser481Leu missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253216 p.Glu440Ala missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253408 p.Glu376Gly missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253653 c.882T>G synonymous_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253692 c.843C>T synonymous_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253904 p.Asn211Asp missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254316 c.219G>A synonymous_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254434 p.Val34Ala missense_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254576 c.-42C>T upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254602 c.-68C>T upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254610 c.-76A>C upstream_gene_variant 0.99 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254654 c.-120A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254678 c.-144A>G upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254690 c.-156T>G upstream_gene_variant 1.0 isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
fbiC 1302694 c.-237C>T upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303857 c.927C>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304262 p.Trp444Cys missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304301 c.1371C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304315 p.Val462Ala missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304330 p.Ala467Asp missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304343 c.1413T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304439 c.1509G>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304442 c.1512T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304465 p.Gly512Asp missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304469 c.1539G>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304472 c.1542T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304481 c.1551T>G synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304487 c.1557C>G synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304496 c.1566T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304505 c.1575G>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304511 c.1581C>G synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304526 c.1596T>G synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304538 c.1608C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304546 p.Val539Ala missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304559 p.Glu543Asp missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304676 c.1746A>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304677 p.Glu583Gln missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304796 c.1866G>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304911 c.1981C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305045 c.2115A>G synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305069 c.2139G>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305093 c.2163C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305181 c.2251_2253delTTGinsCTA synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305195 c.2265T>C synonymous_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305207 c.2277C>G synonymous_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305231 c.2301C>G synonymous_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305234 c.2304G>C synonymous_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305237 c.2307A>G synonymous_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305243 c.2313T>C synonymous_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305244 c.2314T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305252 c.2322G>A synonymous_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305276 c.2346G>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305300 c.2370A>G synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305306 c.2376A>G synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305307 p.Val793Ile missense_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305311 p.Arg794Gln missense_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305318 c.2388C>G synonymous_variant 0.98 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305330 c.2400C>G synonymous_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305332 p.Glu801Gly missense_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305343 p.Asn805Asp missense_variant 0.99 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305405 c.2475A>G synonymous_variant 1.0 clofazimine Not assoc w R - Interim
delamanid Uncertain significance
pretomanid Uncertain significance
sigE 1364257 c.-156G>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
sigE 1364287 c.-126G>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
sigE 1364310 c.-103T>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
sigE 1364427 c.15C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
sigE 1364904 c.492C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
sigE 1364946 c.534C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
Rv1258c 1406466 p.Ser292Leu missense_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
Rv1258c 1406492 p.Ile283Met missense_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
Rv1258c 1407008 c.333C>A synonymous_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
Rv1258c 1407459 c.-119T>C upstream_gene_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
Rv1258c 1407532 c.-192G>C upstream_gene_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
Rv1258c 1407602 c.-262G>A upstream_gene_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
