Run ID: SRR10522763
Sample name:
Date: 2024-04-16T07:57:12.490174
Number of reads: 2931109
Percentage reads mapped: 97.56
Median coverage: 145.0
Strain: M.canetti
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| M.canetti | M.canetti | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 5452 | c.213G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 5731 | c.492C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6007 | c.768C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6454 | c.1215C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6721 | c.1482C>T | synonymous_variant | 0.99 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 7093 | c.1854T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7835 | c.534A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7988 | c.687G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8714 | c.1413A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9182 | c.1881T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9377 | c.2076A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9716 | c.2415T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9740 | c.2439G>A | synonymous_variant | 0.99 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9776 | c.2475T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9817 | c.2517_*53delANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | frameshift_variant&stop_lost&splice_region_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9817 | c.2517_*52delATCAGGCTCGCCCGACGACGATGCGGATCGCGTAGCGATCTGAGGAGGAATCG | frameshift_variant&stop_lost&splice_region_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
| fgd1 | 490666 | c.-117G>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490678 | c.-105_-104insG | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490687 | c.-96T>C | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490734 | c.-49A>T | upstream_gene_variant | 0.17 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491406 | p.Met208Ile | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| mshA | 575060 | c.-288G>C | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 575133 | c.-215C>T | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | Uncertain significance | |||||
| mshA | 575665 | c.318G>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| mshA | 575971 | c.624C>T | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 576285 | p.Val313Ala | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 576757 | c.1410C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| ccsA | 620256 | c.366C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620257 | p.Ile123Ala | missense_variant | 1.0 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620490 | c.600A>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620808 | c.918T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| Rv0565c | 656186 | p.Pro429Ala | missense_variant | 1.0 | ethionamide | |
| Rv0565c | 656502 | c.969C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656547 | c.924C>A | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656800 | p.Thr224Met | missense_variant | 1.0 | ethionamide | |
| Rv0565c | 656838 | c.633A>G | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656973 | c.498A>C | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656985 | c.486T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656989 | p.Lys161Thr | missense_variant | 1.0 | ethionamide | |
| Rv0565c | 657309 | c.162C>G | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | |
| Rv0565c | 657695 | c.-225C>A | upstream_gene_variant | 1.0 | ethionamide | |
| hadA | 731852 | c.-78A>G | upstream_gene_variant | 1.0 | isoniazid | |
| hadA | 732379 | c.450A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| nusG | 733883 | c.-370_-368delGCG | upstream_gene_variant | 1.0 | rifampicin | |
| rpoB | 759351 | c.-456G>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoB | 759911 | c.105C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760715 | c.909C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760812 | p.Ile336Val | missense_variant | 1.0 | rifampicin | |
| rpoB | 761510 | c.1704T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761573 | c.1767C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 763031 | c.3225T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R |
| rpoC | 763259 | c.-111G>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoC | 763660 | c.291T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764107 | c.738C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764134 | c.765C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764152 | c.783C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764159 | c.790C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764195 | p.Ser276Ala | missense_variant | 1.0 | rifampicin | |
| rpoC | 764198 | c.829C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764203 | c.834G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764206 | p.Asp279Glu | missense_variant | 1.0 | rifampicin | |
| rpoC | 764245 | c.876C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764257 | c.888G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764275 | c.906C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764278 | c.909A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764293 | c.924G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764341 | c.972G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764365 | c.996C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764405 | c.1036A>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 764497 | c.1128A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764506 | c.1137C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764510 | c.1141C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764521 | c.1152T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764524 | c.1155C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764527 | c.1158C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764533 | c.1164C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764536 | c.1167G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764539 | c.1170C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764554 | c.1185C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764575 | c.1206T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764578 | c.1209C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764632 | c.1263T>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764650 | c.1281G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764651 | c.1282_1284delTCGinsAGC | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765001 | c.1632C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765082 | c.1713G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765152 | p.Asp595Asn | missense_variant | 1.0 | rifampicin | |
| rpoC | 765409 | c.2040T>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 765478 | c.2109T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 766152 | p.Asp928Gly | missense_variant | 1.0 | rifampicin | |
| rpoC | 766675 | c.3306C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766870 | c.3501C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766900 | c.3531T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766945 | c.3576A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767062 | c.3693C>A | synonymous_variant | 1.0 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 775748 | c.2733T>C | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 776132 | c.2349A>G | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776544 | p.Lys646Arg | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776807 | c.1674G>C | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 776954 | c.1527A>G | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 777294 | p.Gly396Ala | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 777431 | c.1050A>G | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 777964 | p.Val173Ile | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778473 | p.Val3Ala | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778573 | c.-93C>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778654 | c.-174A>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778921 | c.-441G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779439 | c.-959G>T | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
| rplC | 800111 | c.-698C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800155 | c.-654_-653insG | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800970 | c.162T>C | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| rplC | 801003 | c.195G>A | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| rplC | 801267 | c.459A>G | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| Rv1129c | 1253216 | p.Glu440Ala | missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253323 | c.1212G>T | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1253904 | p.Asn211Asp | missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 0.99 | moxifloxacin | Not assoc w R |
