TB-Profiler result

Run: ERR1336825

Summary

Run ID: ERR1336825

Sample name:

Date: 2024-04-15T15:56:44.343253

Number of reads: 7066236

Percentage reads mapped: 92.57

Median coverage: 158.0

Strain: La3;M.canetti

Spoligotype:

Drug-resistance: Sensitive


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La3 M.orygis None 0.32
M.canetti M.canetti None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 72 c.72T>C synonymous_variant 1.0 isoniazid
dnaA 264 c.264C>G synonymous_variant 1.0 isoniazid
dnaA 400 p.Asp134Asn missense_variant 1.0 isoniazid Uncertain significance
dnaA 481 p.Ala161Thr missense_variant 1.0 isoniazid
dnaA 549 c.549C>T synonymous_variant 1.0 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.99 isoniazid
dnaA 747 c.747G>A synonymous_variant 1.0 isoniazid
gyrB 5025 c.-215T>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 5207 c.-33A>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 5440 c.201A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 5452 c.213G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5770 c.531C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6001 c.762G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6004 c.765T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 6433 c.-869C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6436 c.-866C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 7256 c.2017C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8288 c.987T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9074 c.1773G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9218 c.1917C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9734 c.2433A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
Rv0010c 13220 c.339T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv0010c 13259 c.300C>G synonymous_variant 1.0 isoniazid
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13660 c.-102G>A upstream_gene_variant 1.0 isoniazid
fgd1 490666 c.-117G>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490678 c.-105_-104insG upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490687 c.-96T>C upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490734 c.-49A>T upstream_gene_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491406 p.Met208Ile missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575060 c.-288G>C upstream_gene_variant 1.0 ethionamide
isoniazid
mshA 575123 c.-225A>T upstream_gene_variant 1.0 ethionamide
isoniazid
mshA 575133 c.-215C>T upstream_gene_variant 1.0 ethionamide
isoniazid Uncertain significance
mshA 575665 c.318G>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575971 c.624C>T synonymous_variant 1.0 ethionamide
isoniazid
mshA 576285 p.Val313Ala missense_variant 1.0 ethionamide
isoniazid
mshA 576757 c.1410C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ccsA 619654 c.-237A>G upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 619766 c.-125A>G upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 619850 c.-41G>A upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 619875 c.-16C>T upstream_gene_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
ccsA 620158 c.268C>T synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
Rv0565c 656511 p.His320Gln missense_variant 1.0 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657273 c.198G>A synonymous_variant 1.0 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
hadA 731852 c.-78A>G upstream_gene_variant 1.0 isoniazid
hadA 732379 c.450A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
nusG 733883 c.-370_-368delGCG upstream_gene_variant 1.0 rifampicin
rpoB 759351 c.-456G>C upstream_gene_variant 1.0 rifampicin
rpoB 759911 c.105C>T synonymous_variant 1.0 rifampicin
rpoB 760715 c.909C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 1.0 rifampicin
rpoB 761573 c.1767C>A synonymous_variant 1.0 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763259 c.-111G>C upstream_gene_variant 1.0 rifampicin
rpoC 763660 c.291T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764107 c.738C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764134 c.765C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764152 c.783C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764159 c.790C>T synonymous_variant 1.0 rifampicin
rpoC 764195 p.Ser276Ala missense_variant 1.0 rifampicin
rpoC 764198 c.829C>T synonymous_variant 1.0 rifampicin
rpoC 764203 c.834G>T synonymous_variant 1.0 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 1.0 rifampicin
rpoC 764245 c.876C>T synonymous_variant 1.0 rifampicin
rpoC 764257 c.888G>C synonymous_variant 1.0 rifampicin
rpoC 764278 c.909A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>A synonymous_variant 0.99 rifampicin
rpoC 764341 c.972G>A synonymous_variant 1.0 rifampicin