embR 1416226 c.1122T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embR 1416283 c.1065G>A synonymous_variant 1.0 ethambutol Uncertain significance
embR 1416289 c.1059G>A synonymous_variant 1.0 ethambutol Uncertain significance
embR 1416313 c.1035A>C synonymous_variant 1.0 ethambutol Uncertain significance
embR 1416538 c.810T>C synonymous_variant 1.0 ethambutol Uncertain significance
embR 1416616 c.732T>C synonymous_variant 1.0 ethambutol Uncertain significance
embR 1416688 c.660G>C synonymous_variant 1.0 ethambutol Uncertain significance
embR 1416717 c.631C>T synonymous_variant 1.0 ethambutol Uncertain significance
embR 1416847 c.501A>C synonymous_variant 1.0 ethambutol Uncertain significance
embR 1417259 p.Ser30Leu missense_variant 1.0 ethambutol Uncertain significance
embR 1417294 c.54A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embR 1417954 c.-607A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
atpE 1460897 c.-148A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
rrs 1471616 n.-230T>A upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471811 n.-35A>G upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471839 n.-6delT upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473470 n.-188A>G upstream_gene_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474275 n.618T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475416 n.1759T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476219 n.2562T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673499 c.-703T>C upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674079 c.-123C>G upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674384 c.183C>T synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674405 c.204G>A synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674471 c.270G>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674480 c.279T>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674483 c.282G>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674486 c.285T>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674603 c.402G>A synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674620 p.Pro140Gln missense_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674780 c.579T>C synonymous_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1833283 c.-259C>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833367 c.-175G>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833381 c.-161T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833444 c.-98A>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833451 c.-91A>T upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833452 c.-90C>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833454 c.-87delA upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833471 c.-71_-70insC upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833499 c.-43A>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833554 p.Thr5Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1833596 c.55_56delAGinsTC synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833806 c.265C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>A synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834411 c.870T>C synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834414 c.873C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834451 c.910T>C synonymous_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834855 c.1314C>T synonymous_variant 0.99 pyrazinamide Uncertain significance
rpsA 1834912 c.1371A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834916 p.Thr459Ser missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834924 c.1383T>G synonymous_variant 1.0 pyrazinamide Uncertain significance
tsnR 1853394 c.-212C>G upstream_gene_variant 1.0 linezolid Uncertain significance
tsnR 1853429 c.-177G>A upstream_gene_variant 1.0 linezolid Uncertain significance
tsnR 1853636 p.Thr11Ala missense_variant 1.0 linezolid Uncertain significance
tsnR 1853768 p.Arg55Trp missense_variant 1.0 linezolid Uncertain significance
tsnR 1853802 p.Ala66Val missense_variant 1.0 linezolid Uncertain significance
tsnR 1853804 p.Ser67Pro missense_variant 0.98 linezolid Uncertain significance
tsnR 1853902 c.297T>C synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1853926 c.321T>C synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1853954 p.Arg117Gly missense_variant 1.0 linezolid Uncertain significance
tsnR 1853968 c.363C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854028 c.423G>C synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854064 c.459C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854070 c.465C>T synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1854073 c.468C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854076 c.471T>C synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854105 p.Ala167Val missense_variant 1.0 linezolid Uncertain significance
tsnR 1854112 p.Asp169Glu missense_variant 1.0 linezolid Uncertain significance
tsnR 1854114 p.Val170Ala missense_variant 1.0 linezolid Uncertain significance
tsnR 1854116 p.Gly171Pro missense_variant 1.0 linezolid Uncertain significance
tsnR 1854125 p.Ile174Val missense_variant 1.0 linezolid Uncertain significance
tsnR 1854134 c.529C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854289 c.684C>T synonymous_variant 1.0 linezolid Uncertain significance
tsnR 1854292 c.687A>G synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tsnR 1854359 p.Glu252Gln missense_variant 1.0 linezolid Uncertain significance
