TB-Profiler

Lineage	Family	RDs	Frequency
La1.8	M.bovis	None	1.0
La1.8.1	M.bovis	None	1.0
La1	M.bovis	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.82	kanamycin	Uncertain significance	Mutation from literature
amikacin	Uncertain significance	Mutation from literature
capreomycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.83	amikacin	Assoc w R
capreomycin	Assoc w R
kanamycin	Assoc w R
pncA	2289073	p.His57Asp	missense_variant	1.0	pyrazinamide	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	467	p.His156Arg	missense_variant	1.0	isoniazid	Not assoc w R
gyrB	5752	c.513G>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	5752	c.513G>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6446	p.Ala403Ser	missense_variant	1.0	levofloxacin	Not assoc w R
gyrB	6446	p.Ala403Ser	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	8741	c.1440C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8741	c.1440C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9217	p.Asp639Ala	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	9217	p.Asp639Ala	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0010c	13197	p.Thr121Ser	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13228	c.330delG	frameshift_variant	1.0	isoniazid	Uncertain significance
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
fgd1	491742	c.960T>C	synonymous_variant	1.0	clofazimine	Not assoc w R
					pretomanid
					delamanid	Not assoc w R - Interim
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
rpoB	763031	c.3225T>C	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoC	764536	c.1167G>C	synonymous_variant	0.27	rifampicin
rpoC	764548	c.1179G>T	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	764549	c.1180_1182delCCGinsAC	frameshift_variant&missense_variant	0.26	rifampicin
rpoC	764561	p.Pro398Ala	missense_variant	0.31	rifampicin
rpoC	764575	c.1206T>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	764581	c.1212T>C	synonymous_variant	0.27	rifampicin
rpoC	764582	p.Leu405Met	missense_variant	0.27	rifampicin
rpoC	764611	c.1242G>T	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoC	764632	c.1263T>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>T	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoC	764653	c.1284G>C	synonymous_variant	0.23	rifampicin
rpoC	764660	c.1291_1293delGTGinsAC	frameshift_variant&missense_variant	0.21	rifampicin
rpoC	764668	c.1299C>A	synonymous_variant	0.19	rifampicin
rpoC	764671	c.1302G>C	synonymous_variant	0.18	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	1.0	moxifloxacin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
Rv1129c	1254582	c.-48A>G	upstream_gene_variant	1.0	moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
fbiC	1302899	c.-32A>G	upstream_gene_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472123	n.278A>T	non_coding_transcript_exon_variant	0.73	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472558	n.713G>A	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472569	n.724G>A	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>A	non_coding_transcript_exon_variant	0.9	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472606	n.761C>G	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472623	n.778A>C	non_coding_transcript_exon_variant	0.94	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472645	n.800G>C	non_coding_transcript_exon_variant	0.88	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472655	n.810G>T	non_coding_transcript_exon_variant	0.88	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472660	n.815T>A	non_coding_transcript_exon_variant	0.82	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472666	n.821G>T	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472675	n.830T>C	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472677	n.832C>A	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472682	n.837T>A	non_coding_transcript_exon_variant	0.75	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472683	n.838T>C	non_coding_transcript_exon_variant	0.75	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472686	n.841G>A	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472687	n.842A>T	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472694	n.849C>A	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472697	n.852T>C	non_coding_transcript_exon_variant	0.75	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472714	n.869A>T	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472952	n.1107T>C	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472955	n.1110C>T	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472956	n.1111T>C	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472982	n.1137G>A	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472987	n.1142G>A	non_coding_transcript_exon_variant	0.8	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472990	n.1145A>G	non_coding_transcript_exon_variant	0.8	streptomycin	Uncertain significance
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472991	n.1146G>A	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472993	n.1148G>T	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473055	n.1210C>T	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.87	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473097	n.1252G>A	non_coding_transcript_exon_variant	0.82	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473100	n.1255G>A	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	0.82	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473122	n.1277T>A	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473134	n.1289T>C	non_coding_transcript_exon_variant	0.83	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473147	n.1302G>A	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin
					amikacin	Uncertain significance
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473191	n.1346C>T	non_coding_transcript_exon_variant	0.76	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473192	n.1347A>G	non_coding_transcript_exon_variant	0.76	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473205	n.1360T>C	non_coding_transcript_exon_variant	0.76	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473206	n.1361G>A	non_coding_transcript_exon_variant	0.76	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473226	n.1381C>T	non_coding_transcript_exon_variant	0.8	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473269	n.1424C>T	non_coding_transcript_exon_variant	0.88	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.88	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473283	n.1438T>C	non_coding_transcript_exon_variant	0.88	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473288	n.1443delCinsTT	non_coding_transcript_exon_variant	0.87	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.87	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473291	n.1446G>T	non_coding_transcript_exon_variant	0.86	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.87	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473316	n.1471C>T	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473319	n.1474C>T	non_coding_transcript_exon_variant	0.75	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473320	n.1475G>A	non_coding_transcript_exon_variant	0.83	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473324	n.1479G>A	non_coding_transcript_exon_variant	0.83	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin
rrl	1474488	n.831G>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474488	n.831G>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474496	n.839C>A	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474496	n.839C>A	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474497	n.840G>C	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474506	n.849C>G	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474507	n.850G>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474516	n.859C>A	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1474516	n.859C>A	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474583	n.926C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1474583	n.926C>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1474601	n.944C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1474601	n.944C>T	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1474632	n.975G>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1474632	n.975G>T	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1474636	n.979A>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1474636	n.979A>T	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474637	n.980C>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1474637	n.980C>T	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474638	n.981C>G	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1474638	n.981C>G	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1474639	n.982G>C	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1474639	n.982G>C	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1474794	n.1137C>A	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1474794	n.1137C>A	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1474800	n.1143T>C	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474800	n.1143T>C	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1474830	n.1173A>T	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1474830	n.1173A>T	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1474832	n.1175A>T	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1474832	n.1175A>T	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1475753	n.2096C>G	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1475753	n.2096C>G	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1475758	n.2101_2102delACinsG	non_coding_transcript_exon_variant	0.77	capreomycin
rrl	1475758	n.2101_2102delACinsG	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1475768	n.2111_2112delGTinsC	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1475768	n.2111_2112delGTinsC	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1475775	n.2118G>T	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1475775	n.2118G>T	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1475896	n.2239A>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1475896	n.2239A>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1475897	n.2240T>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1475897	n.2240T>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1475963	n.2306G>T	non_coding_transcript_exon_variant	0.77	capreomycin
rrl	1475963	n.2306G>T	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1475981	n.2324G>T	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1475981	n.2324G>T	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.64	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1476160	n.2503T>C	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476160	n.2503T>C	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1476165	n.2508T>A	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476165	n.2508T>A	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1476195	n.2538C>T	non_coding_transcript_exon_variant	0.73	capreomycin
rrl	1476195	n.2538C>T	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.73	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.73	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476211	n.2554G>A	non_coding_transcript_exon_variant	0.72	capreomycin
rrl	1476211	n.2554G>A	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.86	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476297	n.2640C>G	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476297	n.2640C>G	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476298	n.2641C>G	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476298	n.2641C>G	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476309	n.2652G>C	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1476309	n.2652G>C	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476337	n.2680C>T	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476337	n.2680C>T	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.81	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.71	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rpsA	1834859	p.Ala440Thr	missense_variant	1.0	pyrazinamide	Uncertain significance
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2062922	p.Ile603Val	missense_variant	1.0	streptomycin	Not assoc w R
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
ndh	2102193	p.Arg284Trp	missense_variant	1.0	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2103173	c.-132delG	upstream_gene_variant	1.0	ethionamide
					delamanid
					isoniazid
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
katG	2155503	c.609C>T	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156025	c.87C>A	synonymous_variant	1.0	isoniazid	Not assoc w R
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
PPE35	2168011	p.Ser868Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168319	p.Thr765Ile	missense_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223701	c.-537A>G	upstream_gene_variant	1.0	clofazimine
Rv1979c	2223701	c.-537A>G	upstream_gene_variant	1.0	bedaquiline
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
eis	2715125	p.Thr70Ala	missense_variant	1.0	amikacin	Uncertain significance
eis	2715125	p.Thr70Ala	missense_variant	1.0	kanamycin	Uncertain significance
Rv2477c	2782927	c.1116A>G	synonymous_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					amikacin	Not assoc w R - Interim
pepQ	2859606	c.813G>A	synonymous_variant	0.73	clofazimine
pepQ	2859606	c.813G>A	synonymous_variant	0.73	bedaquiline
Rv2681	2997325	p.Ala196Val	missense_variant	1.0	capreomycin	Uncertain significance
Rv2752c	3065988	p.Glu68Asp	missense_variant	1.0	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
thyA	3074111	p.Thr121Ala	missense_variant	1.0	para-aminosalicylic_acid
ald	3086728	c.-92C>T	upstream_gene_variant	1.0	cycloserine
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
ald	3087084	c.266delA	frameshift_variant	1.0	cycloserine
Rv3083	3448783	p.Val94Ile	missense_variant	1.0	ethionamide	Uncertain significance
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624350	c.561G>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624350	c.561G>T	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624593	c.318G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624593	c.318G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624710	c.201G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624710	c.201G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
rpoA	3878630	c.-124delC	upstream_gene_variant	1.0	rifampicin	Not assoc w R
clpC1	4038403	c.2302T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
glpK	4138377	p.Val460Ala	missense_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
glpK	4138977	p.Gly260Ala	missense_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Not assoc w R
					isoniazid	Uncertain significance
embC	4240671	p.Thr270Ile	missense_variant	1.0	ethambutol	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embC	4242970	c.3108C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244220	c.988C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4246551	p.Asn13Ser	missense_variant	1.0	ethambutol	Not assoc w R
embB	4246864	c.351C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
aftB	4267858	p.Ile327Val	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269351	c.483C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result