Run ID: 2de98e7a-dd72-4756-984e-647c8651dc30
Sample name:
Date: 31-08-2023 00:46:25
Number of reads: 2028100
Percentage reads mapped: 90.02
Median coverage: 77
Strain: lineage2.2.1
Spoligotype:
Drug-resistance: RR-TB
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage2 | East-Asian | RD105 | 0.97 |
| lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 0.99 |
| lineage2.2.1 | East-Asian (Beijing) | RD105;RD207;RD181 | 0.97 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | rpoB | p.Ser450Met | Assoc w R - interim | |
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| moxifloxacin | ||||
| levofloxacin | ||||
| bedaquiline | ||||
| delamanid | ||||
| pretomanid | ||||
| linezolid | ||||
| streptomycin | rrs | n.462C>T | Uncertain significance | |
| amikacin | ||||
| kanamycin | ||||
| capreomycin | ||||
| clofazimine | ||||
| ethionamide | ||||
| para-aminosalicylic_acid | ||||
| cycloserine |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| rpoB | 761154 | p.Ser450Met | missense_variant | 0.95 | rifampicin | Assoc w R - interim | |
| rrs | 1472307 | n.462C>T | non_coding_transcript_exon_variant | 0.13 | streptomycin | Uncertain significance |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7391 | c.90C>T | synonymous_variant | 0.13 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7394 | c.93T>C | synonymous_variant | 0.16 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7406 | c.105G>C | synonymous_variant | 0.17 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7427 | c.126G>C | synonymous_variant | 0.16 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7442 | c.141G>C | synonymous_variant | 0.15 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7451 | c.150C>G | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7457 | c.156T>C | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7475 | c.174A>G | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7480 | p.Phe60Tyr | missense_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7484 | c.183T>C | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7514 | c.213C>G | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7523 | c.222C>A | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7532 | c.231T>C | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7541 | c.240C>G | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7547 | c.246C>T | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7562 | c.261C>T | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7571 | c.270G>C | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7595 | c.294C>G | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7601 | c.300C>G | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7607 | c.306C>G | synonymous_variant | 0.13 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7622 | c.321C>T | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7625 | c.324G>C | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7631 | c.330G>C | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7637 | c.336C>G | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7658 | c.357A>G | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8324 | c.1023T>C | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8330 | c.1029C>G | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8337 | c.1036_1038delCTAinsTTG | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8342 | c.1041G>C | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8393 | c.1092T>C | synonymous_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8619 | c.1318T>C | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9029 | c.1728T>C | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9032 | c.1731T>C | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9050 | p.Asp583Glu | missense_variant | 0.1 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9051 | c.1750T>C | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9056 | c.1755C>G | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9062 | c.1761C>G | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9065 | c.1764C>G | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9068 | c.1767G>C | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9071 | c.1770G>C | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9080 | c.1779G>T | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9089 | c.1788G>C | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9099 | c.1798_1800delTTAinsCTG | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9104 | c.1803C>G | synonymous_variant | 0.12 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9200 | c.1899A>G | synonymous_variant | 0.11 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | delamanid | |