rpoC 764365 c.996C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 1.0 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 1.0 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.99 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 1.0 rifampicin
rpoC 764536 c.1167G>C synonymous_variant 0.97 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 1.0 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 1.0 rifampicin
rpoC 764632 c.1263T>G synonymous_variant 1.0 rifampicin
rpoC 764650 c.1281G>C synonymous_variant 1.0 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 1.0 rifampicin
rpoC 765001 c.1632C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>A synonymous_variant 1.0 rifampicin
rpoC 765152 p.Asp595Asn missense_variant 1.0 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766152 p.Asp928Gly missense_variant 1.0 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 1.0 rifampicin
rpoC 766870 c.3501C>T synonymous_variant 1.0 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 1.0 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 1.0 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775748 c.2733T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776132 c.2349A>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776432 c.2049G>A synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776807 c.1674G>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776818 p.Ile555Val missense_variant 1.0 clofazimine
bedaquiline
mmpL5 776993 c.1488A>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777140 c.1341G>A synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777251 c.1230C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 777254 c.1227G>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777284 c.1197C>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777296 c.1185C>T synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777431 c.1050A>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777497 c.984A>G synonymous_variant 1.0 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 777512 c.969T>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777591 p.Ser297Gln missense_variant 1.0 clofazimine
bedaquiline
mmpL5 777593 c.888G>A synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777596 c.885G>A synonymous_variant 0.99 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 777755 c.726C>T synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 777800 c.681C>T synonymous_variant 1.0 clofazimine
bedaquiline
mmpR5 778136 c.-854T>C upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpL5 778216 p.Ser89Gly missense_variant 1.0 clofazimine
bedaquiline
mmpL5 778282 p.Asp67Asn missense_variant 1.0 clofazimine
bedaquiline
mmpL5 778304 p.Ile59Met missense_variant 1.0 clofazimine
bedaquiline
mmpL5 778470 p.Gln4Arg missense_variant 1.0 clofazimine
bedaquiline
mmpL5 778510 c.-30T>C upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpL5 778573 c.-93C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpL5 778654 c.-174A>G upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpL5 779295 c.-815A>G upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpL5 779439 c.-959G>T upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpR5 779468 p.Arg160Gln missense_variant 1.0 clofazimine
bedaquiline
rpsL 781291 c.-269G>C upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid
Rv1129c 1253093 p.Ser481Leu missense_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253216 p.Glu440Ala missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1253408 p.Glu376Gly missense_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253653 c.882T>G synonymous_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253692 c.843C>T synonymous_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253814 p.Gln241Glu missense_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253904 p.Asn211Asp missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254316 c.219G>A synonymous_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254434 p.Val34Ala missense_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254576 c.-42C>T upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254602 c.-68C>T upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254610 c.-76A>C upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254654 c.-120A>G upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254678 c.-144A>G upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254690 c.-156T>G upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
fbiC 1302694 c.-237C>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1302810 c.-121C>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1302860 c.-71G>A upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1302870 c.-61G>C upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1302948 c.18T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303288 p.Ser120Gly missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303747 p.Thr273Ala missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303860 c.930A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304141 p.Ala404Gly missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304330 p.Ala467Asp missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304707 p.Val593Ile missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
Rv1258c 1406466 p.Ser292Leu missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
Rv1258c 1406492 p.Ile283Met missense_variant 1.0 streptomycin
isoniazid
pyrazinamide
Rv1258c 1407008 c.333C>A synonymous_variant 1.0 streptomycin
isoniazid
pyrazinamide
Rv1258c 1407548 c.-208C>G upstream_gene_variant 1.0 streptomycin
isoniazid
pyrazinamide
embR 1417294 c.54A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embR 1417454 c.-107C>A upstream_gene_variant 1.0 ethambutol
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417598 c.-251G>A upstream_gene_variant 1.0 ethambutol
embR 1417925 c.-578C>T upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471845 n.4dupT non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473420 n.-238A>T upstream_gene_variant 1.0 capreomycin
linezolid
rrl 1473558 n.-100T>C upstream_gene_variant 1.0 capreomycin
linezolid
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673499 c.-703T>C upstream_gene_variant 1.0 ethionamide
isoniazid Uncertain significance
fabG1 1674079 p.Pro214Ala missense_variant 1.0 ethionamide
isoniazid
inhA 1674384 c.183C>T synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674405 c.204G>A synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674483 c.282G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674603 c.402G>A synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674620 p.Pro140Gln missense_variant 1.0 ethionamide
isoniazid
inhA 1674780 c.579T>C synonymous_variant 1.0 ethionamide
isoniazid
rpsA 1833381 c.-161T>C upstream_gene_variant 1.0 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1833596 c.55_56delAGinsTC synonymous_variant 1.0 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833907 c.366G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834648 c.1107C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834912 c.1371A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1853623 c.18G>C synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1853636 p.Thr11Ala missense_variant 1.0 linezolid Uncertain significance
tsnR 1853838 p.Ala78Val missense_variant 1.0 linezolid
tsnR 1854005 p.Ala134Ser missense_variant 1.0 linezolid
tsnR 1854134 c.529C>T synonymous_variant 1.0 linezolid
tsnR 1854295 c.690C>T synonymous_variant 1.0 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917519 c.-421C>T upstream_gene_variant 1.0 capreomycin
tlyA 1917606 c.-334G>C upstream_gene_variant 1.0 capreomycin
tlyA 1917653 c.-287A>G upstream_gene_variant 1.0 capreomycin
tlyA 1917807 c.-133T>G upstream_gene_variant 1.0 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918149 c.210A>C synonymous_variant 1.0 capreomycin
tlyA 1918150 p.Val71Leu missense_variant 1.0 capreomycin
tlyA 1918242 c.303G>C synonymous_variant 1.0 capreomycin
tlyA 1918587 p.Gln216His missense_variant 1.0 capreomycin
tlyA 1918604 p.Ser222Thr missense_variant 1.0 capreomycin
bacA 2061041 c.1899_*1767del frameshift_variant&stop_lost&splice_region_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063040 c.1689C>T synonymous_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063391 c.1338C>G synonymous_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101777 c.1266C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2101795 c.1248G>C synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2101945 c.1098C>T synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2103182 c.-140C>G upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2153989 p.Val708Ala missense_variant 1.0 isoniazid
katG 2154055 p.Lys686Thr missense_variant 1.0 isoniazid
katG 2154060 c.2052T>C synonymous_variant 1.0 isoniazid
katG 2154190 p.Leu641Ser missense_variant 1.0 isoniazid
katG 2154252 c.1860T>C synonymous_variant 1.0 isoniazid
katG 2154435 c.1677T>C synonymous_variant 1.0 isoniazid
katG 2154531 c.1581A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2154594 c.1518G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2154678 c.1434G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2154870 c.1242G>A synonymous_variant 1.0 isoniazid
katG 2155062 c.1050T>C synonymous_variant 1.0 isoniazid
katG 2155065 c.1047C>G synonymous_variant 1.0 isoniazid
katG 2155068 c.1044T>C synonymous_variant 1.0 isoniazid
katG 2155071 c.1041T>G synonymous_variant 1.0 isoniazid
katG 2155074 c.1038C>T synonymous_variant 1.0 isoniazid
katG 2155080 c.1032G>C synonymous_variant 1.0 isoniazid
katG 2155085 c.1027C>T synonymous_variant 1.0 isoniazid
katG 2155092 c.1020G>A synonymous_variant 1.0 isoniazid
katG 2155104 c.1008G>C synonymous_variant 1.0 isoniazid
katG 2155119 c.993T>C synonymous_variant 1.0 isoniazid
