TB-Profiler result

Run: ERR2027233
Summary

Run ID: ERR2027233

Sample name:

Date: 2025-09-15T14:10:13.046326

Number of reads: 2807790

Percentage reads mapped: 56.34

Median coverage: 53.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 100.0
lineage4.1 Euro-American None 100.0
lineage4.1.2 Euro-American None 100.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 1.0 clofazimine Not assoc w R
delamanid Uncertain significance
pretomanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
rpoB 760115 c.309C>T synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762176 c.2370T>G synonymous_variant 0.23 rifampicin Uncertain significance
rpoB 762181 p.Asp792Ala missense_variant 0.25 rifampicin Uncertain significance
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.35 rifampicin Uncertain significance
rpoB 762221 c.2415G>A synonymous_variant 0.35 rifampicin Uncertain significance
rpoB 762223 p.Thr806Ser missense_variant 0.32 rifampicin Uncertain significance
rpoB 762225 p.Glu807Gln missense_variant 0.32 rifampicin Uncertain significance
rpoB 762233 c.2427G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.29 rifampicin Uncertain significance
rpoB 762243 p.Arg813Lys missense_variant 0.3 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762911 p.Ile1035Met missense_variant 0.33 rifampicin Uncertain significance
rpoB 762920 c.3114C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762939 p.Met1045Leu missense_variant 0.4 rifampicin Uncertain significance
rpoB 762942 p.Ile1046Val missense_variant 0.4 rifampicin Uncertain significance
rpoC 762965 c.-405T>C upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoC 762980 c.-390T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoC 764557 p.Asn396Lys missense_variant 0.62 rifampicin Uncertain significance
rpoC 764560 c.1191T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764576 p.Ser403Ala missense_variant 0.92 rifampicin Uncertain significance
rpoC 764582 p.Leu405Met missense_variant 0.93 rifampicin Uncertain significance
rpoC 764585 p.Leu406Ile missense_variant 0.93 rifampicin Uncertain significance
rpoC 764605 c.1236G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.93 rifampicin Uncertain significance
rpoC 764632 c.1263T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764672 p.Gln435Tyr missense_variant 0.85 rifampicin Uncertain significance
rpoC 764677 c.1308C>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764678 p.Lys437Arg missense_variant 0.84 rifampicin Uncertain significance
rpoC 764695 c.1326T>C synonymous_variant 0.81 rifampicin Uncertain significance
rpoC 764701 c.1332C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Lys missense_variant 0.81 rifampicin Uncertain significance
rpoC 764716 c.1347G>T synonymous_variant 0.8 rifampicin Uncertain significance
rpoC 764737 c.1368G>C synonymous_variant 0.26 rifampicin Uncertain significance
rpoC 764851 c.1482C>T synonymous_variant 0.57 rifampicin Uncertain significance
rpoC 764858 p.Leu497Met missense_variant 0.68 rifampicin Uncertain significance
rpoC 764869 c.1500C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.67 rifampicin Uncertain significance
rpoC 764887 c.1518G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.65 rifampicin Uncertain significance
rpoC 764902 c.1533C>G synonymous_variant 0.66 rifampicin Uncertain significance
rpoC 764911 c.1542A>G synonymous_variant 0.7 rifampicin Uncertain significance
rpoC 764912 p.Met515Val missense_variant 0.7 rifampicin Uncertain significance
rpoC 764918 p.Val517Ile missense_variant 0.7 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.67 rifampicin Uncertain significance
rpoC 764941 c.1572G>A synonymous_variant 0.7 rifampicin Uncertain significance
rpoC 764948 c.1579T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.75 rifampicin Uncertain significance
rpoC 764956 c.1587T>C synonymous_variant 0.76 rifampicin Uncertain significance
rpoC 764957 p.Glu530Thr missense_variant 0.76 rifampicin Uncertain significance
rpoC 764968 c.1599T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764998 c.1629G>C synonymous_variant 0.48 rifampicin Uncertain significance
rpoC 765002 p.Leu545Val missense_variant 0.32 rifampicin Uncertain significance
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472153 n.308G>A non_coding_transcript_exon_variant 0.28 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472164 n.319G>A non_coding_transcript_exon_variant 0.69 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.79 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.81 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.85 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472235 n.390G>C non_coding_transcript_exon_variant 0.84 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472240 n.395G>C non_coding_transcript_exon_variant 0.82 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.82 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472243 n.398G>A non_coding_transcript_exon_variant 0.82 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472253 n.408G>T non_coding_transcript_exon_variant 0.76 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472256 n.411T>A non_coding_transcript_exon_variant 0.76 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.77 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472277 n.432C>G non_coding_transcript_exon_variant 0.48 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472333 n.488G>T non_coding_transcript_exon_variant 0.31 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.49 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472349 n.504A>T non_coding_transcript_exon_variant 0.52 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472374 n.529T>A non_coding_transcript_exon_variant 0.59 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.55 amikacin Not assoc w R
