Run ID: ERR11465279
Sample name:
Date: 2024-10-05T05:21:03.985732
Number of reads: 2618852
Percentage reads mapped: 99.06
Median coverage: 68.0
Strain: lineage4.3.4.1
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.3 | Euro-American (LAM) | None | 1.0 |
lineage4.3.4.1 | Euro-American (LAM) | RD174 | 1.0 |
lineage4 | Euro-American | None | 1.0 |
lineage4.3.4 | Euro-American (LAM) | RD174 | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 6760 | c.-542G>C | upstream_gene_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6763 | c.1524G>C | synonymous_variant | 0.13 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6778 | c.-524C>T | upstream_gene_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6808 | c.1569C>G | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6811 | c.1572C>T | synonymous_variant | 0.13 | levofloxacin | |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6841 | c.1602T>C | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6844 | c.-458T>C | upstream_gene_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7427 | c.126G>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7592 | c.291G>C | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7619 | c.318C>G | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7626 | c.325C>T | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7631 | c.330G>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7637 | c.336C>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7728 | c.427_429delAGGinsCGC | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
Rv0010c | 13483 | p.Ala26Thr | missense_variant | 1.0 | isoniazid | Uncertain significance |
ccsA | 620316 | c.426G>C | synonymous_variant | 0.15 | kanamycin | Not assoc w R - Interim |
capreomycin | ||||||
amikacin | Not assoc w R - Interim | |||||
ccsA | 620319 | c.429C>T | synonymous_variant | 0.15 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
nusG | 734508 | c.255C>G | synonymous_variant | 0.14 | rifampicin | |
nusG | 734511 | c.258C>A | synonymous_variant | 0.14 | rifampicin | |
nusG | 734820 | c.567A>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
nusG | 734826 | c.573A>C | synonymous_variant | 0.17 | rifampicin | |
nusG | 734895 | c.642A>G | synonymous_variant | 0.15 | rifampicin | |
mmaA3 | 737358 | c.792A>C | synonymous_variant | 0.17 | isoniazid | |
rpoB | 760310 | c.504G>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760316 | c.510C>G | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760357 | p.Thr184Ser | missense_variant | 0.13 | rifampicin | Uncertain significance |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.15 | rifampicin | Uncertain significance |
rpoB | 760400 | c.594G>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoB | 760611 | c.805_807delTTGinsCTC | synonymous_variant | 0.15 | rifampicin | |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762104 | c.2298C>T | synonymous_variant | 0.16 | rifampicin | |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.13 | rifampicin | Uncertain significance |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 763468 | c.99G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763501 | c.132C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 763600 | c.231C>G | synonymous_variant | 0.11 | rifampicin | |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763675 | c.306C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763714 | c.345G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 763723 | c.354G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 763732 | c.363C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763792 | p.Glu141Asp | missense_variant | 0.14 | rifampicin | |
rpoC | 763807 | c.438T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763813 | c.444C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 763819 | c.450G>T | synonymous_variant | 0.13 | rifampicin | |
rpoC | 764032 | p.Asp221Glu | missense_variant | 0.15 | rifampicin | |
rpoC | 764040 | p.Ser224Asn | missense_variant | 0.17 | rifampicin | |
rpoC | 764044 | c.675T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764056 | c.687G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764059 | c.690G>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764071 | c.702G>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764083 | c.714A>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764084 | p.Asn239Val | missense_variant | 0.22 | rifampicin | |
rpoC | 764101 | c.732C>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764102 | p.Val245Gln | missense_variant | 0.21 | rifampicin | |
rpoC | 764134 | c.765C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764140 | c.771C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764143 | c.774G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764147 | p.Ser260Ala | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoC | 764153 | p.Gln262Lys | missense_variant | 0.2 | rifampicin | |
rpoC | 764161 | c.792G>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764176 | c.807C>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764182 | p.Asp271Glu | missense_variant | 0.18 | rifampicin | Uncertain significance |
rpoC | 764188 | c.819A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764194 | p.Glu275Asp | missense_variant | 0.14 | rifampicin | |
rpoC | 764195 | p.Ser276Glu | missense_variant | 0.14 | rifampicin | |
rpoC | 764203 | c.834G>C | synonymous_variant | 0.12 | rifampicin | |
rpoC | 764206 | p.Asp279Glu | missense_variant | 0.12 | rifampicin | |
rpoC | 764215 | c.846A>G | synonymous_variant | 0.12 | rifampicin | |
rpoC | 764239 | c.870T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764245 | c.876C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764257 | c.888G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764347 | c.978G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764353 | c.984G>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764434 | c.1065A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764449 | c.1080G>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764452 | c.1083T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764455 | c.1086G>A | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764485 | c.1116G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764491 | c.1122G>T | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764500 | c.1131C>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764503 | c.1134G>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764510 | c.1141C>T | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764533 | c.1164C>T | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764536 | c.1167G>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764548 | c.1179G>A | synonymous_variant | 0.36 | rifampicin | |
rpoC | 764566 | c.1197C>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764578 | c.1209C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764686 | c.1317C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764713 | c.1344G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764716 | c.1347G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764791 | c.1422C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764797 | c.1428G>C | synonymous_variant | 0.12 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764953 | c.1584G>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764956 | c.1587T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764995 | c.1626C>G | synonymous_variant | 0.89 | rifampicin | Not assoc w R |
rpoC | 766741 | c.3372G>C | synonymous_variant | 0.13 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
sigE | 1364434 | p.Arg8Trp | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
sigE | 1364961 | c.549A>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