katG 2155137 c.975G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2155190 p.Thr308Ala missense_variant 1.0 isoniazid
katG 2155205 p.Ser303Thr missense_variant 1.0 isoniazid
katG 2155233 c.879G>C synonymous_variant 1.0 isoniazid
katG 2155236 c.876G>A synonymous_variant 1.0 isoniazid
katG 2155326 c.786A>C synonymous_variant 1.0 isoniazid
katG 2155491 c.621T>C synonymous_variant 1.0 isoniazid
katG 2155508 p.Ala202Ser missense_variant 1.0 isoniazid Uncertain significance
katG 2155971 c.141A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2156055 c.57C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2156690 c.-579A>C upstream_gene_variant 1.0 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168318 c.2295T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2169461 p.Val384Ala missense_variant 1.0 pyrazinamide
PPE35 2169605 c.1008T>C synonymous_variant 1.0 pyrazinamide
PPE35 2169623 c.990T>C synonymous_variant 1.0 pyrazinamide
PPE35 2169643 p.Ala324Ser missense_variant 1.0 pyrazinamide
PPE35 2169668 c.945C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2169686 c.927T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2169717 p.Asn299Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2169740 c.873C>T synonymous_variant 1.0 pyrazinamide
PPE35 2169767 c.846A>G synonymous_variant 0.99 pyrazinamide
PPE35 2169779 c.834A>G synonymous_variant 1.0 pyrazinamide
PPE35 2169809 c.804A>T synonymous_variant 1.0 pyrazinamide
PPE35 2169819 p.Asn265Ser missense_variant 1.0 pyrazinamide
PPE35 2169839 c.774C>T synonymous_variant 1.0 pyrazinamide
PPE35 2169857 c.756A>G synonymous_variant 1.0 pyrazinamide
PPE35 2169887 c.726C>T synonymous_variant 1.0 pyrazinamide
PPE35 2169932 c.681C>T synonymous_variant 1.0 pyrazinamide
PPE35 2169940 p.Gly225Arg missense_variant 1.0 pyrazinamide
PPE35 2169948 p.Asn222Ile missense_variant 1.0 pyrazinamide
PPE35 2169956 c.657T>C synonymous_variant 1.0 pyrazinamide
PPE35 2169959 c.654C>T synonymous_variant 1.0 pyrazinamide
PPE35 2169974 c.639T>C synonymous_variant 1.0 pyrazinamide
PPE35 2169977 c.636C>T synonymous_variant 1.0 pyrazinamide
PPE35 2169989 c.624C>T synonymous_variant 1.0 pyrazinamide
PPE35 2169992 c.621C>T synonymous_variant 1.0 pyrazinamide
PPE35 2169996 p.Ser206Asn missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2169998 c.615T>C synonymous_variant 1.0 pyrazinamide
PPE35 2170010 c.603G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170016 c.597C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170028 p.Met195Ile missense_variant 1.0 pyrazinamide
PPE35 2170035 p.Val193Ala missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170125 p.Val163Ala missense_variant 0.99 pyrazinamide
PPE35 2170133 c.480G>C synonymous_variant 1.0 pyrazinamide
PPE35 2170148 c.465T>C synonymous_variant 1.0 pyrazinamide
PPE35 2170156 p.Ala153Thr missense_variant 1.0 pyrazinamide
PPE35 2170169 c.444A>G synonymous_variant 1.0 pyrazinamide
PPE35 2170175 c.438G>C synonymous_variant 1.0 pyrazinamide
PPE35 2170232 c.381T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170246 p.Ser123Ala missense_variant 1.0 pyrazinamide
PPE35 2170247 p.Ile122Met missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170250 c.363G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170261 p.Ile118Val missense_variant 1.0 pyrazinamide
PPE35 2170263 p.Leu117Arg missense_variant 1.0 pyrazinamide
PPE35 2170267 p.Gly116Ser missense_variant 1.0 pyrazinamide
PPE35 2170268 c.345C>T synonymous_variant 1.0 pyrazinamide
PPE35 2170272 p.Arg114Pro missense_variant 1.0 pyrazinamide
PPE35 2170306 p.Ala103Thr missense_variant 1.0 pyrazinamide
PPE35 2170314 p.Val100Ala missense_variant 1.0 pyrazinamide
PPE35 2170319 c.294G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170330 p.Ala95Thr missense_variant 1.0 pyrazinamide
PPE35 2170334 p.Met93Ile missense_variant 1.0 pyrazinamide
PPE35 2170351 p.Thr88Ala missense_variant 1.0 pyrazinamide
PPE35 2170485 p.Val43Ala missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170499 c.114A>G synonymous_variant 1.0 pyrazinamide
PPE35 2170505 c.108C>G synonymous_variant 1.0 pyrazinamide
PPE35 2170511 c.102G>T synonymous_variant 1.0 pyrazinamide
PPE35 2170553 c.60C>A synonymous_variant 1.0 pyrazinamide
PPE35 2170585 p.Ile10Val missense_variant 1.0 pyrazinamide
PPE35 2170601 c.12A>G synonymous_variant 1.0 pyrazinamide
PPE35 2170620 c.-9_-8insT upstream_gene_variant 1.0 pyrazinamide
PPE35 2170671 c.-59G>C upstream_gene_variant 1.0 pyrazinamide
PPE35 2170676 c.-64A>T upstream_gene_variant 1.0 pyrazinamide
PPE35 2170677 c.-65G>A upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170679 c.-67A>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170681 c.-69G>C upstream_gene_variant 1.0 pyrazinamide
PPE35 2170690 c.-78A>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170693 c.-81C>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170694 c.-82T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170703 c.-91T>A upstream_gene_variant 1.0 pyrazinamide
PPE35 2170717 c.-105C>T upstream_gene_variant 1.0 pyrazinamide
PPE35 2170720 c.-108A>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170722 c.-110G>A upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170723 c.-111C>T upstream_gene_variant 1.0 pyrazinamide
PPE35 2170726 c.-115delT upstream_gene_variant 1.0 pyrazinamide
PPE35 2170747 c.-135A>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170766 c.-154T>C upstream_gene_variant 1.0 pyrazinamide
PPE35 2170770 c.-158T>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170780 c.-168G>A upstream_gene_variant 1.0 pyrazinamide
PPE35 2170796 c.-184C>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170809 c.-198delA upstream_gene_variant 1.0 pyrazinamide
PPE35 2170812 c.-200G>C upstream_gene_variant 0.99 pyrazinamide
PPE35 2170839 c.-227C>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170848 c.-236A>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170849 c.-237T>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170860 c.-248A>C upstream_gene_variant 1.0 pyrazinamide
PPE35 2170868 c.-256T>A upstream_gene_variant 1.0 pyrazinamide
PPE35 2170871 c.-259A>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170895 c.-283C>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170924 c.-312T>C upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2221723 p.Arg481His missense_variant 1.0 clofazimine
bedaquiline
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2222357 p.Thr270Ala missense_variant 0.99 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2222504 p.Met221Leu missense_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223083 p.Ile28Val missense_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223146 p.Arg7Gly missense_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223255 c.-91A>G upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223276 c.-113_-112insGC upstream_gene_variant 0.97 clofazimine
bedaquiline
Rv1979c 2223290 c.-126A>G upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223316 c.-152T>C upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223391 c.-227A>C upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223448 c.-284C>T upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223532 c.-368G>C upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223561 c.-397G>A upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223775 c.-611T>C upstream_gene_variant 1.0 clofazimine
bedaquiline
pncA 2289104 c.138A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
pncA 2289700 c.-459T>C upstream_gene_variant 1.0 pyrazinamide
pncA 2289827 c.-586A>G upstream_gene_variant 1.0 pyrazinamide
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2519287 c.1173T>C synonymous_variant 1.0 isoniazid
eis 2714202 c.1131C>T synonymous_variant 1.0 amikacin
kanamycin
eis 2714421 c.912A>G synonymous_variant 1.0 amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
eis 2714964 c.369C>T synonymous_variant 1.0 amikacin
kanamycin
eis 2715590 c.-258A>T upstream_gene_variant 1.0 amikacin
kanamycin
eis 2715607 c.-275G>A upstream_gene_variant 1.0 amikacin
kanamycin
ahpC 2725905 c.-288C>A upstream_gene_variant 1.0 isoniazid
folC 2747204 p.Ala132Gln missense_variant 0.99 para-aminosalicylic_acid
folC 2747572 c.27T>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747575 c.24G>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747628 c.-30G>C upstream_gene_variant 1.0 para-aminosalicylic_acid
folC 2747631 c.-33C>G upstream_gene_variant 1.0 para-aminosalicylic_acid
folC 2747691 c.-93A>G upstream_gene_variant 1.0 para-aminosalicylic_acid
Rv2477c 2783425 c.618C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2784328 c.-286C>T upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>G upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859490 p.Val310Ala missense_variant 1.0 clofazimine
bedaquiline
ribD 2987614 c.766delA frameshift_variant 1.0 para-aminosalicylic_acid
Rv2680 2995798 c.-307T>C upstream_gene_variant 1.0 capreomycin
Rv2680 2996009 c.-96T>C upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2680 2996010 c.-95C>A upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2680 2996440 c.336G>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2680 2996578 c.474C>A synonymous_variant 0.99 capreomycin Not assoc w R - Interim
Rv2681 2997054 p.Ser106Gly missense_variant 1.0 capreomycin Uncertain significance