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.49 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472390 n.545T>C non_coding_transcript_exon_variant 0.48 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472391 n.546C>T non_coding_transcript_exon_variant 0.47 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472412 n.567A>C non_coding_transcript_exon_variant 0.23 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472414 n.569C>T non_coding_transcript_exon_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472415 n.570T>G non_coding_transcript_exon_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.29 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472599 n.754G>A non_coding_transcript_exon_variant 0.31 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.49 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472648 n.803G>C non_coding_transcript_exon_variant 0.41 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.26 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472697 n.852T>A non_coding_transcript_exon_variant 0.51 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472707 n.862A>G non_coding_transcript_exon_variant 0.85 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.89 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472716 n.871C>G non_coding_transcript_exon_variant 0.91 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.94 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.95 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.96 amikacin Not assoc w R
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.96 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.95 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.94 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472827 n.982G>C non_coding_transcript_exon_variant 0.76 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.72 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472837 n.992C>T non_coding_transcript_exon_variant 0.29 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.52 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472887 n.1042G>C non_coding_transcript_exon_variant 0.91 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.98 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.98 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.98 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472959 n.1114T>A non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472987 n.1142G>T non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.99 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
streptomycin Uncertain significance
rrs 1472996 n.1151T>C non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473002 n.1157G>T non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473008 n.1163C>A non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473044 n.1199C>G non_coding_transcript_exon_variant 0.98 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473051 n.1206T>C non_coding_transcript_exon_variant 0.98 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473053 n.1208T>G non_coding_transcript_exon_variant 0.97 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.97 amikacin Not assoc w R
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.95 amikacin Not assoc w R
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473070 n.1225G>A non_coding_transcript_exon_variant 0.94 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.67 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473084 n.1239T>G non_coding_transcript_exon_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.26 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473131 n.1286G>A non_coding_transcript_exon_variant 0.38 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473139 n.1294T>C non_coding_transcript_exon_variant 0.83 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.87 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.87 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.9 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.91 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.92 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473201 n.1356A>T non_coding_transcript_exon_variant 0.91 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.91 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473248 n.1403G>A non_coding_transcript_exon_variant 0.34 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473249 n.1404T>C non_coding_transcript_exon_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473352 n.1507C>T non_coding_transcript_exon_variant 0.25 amikacin Not assoc w R
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1475783 n.2126T>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2170226 c.386delA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4038773 c.1932T>C synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4038776 p.Glu643Asp missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4038781 p.Leu642Phe missense_variant 0.26 pyrazinamide Uncertain significance
clpC1 4038795 p.Ser637Ile missense_variant 0.26 pyrazinamide Uncertain significance
clpC1 4038805 p.Ile634Val missense_variant 0.27 pyrazinamide Uncertain significance
clpC1 4038806 p.Glu633Asp missense_variant 0.27 pyrazinamide Uncertain significance
clpC1 4038809 p.Gln632Pro missense_variant 0.27 pyrazinamide Uncertain significance
clpC1 4038812 c.1893T>C synonymous_variant 0.27 pyrazinamide Uncertain significance
clpC1 4038835 p.Phe624Leu missense_variant 0.35 pyrazinamide Uncertain significance
clpC1 4038841 p.Val622Leu missense_variant 0.33 pyrazinamide Uncertain significance
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.35 pyrazinamide Uncertain significance
clpC1 4038849 p.Phe619Tyr missense_variant 0.35 pyrazinamide Uncertain significance
clpC1 4038851 c.1854G>C synonymous_variant 0.36 pyrazinamide Uncertain significance
clpC1 4038860 c.1845G>T synonymous_variant 0.34 pyrazinamide Uncertain significance
clpC1 4038878 c.1827A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038890 p.Glu605Asp missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039674 p.Pro344Lys missense_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039697 c.1008C>T synonymous_variant 0.62 pyrazinamide Uncertain significance
clpC1 4039730 c.975C>G synonymous_variant 0.52 pyrazinamide Uncertain significance
clpC1 4039739 c.966C>G synonymous_variant 0.34 pyrazinamide Uncertain significance
clpC1 4039742 c.963C>T synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4040054 c.651G>A synonymous_variant 0.38 pyrazinamide Uncertain significance
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance