TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472644	n.799C>T	non_coding_transcript_exon_variant	0.77	streptomycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrB	6454	c.1215C>T	synonymous_variant	0.99	levofloxacin	Not assoc w R - Interim
gyrB	6454	c.1215C>T	synonymous_variant	0.99	moxifloxacin	Not assoc w R - Interim
gyrB	6721	c.1482C>T	synonymous_variant	0.99	levofloxacin	Not assoc w R - Interim
gyrB	6721	c.1482C>T	synonymous_variant	0.99	moxifloxacin	Not assoc w R - Interim
gyrA	6739	c.-563C>T	upstream_gene_variant	0.99	levofloxacin
gyrA	6739	c.-563C>T	upstream_gene_variant	0.99	moxifloxacin
rplC	801267	c.459A>G	synonymous_variant	0.97	linezolid	Not assoc w R - Interim
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472119	n.274G>A	non_coding_transcript_exon_variant	0.92	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472251	n.406G>A	non_coding_transcript_exon_variant	0.95	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472282	n.437T>G	non_coding_transcript_exon_variant	0.34	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472285	n.440A>G	non_coding_transcript_exon_variant	0.83	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472286	n.441C>G	non_coding_transcript_exon_variant	0.21	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472289	n.444T>G	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472290	n.445C>G	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472298	n.453_462delGTCCGGGTTCinsCGTTT	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472309	n.464_470delCTCGGATinsG	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472324	n.479G>C	non_coding_transcript_exon_variant	0.98	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472325	n.480G>C	non_coding_transcript_exon_variant	0.99	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472328	n.483G>C	non_coding_transcript_exon_variant	0.35	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472332	n.487_488delAGinsGA	non_coding_transcript_exon_variant	0.3	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472338	n.493A>G	non_coding_transcript_exon_variant	0.41	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472379	n.534T>C	non_coding_transcript_exon_variant	0.66	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472382	n.537G>A	non_coding_transcript_exon_variant	0.28	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472400	n.555C>T	non_coding_transcript_exon_variant	0.64	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472416	n.571C>T	non_coding_transcript_exon_variant	0.51	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472422	n.577T>C	non_coding_transcript_exon_variant	0.41	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472431	n.586G>A	non_coding_transcript_exon_variant	0.59	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472435	n.590T>C	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472438	n.593T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472439	n.594C>T	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472447	n.602C>T	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472448	n.603T>C	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472450	n.605A>G	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472451	n.606C>G	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472452	n.607G>A	non_coding_transcript_exon_variant	0.83	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472461	n.616G>C	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472464	n.619A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472471	n.626G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472476	n.631A>G	non_coding_transcript_exon_variant	0.19	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472484	n.639A>T	non_coding_transcript_exon_variant	0.44	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472489	n.644A>T	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472494	n.649A>G	non_coding_transcript_exon_variant	0.67	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472496	n.651T>A	non_coding_transcript_exon_variant	0.59	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472498	n.653C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472569	n.724G>A	non_coding_transcript_exon_variant	0.69	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.22	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.69	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.28	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472597	n.752G>A	non_coding_transcript_exon_variant	0.64	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472607	n.762G>A	non_coding_transcript_exon_variant	0.77	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472655	n.810G>T	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472660	n.815T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472673	n.828_842delTTTCCTTCCTTGGGAinsGGACATTCCACGTTT	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472692	n.847T>C	non_coding_transcript_exon_variant	0.9	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472714	n.869A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472755	n.910G>A	non_coding_transcript_exon_variant	0.61	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472790	n.945T>C	non_coding_transcript_exon_variant	0.57	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472824	n.979T>A	non_coding_transcript_exon_variant	0.59	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472825	n.980G>A	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472954	n.1109T>C	non_coding_transcript_exon_variant	0.88	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472956	n.1111T>C	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472973	n.1128A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472990	n.1145A>G	non_coding_transcript_exon_variant	0.98	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472992	n.1147A>G	non_coding_transcript_exon_variant	0.88	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473005	n.1160C>T	non_coding_transcript_exon_variant	0.91	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473055	n.1210C>T	non_coding_transcript_exon_variant	0.95	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473080	n.1235C>T	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473081	n.1236C>T	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>T	non_coding_transcript_exon_variant	0.97	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>A	non_coding_transcript_exon_variant	0.97	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473101	n.1256C>T	non_coding_transcript_exon_variant	0.36	kanamycin	Uncertain significance
					capreomycin
					streptomycin
					amikacin	Uncertain significance
rrs	1473102	n.1257C>T	non_coding_transcript_exon_variant	0.61	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.9	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473123	n.1278A>T	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473130	n.1285G>A	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.97	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473172	n.1327T>G	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473173	n.1328C>T	non_coding_transcript_exon_variant	0.97	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473221	n.1376C>T	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473252	n.1407T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.98	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>C	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473277	n.1432G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473288	n.1443_1455delCTCGGGAGGGAGCinsGCGTTTGCGGGGGGAGT	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473301	n.1456T>G	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473316	n.1471C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475991	n.2334T>C	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1475991	n.2334T>C	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1475995	n.2338G>C	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1475995	n.2338G>C	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1475998	n.2341C>T	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1475998	n.2341C>T	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1476001	n.2344T>C	non_coding_transcript_exon_variant	0.47	capreomycin	Uncertain significance
rrl	1476001	n.2344T>C	non_coding_transcript_exon_variant	0.47	linezolid	Uncertain significance
rrl	1476007	n.2350T>C	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1476007	n.2350T>C	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1476040	n.2383C>T	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1476040	n.2383C>T	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.41	capreomycin	Uncertain significance
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.41	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476088	n.2431A>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476088	n.2431A>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476099	n.2442A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476099	n.2442A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476103	n.2446C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476103	n.2446C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476105	n.2448G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476105	n.2448G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476106	n.2449A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476106	n.2449A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476110	n.2453G>C	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1476110	n.2453G>C	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1476113	n.2456T>G	non_coding_transcript_exon_variant	0.44	capreomycin
rrl	1476113	n.2456T>G	non_coding_transcript_exon_variant	0.44	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1476179	n.2522C>T	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1476179	n.2522C>T	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.88	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.88	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.32	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.25	capreomycin
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1476207	n.2550T>C	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1476207	n.2550T>C	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476221	n.2564T>C	non_coding_transcript_exon_variant	0.36	capreomycin	Uncertain significance
rrl	1476221	n.2564T>C	non_coding_transcript_exon_variant	0.36	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.37	capreomycin	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.37	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476253	n.2596A>G	non_coding_transcript_exon_variant	0.49	capreomycin
rrl	1476253	n.2596A>G	non_coding_transcript_exon_variant	0.49	linezolid
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.72	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1476267	n.2610G>T	non_coding_transcript_exon_variant	0.28	capreomycin
rrl	1476267	n.2610G>T	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1476279	n.2622G>A	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1476279	n.2622G>A	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1476299	n.2642C>G	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1476299	n.2642C>G	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1476308	n.2651G>C	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1476308	n.2651G>C	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1476337	n.2680C>T	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1476337	n.2680C>T	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
inhA	1674611	p.Ile137Thr	missense_variant	0.2	isoniazid
inhA	1674611	p.Ile137Thr	missense_variant	0.2	ethionamide
inhA	1674684	p.Met161Ile	missense_variant	0.99	isoniazid
inhA	1674684	p.Met161Ile	missense_variant	0.99	ethionamide
ethA	4326740	p.Arg245His	missense_variant	0.84	ethionamide	Uncertain significance
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin	rrs	n.799C>T	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result