Run ID: ERR1336821
Sample name:
Date: 2024-10-05T08:22:44.702194
Number of reads: 9235463
Percentage reads mapped: 93.74
Median coverage: 207.0
Strain: La3;M.canetti
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| La3 | M.orygis | None | 0.37 |
| M.canetti | M.canetti | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| dnaA | 72 | c.72T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 264 | c.264C>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 400 | p.Asp134Asn | missense_variant | 1.0 | isoniazid | Uncertain significance |
| dnaA | 481 | p.Ala161Thr | missense_variant | 1.0 | isoniazid | |
| dnaA | 549 | c.549C>T | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 708 | c.708T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 747 | c.747G>A | synonymous_variant | 1.0 | isoniazid | |
| gyrB | 5025 | c.-215T>A | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5207 | c.-33A>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5440 | c.201A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5452 | c.213G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 5770 | c.531C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6001 | c.762G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6004 | c.765T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6286 | c.1047T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6433 | c.-869C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6436 | c.-866C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7256 | c.2017C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 8288 | c.987T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9074 | c.1773G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9218 | c.1917C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9734 | c.2433A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| Rv0010c | 13220 | c.339T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| Rv0010c | 13259 | c.300C>G | synonymous_variant | 1.0 | isoniazid | |
| Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
| Rv0010c | 13660 | c.-102G>A | upstream_gene_variant | 1.0 | isoniazid | |
| fgd1 | 490666 | c.-117G>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 490678 | c.-105_-104insG | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 490687 | c.-96T>C | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 490734 | c.-49A>T | upstream_gene_variant | 0.21 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491406 | p.Met208Ile | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | Not assoc w R - Interim | |||||
| clofazimine | Not assoc w R | |||||
| mshA | 575060 | c.-288G>C | upstream_gene_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575123 | c.-225A>T | upstream_gene_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575133 | c.-215C>T | upstream_gene_variant | 1.0 | isoniazid | Uncertain significance |
| ethionamide | ||||||
| mshA | 575665 | c.318G>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | Not assoc w R - Interim | |||||
| mshA | 575971 | c.624C>T | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 576285 | p.Val313Ala | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 576757 | c.1410C>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | Not assoc w R - Interim | |||||
| ccsA | 619654 | c.-237A>G | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 619766 | c.-125A>G | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 619850 | c.-41G>A | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 619875 | c.-16C>T | upstream_gene_variant | 1.0 | kanamycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| ccsA | 620158 | c.268C>T | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620607 | c.717T>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| Rv0565c | 656511 | p.His320Gln | missense_variant | 1.0 | ethionamide | |
| Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv0565c | 657273 | c.198G>A | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | |
| hadA | 731852 | c.-78A>G | upstream_gene_variant | 1.0 | isoniazid | |
| hadA | 732379 | c.450A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| nusG | 733883 | c.-370_-368delGCG | upstream_gene_variant | 1.0 | rifampicin | |
| mmaA3 | 737397 | c.753G>C | synonymous_variant | 1.0 | isoniazid | |
| mmaA3 | 738177 | c.-28G>T | upstream_gene_variant | 1.0 | isoniazid | |
| rpoB | 759351 | c.-456G>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoB | 759911 | c.105C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760715 | c.909C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761510 | c.1704T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761573 | c.1767C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
| rpoC | 763259 | c.-111G>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoC | 763660 | c.291T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764107 | c.738C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764134 | c.765C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764152 | c.783C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764159 | c.790C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764195 | p.Ser276Ala | missense_variant | 1.0 | rifampicin | |
| rpoC | 764198 | c.829C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764203 | c.834G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764206 | p.Asp279Glu | missense_variant | 1.0 | rifampicin | |
| rpoC | 764245 | c.876C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764257 | c.888G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764278 | c.909A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764293 | c.924G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764341 | c.972G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764365 | c.996C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764405 | c.1036A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764497 | c.1128A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764506 | c.1137C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764510 | c.1141C>T | synonymous_variant | 0.99 | rifampicin | Not assoc w R - Interim |
| rpoC | 764521 | c.1152T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764524 | c.1155C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764527 | c.1158C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764533 | c.1164C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764536 | c.1167G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764539 | c.1170C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764554 | c.1185C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764575 | c.1206T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764578 | c.1209C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764632 | c.1263T>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764650 | c.1281G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764651 | c.1282_1284delTCGinsAGC | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765001 | c.1632C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765082 | c.1713G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765152 | p.Asp595Asn | missense_variant | 1.0 | rifampicin | |