tlyA 1917519 c.-421C>T upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917606 c.-334G>C upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917653 c.-287A>G upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917807 c.-133T>G upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917849 c.-91G>A upstream_gene_variant 1.0 capreomycin Uncertain significance
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918149 c.210A>C synonymous_variant 1.0 capreomycin Uncertain significance
tlyA 1918150 p.Val71Leu missense_variant 1.0 capreomycin Uncertain significance
tlyA 1918242 c.303G>C synonymous_variant 1.0 capreomycin Uncertain significance
tlyA 1918587 p.Gln216His missense_variant 1.0 capreomycin Uncertain significance
tlyA 1918604 p.Ser222Thr missense_variant 1.0 capreomycin Uncertain significance
bacA 2061039 c.1899_*1769del frameshift_variant&stop_lost&splice_region_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
bacA 2062922 p.Ile603Val missense_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
streptomycin Not assoc w R
bacA 2063040 c.1689C>T synonymous_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
bacA 2063391 c.1338C>G synonymous_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
ndh 2101777 c.1266C>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101795 c.1248G>C synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2101945 c.1098C>T synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102644 c.399A>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102680 c.363T>C synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102791 c.252A>G synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2102797 c.246C>T synonymous_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2103028 p.Gln5His missense_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2103173 c.-132_-131insGG upstream_gene_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2103247 c.-205C>T upstream_gene_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
ndh 2103268 c.-226A>G upstream_gene_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
katG 2153989 p.Val708Ala missense_variant 1.0 isoniazid Uncertain significance
katG 2154055 p.Lys686Thr missense_variant 1.0 isoniazid Uncertain significance
katG 2154060 c.2052T>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2154190 p.Leu641Ser missense_variant 1.0 isoniazid Uncertain significance
katG 2154252 c.1860T>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2154435 c.1677T>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2154531 c.1581A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2154594 c.1518G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2154678 c.1434G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2154870 c.1242G>A synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155062 c.1050T>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155065 c.1047C>G synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155068 c.1044T>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155071 c.1041T>G synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155074 c.1038C>T synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155080 c.1032G>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155085 c.1027C>T synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155092 c.1020G>A synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155104 c.1008G>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155119 c.993T>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155137 c.975G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2155190 p.Thr308Ala missense_variant 1.0 isoniazid Uncertain significance
katG 2155205 p.Ser303Thr missense_variant 1.0 isoniazid Uncertain significance
katG 2155233 c.879G>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155236 c.876G>A synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155326 c.786A>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155491 c.621T>C synonymous_variant 1.0 isoniazid Uncertain significance
katG 2155508 p.Ala202Ser missense_variant 1.0 isoniazid Uncertain significance
katG 2155971 c.141A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2156055 c.57C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2156661 c.-550C>G upstream_gene_variant 1.0 isoniazid Uncertain significance
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167934 c.2679G>A synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168269 p.Gly782Ser missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168342 c.2271T>C synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168567 c.2046A>G synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168612 c.2001C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168882 c.1731T>C synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2169263 c.1350C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2169304 p.Met437Leu missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2169686 c.927T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2169717 p.Asn299Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170178 c.435T>A synonymous_variant 0.99 pyrazinamide Uncertain significance