| mshA | 575907 | p.Ala187Val | missense_variant | 0.96 | ethionamide | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| ccsA | 620346 | c.456C>G | synonymous_variant | 0.1 | capreomycin | |
| amikacin | ||||||
| ccsA | 620625 | p.Ile245Met | missense_variant | 1.0 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| rpoB | 760181 | c.375T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 760184 | c.378A>G | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 760196 | c.390C>G | synonymous_variant | 0.1 | rifampicin | |
| rpoB | 760223 | c.417T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 760235 | c.429T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 760283 | c.477G>C | synonymous_variant | 0.1 | rifampicin | |
| rpoB | 761207 | c.1401C>T | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 761213 | c.1407G>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 761219 | c.1413G>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 761249 | c.1443A>G | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 761255 | c.1449T>G | synonymous_variant | 0.1 | rifampicin | |
| rpoB | 761261 | c.1455G>T | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 761306 | c.1500C>G | synonymous_variant | 0.14 | rifampicin | |
| rpoB | 761312 | c.1506G>C | synonymous_variant | 0.16 | rifampicin | |
| rpoB | 761327 | c.1521A>G | synonymous_variant | 0.19 | rifampicin | |
| rpoB | 761330 | c.1524G>C | synonymous_variant | 0.19 | rifampicin | |
| rpoB | 761354 | c.1548C>T | synonymous_variant | 0.17 | rifampicin | |
| rpoB | 761360 | c.1554T>C | synonymous_variant | 0.13 | rifampicin | |
| rpoB | 761362 | p.Ser519Thr | missense_variant | 0.13 | rifampicin | |
| rpoB | 761373 | p.Val523His | missense_variant | 0.12 | rifampicin | |
| rpoB | 761492 | c.1686G>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 761510 | c.1704T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 762233 | c.2427G>C | synonymous_variant | 0.1 | rifampicin | |
| rpoB | 762246 | c.2440C>T | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 762254 | c.2448T>G | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 762257 | c.2451C>G | synonymous_variant | 0.12 | rifampicin | |
| rpoB | 762284 | c.2478G>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 762293 | c.2487T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoB | 762317 | c.2511A>G | synonymous_variant | 0.1 | rifampicin | |
| rpoB | 762329 | c.2523G>C | synonymous_variant | 0.13 | rifampicin | |
| rpoB | 762338 | c.2532T>C | synonymous_variant | 0.13 | rifampicin | |
| rpoB | 762347 | c.2541T>C | synonymous_variant | 0.13 | rifampicin | |
| rpoB | 762362 | p.Glu852Asp | missense_variant | 0.13 | rifampicin | |
| rpoB | 762369 | c.2563T>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 762398 | c.-972T>C | upstream_gene_variant | 0.12 | rifampicin | |
| rpoC | 762401 | c.-969G>C | upstream_gene_variant | 0.12 | rifampicin | |
| rpoC | 762404 | c.-966T>C | upstream_gene_variant | 0.13 | rifampicin | |
| rpoC | 762410 | c.-960T>C | upstream_gene_variant | 0.15 | rifampicin | |
| rpoC | 762416 | c.-954A>G | upstream_gene_variant | 0.15 | rifampicin | |
| rpoC | 762419 | c.-951C>G | upstream_gene_variant | 0.15 | rifampicin | |
| rpoC | 762434 | c.-936T>C | upstream_gene_variant | 0.14 | rifampicin | |
| rpoC | 762857 | c.-513C>G | upstream_gene_variant | 0.12 | rifampicin | |
| rpoC | 762860 | c.-510G>C | upstream_gene_variant | 0.12 | rifampicin | |
| rpoC | 762863 | c.-507T>C | upstream_gene_variant | 0.12 | rifampicin | |
| rpoC | 762926 | c.-444C>T | upstream_gene_variant | 0.18 | rifampicin | |
| rpoC | 762929 | c.-441G>C | upstream_gene_variant | 0.2 | rifampicin | |
| rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.15 | rifampicin | |
| rpoC | 762995 | c.-375G>T | upstream_gene_variant | 0.15 | rifampicin | |
| rpoC | 763013 | c.-357C>G | upstream_gene_variant | 0.15 | rifampicin | |
| rpoC | 763025 | c.-345C>T | upstream_gene_variant | 0.14 | rifampicin | |