| rpoC | 765409 | c.2040T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765478 | c.2109T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766152 | p.Asp928Gly | missense_variant | 1.0 | rifampicin | |
| rpoC | 766675 | c.3306C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766870 | c.3501C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766900 | c.3531T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766945 | c.3576A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767062 | c.3693C>A | synonymous_variant | 1.0 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| mmpL5 | 775748 | c.2733T>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| mmpL5 | 776132 | c.2349A>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776432 | c.2049G>A | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776807 | c.1674G>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776818 | p.Ile555Val | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 776993 | c.1488A>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777140 | c.1341G>A | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777251 | c.1230C>T | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R - Interim | |||||
| mmpL5 | 777254 | c.1227G>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777284 | c.1197C>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777296 | c.1185C>T | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777431 | c.1050A>G | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777497 | c.984A>G | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R - Interim | |||||
| mmpL5 | 777512 | c.969T>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777591 | p.Ser297Gln | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777593 | c.888G>A | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777596 | c.885G>A | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R - Interim | |||||
| mmpL5 | 777755 | c.726C>T | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 777800 | c.681C>T | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpR5 | 778136 | c.-854T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 778216 | p.Ser89Gly | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 778282 | p.Asp67Asn | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 778304 | p.Ile59Met | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 778470 | p.Gln4Arg | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 778510 | c.-30T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 778573 | c.-93C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 778654 | c.-174A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 779295 | c.-815A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 779439 | c.-959G>T | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpR5 | 779468 | p.Arg160Gln | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| rpsL | 781291 | c.-269G>C | upstream_gene_variant | 1.0 | streptomycin | |
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| Rv1129c | 1253093 | p.Ser481Leu | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1253216 | p.Glu440Ala | missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| Rv1129c | 1253408 | p.Glu376Gly | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1253653 | c.882T>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1253692 | c.843C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1253814 | p.Gln241Glu | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1253904 | p.Asn211Asp | missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| Rv1129c | 1254316 | c.219G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254434 | p.Val34Ala | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| Rv1129c | 1254576 | c.-42C>T | upstream_gene_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| Rv1129c | 1254602 | c.-68C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254610 | c.-76A>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254654 | c.-120A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254678 | c.-144A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254690 | c.-156T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| fbiC | 1302694 | c.-237C>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1302810 | c.-121C>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1302860 | c.-71G>A | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1302870 | c.-61G>C | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1302948 | c.18T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1303288 | p.Ser120Gly | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1303747 | p.Thr273Ala | missense_variant | 1.0 | pretomanid | |
| delamanid | Uncertain significance | |||||
| clofazimine | Uncertain significance | |||||
| fbiC | 1303860 | c.930A>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304064 | c.1134G>A | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304141 | p.Ala404Gly | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304330 | p.Ala467Asp | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304707 | p.Val593Ile | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304907 | c.1977C>A | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| Rv1258c | 1406466 | p.Ser292Leu | missense_variant | 1.0 | streptomycin | Uncertain significance |
| pyrazinamide | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1258c | 1406492 | p.Ile283Met | missense_variant | 1.0 | streptomycin | |
| pyrazinamide | ||||||
| isoniazid | ||||||
| Rv1258c | 1407008 | c.333C>A | synonymous_variant | 1.0 | streptomycin | |
| pyrazinamide | ||||||
| isoniazid | ||||||
| Rv1258c | 1407548 | c.-208C>G | upstream_gene_variant | 1.0 | streptomycin | |
| pyrazinamide | ||||||
| isoniazid | ||||||
| embR | 1417294 | c.54A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embR | 1417454 | c.-107C>A | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417598 | c.-251G>A | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417925 | c.-578C>T | upstream_gene_variant | 0.99 | ethambutol | |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| rrs | 1471845 | n.4dupT | non_coding_transcript_exon_variant | 0.99 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| rrl | 1473420 | n.-238A>T | upstream_gene_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1473558 | n.-100T>C | upstream_gene_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1474291 | n.634_649delTTTCCTCTCCGGAGGAinsC | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1474308 | n.651G>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1474310 | n.653T>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1475209 | n.1552G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | ||||||
| rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1475655 | n.1998T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| inhA | 1673257 | c.-945C>G | upstream_gene_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674816 | c.615T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | Not assoc w R - Interim | |||||
| rpsA | 1833367 | c.-175G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833370 | c.-172G>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833381 | c.-161T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833435 | c.-107G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833471 | c.-71_-70insC | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833512 | c.-29delC | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833554 | p.Thr5Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1833568 | c.27G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834169 | p.Thr210Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1834912 | c.1371A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| tsnR | 1854005 | p.Ala134Ser | missense_variant | 1.0 | linezolid | |
| tsnR | 1854134 | c.529C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854295 | c.690C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
| tlyA | 1917519 | c.-421C>T | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917606 | c.-334G>C | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917653 | c.-287A>G | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917807 | c.-133T>G | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
| tlyA | 1918149 | c.210A>C | synonymous_variant | 1.0 | capreomycin | |
| tlyA | 1918150 | p.Val71Leu | missense_variant | 1.0 | capreomycin | |
| tlyA | 1918242 | c.303G>C | synonymous_variant | 1.0 | capreomycin | |
| tlyA | 1918587 | p.Gln216His | missense_variant | 1.0 | capreomycin | |
| tlyA | 1918604 | p.Ser222Thr | missense_variant | 1.0 | capreomycin | |
| bacA | 2061039 | c.1899_*1769del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | kanamycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | kanamycin | Not assoc w R |
| capreomycin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| bacA | 2063040 | c.1689C>T | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| bacA | 2063391 | c.1338C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| ndh | 2101777 | c.1266C>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| delamanid | ||||||
| ethionamide | Not assoc w R - Interim | |||||
| ndh | 2101795 | c.1248G>C | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2101945 | c.1098C>T | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2103182 | c.-140C>G | upstream_gene_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| katG | 2153989 | p.Val708Ala | missense_variant | 1.0 | isoniazid | |
| katG | 2154055 | p.Lys686Thr | missense_variant | 1.0 | isoniazid | |
| katG | 2154060 | c.2052T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2154190 | p.Leu641Ser | missense_variant | 1.0 | isoniazid | |
| katG | 2154252 | c.1860T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2154435 | c.1677T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2154531 | c.1581A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2154594 | c.1518G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2154678 | c.1434G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
| katG | 2154870 | c.1242G>A | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155062 | c.1050T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155065 | c.1047C>G | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155068 | c.1044T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155071 | c.1041T>G | synonymous_variant | 0.99 | isoniazid | |
| katG | 2155074 | c.1038C>T | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155080 | c.1032G>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155085 | c.1027C>T | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155092 | c.1020G>A | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155104 | c.1008G>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155119 | c.993T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155137 | c.975G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2155190 | p.Thr308Ala | missense_variant | 1.0 | isoniazid | |
| katG | 2155205 | p.Ser303Thr | missense_variant | 1.0 | isoniazid | |
| katG | 2155233 | c.879G>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155236 | c.876G>A | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155326 | c.786A>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155491 | c.621T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155508 | p.Ala202Ser | missense_variant | 1.0 | isoniazid | Uncertain significance |
| katG | 2155971 | c.141A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2156055 | c.57C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2156690 | c.-579A>C | upstream_gene_variant | 1.0 | isoniazid | |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
| PPE35 | 2168318 | c.2295T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169461 | p.Val384Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169605 | c.1008T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169623 | c.990T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169643 | p.Ala324Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169668 | c.945C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169686 | c.927T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169717 | p.Asn299Ile | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169740 | c.873C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169767 | c.846A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169779 | c.834A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169809 | c.804A>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169819 | p.Asn265Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169839 | c.774C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169857 | c.756A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169887 | c.726C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169932 | c.681C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169940 | p.Gly225Arg | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169948 | p.Asn222Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169956 | c.657T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169959 | c.654C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169974 | c.639T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169977 | c.636C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169989 | c.624C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169992 | c.621C>T | synonymous_variant | 0.99 | pyrazinamide | |
| PPE35 | 2169996 | p.Ser206Asn | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169998 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170010 | c.603G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170016 | c.597C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170028 | p.Met195Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170035 | p.Val193Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170125 | p.Val163Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170133 | c.480G>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170148 | c.465T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170156 | p.Ala153Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170169 | c.444A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170175 | c.438G>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170232 | c.381T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170246 | p.Ser123Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170247 | p.Ile122Met | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170250 | c.363G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170261 | p.Ile118Val | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170263 | p.Leu117Arg | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170267 | p.Gly116Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170268 | c.345C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170272 | p.Arg114Pro | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170306 | p.Ala103Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170314 | p.Val100Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170319 | c.294G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170330 | p.Ala95Thr | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170334 | p.Met93Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170351 | p.Thr88Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170485 | p.Val43Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170499 | c.114A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170505 | c.108C>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170511 | c.102G>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170553 | c.60C>A | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170585 | p.Ile10Val | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170601 | c.12A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170620 | c.-9_-8insT | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170671 | c.-59G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170676 | c.-64A>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170677 | c.-65G>A | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170679 | c.-67A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170681 | c.-69G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170690 | c.-78A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170693 | c.-81C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170694 | c.-82T>C | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170703 | c.-91T>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170717 | c.-105C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170720 | c.-108A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170722 | c.-110G>A | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170723 | c.-111C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170726 | c.-115delT | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170747 | c.-135A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170766 | c.-154T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170770 | c.-158T>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170780 | c.-168G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170796 | c.-184C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170809 | c.-198delA | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170812 | c.-200G>C | upstream_gene_variant | 0.99 | pyrazinamide | |
| PPE35 | 2170839 | c.-227C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170848 | c.-236A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170849 | c.-237T>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170860 | c.-248A>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170868 | c.-256T>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170871 | c.-259A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170895 | c.-283C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170924 | c.-312T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| Rv1979c | 2221723 | p.Arg481His | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| Rv1979c | 2222357 | p.Thr270Ala | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| clofazimine | Uncertain significance | |||||
| Rv1979c | 2222504 | p.Met221Leu | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223083 | p.Ile28Val | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223146 | p.Arg7Gly | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223255 | c.-91A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223276 | c.-113_-112insGC | upstream_gene_variant | 0.91 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223290 | c.-126A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| Rv1979c | 2223316 | c.-152T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223391 | c.-227A>C | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223448 | c.-284C>T | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223532 | c.-368G>C | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223561 | c.-397G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223775 | c.-611T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| pncA | 2289104 | c.138A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| pncA | 2289700 | c.-459T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289827 | c.-586A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519287 | c.1173T>C | synonymous_variant | 1.0 | isoniazid | |
| eis | 2714202 | c.1131C>T | synonymous_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| eis | 2714421 | c.912A>G | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| eis | 2714964 | c.369C>T | synonymous_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| eis | 2715590 | c.-258A>T | upstream_gene_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| eis | 2715607 | c.-275G>A | upstream_gene_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| ahpC | 2725905 | c.-288C>A | upstream_gene_variant | 1.0 | isoniazid | |
| ahpC | 2726226 | p.Ala12Thr | missense_variant | 1.0 | isoniazid | |
| ahpC | 2726507 | c.315G>A | synonymous_variant | 0.99 | isoniazid | |
| folC | 2746174 | c.1425A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747204 | p.Ala132Gln | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747572 | c.27T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747575 | c.24G>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747628 | c.-30G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747631 | c.-33C>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747691 | c.-93A>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2477c | 2783065 | c.978C>T | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2783086 | p.Asn319Ser | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783092 | c.951A>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2783095 | c.948C>A | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2784617 | c.-575T>C | upstream_gene_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| pepQ | 2859490 | p.Val310Ala | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| ribD | 2987614 | c.766delA | frameshift_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2680 | 2995798 | c.-307T>C | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2680 | 2996009 | c.-96T>C | upstream_gene_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2680 | 2996010 | c.-95C>A | upstream_gene_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2680 | 2996440 | c.336G>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2680 | 2996578 | c.474C>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997054 | p.Ser106Gly | missense_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2681 | 2997059 | c.321C>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997122 | c.384A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997293 | c.555G>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2752c | 3064637 | p.Val519Met | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3065131 | p.Ala354Val | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3065573 | p.Glu207Gln | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066158 | p.Thr12Ala | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| ethambutol | Uncertain significance | |||||
| Rv2752c | 3066367 | c.-176G>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066417 | c.-226C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066905 | c.-714T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066996 | c.-805T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| thyX | 3067355 | c.591A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067439 | c.507A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067980 | c.-35T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074160 | c.312A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074445 | c.27C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074529 | c.-58G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074580 | c.-109T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| ald | 3086759 | c.-61A>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086760 | c.-60A>G | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086767 | c.-53A>T | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3087122 | c.303T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087140 | c.321G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087197 | c.378A>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087380 | c.561C>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087381 | p.Asn188Gly | missense_variant | 1.0 | cycloserine | |
| ald | 3087563 | c.744A>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087644 | c.825C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087671 | c.852C>T | synonymous_variant | 1.0 | cycloserine | |
| fbiD | 3339049 | c.-69C>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiD | 3339108 | c.-10G>A | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiD | 3339549 | c.432T>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| Rv3083 | 3448349 | c.-155C>T | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448403 | c.-101G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448452 | c.-52G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448453 | c.-51G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448474 | c.-30G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448481 | c.-23G>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448487 | c.-17T>G | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448495 | c.-9G>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448545 | c.42A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448588 | p.Asp29Asn | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448606 | c.103C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448611 | c.108A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448686 | c.183C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3448714 | p.Asp71His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448869 | p.His122Gln | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448905 | c.402T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448972 | p.His157Asp | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449028 | c.525T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449029 | p.Ser176Ala | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449305 | c.802T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449400 | c.897C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449454 | c.951G>A | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449868 | c.1365C>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449877 | c.1374T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449885 | p.Arg461Lys | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3236c | 3611968 | c.1149T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612208 | c.909G>C | synonymous_variant | 1.0 | pyrazinamide | |
| Rv3236c | 3612250 | c.867A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612319 | c.798G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3612322 | c.795G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3613038 | c.79C>A | synonymous_variant | 1.0 | pyrazinamide | |
| Rv3236c | 3613056 | c.61C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| Rv3236c | 3613799 | c.-683G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| lpqB | 3623807 | c.1104T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| lpqB | 3623900 | c.1011C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | rifampicin | Not assoc w R |
| bedaquiline | Uncertain significance | |||||