PPE35 2170232 c.381T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170394 c.219G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170440 p.Gln58Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170452 p.Gly54Asp missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170485 p.Val43Ala missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170499 c.114A>G synonymous_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170764 c.-152C>T upstream_gene_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2221723 p.Arg481His missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2222357 p.Thr270Ala missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2222504 p.Met221Leu missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2222598 c.567C>T synonymous_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2222897 p.Ile90Val missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223146 p.Arg7Gly missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223255 c.-91A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223448 c.-284C>T upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223691 c.-527G>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
pncA 2288705 c.537C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
pncA 2288792 c.450C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
pncA 2289104 c.138A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
pncA 2289132 p.Glu37Ala missense_variant 1.0 pyrazinamide Uncertain significance
pncA 2289420 c.-179T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
pncA 2289439 c.-198C>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
pncA 2289622 c.-381C>T upstream_gene_variant 1.0 pyrazinamide Uncertain significance
pncA 2289820 c.-579T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
pncA 2290000 c.-759C>T upstream_gene_variant 1.0 pyrazinamide Uncertain significance
pncA 2290015 c.-774A>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
pncA 2290159 c.-918A>T upstream_gene_variant 1.0 pyrazinamide Uncertain significance
kasA 2517969 c.-146C>T upstream_gene_variant 1.0 isoniazid Uncertain significance
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid Uncertain significance
kasA 2518265 p.Val51Ile missense_variant 1.0 isoniazid Uncertain significance
kasA 2518279 c.165T>C synonymous_variant 1.0 isoniazid Uncertain significance
kasA 2518282 c.168A>G synonymous_variant 1.0 isoniazid Uncertain significance
kasA 2518283 p.Ala57Pro missense_variant 1.0 isoniazid Uncertain significance
kasA 2518297 c.183C>T synonymous_variant 1.0 isoniazid Uncertain significance
kasA 2518300 c.186T>C synonymous_variant 1.0 isoniazid Uncertain significance
kasA 2519041 c.927C>T synonymous_variant 0.99 isoniazid Uncertain significance
kasA 2519077 c.963G>C synonymous_variant 0.99 isoniazid Uncertain significance
kasA 2519140 c.1026G>C synonymous_variant 1.0 isoniazid Uncertain significance
kasA 2519287 c.1173T>C synonymous_variant 1.0 isoniazid Uncertain significance
ahpC 2725905 c.-288C>A upstream_gene_variant 1.0 isoniazid Uncertain significance
ahpC 2726226 p.Ala12Thr missense_variant 1.0 isoniazid Uncertain significance
folC 2746174 c.1425A>C synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2746266 p.Ser445Ala missense_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2746515 c.1084C>T synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2746519 c.1080T>C synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2746771 c.828A>G synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747425 c.174C>G synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747549 p.Val17Ala missense_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747607 c.-9T>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747628 c.-30G>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747631 c.-33C>G upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747675 c.-77A>G upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747681 c.-83G>A upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
folC 2747691 c.-93A>G upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
Rv2477c 2782370 p.Gly558Asp missense_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782414 p.Asp543Glu missense_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782612 c.1431T>C synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782846 p.Arg399Gln missense_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782879 c.1164C>T synonymous_variant 1.0 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
Rv2477c 2782882 c.1161T>C synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783040 p.Ala335Thr missense_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783086 p.Asn319Ser missense_variant 0.99 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783092 c.951A>G synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Not assoc w R - Interim
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
Rv2477c 2783095 c.948C>A synonymous_variant 0.99 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783374 c.669G>C synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783593 c.450T>C synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783992 c.51T>C synonymous_variant 1.0 amikacin Uncertain significance
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
Rv2477c 2784083 c.-41T>C upstream_gene_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784098 c.-56G>C upstream_gene_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784396 c.-354A>G upstream_gene_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784399 c.-357G>A upstream_gene_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784432 c.-390A>G upstream_gene_variant 1.0 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
pepQ 2859490 p.Val310Ala missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
ribD 2987614 c.766delA frameshift_variant 1.0 para-aminosalicylic_acid Uncertain significance
Rv2680 2996009 c.-96T>C upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2680 2996010 c.-95C>A upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2680 2996040 c.-65A>T upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2680 2996142 p.Glu13Val missense_variant 1.0 capreomycin Uncertain significance