| rpoC | 763028 | c.-342T>C | upstream_gene_variant | 0.14 | rifampicin | |
| rpoC | 763031 | c.-339T>G | upstream_gene_variant | 1.0 | rifampicin | |
| rpoC | 763034 | c.-336C>G | upstream_gene_variant | 0.16 | rifampicin | |
| rpoC | 763040 | c.-330C>G | upstream_gene_variant | 0.16 | rifampicin | |
| rpoC | 763070 | c.-300T>C | upstream_gene_variant | 0.15 | rifampicin | |
| rpoC | 763085 | c.-285C>G | upstream_gene_variant | 0.15 | rifampicin | |
| rpoC | 763115 | c.-255T>C | upstream_gene_variant | 0.13 | rifampicin | |
| rpoC | 763136 | c.-234C>T | upstream_gene_variant | 0.11 | rifampicin | |
| rpoC | 763872 | p.Gly168Ala | missense_variant | 0.1 | rifampicin | |
| rpoC | 763876 | p.Glu169Asp | missense_variant | 0.1 | rifampicin | |
| rpoC | 763879 | c.510A>G | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 763954 | c.585C>G | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 763963 | c.594C>T | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 763987 | c.618C>T | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 763991 | p.Ile208Leu | missense_variant | 0.1 | rifampicin | |
| rpoC | 763996 | c.627T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 764002 | c.633C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 764005 | c.636G>C | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 764024 | c.655_657delTTGinsCTC | synonymous_variant | 0.13 | rifampicin | |
| rpoC | 764044 | c.675T>C | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 764059 | c.690G>T | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 764098 | c.729A>G | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 764188 | c.819A>G | synonymous_variant | 0.15 | rifampicin | |
| rpoC | 764195 | p.Ser276Ile | missense_variant | 0.15 | rifampicin | |
| rpoC | 764203 | c.834G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 764206 | c.837T>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 764215 | c.846A>G | synonymous_variant | 0.15 | rifampicin | |
| rpoC | 764236 | c.867G>A | synonymous_variant | 0.13 | rifampicin | |
| rpoC | 764248 | c.879C>G | synonymous_variant | 0.13 | rifampicin | |
| rpoC | 764257 | c.888G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 764266 | c.897T>C | synonymous_variant | 0.16 | rifampicin | |
| rpoC | 764269 | c.900G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 764272 | c.903G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 764278 | c.909A>G | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 764338 | c.969G>A | synonymous_variant | 0.2 | rifampicin | |
| rpoC | 764353 | c.984G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 764365 | c.996C>T | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 764380 | c.1011G>C | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 764381 | c.1012_1013delTCinsAG | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 764387 | c.1018_1020delTTGinsCTC | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 764405 | c.1036A>C | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 764461 | c.1092A>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 764510 | c.1141C>T | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 764521 | c.1152T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 764554 | c.1185C>T | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 764560 | c.1191T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 764566 | c.1197C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 764575 | c.1206T>G | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 764581 | c.1212T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 764593 | c.1224C>T | synonymous_variant | 0.16 | rifampicin | |
| rpoC | 764611 | c.1242G>T | synonymous_variant | 0.15 | rifampicin | |
| rpoC | 764650 | c.1281G>C | synonymous_variant | 0.19 | rifampicin | |
| rpoC | 764651 | c.1282_1284delTCGinsAGC | synonymous_variant | 0.18 | rifampicin | |
| rpoC | 764752 | c.1383G>C | synonymous_variant | 0.21 | rifampicin | |
| rpoC | 764764 | c.1395T>C | synonymous_variant | 0.22 | rifampicin | |
| rpoC | 764809 | c.1440C>T | synonymous_variant | 0.19 | rifampicin | |
| rpoC | 764815 | c.1446A>G | synonymous_variant | 0.19 | rifampicin | |
| rpoC | 764827 | c.1458G>C | synonymous_variant | 0.14 | rifampicin | |
| rpoC | 764858 | c.1489T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 765478 | c.2109T>C | synonymous_variant | 0.16 | rifampicin | |