| lpqB | 3624895 | c.16T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| lpqB | 3624901 | p.Thr4Ala | missense_variant | 1.0 | rifampicin | Uncertain significance |
| bedaquiline | ||||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
| bedaquiline | Uncertain significance | |||||
| lpqB | 3625066 | c.-156G>A | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3626362 | c.252A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3626415 | p.Asn67Asp | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3626443 | c.171T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3626461 | c.153A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrA | 3627437 | c.-88T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| bedaquiline | ||||||
| mtrA | 3627734 | c.-385A>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3627802 | c.-453T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3627831 | c.-482T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3627839 | c.-490T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| fbiB | 3640899 | c.-636G>A | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiB | 3640980 | c.-555C>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiB | 3641909 | c.375T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiB | 3642467 | c.933T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiB | 3642599 | c.1065C>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| alr | 3840226 | p.Thr399Ala | missense_variant | 1.0 | cycloserine | |
| alr | 3840527 | c.894A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840719 | c.702A>G | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840791 | c.630T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840796 | p.Asp209Asn | missense_variant | 1.0 | cycloserine | |
| alr | 3840914 | c.507G>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840994 | p.His143Asp | missense_variant | 1.0 | cycloserine | |
| alr | 3841112 | p.Asp103Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841116 | p.Ala102Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841172 | c.249A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841199 | c.222T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841362 | p.Thr20Lys | missense_variant | 1.0 | cycloserine | |
| alr | 3841419 | p.Val1Ala | missense_variant | 1.0 | cycloserine | |
| alr | 3841428 | c.-8A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841531 | c.-111A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841532 | c.-112A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841539 | c.-119C>T | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841546 | c.-126C>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841568 | c.-148G>A | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841595 | c.-175T>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841600 | c.-180G>A | upstream_gene_variant | 1.0 | cycloserine | |
| rpoA | 3877886 | c.622C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878001 | c.507A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878043 | c.465G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878124 | c.384G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878619 | c.-113delC | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878630 | c.-124_-123insCC | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878968 | c.-461T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3879193 | c.-686G>A | upstream_gene_variant | 1.0 | rifampicin | |
| ddn | 3986805 | c.-39G>C | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| ddn | 3987050 | c.207C>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| ddn | 3987287 | c.444T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clpC1 | 4038227 | c.2478G>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038443 | c.2262G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038683 | c.2022T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038746 | c.1959C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038779 | c.1926C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038848 | c.1857C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038860 | c.1845G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038878 | c.1827A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038974 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039046 | c.1659C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039058 | c.1647C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039094 | c.1611C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039100 | c.1605C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039274 | c.1431G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039336 | c.1369C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039352 | c.1353C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039448 | c.1257A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039454 | c.1251A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039502 | c.1203C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039682 | c.1023C>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039700 | c.1005C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039718 | c.987C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039817 | c.888A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039820 | c.885T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039823 | c.882T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040045 | c.660C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040048 | c.657C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040063 | c.642G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040090 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040093 | c.612C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040147 | c.558A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040159 | c.546G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040162 | c.543G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040213 | c.492T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040267 | c.438A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040273 | c.432T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040276 | c.429C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040279 | c.426C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040363 | c.342A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040393 | c.312G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040411 | c.294T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040423 | c.282A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040450 | c.255A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040471 | c.234T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040480 | c.225T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040534 | c.171A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040551 | c.154T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040573 | c.132T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040657 | c.48T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040879 | c.-177_-175delTGGinsCGGT | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4043932 | p.Met117Thr | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| panD | 4044243 | c.39C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| panD | 4044533 | c.-252T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044569 | c.-289_-288delCGinsGC | upstream_gene_variant | 1.0 | pyrazinamide | |