Rv2681 2996356 c.-383G>A upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2681 2996404 c.-335T>A upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2681 2996885 c.147C>T synonymous_variant 1.0 capreomycin Uncertain significance
Rv2681 2996891 c.153C>G synonymous_variant 1.0 capreomycin Uncertain significance
Rv2681 2997008 c.270C>T synonymous_variant 1.0 capreomycin Uncertain significance
Rv2681 2997054 p.Ser106Gly missense_variant 1.0 capreomycin Uncertain significance
Rv2681 2997059 c.321C>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997668 c.930G>T synonymous_variant 1.0 capreomycin Uncertain significance
Rv2752c 3064637 p.Val519Met missense_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3065131 p.Ala354Val missense_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066158 p.Thr12Ala missense_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066367 c.-176G>T upstream_gene_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066417 c.-226C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066905 c.-714T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066996 c.-805T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
thyX 3067355 c.591A>C synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyX 3067439 c.507A>G synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyX 3067980 c.-35T>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyA 3074160 c.312A>G synonymous_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyA 3074529 c.-58G>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
thyA 3074580 c.-109T>C upstream_gene_variant 1.0 para-aminosalicylic_acid Uncertain significance
ald 3086623 c.-197A>G upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086671 c.-149T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086707 c.-113G>C upstream_gene_variant 0.99 cycloserine Uncertain significance
ald 3086733 c.-87G>A upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086753 c.-67A>G upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086758 c.-62C>T upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086760 c.-60A>T upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086771 c.-49T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086773 c.-47A>G upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086788 c.-32T>A upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086797 c.-23G>A upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086803 c.-17T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086929 p.Ala37Gly missense_variant 1.0 cycloserine Uncertain significance
ald 3087020 c.201C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087065 c.246C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087070 p.Arg84Leu missense_variant 1.0 cycloserine Uncertain significance
ald 3087074 c.255G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087077 c.258A>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087079 p.His87Arg missense_variant 1.0 cycloserine Uncertain significance
ald 3087140 c.321G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087149 c.330C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087152 c.333C>T synonymous_variant 0.99 cycloserine Uncertain significance
ald 3087155 c.336C>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087158 c.339G>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087164 c.345T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087293 c.474G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087316 p.Val166Ala missense_variant 1.0 cycloserine Uncertain significance
ald 3087344 c.525C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087380 c.561C>G synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087381 p.Asn188Gly missense_variant 1.0 cycloserine Uncertain significance
ald 3087401 c.582T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087500 c.681T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087512 c.693T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087527 c.708T>C synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087533 c.714C>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087560 c.741C>T synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087644 c.825C>T synonymous_variant 0.99 cycloserine Uncertain significance
ald 3087653 c.834A>G synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087743 c.924G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087758 c.939G>A synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087800 p.His327Gln missense_variant 1.0 cycloserine Uncertain significance
ald 3087833 c.1014A>G synonymous_variant 1.0 cycloserine Uncertain significance
ald 3087857 c.1038C>T synonymous_variant 1.0 cycloserine Uncertain significance
fbiD 3339049 c.-69C>T upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiD 3339402 c.285C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
fbiD 3339568 c.451C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
Rv3083 3448349 c.-155C>T upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448403 c.-101G>A upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448452 c.-52G>A upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448453 c.-51G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448474 c.-30G>T upstream_gene_variant 0.99 ethionamide Uncertain significance
Rv3083 3448495 c.-9G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448611 c.108A>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3448972 p.His157Asp missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3449028 c.525T>C synonymous_variant 1.0 ethionamide Uncertain significance