| rpoC | 765499 | c.2130C>G | synonymous_variant | 0.19 | rifampicin | |
| rpoC | 765529 | c.2160C>T | synonymous_variant | 0.18 | rifampicin | |
| rpoC | 765541 | c.2172C>G | synonymous_variant | 0.18 | rifampicin | |
| rpoC | 765553 | c.2184C>T | synonymous_variant | 0.17 | rifampicin | |
| rpoC | 765556 | c.2187G>C | synonymous_variant | 0.17 | rifampicin | |
| rpoC | 765559 | c.2190G>C | synonymous_variant | 0.17 | rifampicin | |
| rpoC | 765580 | c.2211G>C | synonymous_variant | 0.16 | rifampicin | |
| rpoC | 765613 | p.His748Gln | missense_variant | 0.11 | rifampicin | |
| rpoC | 765625 | c.2256C>G | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 765700 | c.2331T>C | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 765751 | c.2382C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 765772 | c.2403C>G | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 765784 | c.2415C>G | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 765850 | c.2481G>C | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 765883 | c.2514C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 765886 | c.2517C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 765892 | c.2523T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 765937 | c.2568T>C | synonymous_variant | 0.22 | rifampicin | |
| rpoC | 765967 | c.2598C>T | synonymous_variant | 0.23 | rifampicin | |
| rpoC | 765982 | c.2613C>G | synonymous_variant | 0.23 | rifampicin | |
| rpoC | 765994 | c.2625A>T | synonymous_variant | 0.25 | rifampicin | |
| rpoC | 766010 | c.2641_2642delTCinsAG | synonymous_variant | 0.22 | rifampicin | |
| rpoC | 766021 | c.2652G>C | synonymous_variant | 0.2 | rifampicin | |
| rpoC | 766027 | c.2658G>C | synonymous_variant | 0.21 | rifampicin | |
| rpoC | 766030 | c.2661C>G | synonymous_variant | 0.21 | rifampicin | |
| rpoC | 766043 | p.Gln892Glu | missense_variant | 0.19 | rifampicin | |
| rpoC | 766054 | c.2685C>G | synonymous_variant | 0.2 | rifampicin | |
| rpoC | 766082 | p.Ala905Gln | missense_variant | 0.18 | rifampicin | |
| rpoC | 766096 | c.2727G>C | synonymous_variant | 0.16 | rifampicin | |
| rpoC | 766129 | c.2760C>G | synonymous_variant | 0.13 | rifampicin | |
| rpoC | 766135 | c.2766G>A | synonymous_variant | 0.13 | rifampicin | |
| rpoC | 766141 | c.2772C>T | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 766142 | c.2773C>T | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 766381 | c.3012C>T | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 766384 | c.3015A>G | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 766390 | c.3021C>T | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 766408 | c.3039C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 766411 | c.3042C>G | synonymous_variant | 0.1 | rifampicin | |
| rpoC | 766426 | c.3057C>T | synonymous_variant | 0.12 | rifampicin | |
| rpoC | 766447 | c.3078T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoC | 766462 | c.3093G>C | synonymous_variant | 0.11 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 776182 | p.Asp767Asn | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| rpsL | 781748 | c.189C>G | synonymous_variant | 0.1 | streptomycin | |
| rpsL | 781772 | c.213C>A | synonymous_variant | 0.1 | streptomycin | |
| rplC | 800648 | c.-161A>T | upstream_gene_variant | 0.1 | linezolid | |
| rplC | 800693 | c.-116A>G | upstream_gene_variant | 0.14 | linezolid | |
| rplC | 800703 | c.-106T>C | upstream_gene_variant | 0.12 | linezolid | |
| rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.1 | linezolid | |
| rplC | 800720 | c.-89T>C | upstream_gene_variant | 0.1 | linezolid | |
| rplC | 800723 | c.-86C>G | upstream_gene_variant | 0.1 | linezolid | |
| rplC | 800747 | c.-62C>G | upstream_gene_variant | 0.12 | linezolid | |
| rplC | 800771 | c.-38C>T | upstream_gene_variant | 0.13 | linezolid | |
| rplC | 800794 | c.-15A>G | upstream_gene_variant | 0.12 | linezolid | |
| rplC | 800796 | c.-13A>G | upstream_gene_variant | 0.13 | linezolid | |
| rplC | 800798 | c.-10_-9delGG | upstream_gene_variant | 0.13 | linezolid | |
| rplC | 800814 | c.6A>G | synonymous_variant | 0.14 | linezolid | |
| rplC | 800817 | c.9A>T | synonymous_variant | 0.14 | linezolid | |
| rplC | 800844 | c.36T>C | synonymous_variant | 0.12 | linezolid | |
| fbiC | 1304778 | c.1848T>C | synonymous_variant | 0.12 | delamanid | |
| fbiC | 1304784 | c.1854T>C | synonymous_variant | 0.12 | delamanid | |
| fbiC | 1304787 | c.1857T>G | synonymous_variant | 0.12 | delamanid | |
| fbiC | 1304808 | c.1878C>G | synonymous_variant | 0.12 | delamanid | |
| fbiC | 1304811 | c.1881C>G | synonymous_variant | 0.12 | delamanid | |
| fbiC | 1304817 | c.1887T>C | synonymous_variant | 0.13 | delamanid | |
| fbiC | 1304829 | c.1899T>C | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304832 | c.1902C>T | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304862 | c.1932G>A | synonymous_variant | 0.1 | delamanid | |
| fbiC | 1304869 | c.1939C>T | synonymous_variant | 0.1 | delamanid | |
| fbiC | 1304875 | p.Ile649Val | missense_variant | 0.1 | delamanid | |
| fbiC | 1304883 | p.Glu651Asp | missense_variant | 0.11 | delamanid | |
| fbiC | 1304891 | p.Ile654Thr | missense_variant | 0.11 | delamanid | |
| fbiC | 1304893 | p.Gly655Ser | missense_variant | 0.11 | delamanid | |
| fbiC | 1304907 | c.1977C>G | synonymous_variant | 0.11 | delamanid | |
| fbiC | 1304910 | c.1980G>C | synonymous_variant | 0.1 | delamanid | |
| Rv1258c | 1406760 | c.580_581insC | frameshift_variant | 1.0 | streptomycin | Uncertain significance |
| pyrazinamide | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1472300 | n.455C>T | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrl | 1473756 | n.99G>A | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.15 | linezolid | |
| rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 0.21 | linezolid | |
| rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.21 | linezolid | Uncertain significance |
| rrl | 1473899 | n.242A>C | non_coding_transcript_exon_variant | 0.21 | linezolid | |
| rrl | 1473943 | n.286G>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| rrl | 1473986 | n.329T>C | non_coding_transcript_exon_variant | 0.18 | linezolid | Uncertain significance |
| rrl | 1473987 | n.330G>A | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| rrl | 1473995 | n.338G>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 0.2 | linezolid | Uncertain significance |
| rrl | 1474009 | n.352A>G | non_coding_transcript_exon_variant | 0.19 | linezolid | |
| rrl | 1474012 | n.355C>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| rrl | 1474093 | n.436G>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1474099 | n.442G>A | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1474103 | n.446A>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1474639 | n.982G>A | non_coding_transcript_exon_variant | 0.14 | linezolid | Uncertain significance |
| rrl | 1474904 | n.1247G>A | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1474956 | n.1299C>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1474961 | n.1304T>G | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1474963 | n.1306G>A | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1474964 | n.1307T>C | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1474970 | n.1313G>A | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| rrl | 1475199 | n.1542G>A | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475206 | n.1549C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475209 | n.1552G>C | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475213 | n.1556C>T | non_coding_transcript_exon_variant | 0.13 | linezolid | |
| rrl | 1475249 | n.1592T>C | non_coding_transcript_exon_variant | 0.12 | linezolid | Uncertain significance |
| rrl | 1475252 | n.1595C>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475369 | n.1712G>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1475402 | n.1745C>T | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.18 | linezolid | |
| rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.17 | linezolid | |
| rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.16 | linezolid | |
| rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.14 | linezolid | |
| rrl | 1475599 | n.1942A>G | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.1 | linezolid | |
| rpsA | 1833742 | c.201A>G | synonymous_variant | 0.11 | pyrazinamide | |
| rpsA | 1833745 | c.204G>C | synonymous_variant | 0.1 | pyrazinamide | |
| rpsA | 1833748 | c.207C>G | synonymous_variant | 0.11 | pyrazinamide | |