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| Rv1129c | 1254602 | c.-68C>T | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254604 | c.-70C>T | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254654 | c.-120A>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254678 | c.-144A>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| fbiC | 1302694 | c.-237C>T | upstream_gene_variant | 0.99 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302810 | c.-121C>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302860 | c.-71G>A | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303695 | c.765T>C | synonymous_variant | 0.99 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304598 | c.1668C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| Rv1258c | 1406466 | p.Ser292Leu | missense_variant | 1.0 | streptomycin | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| pyrazinamide | Uncertain significance | |||||
| Rv1258c | 1406492 | c.849C>A | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| pyrazinamide | Not assoc w R - Interim | |||||
| Rv1258c | 1406496 | p.Ala282Val | missense_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| embR | 1417294 | c.54A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embR | 1417454 | c.-107C>A | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417748 | c.-401T>C | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1418025 | c.-678G>A | upstream_gene_variant | 1.0 | ethambutol | |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471850 | n.5_6delGTinsTGG | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrl | 1473658 | n.1T>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1474414 | n.757C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1474438 | n.781A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| fabG1 | 1673257 | c.-183C>G | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674816 | c.615T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| rpsA | 1833367 | c.-175G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833370 | c.-172G>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833381 | c.-161T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833435 | c.-107G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833471 | c.-71_-70insC | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833512 | c.-29delC | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833554 | p.Thr5Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1833568 | c.27G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834169 | p.Thr210Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1834912 | c.1371A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
| tlyA | 1917606 | c.-334G>C | upstream_gene_variant | 0.99 | capreomycin | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
| bacA | 2061040 | c.1898_*1768del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | streptomycin | Not assoc w R |
| kanamycin | Not assoc w R | |||||
| capreomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| bacA | 2064378 | c.351C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| kanamycin | Not assoc w R - Interim | |||||
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| ndh | 2101777 | c.1266C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| delamanid | ||||||
| isoniazid | Not assoc w R - Interim | |||||
| ndh | 2102353 | p.Gln230His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| delamanid | ||||||
| isoniazid | Uncertain significance | |||||
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
| katG | 2156055 | c.57C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2156658 | c.-547A>G | upstream_gene_variant | 1.0 | isoniazid | |
| PPE35 | 2167777 | p.Leu946Val | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
| PPE35 | 2168522 | c.2091T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168531 | c.2082G>A | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168564 | c.2049T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168567 | c.2046A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168575 | p.Ala680Pro | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168588 | c.2025G>A | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168621 | c.1992C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168633 | c.1980C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169461 | p.Val384Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169605 | c.1008T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169623 | c.990T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169643 | p.Ala324Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169668 | c.945C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169686 | c.927T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169717 | p.Asn299Ile | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169740 | c.873C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169767 | c.846A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169779 | c.834A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169809 | c.804A>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169819 | p.Asn265Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169839 | c.774C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169857 | c.756A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169887 | c.726C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169932 | c.681C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169940 | p.Gly225Arg | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169948 | p.Asn222Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169956 | c.657T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169959 | c.654C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169974 | c.639T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169977 | c.636C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169989 | c.624C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169992 | c.621C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169996 | p.Ser206Asn | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169998 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170010 | c.603G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170016 | c.597C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170028 | p.Met195Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170035 | p.Val193Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170125 | p.Val163Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170133 | c.480G>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170148 | c.465T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170156 | p.Ala153Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170169 | c.444A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170175 | c.438G>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170232 | c.381T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170246 | p.Ser123Ala | missense_variant | 0.99 | pyrazinamide | |
| PPE35 | 2170247 | p.Ile122Met | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170250 | c.363G>A | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170261 | p.Ile118Val | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170267 | p.Gly116Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170268 | c.345C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170306 | p.Ala103Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170314 | p.Val100Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170319 | c.294G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170330 | p.Ala95Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170334 | p.Met93Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170351 | p.Thr88Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170485 | p.Val43Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170499 | c.114A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170505 | c.108C>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170511 | c.102G>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170553 | c.60C>A | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170585 | p.Ile10Val | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170601 | c.12A>G | synonymous_variant | 0.98 | pyrazinamide | |
