TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472644	n.799C>T	non_coding_transcript_exon_variant	0.47	streptomycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
rrs	1472119	n.274G>A	non_coding_transcript_exon_variant	0.96	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472251	n.406G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472282	n.437T>G	non_coding_transcript_exon_variant	0.75	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472284	n.439C>T	non_coding_transcript_exon_variant	0.67	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472286	n.441C>G	non_coding_transcript_exon_variant	0.87	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472289	n.444T>G	non_coding_transcript_exon_variant	0.27	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472290	n.445C>G	non_coding_transcript_exon_variant	0.25	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472293	n.448C>A	non_coding_transcript_exon_variant	0.91	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472297	n.453_465delGTCCGGGTTCTCT	non_coding_transcript_exon_variant	0.9	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472313	n.468delGinsAA	non_coding_transcript_exon_variant	0.88	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472315	n.470T>G	non_coding_transcript_exon_variant	0.44	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472324	n.479G>C	non_coding_transcript_exon_variant	0.48	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472325	n.480G>C	non_coding_transcript_exon_variant	0.48	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472328	n.483G>C	non_coding_transcript_exon_variant	0.84	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472332	n.487_488delAGinsGA	non_coding_transcript_exon_variant	0.86	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472338	n.493A>G	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472379	n.534T>C	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472400	n.555C>T	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472412	n.567A>G	non_coding_transcript_exon_variant	0.23	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472416	n.571C>T	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472422	n.577T>C	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472427	n.582T>G	non_coding_transcript_exon_variant	0.4	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472435	n.590T>C	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472436	n.591G>T	non_coding_transcript_exon_variant	0.91	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472437	n.592T>G	non_coding_transcript_exon_variant	0.91	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472438	n.593T>C	non_coding_transcript_exon_variant	0.91	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472448	n.603T>C	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472449	n.604_606delCACinsTCT	non_coding_transcript_exon_variant	0.97	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472462	n.617T>G	non_coding_transcript_exon_variant	0.97	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472464	n.619A>G	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472473	n.628G>T	non_coding_transcript_exon_variant	0.91	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472474	n.629C>G	non_coding_transcript_exon_variant	0.91	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472476	n.631A>G	non_coding_transcript_exon_variant	0.95	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472494	n.649A>G	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472496	n.651T>A	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472498	n.653C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472569	n.724G>A	non_coding_transcript_exon_variant	0.45	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.51	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.49	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.52	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472597	n.752G>A	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472607	n.762G>A	non_coding_transcript_exon_variant	0.46	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.51	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472655	n.810G>T	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472660	n.815T>C	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472673	n.828_842delTTTCCTTCCTTGGGAinsGGCCACCCGTGGTT	non_coding_transcript_exon_variant	0.52	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472673	n.828_842delTTTCCTTCCTTGGGAinsGGACATTCCACGTTT	non_coding_transcript_exon_variant	0.47	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472690	n.845C>T	non_coding_transcript_exon_variant	0.46	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin
rrs	1472692	n.847T>C	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472707	n.862A>T	non_coding_transcript_exon_variant	0.49	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472714	n.869A>G	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472755	n.910G>A	non_coding_transcript_exon_variant	0.36	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472790	n.945T>C	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472824	n.979T>A	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472825	n.980G>A	non_coding_transcript_exon_variant	0.88	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472840	n.995A>G	non_coding_transcript_exon_variant	0.54	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472952	n.1107T>C	non_coding_transcript_exon_variant	0.31	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472955	n.1110C>T	non_coding_transcript_exon_variant	0.32	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472956	n.1111T>C	non_coding_transcript_exon_variant	0.56	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	0.56	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472987	n.1142G>A	non_coding_transcript_exon_variant	0.27	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472990	n.1145A>G	non_coding_transcript_exon_variant	0.5	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473005	n.1160C>T	non_coding_transcript_exon_variant	0.31	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.63	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473055	n.1210C>T	non_coding_transcript_exon_variant	0.62	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.62	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.61	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473080	n.1235C>T	non_coding_transcript_exon_variant	0.43	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473081	n.1236C>T	non_coding_transcript_exon_variant	0.43	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.39	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>T	non_coding_transcript_exon_variant	0.36	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>A	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473102	n.1257C>T	non_coding_transcript_exon_variant	0.31	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.4	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.39	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473221	n.1376C>T	non_coding_transcript_exon_variant	0.32	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473252	n.1407T>C	non_coding_transcript_exon_variant	0.5	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.5	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrl	1475937	n.2280A>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1475937	n.2280A>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1475945	n.2288C>A	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1475945	n.2288C>A	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.95	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1475989	n.2332T>C	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1475989	n.2332T>C	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1475992	n.2335T>C	non_coding_transcript_exon_variant	0.34	capreomycin
rrl	1475992	n.2335T>C	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1475995	n.2338G>C	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1475995	n.2338G>C	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475996	n.2339T>C	non_coding_transcript_exon_variant	0.33	capreomycin
rrl	1475996	n.2339T>C	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1475997	n.2340A>G	non_coding_transcript_exon_variant	0.52	capreomycin
rrl	1475997	n.2340A>G	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1475998	n.2341C>T	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1475998	n.2341C>T	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1476001	n.2344T>C	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1476001	n.2344T>C	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1476007	n.2350T>C	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1476007	n.2350T>C	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476029	n.2372A>G	non_coding_transcript_exon_variant	0.39	capreomycin
rrl	1476029	n.2372A>G	non_coding_transcript_exon_variant	0.39	linezolid
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.4	capreomycin	Uncertain significance
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.4	linezolid
rrl	1476033	n.2376T>G	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1476033	n.2376T>G	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1476035	n.2378G>C	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1476035	n.2378G>C	non_coding_transcript_exon_variant	0.55	linezolid
rrl	1476040	n.2383C>T	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1476040	n.2383C>T	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1476046	n.2389G>T	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1476046	n.2389G>T	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1476113	n.2456T>G	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1476113	n.2456T>G	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.43	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.43	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476165	n.2508T>A	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1476165	n.2508T>A	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476179	n.2522C>T	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1476179	n.2522C>T	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.99	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.99	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1476205	n.2548A>C	non_coding_transcript_exon_variant	0.53	capreomycin
rrl	1476205	n.2548A>C	non_coding_transcript_exon_variant	0.53	linezolid
rrl	1476207	n.2550T>C	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1476207	n.2550T>C	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1476213	n.2556G>A	non_coding_transcript_exon_variant	0.52	capreomycin
rrl	1476213	n.2556G>A	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476221	n.2564T>C	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1476221	n.2564T>C	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476253	n.2596A>G	non_coding_transcript_exon_variant	0.25	capreomycin
rrl	1476253	n.2596A>G	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1476255	n.2598A>G	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1476255	n.2598A>G	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.78	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476267	n.2610G>T	non_coding_transcript_exon_variant	0.71	capreomycin
rrl	1476267	n.2610G>T	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1476276	n.2619C>A	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1476276	n.2619C>A	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1476279	n.2622G>A	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1476279	n.2622G>A	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1476299	n.2642C>G	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1476299	n.2642C>G	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1476308	n.2651G>C	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1476308	n.2651G>C	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1476337	n.2680C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476337	n.2680C>T	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
pncA	2289047	c.195C>T	synonymous_variant	1.0	pyrazinamide	Not assoc w R
ethR	4327027	c.-522C>T	upstream_gene_variant	1.0	ethionamide

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin	rrs	n.799C>T	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result