sigE | 1364964 | c.552T>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
Rv1258c | 1406209 | p.Ala378Thr | missense_variant | 1.0 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471986 | n.141C>T | non_coding_transcript_exon_variant | 0.17 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.2 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472327 | n.482G>A | non_coding_transcript_exon_variant | 0.22 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472328 | n.483G>C | non_coding_transcript_exon_variant | 0.22 | kanamycin | |
capreomycin | ||||||
streptomycin | Uncertain significance | |||||
amikacin | ||||||
rrs | 1472489 | n.644A>G | non_coding_transcript_exon_variant | 0.14 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.24 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472973 | n.1128A>T | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473770 | n.113T>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473788 | n.131A>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473807 | n.150T>C | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473812 | n.155G>A | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473813 | n.156C>A | non_coding_transcript_exon_variant | 0.13 | capreomycin | |
linezolid | ||||||
rrl | 1473814 | n.157A>C | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473815 | n.158T>G | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473822 | n.165A>G | non_coding_transcript_exon_variant | 0.12 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473829 | n.172G>C | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473830 | n.173T>G | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1473831 | n.174G>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473832 | n.175C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473836 | n.179A>G | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1473876 | n.219G>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474174 | n.517A>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474202 | n.545T>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475376 | n.1719A>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1475380 | n.1723C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475707 | n.2050T>G | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1475884 | n.2227A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475916 | n.2259C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476165 | n.2508T>A | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rpsA | 1833781 | c.240T>G | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834255 | c.714C>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834387 | c.846C>T | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1834540 | c.999G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834543 | c.1002C>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834708 | c.1167C>T | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834720 | c.1179C>G | synonymous_variant | 0.17 | pyrazinamide | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
PPE35 | 2169910 | p.Asn235Tyr | missense_variant | 0.16 | pyrazinamide | |
Rv1979c | 2222854 | p.Ile104Thr | missense_variant | 1.0 | bedaquiline | Uncertain significance |
clofazimine | Uncertain significance | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
ribD | 2987373 | p.Val179Met | missense_variant | 1.0 | para-aminosalicylic_acid | |
thyA | 3073868 | p.Thr202Ala | missense_variant | 1.0 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
Rv3236c | 3612009 | p.Ala370Thr | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
rpoA | 3877638 | c.870T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877656 | c.852T>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3877668 | c.840A>G | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3877671 | c.837C>G | synonymous_variant | 0.13 | rifampicin | |
rpoA | 3877677 | c.831G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoA | 3877680 | c.828G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoA | 3877686 | c.822A>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoA | 3877695 | c.813C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3877704 | c.804G>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877728 | c.780C>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3877734 | c.774G>C | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3877740 | c.768G>C | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3877743 | c.765T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoA | 3877749 | c.759C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3877763 | c.745C>T | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3877764 | c.744C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3877770 | c.738A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3877773 | c.735G>T | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoA | 3877797 | c.711G>C | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3877848 | c.660C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3877875 | c.633T>G | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3877878 | c.630G>A | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3877884 | c.624G>T | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3877887 | c.621G>T | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3877893 | c.615C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3877899 | p.Ser203Thr | missense_variant | 0.19 | rifampicin | |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3877908 | c.600T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3877920 | c.588G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3877926 | c.582G>C | synonymous_variant | 0.14 | rifampicin | |
clpC1 | 4038287 | c.2418C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038761 | c.1944C>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038767 | c.1938G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038779 | c.1926C>T | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038905 | c.1800A>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038911 | c.1794G>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038917 | c.1788C>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038923 | c.1782A>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038932 | c.1773G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038986 | c.1719C>T | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039001 | c.1704C>T | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039064 | c.1641C>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039067 | c.1638G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039082 | c.1623C>T | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039085 | c.1620A>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039091 | c.1614G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039118 | c.1587C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039139 | c.1566G>A | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039169 | c.1536A>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039979 | c.726C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039988 | c.717C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039991 | c.714G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R |
clpC1 | 4040105 | c.600C>G | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4040450 | c.255A>G | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040644 | c.61A>C | synonymous_variant | 0.12 | pyrazinamide | |
panD | 4044210 | c.72C>G | synonymous_variant | 0.14 | pyrazinamide | |
panD | 4044258 | c.24G>C | synonymous_variant | 0.17 | pyrazinamide | |
panD | 4044261 | c.21G>A | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4408156 | p.Leu16Arg | missense_variant | 1.0 | streptomycin | Not assoc w R |