| PPE35 | 2170620 | c.-9_-8insT | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170671 | c.-59G>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170676 | c.-64A>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170677 | c.-65G>A | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170679 | c.-67A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170681 | c.-69G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170690 | c.-78A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170693 | c.-81C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170694 | c.-82T>C | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170695 | c.-83C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170703 | c.-91T>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170717 | c.-105C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170720 | c.-108A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170722 | c.-110G>A | upstream_gene_variant | 0.98 | pyrazinamide | Uncertain significance |
| PPE35 | 2170723 | c.-111C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170726 | c.-115delT | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170766 | c.-154T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170770 | c.-158T>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170780 | c.-168G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170796 | c.-184C>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170809 | c.-198delA | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170812 | c.-200G>C | upstream_gene_variant | 0.97 | pyrazinamide | |
| PPE35 | 2170839 | c.-227C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170848 | c.-236A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170849 | c.-237T>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170858 | c.-246A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170860 | c.-248A>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170868 | c.-256T>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170871 | c.-259A>G | upstream_gene_variant | 0.97 | pyrazinamide | |
| PPE35 | 2170890 | c.-278G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170895 | c.-283C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170924 | c.-312T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2222357 | p.Thr270Ala | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2223318 | c.-154A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| pncA | 2288855 | c.387T>C | synonymous_variant | 1.0 | pyrazinamide | |
| pncA | 2289104 | c.138A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| pncA | 2289323 | c.-82G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289664 | c.-423G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289820 | c.-579T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2290120 | c.-879T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519287 | c.1173T>C | synonymous_variant | 1.0 | isoniazid | |
| eis | 2714274 | c.1059G>A | synonymous_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2714714 | p.Ala207Thr | missense_variant | 1.0 | amikacin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| eis | 2714994 | c.339T>C | synonymous_variant | 1.0 | amikacin | Not assoc w R - Interim |
| kanamycin | Not assoc w R - Interim | |||||
| ahpC | 2725905 | c.-288C>A | upstream_gene_variant | 1.0 | isoniazid | |
| folC | 2747204 | p.Ala132Gln | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747572 | c.27T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747575 | c.24G>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747628 | c.-30G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747631 | c.-33C>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747691 | c.-93A>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2477c | 2783425 | c.618C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2784328 | c.-286C>T | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784432 | c.-390A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| pepQ | 2859490 | p.Val310Ala | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| ribD | 2987505 | c.667C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| ribD | 2987614 | c.766delA | frameshift_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2680 | 2995798 | c.-307T>C | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2680 | 2996009 | c.-96T>C | upstream_gene_variant | 0.86 | capreomycin | Uncertain significance |
| Rv2680 | 2996010 | c.-95C>A | upstream_gene_variant | 0.86 | capreomycin | Uncertain significance |
| Rv2681 | 2997054 | p.Ser106Gly | missense_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2681 | 2997059 | c.321C>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997293 | c.555G>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2752c | 3064627 | p.Asn522Ser | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3064812 | c.1380C>A | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3065499 | c.693A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066354 | c.-163G>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066882 | c.-691C>T | upstream_gene_variant | 0.99 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066905 | c.-714T>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| thyX | 3067239 | p.Ala236Asp | missense_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067444 | p.Arg168Cys | missense_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074160 | c.312A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074238 | c.234C>T | synonymous_variant | 0.99 | para-aminosalicylic_acid | |
| thyA | 3074247 | c.225C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3087122 | c.303T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087140 | c.321G>A | synonymous_variant | 1.0 | cycloserine | |
| fbiD | 3339402 | c.285C>T | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| fbiD | 3339568 | c.451C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| Rv3083 | 3448325 | c.-179G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448403 | c.-101G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448453 | c.-51G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448474 | c.-30G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448495 | c.-9G>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448588 | p.Asp29Asn | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448611 | c.108A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448905 | c.402T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448972 | p.His157Asp | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449028 | c.525T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449029 | p.Ser176Ala | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449237 | p.Arg245Lys | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449305 | c.802T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449400 | c.897C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449421 | c.918T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449622 | c.1119T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449652 | c.1149T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449767 | p.Thr422Val | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449778 | c.1275T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449802 | c.1299T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449820 | c.1317G>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449832 | c.1329T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449835 | c.1332G>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449868 | c.1365C>A | synonymous_variant | 0.99 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449877 | c.1374T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449885 | p.Arg461Lys | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449940 | c.1437T>C | synonymous_variant | 1.0 | ethionamide | |
| whiB7 | 3568687 | c.-8A>T | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| Rv3236c | 3611968 | c.1149T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612211 | c.906A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612250 | c.867A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612301 | c.816G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612541 | c.576G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612561 | p.Thr186Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| Rv3236c | 3612577 | c.540G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612580 | c.537C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612709 | c.408G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3613056 | c.61C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3625006 | c.1608A>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3626461 | c.153A>G | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3626999 | c.351G>A | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3627190 | c.160T>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3627715 | c.-366G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | Uncertain significance | |||||
