TB-Profiler result

Run: ERR11465279
Summary

Run ID: ERR11465279

Sample name:

Date: 2024-04-14T09:13:49.452789

Number of reads: 2618852

Percentage reads mapped: 99.06

Median coverage: 68.0

Strain: lineage4.3.4.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4.3.4.1 Euro-American (LAM) RD174 1.0
lineage4 Euro-American None 1.0
lineage4.3.4 Euro-American (LAM) RD174 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6760 c.-542G>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.13 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7619 c.318C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13483 p.Ala26Thr missense_variant 1.0 isoniazid Uncertain significance
ccsA 620316 c.426G>C synonymous_variant 0.15 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620319 c.429C>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
nusG 734508 c.255C>G synonymous_variant 0.14 rifampicin
nusG 734511 c.258C>A synonymous_variant 0.14 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.17 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.15 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.15 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.16 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.13 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.15 rifampicin Uncertain significance
rpoB 760400 c.594G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.15 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762104 c.2298C>T synonymous_variant 0.16 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.13 rifampicin Uncertain significance
rpoC 763456 c.87A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.16 rifampicin
rpoC 763501 c.132C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763600 c.231C>G synonymous_variant 0.11 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.15 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.17 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.14 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.18 rifampicin
rpoC 763819 c.450G>T synonymous_variant 0.13 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.15 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.17 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.2 rifampicin
rpoC 764056 c.687G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764059 c.690G>C synonymous_variant 0.23 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.2 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.22 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Gln missense_variant 0.21 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 764153 p.Gln262Lys missense_variant 0.2 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.23 rifampicin
rpoC 764176 c.807C>T synonymous_variant 0.18 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.18 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.14 rifampicin
rpoC 764195 p.Ser276Glu missense_variant 0.14 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.12 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.12 rifampicin
rpoC 764215 c.846A>G synonymous_variant 0.12 rifampicin
rpoC 764239 c.870T>C synonymous_variant 0.15 rifampicin
rpoC 764245 c.876C>T synonymous_variant 0.16 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.14 rifampicin
rpoC 764347 c.978G>C synonymous_variant 0.14 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764449 c.1080G>C synonymous_variant 0.18 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.18 rifampicin
rpoC 764455 c.1086G>A synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.24 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.24 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.24 rifampicin
rpoC 764503 c.1134G>T synonymous_variant 0.23 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.24 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.36 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.18 rifampicin
rpoC 764686 c.1317C>T synonymous_variant 0.16 rifampicin
rpoC 764713 c.1344G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.12 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.18 rifampicin
rpoC 764956 c.1587T>C synonymous_variant 0.17 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.89 rifampicin Not assoc w R
rpoC 766741 c.3372G>C synonymous_variant 0.13 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
sigE 1364434 p.Arg8Trp missense_variant 1.0 pyrazinamide Not assoc w R
sigE 1364961 c.549A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
sigE 1364964 c.552T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
Rv1258c 1406209 p.Ala378Thr missense_variant 1.0 streptomycin
isoniazid
pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1473813 n.156C>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475376 n.1719A>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid Uncertain significance
rrl 1475380 n.1723C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475707 n.2050T>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rpsA 1833781 c.240T>G synonymous_variant 0.13 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.13 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834255 c.714C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.12 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834708 c.1167C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.17 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2169910 p.Asn235Tyr missense_variant 0.16 pyrazinamide
Rv1979c 2222854 p.Ile104Thr missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
ribD 2987373 p.Val179Met missense_variant 1.0 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877638 c.870T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.14 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.13 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.19 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.24 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.23 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877763 c.745C>T synonymous_variant 0.23 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>T synonymous_variant 0.22 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>C synonymous_variant 0.27 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.26 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.2 rifampicin
rpoA 3877878 c.630G>A synonymous_variant 0.2 rifampicin
rpoA 3877884 c.624G>T synonymous_variant 0.21 rifampicin
rpoA 3877887 c.621G>T synonymous_variant 0.21 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877899 p.Ser203Thr missense_variant 0.19 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.14 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038740 c.1965G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038761 c.1944C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038779 c.1926C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038782 c.1923G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.13 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.13 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.14 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038986 c.1719C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1704C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039139 c.1566G>A synonymous_variant 0.16 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039991 c.714G>A synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4040105 c.600C>G synonymous_variant 0.12 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040644 c.61A>C synonymous_variant 0.12 pyrazinamide
panD 4044210 c.72C>G synonymous_variant 0.14 pyrazinamide
panD 4044258 c.24G>C synonymous_variant 0.17 pyrazinamide
panD 4044261 c.21G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R