Rv3083 3449029 p.Ser176Ala missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3449305 c.802T>C synonymous_variant 1.0 ethionamide Uncertain significance
Rv3083 3449400 c.897C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449454 c.951G>A synonymous_variant 1.0 ethionamide Uncertain significance
Rv3083 3449868 c.1365C>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449877 c.1374T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449885 p.Arg461Lys missense_variant 1.0 ethionamide Uncertain significance
whiB7 3568557 c.123A>G synonymous_variant 1.0 amikacin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
whiB7 3568568 p.Val38Ile missense_variant 1.0 amikacin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625006 c.1608A>C synonymous_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626461 c.153A>G synonymous_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrA 3626999 c.351G>A synonymous_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrA 3627437 c.-88T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627734 c.-385A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627802 c.-453T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627831 c.-482T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627839 c.-490T>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
fbiB 3641840 c.306T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiB 3642254 c.720G>A synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiB 3642467 c.933T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiB 3642599 c.1065C>T synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
alr 3840197 c.1152T>G synonymous_variant 1.0 cycloserine Uncertain significance
alr 3840527 c.822A>C synonymous_variant 1.0 cycloserine Uncertain significance
alr 3840719 c.630A>G synonymous_variant 1.0 cycloserine Uncertain significance
alr 3840761 c.588G>A synonymous_variant 1.0 cycloserine Uncertain significance
alr 3840914 c.435G>C synonymous_variant 1.0 cycloserine Uncertain significance
alr 3840994 p.His119Asp missense_variant 1.0 cycloserine Uncertain significance
alr 3841017 p.Leu111Gln missense_variant 1.0 cycloserine Uncertain significance
alr 3841172 c.177A>G synonymous_variant 1.0 cycloserine Uncertain significance
alr 3841199 c.150T>C synonymous_variant 1.0 cycloserine Uncertain significance
alr 3841220 c.129C>T synonymous_variant 1.0 cycloserine Uncertain significance
alr 3841419 c.-71T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
alr 3841531 c.-183A>G upstream_gene_variant 1.0 cycloserine Uncertain significance
alr 3841532 c.-184A>G upstream_gene_variant 1.0 cycloserine Uncertain significance
alr 3841539 c.-191C>T upstream_gene_variant 1.0 cycloserine Uncertain significance
alr 3841546 c.-198C>G upstream_gene_variant 1.0 cycloserine Uncertain significance
alr 3841549 c.-201C>T upstream_gene_variant 1.0 cycloserine Uncertain significance
alr 3841568 c.-220G>A upstream_gene_variant 1.0 cycloserine Uncertain significance
alr 3841584 c.-236C>A upstream_gene_variant 1.0 cycloserine Uncertain significance
alr 3841611 c.-264_-263insA upstream_gene_variant 1.0 cycloserine Uncertain significance
rpoA 3877886 c.622C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>T synonymous_variant 1.0 rifampicin Uncertain significance
rpoA 3878124 c.384G>A synonymous_variant 1.0 rifampicin Uncertain significance
rpoA 3878619 c.-113delC upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878630 c.-124_-123insC upstream_gene_variant 0.99 rifampicin Uncertain significance
rpoA 3878947 c.-440G>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.99 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3879193 c.-686G>A upstream_gene_variant 1.0 rifampicin Uncertain significance
ddn 3987179 c.336G>T synonymous_variant 1.0 delamanid Uncertain significance
pretomanid Uncertain significance
ddn 3987257 c.414C>G synonymous_variant 1.0 delamanid Uncertain significance
pretomanid Uncertain significance
clpC1 4038227 c.2478G>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038443 c.2262G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038683 c.2022T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038746 c.1959C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038779 c.1926C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038848 c.1857C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039046 c.1659C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039058 c.1647C>T synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4039094 c.1611C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039100 c.1605C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039336 c.1369C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039352 c.1353C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039448 c.1257A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039502 c.1203C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039682 c.1023C>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039700 c.1005C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039718 c.987C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>C synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>G synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4040045 c.660C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040063 c.642G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.615T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040147 c.558A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040159 c.546G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040213 c.492T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.429C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040363 c.342A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040393 c.312G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4040450 c.255A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040471 c.234T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4040534 c.171A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040551 c.154T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040573 c.132T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040657 c.48T>G synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4040879 c.-177_-175delTGGinsCGGT upstream_gene_variant 1.0 pyrazinamide Uncertain significance