| mtrA | 3627734 | c.-385A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627802 | c.-453T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627831 | c.-482T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627839 | c.-490T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| fbiB | 3641840 | c.306T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642254 | c.720G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642467 | c.933T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| alr | 3840527 | c.894A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840719 | c.702A>G | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840791 | c.630T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840796 | p.Asp209Asn | missense_variant | 1.0 | cycloserine | |
| alr | 3840914 | c.507G>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840994 | p.His143Asp | missense_variant | 1.0 | cycloserine | |
| alr | 3841112 | p.Asp103Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841116 | p.Ala102Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841172 | c.249A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841199 | c.222T>C | synonymous_variant | 1.0 | cycloserine | |
| rpoA | 3877647 | c.861C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878001 | c.507A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| ddn | 3986805 | c.-39G>C | upstream_gene_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| ddn | 3987050 | c.207C>T | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| ddn | 3987287 | c.444T>C | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| clpC1 | 4038227 | c.2478G>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038443 | c.2262G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038683 | c.2022T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038746 | c.1959C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038779 | c.1926C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038848 | c.1857C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038860 | c.1845G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038878 | c.1827A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038974 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039046 | c.1659C>T | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039058 | c.1647C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039094 | c.1611C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039100 | c.1605C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039274 | c.1431G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039336 | c.1369C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039352 | c.1353C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039448 | c.1257A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039454 | c.1251A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039502 | c.1203C>T | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039682 | c.1023C>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039700 | c.1005C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039718 | c.987C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039817 | c.888A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039820 | c.885T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039823 | c.882T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040045 | c.660C>G | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040048 | c.657C>T | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040063 | c.642G>C | synonymous_variant | 0.98 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040090 | c.615T>C | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040093 | c.612C>G | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040147 | c.558A>G | synonymous_variant | 0.98 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040159 | c.546G>A | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040162 | c.543G>C | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040213 | c.492T>C | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040267 | c.438A>G | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040273 | c.432T>C | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040276 | c.429C>G | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040279 | c.426C>G | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040363 | c.342A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040393 | c.312G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040411 | c.294T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040423 | c.282A>G | synonymous_variant | 0.98 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040450 | c.255A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040471 | c.234T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040480 | c.225T>C | synonymous_variant | 0.99 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040534 | c.171A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040551 | c.154T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040573 | c.132T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040657 | c.48T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040879 | c.-177_-175delTGGinsCGGT | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4043932 | p.Met117Thr | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| panD | 4044243 | c.39C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| panD | 4044533 | c.-252T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044569 | c.-289_-288delCGinsGC | upstream_gene_variant | 1.0 | pyrazinamide | |
| glpK | 4138259 | c.1497T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| glpK | 4139096 | p.Leu220Phe | missense_variant | 0.99 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4139183 | c.572dupG | frameshift_variant | 0.25 | ethambutol | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| glpK | 4139321 | c.435T>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139420 | c.336T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139477 | c.279A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4139813 | c.-58T>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4139934 | c.-179A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| embC | 4239032 | c.-831T>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239110 | c.-753C>T | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239764 | c.-99G>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4240237 | c.375G>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4243377 | p.Ser49Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243690 | p.Met153Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243919 | c.687G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4244154 | p.Thr308Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4244312 | c.1080T>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245023 | c.1791A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245701 | c.2469G>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embB | 4247815 | c.1302C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248195 | p.Lys561Met | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248439 | c.1926C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248664 | c.2151G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248721 | c.2208C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248744 | p.Val744Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248853 | c.2340G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4249069 | c.2556A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| aftB | 4267412 | c.1425T>C | synonymous_variant | 1.0 | ethambutol | |
| aftB | 4268588 | c.249G>T | synonymous_variant | 1.0 | ethambutol | |
| aftB | 4268615 | c.222C>T | synonymous_variant | 1.0 | ethambutol | |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269811 | p.Gln8Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| ubiA | 4270065 | c.-232C>T | upstream_gene_variant | 0.99 | ethambutol | |
| ethA | 4326463 | c.1011C>T | synonymous_variant | 0.99 | ethionamide | Not assoc w R - Interim |
| ethA | 4326740 | p.Arg245His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| ethR | 4327547 | c.-2_-1insA | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
| amikacin | Not assoc w R | |||||
| kanamycin | Not assoc w R | |||||
| whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338741 | c.-220A>G | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338785 | c.-266_-264delGGCinsAG | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338878 | c.-357C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
| gid | 4408185 | c.18C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