| rpsA | 1834177 | c.636A>C | synonymous_variant | 1.0 | pyrazinamide | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | |
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Uncertain significance |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| kasA | 2518474 | c.360G>A | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518480 | c.366T>C | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518483 | c.369C>G | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518504 | c.390T>C | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518506 | p.Ala131Glu | missense_variant | 0.11 | isoniazid | |
| kasA | 2518519 | c.405G>C | synonymous_variant | 0.14 | isoniazid | |
| kasA | 2518528 | c.414C>G | synonymous_variant | 0.15 | isoniazid | |
| kasA | 2518540 | c.426T>C | synonymous_variant | 0.14 | isoniazid | |
| kasA | 2518561 | c.447T>C | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518567 | c.453G>C | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518570 | c.456G>C | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518574 | p.Ile154Val | missense_variant | 0.11 | isoniazid | |
| kasA | 2518579 | c.465T>C | synonymous_variant | 0.13 | isoniazid | |
| kasA | 2518588 | c.474T>C | synonymous_variant | 0.14 | isoniazid | |
| kasA | 2518591 | c.477G>C | synonymous_variant | 0.15 | isoniazid | |
| kasA | 2518609 | p.Met165Ile | missense_variant | 0.14 | isoniazid | |
| kasA | 2518624 | c.510C>G | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518639 | c.525G>C | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518696 | c.582C>G | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518702 | c.588C>T | synonymous_variant | 0.13 | isoniazid | |
| kasA | 2518705 | c.591T>C | synonymous_variant | 0.13 | isoniazid | |
| kasA | 2518711 | c.597A>G | synonymous_variant | 0.12 | isoniazid | |
| kasA | 2518714 | c.600A>C | synonymous_variant | 0.13 | isoniazid | |
| kasA | 2518732 | c.618C>G | synonymous_variant | 0.11 | isoniazid | |
| kasA | 2518768 | c.654C>T | synonymous_variant | 0.12 | isoniazid | |
| kasA | 2518777 | c.663C>T | synonymous_variant | 0.12 | isoniazid | |
| kasA | 2518783 | c.669T>C | synonymous_variant | 0.1 | isoniazid | |
| kasA | 2518789 | c.675G>C | synonymous_variant | 0.11 | isoniazid | |
| Rv2752c | 3065207 | p.Thr329Pro | missense_variant | 0.96 | rifampicin | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| Rv2752c | 3065481 | c.711T>C | synonymous_variant | 0.1 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065487 | c.705T>G | synonymous_variant | 0.11 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065499 | c.693A>C | synonymous_variant | 0.1 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065502 | p.Asp230Glu | missense_variant | 0.1 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065508 | c.684T>C | synonymous_variant | 0.1 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065523 | c.669C>T | synonymous_variant | 0.1 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065532 | c.660A>G | synonymous_variant | 0.11 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065535 | c.657C>T | synonymous_variant | 0.11 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065538 | c.654G>C | synonymous_variant | 0.11 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065541 | c.651A>G | synonymous_variant | 0.11 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065553 | c.639A>G | synonymous_variant | 0.12 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065562 | c.630T>C | synonymous_variant | 0.11 | rifampicin | |
| isoniazid | ||||||
| thyX | 3067325 | c.621A>G | synonymous_variant | 0.13 | para-aminosalicylic_acid | |
| thyX | 3067349 | c.597G>C | synonymous_variant | 0.12 | para-aminosalicylic_acid | |
| thyX | 3067355 | c.591A>C | synonymous_variant | 0.12 | para-aminosalicylic_acid | |
| thyX | 3067367 | c.579G>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
| thyX | 3067373 | c.573C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
| thyX | 3067376 | c.570G>A | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
| thyX | 3067391 | c.555G>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
| thyX | 3067394 | c.552G>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
| thyX | 3067439 | c.507A>G | synonymous_variant | 0.21 | para-aminosalicylic_acid | |
| thyX | 3067445 | c.501C>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