panD 4043932 p.Met117Thr missense_variant 1.0 pyrazinamide Uncertain significance
panD 4044243 c.39C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
panD 4044533 c.-252T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
panD 4044569 c.-289_-288delCGinsGC upstream_gene_variant 1.0 pyrazinamide Uncertain significance
glpK 4138259 c.1497T>C synonymous_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R
glpK 4139096 p.Leu220Phe missense_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139183 c.572dupG frameshift_variant 0.22 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139321 c.435T>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
isoniazid Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
glpK 4139420 c.336T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
isoniazid Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
glpK 4139477 c.279A>G synonymous_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139813 c.-58T>G upstream_gene_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139934 c.-179A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
embC 4239032 c.-831T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239110 c.-753C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239142 c.-721C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239146 c.-717A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239158 c.-705C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239215 c.-648T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239284 c.-579C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239377 c.-486C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239453 c.-410G>A upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239648 c.-215A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240237 c.375G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240587 p.Gly242Ala missense_variant 1.0 ethambutol Uncertain significance
embC 4240590 p.Ala243Val missense_variant 1.0 ethambutol Uncertain significance
embC 4240604 c.742C>T synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240732 c.870C>T synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240786 c.924C>T synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240831 c.969T>G synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240867 c.1005T>G synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240870 c.1008T>C synonymous_variant 0.99 ethambutol Uncertain significance
embC 4240871 p.Val337Ile missense_variant 1.0 ethambutol Uncertain significance
embC 4240879 c.1017G>C synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240880 p.Ala340Thr missense_variant 1.0 ethambutol Uncertain significance
embC 4240886 p.Ile342Val missense_variant 1.0 ethambutol Uncertain significance
embC 4240897 c.1035C>G synonymous_variant 1.0 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240903 c.1041C>G synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240936 c.1074A>C synonymous_variant 1.0 ethambutol Uncertain significance
embC 4240981 c.1119G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241023 c.1161T>C synonymous_variant 1.0 ethambutol Uncertain significance
embC 4241035 c.1173G>A synonymous_variant 1.0 ethambutol Uncertain significance
embC 4241248 c.1386G>T synonymous_variant 1.0 ethambutol Uncertain significance
embC 4241710 c.1848G>A synonymous_variant 1.0 ethambutol Uncertain significance
embC 4241758 c.1896G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241882 p.Leu674Met missense_variant 1.0 ethambutol Uncertain significance
embC 4241957 c.2095C>A synonymous_variant 1.0 ethambutol Uncertain significance
embA 4242325 c.-908C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embA 4242487 c.-746G>A upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4242499 p.Arg879Ser missense_variant 1.0 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242655 c.-578A>G upstream_gene_variant 1.0 ethambutol Uncertain significance
embA 4242946 c.-287T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4243131 p.Pro1090Arg missense_variant 1.0 ethambutol Uncertain significance
embA 4243628 c.396A>G synonymous_variant 1.0 ethambutol Uncertain significance
embA 4243690 p.Met153Thr missense_variant 1.0 ethambutol Uncertain significance
embA 4243961 c.729G>A synonymous_variant 1.0 ethambutol Uncertain significance
embA 4244154 p.Thr308Pro missense_variant 1.0 ethambutol Uncertain significance
embA 4244177 c.945G>C synonymous_variant 1.0 ethambutol Uncertain significance
embA 4244178 p.Ala316Thr missense_variant 1.0 ethambutol Uncertain significance
embA 4244312 c.1080T>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4244456 c.1224C>T synonymous_variant 1.0 ethambutol Uncertain significance
embA 4244534 c.1302T>C synonymous_variant 1.0 ethambutol Uncertain significance
embA 4244778 p.Ser516Ala missense_variant 1.0 ethambutol Uncertain significance