| glpK | 4138259 | c.1497T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| ethambutol | Not assoc w R | |||||
| glpK | 4139096 | p.Leu220Phe | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4139321 | c.435T>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| glpK | 4139420 | c.336T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| glpK | 4139477 | c.279A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4139813 | c.-58T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4139934 | c.-179A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| embC | 4239575 | c.-288C>T | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239600 | c.-263A>G | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4240060 | c.198G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240106 | p.Leu82Met | missense_variant | 1.0 | ethambutol | |
| embC | 4240237 | c.375G>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4240499 | p.Ser213Arg | missense_variant | 1.0 | ethambutol | |
| embC | 4240533 | p.Ser224Thr | missense_variant | 1.0 | ethambutol | |
| embC | 4240559 | p.Ala233Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4240587 | p.Gly242Ala | missense_variant | 1.0 | ethambutol | |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4241698 | c.1836G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241710 | c.1848G>A | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241758 | c.1896G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4241809 | c.1947A>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241920 | c.2058C>T | synonymous_variant | 0.99 | ethambutol | |
| embC | 4241921 | p.Gly687Arg | missense_variant | 0.99 | ethambutol | |
| embC | 4242092 | c.2230T>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4242325 | c.-908C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4242460 | c.-773G>C | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4242655 | c.-578A>G | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4242946 | c.-287T>C | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4243131 | p.Pro1090Arg | missense_variant | 1.0 | ethambutol | |
| embA | 4243628 | c.396A>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4243690 | p.Met153Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243961 | c.729G>A | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244154 | p.Thr308Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4244177 | c.945G>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244178 | p.Ala316Thr | missense_variant | 1.0 | ethambutol | |
| embA | 4244312 | c.1080T>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4244456 | c.1224C>T | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244534 | c.1302T>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244778 | p.Ser516Ala | missense_variant | 1.0 | ethambutol | |
| embA | 4244846 | c.1614C>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245023 | c.1791A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245594 | p.Ser788Thr | missense_variant | 1.0 | ethambutol | |
| embB | 4246226 | c.-288C>A | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4246443 | p.Asp1071Asn | missense_variant | 1.0 | ethambutol | |
| embA | 4246485 | p.Gly1085Ser | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4246544 | p.Thr11Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4246582 | c.69T>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4246682 | p.Asp57Asn | missense_variant | 1.0 | ethambutol | |
| embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embB | 4247815 | c.1302C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248070 | c.1557T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248226 | c.1713G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| aftB | 4267412 | c.1425T>C | synonymous_variant | 1.0 | ethambutol | |
| aftB | 4268588 | c.249G>T | synonymous_variant | 1.0 | ethambutol | |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| aftB | 4269783 | c.-947G>A | upstream_gene_variant | 1.0 | ethambutol | |
| ubiA | 4269811 | p.Gln8Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| ubiA | 4269853 | c.-20C>T | upstream_gene_variant | 1.0 | ethambutol | |
| ubiA | 4269945 | c.-112G>C | upstream_gene_variant | 1.0 | ethambutol | |
| ethA | 4326463 | c.1011C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| ethA | 4326740 | p.Arg245His | missense_variant | 1.0 | ethionamide | Uncertain significance |
| ethR | 4327547 | c.-2_-1insA | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 0.54 | kanamycin | Not assoc w R |
| capreomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 0.46 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| whiB6 | 4338741 | c.-220A>G | upstream_gene_variant | 0.48 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| whiB6 | 4338785 | c.-266_-264delGGCinsAG | upstream_gene_variant | 0.49 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| whiB6 | 4338878 | c.-357C>T | upstream_gene_variant | 0.56 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| gid | 4407568 | p.Ala212Val | missense_variant | 1.0 | streptomycin | |
| gid | 4407572 | p.Ile211Val | missense_variant | 1.0 | streptomycin | |
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
| gid | 4407703 | p.Ala167Val | missense_variant | 1.0 | streptomycin | |
| gid | 4407705 | c.498G>T | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407782 | p.Ala141Thr | missense_variant | 1.0 | streptomycin | Uncertain significance |
| gid | 4407822 | c.381A>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407943 | p.Gln87Arg | missense_variant | 1.0 | streptomycin | Uncertain significance |
| gid | 4407951 | c.252G>T | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408008 | c.195C>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408110 | p.Val31Ala | missense_variant | 1.0 | streptomycin | |
| gid | 4408113 | c.90T>C | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408153 | p.Gly17Asp | missense_variant | 1.0 | streptomycin | |
| gid | 4408176 | c.27T>C | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408228 | c.-28_-27delCA | upstream_gene_variant | 0.96 | streptomycin |