| thyX | 3067457 | c.489C>G | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
| thyX | 3067465 | p.Ile161Val | missense_variant | 0.19 | para-aminosalicylic_acid | |
| thyX | 3067475 | c.471A>G | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
| thyX | 3067490 | c.456C>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
| thyX | 3067493 | c.453A>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
| thyX | 3067515 | p.Ser144Thr | missense_variant | 0.19 | para-aminosalicylic_acid | |
| thyX | 3067530 | p.Ala139Ser | missense_variant | 0.15 | para-aminosalicylic_acid | |
| thyX | 3067545 | p.Glu134Ala | missense_variant | 0.17 | para-aminosalicylic_acid | |
| thyX | 3067549 | p.Thr133Ala | missense_variant | 0.16 | para-aminosalicylic_acid | |
| thyX | 3067556 | p.His130Gln | missense_variant | 0.12 | para-aminosalicylic_acid | |
| thyX | 3067559 | c.387C>G | synonymous_variant | 0.13 | para-aminosalicylic_acid | |
| thyX | 3067565 | p.Asp127Glu | missense_variant | 0.12 | para-aminosalicylic_acid | |
| thyX | 3067570 | p.Ala126Pro | missense_variant | 0.13 | para-aminosalicylic_acid | |
| thyX | 3067577 | c.369G>A | synonymous_variant | 0.12 | para-aminosalicylic_acid | |
| thyX | 3067583 | c.363C>G | synonymous_variant | 0.13 | para-aminosalicylic_acid | |
| thyX | 3067601 | p.Arg115His | missense_variant | 0.12 | para-aminosalicylic_acid | |
| thyX | 3067611 | p.Lys112Thr | missense_variant | 0.11 | para-aminosalicylic_acid | |
| thyX | 3067619 | c.327A>C | synonymous_variant | 0.11 | para-aminosalicylic_acid | |
| thyX | 3067631 | c.315C>G | synonymous_variant | 0.12 | para-aminosalicylic_acid | |
| thyX | 3067634 | c.312C>G | synonymous_variant | 0.12 | para-aminosalicylic_acid | |
| thyX | 3067652 | c.294T>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
| thyX | 3067661 | c.285C>G | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
| thyX | 3067685 | c.261A>C | synonymous_variant | 0.14 | para-aminosalicylic_acid | |
| thyX | 3067691 | p.Ile85Leu | missense_variant | 0.13 | para-aminosalicylic_acid | |
| thyX | 3067694 | c.252G>C | synonymous_variant | 0.14 | para-aminosalicylic_acid | |
| thyX | 3067718 | c.228C>G | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
| thyX | 3067721 | c.225T>C | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
| thyX | 3067727 | c.219A>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
| thyX | 3067736 | p.Phe70Leu | missense_variant | 0.19 | para-aminosalicylic_acid | |
| thyX | 3067739 | c.207T>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
| thyX | 3067761 | p.Arg62Lys | missense_variant | 0.16 | para-aminosalicylic_acid | |
| thyX | 3067765 | p.Leu61Ile | missense_variant | 0.15 | para-aminosalicylic_acid | |
| thyX | 3067772 | c.174C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
| thyX | 3067781 | c.165C>A | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
| thyX | 3067793 | c.153T>C | synonymous_variant | 0.1 | para-aminosalicylic_acid | |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpoA | 3877986 | c.522G>C | synonymous_variant | 0.13 | rifampicin | |
| rpoA | 3877989 | c.519A>G | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878001 | c.507A>G | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878022 | c.486T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoA | 3878040 | c.468T>C | synonymous_variant | 0.11 | rifampicin | |
| rpoA | 3878043 | c.465G>A | synonymous_variant | 0.11 | rifampicin | |
| rpoA | 3878055 | c.453A>G | synonymous_variant | 0.1 | rifampicin | |
| rpoA | 3878058 | c.450G>T | synonymous_variant | 0.11 | rifampicin | |
| rpoA | 3878061 | c.447G>C | synonymous_variant | 0.1 | rifampicin | |
| rpoA | 3878094 | c.414C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoA | 3878103 | c.405A>G | synonymous_variant | 0.11 | rifampicin | |
| rpoA | 3878106 | c.402G>C | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878118 | c.390T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878130 | c.378C>G | synonymous_variant | 0.11 | rifampicin | |
| rpoA | 3878141 | p.Met123Leu | missense_variant | 0.13 | rifampicin | |
| rpoA | 3878143 | p.Gly122Asp | missense_variant | 0.12 | rifampicin | Uncertain significance |
| rpoA | 3878157 | c.351C>G | synonymous_variant | 0.1 | rifampicin | |