embA 4244846 c.1614C>G synonymous_variant 1.0 ethambutol Uncertain significance
embA 4245023 c.1791A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4245594 p.Ser788Thr missense_variant 1.0 ethambutol Uncertain significance
embB 4246226 c.-288C>A upstream_gene_variant 1.0 ethambutol Uncertain significance
embA 4246443 p.Asp1071Asn missense_variant 1.0 ethambutol Uncertain significance
embA 4246485 p.Gly1085Ser missense_variant 1.0 ethambutol Uncertain significance
embB 4246582 c.69T>A synonymous_variant 1.0 ethambutol Uncertain significance
embB 4246682 p.Asp57Asn missense_variant 1.0 ethambutol Uncertain significance
embB 4246969 c.456T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247246 c.736_788delGGCTCAATTGCCCAGCTCCTCCTCAGGCCGTTCCGGCCTGCATCGTCGCCGGG frameshift_variant 1.0 ethambutol Uncertain significance
embB 4247305 c.792C>G synonymous_variant 1.0 ethambutol Uncertain significance
embB 4247357 p.Val282Met missense_variant 1.0 ethambutol Uncertain significance
embB 4247584 c.1071C>T synonymous_variant 1.0 ethambutol Uncertain significance
embB 4247590 c.1077A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247662 c.1149C>T synonymous_variant 1.0 ethambutol Uncertain significance
embB 4247916 p.Arg468His missense_variant 1.0 ethambutol Uncertain significance
embB 4248070 c.1557T>C synonymous_variant 1.0 ethambutol Uncertain significance
embB 4248206 p.Ser565Gly missense_variant 1.0 ethambutol Uncertain significance
embB 4248226 c.1713G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248532 c.2019C>T synonymous_variant 1.0 ethambutol Uncertain significance
embB 4248676 c.2163C>T synonymous_variant 1.0 ethambutol Uncertain significance
embB 4248931 c.2418C>G synonymous_variant 1.0 ethambutol Uncertain significance
embB 4249009 c.2496G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4249102 c.2589T>C synonymous_variant 1.0 ethambutol Uncertain significance
embB 4249334 p.Ala941Ser missense_variant 1.0 ethambutol Uncertain significance
embB 4249351 c.2838C>T synonymous_variant 1.0 ethambutol Uncertain significance
embB 4249429 c.2916C>G synonymous_variant 1.0 ethambutol Uncertain significance
embB 4249456 c.2943G>A synonymous_variant 1.0 ethambutol Uncertain significance
embB 4249786 c.3273G>A synonymous_variant 1.0 ethambutol Uncertain significance
embB 4249801 c.3288T>C synonymous_variant 1.0 ethambutol Uncertain significance
aftB 4267412 c.1425T>C synonymous_variant 1.0 ethambutol Uncertain significance
aftB 4268588 c.249G>T synonymous_variant 1.0 ethambutol Uncertain significance
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4269783 c.-947G>A upstream_gene_variant 1.0 ethambutol Uncertain significance
ubiA 4269811 p.Gln8Arg missense_variant 1.0 ethambutol Uncertain significance
ubiA 4269853 c.-20C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
ethA 4326025 c.1449G>A synonymous_variant 1.0 ethionamide Uncertain significance
ethA 4326205 c.1269C>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
ethA 4326403 c.1071C>T synonymous_variant 1.0 ethionamide Uncertain significance
ethA 4326409 c.1065T>C synonymous_variant 1.0 ethionamide Uncertain significance
ethA 4326487 c.987A>T synonymous_variant 1.0 ethionamide Uncertain significance
ethA 4326538 c.936G>A synonymous_variant 1.0 ethionamide Uncertain significance
ethA 4326678 p.Ser266Gly missense_variant 1.0 ethionamide Uncertain significance
ethR 4326733 c.-816C>G upstream_gene_variant 1.0 ethionamide Uncertain significance
ethR 4326760 c.-789T>C upstream_gene_variant 1.0 ethionamide Uncertain significance
ethA 4327001 p.Val158Ala missense_variant 0.99 ethionamide Uncertain significance
ethA 4327003 c.471C>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
ethA 4327092 p.Ala128Thr missense_variant 0.99 ethionamide Uncertain significance
ethR 4327342 c.-207G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
ethA 4327546 c.-74_-73insC upstream_gene_variant 1.0 ethionamide Uncertain significance
ethA 4327842 c.-369G>A upstream_gene_variant 1.0 ethionamide Uncertain significance
ethA 4328231 c.-758G>A upstream_gene_variant 1.0 ethionamide Uncertain significance
ethA 4328308 c.-835G>C upstream_gene_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338741 c.-220A>G upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338785 c.-266_-264delGGCinsAG upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338878 c.-357C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407568 p.Ala212Val missense_variant 1.0 streptomycin Uncertain significance
gid 4407572 p.Ile211Val missense_variant 1.0 streptomycin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407703 p.Ala167Val missense_variant 1.0 streptomycin Uncertain significance
gid 4407705 c.498G>T synonymous_variant 1.0 streptomycin Uncertain significance
gid 4407782 p.Ala141Thr missense_variant 1.0 streptomycin Uncertain significance
gid 4407822 c.381A>G synonymous_variant 1.0 streptomycin Uncertain significance
gid 4407943 p.Gln87Arg missense_variant 1.0 streptomycin Uncertain significance
gid 4407951 c.252G>T synonymous_variant 1.0 streptomycin Uncertain significance
gid 4408008 c.195C>G synonymous_variant 1.0 streptomycin Uncertain significance
gid 4408110 p.Val31Ala missense_variant 1.0 streptomycin Uncertain significance
gid 4408113 c.90T>C synonymous_variant 1.0 streptomycin Uncertain significance
gid 4408153 p.Gly17Asp missense_variant 1.0 streptomycin Uncertain significance
gid 4408176 c.27T>C synonymous_variant 1.0 streptomycin Uncertain significance
gid 4408228 c.-28_-27delCA upstream_gene_variant 0.89 streptomycin Uncertain significance