| rpoA | 3878181 | c.327C>T | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878187 | c.321C>G | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878193 | c.315T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878199 | c.309T>C | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878217 | c.291A>G | synonymous_variant | 0.11 | rifampicin | |
| rpoA | 3878226 | c.282C>G | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878232 | c.276G>C | synonymous_variant | 0.12 | rifampicin | |
| rpoA | 3878247 | c.261G>C | synonymous_variant | 0.16 | rifampicin | |
| rpoA | 3878271 | c.237T>C | synonymous_variant | 0.19 | rifampicin | |
| rpoA | 3878284 | p.Glu75Ala | missense_variant | 0.18 | rifampicin | |
| rpoA | 3878292 | c.216T>C | synonymous_variant | 0.18 | rifampicin | |
| rpoA | 3878298 | c.210A>G | synonymous_variant | 0.18 | rifampicin | |
| rpoA | 3878304 | c.204G>C | synonymous_variant | 0.19 | rifampicin | |
| rpoA | 3878313 | c.195G>C | synonymous_variant | 0.2 | rifampicin | |
| rpoA | 3878322 | c.186A>G | synonymous_variant | 0.21 | rifampicin | |
| rpoA | 3878331 | c.177A>G | synonymous_variant | 0.18 | rifampicin | |
| rpoA | 3878334 | c.174T>C | synonymous_variant | 0.19 | rifampicin | |
| rpoA | 3878337 | c.171T>C | synonymous_variant | 0.19 | rifampicin | |
| rpoA | 3878340 | c.168C>T | synonymous_variant | 0.2 | rifampicin | |
| rpoA | 3878346 | c.162T>C | synonymous_variant | 0.19 | rifampicin | |
| rpoA | 3878364 | c.144A>T | synonymous_variant | 0.19 | rifampicin | |
| rpoA | 3878367 | c.141C>G | synonymous_variant | 0.19 | rifampicin | |
| rpoA | 3878376 | c.132G>C | synonymous_variant | 0.18 | rifampicin | |
| rpoA | 3878385 | c.123C>G | synonymous_variant | 0.18 | rifampicin | |
| rpoA | 3878388 | c.120C>G | synonymous_variant | 0.18 | rifampicin | |
| rpoA | 3878391 | c.117T>C | synonymous_variant | 0.19 | rifampicin | |
| rpoA | 3878415 | c.93C>T | synonymous_variant | 0.17 | rifampicin | |
| rpoA | 3878424 | c.84G>C | synonymous_variant | 0.17 | rifampicin | |
| rpoA | 3878436 | c.72A>G | synonymous_variant | 0.13 | rifampicin | |
| rpoA | 3878442 | c.66G>C | synonymous_variant | 0.13 | rifampicin | |
| clpC1 | 4038695 | c.2010C>G | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4038749 | c.1956C>G | synonymous_variant | 0.16 | pyrazinamide | |
| clpC1 | 4038755 | c.1950G>T | synonymous_variant | 0.17 | pyrazinamide | |
| clpC1 | 4038770 | c.1935C>T | synonymous_variant | 0.15 | pyrazinamide | |
| clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.15 | pyrazinamide | |
| clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.18 | pyrazinamide | |
| clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.16 | pyrazinamide | |
| clpC1 | 4038821 | c.1884G>A | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4038845 | c.1860G>C | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4038860 | c.1845G>C | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.11 | pyrazinamide | |
| clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040036 | c.669C>G | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040105 | c.600C>G | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4040147 | c.558A>G | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4040162 | c.543G>C | synonymous_variant | 0.15 | pyrazinamide | |
| clpC1 | 4040165 | c.540G>C | synonymous_variant | 0.15 | pyrazinamide | |
| clpC1 | 4040171 | c.534C>G | synonymous_variant | 0.15 | pyrazinamide | |
| clpC1 | 4040201 | c.504C>G | synonymous_variant | 0.12 | pyrazinamide | |
| clpC1 | 4040204 | c.501G>C | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040207 | c.498T>G | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040210 | c.495G>C | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040213 | c.490_492delTCTinsAGC | synonymous_variant | 0.1 | pyrazinamide | |
| clpC1 | 4040246 | c.459C>G | synonymous_variant | 0.11 | pyrazinamide | |
| clpC1 | 4040249 | c.456A>G | synonymous_variant | 0.13 | pyrazinamide | |
| clpC1 | 4040267 | c.438A>G | synonymous_variant | 0.12 | pyrazinamide | |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4243460 | c.228C>T | synonymous_variant | 1.0 | ethambutol | |
| aftB | 4267647 | p.Asp397Gly | missense_variant | 0.96 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407927 | p.Glu92Asp | missense_variant | 1.0 | streptomycin | Uncertain significance |