Rv2681 2997059 c.321C>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997122 c.384A>G synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997293 c.555G>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2752c 3064637 p.Val519Met missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065131 p.Ala354Val missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065573 p.Glu207Gln missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066158 p.Thr12Ala missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066367 c.-176G>T upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066417 c.-226C>T upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066905 c.-714T>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066996 c.-805T>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067355 c.591A>C synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067980 c.-35T>C upstream_gene_variant 1.0 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074445 c.27C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074529 c.-58G>C upstream_gene_variant 1.0 para-aminosalicylic_acid
thyA 3074580 c.-109T>C upstream_gene_variant 1.0 para-aminosalicylic_acid
ald 3086759 c.-61A>C upstream_gene_variant 1.0 cycloserine
ald 3086760 c.-60A>G upstream_gene_variant 1.0 cycloserine
ald 3086767 c.-53A>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087122 c.303T>C synonymous_variant 1.0 cycloserine
ald 3087140 c.321G>A synonymous_variant 1.0 cycloserine
ald 3087197 c.378A>G synonymous_variant 1.0 cycloserine
ald 3087380 c.561C>G synonymous_variant 1.0 cycloserine
ald 3087381 p.Asn188Gly missense_variant 1.0 cycloserine
ald 3087563 c.744A>G synonymous_variant 1.0 cycloserine
ald 3087644 c.825C>T synonymous_variant 1.0 cycloserine
ald 3087671 c.852C>T synonymous_variant 1.0 cycloserine
fbiD 3339049 c.-69C>T upstream_gene_variant 0.99 clofazimine
pretomanid
delamanid
fbiD 3339108 c.-10G>A upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiD 3339549 c.432T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
Rv3083 3448349 c.-155C>T upstream_gene_variant 1.0 ethionamide
Rv3083 3448403 c.-101G>A upstream_gene_variant 1.0 ethionamide
Rv3083 3448452 c.-52G>A upstream_gene_variant 1.0 ethionamide
Rv3083 3448453 c.-51G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448474 c.-30G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448481 c.-23G>C upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448487 c.-17T>G upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448495 c.-9G>C upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448545 c.42A>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3448588 p.Asp29Asn missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3448606 c.103C>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3448611 c.108A>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3448686 c.183C>T synonymous_variant 1.0 ethionamide
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3448869 p.His122Gln missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3448905 c.402T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3448972 p.His157Asp missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3449028 c.525T>C synonymous_variant 1.0 ethionamide
Rv3083 3449029 p.Ser176Ala missense_variant 0.99 ethionamide Uncertain significance
Rv3083 3449305 c.802T>C synonymous_variant 1.0 ethionamide
Rv3083 3449400 c.897C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449454 c.951G>A synonymous_variant 1.0 ethionamide
Rv3083 3449868 c.1365C>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449877 c.1374T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449885 p.Arg461Lys missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3611968 c.1149T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612208 c.909G>C synonymous_variant 1.0 pyrazinamide
Rv3236c 3612250 c.867A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612319 c.798G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612322 c.795G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3613038 c.79C>A synonymous_variant 1.0 pyrazinamide
Rv3236c 3613056 c.61C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3613799 c.-683G>C upstream_gene_variant 1.0 pyrazinamide
lpqB 3623807 c.1104T>G synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3623900 c.1011C>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624895 c.16T>C synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624901 p.Thr4Ala missense_variant 1.0 bedaquiline
rifampicin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625066 c.-156G>A upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrB 3626362 c.252A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626415 p.Asn67Asp missense_variant 1.0 bedaquiline
rifampicin
mtrB 3626443 c.171T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626461 c.153A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627437 c.-88T>C upstream_gene_variant 1.0 bedaquiline
rifampicin Uncertain significance
mtrA 3627734 c.-385A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627802 c.-453T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627831 c.-482T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627839 c.-490T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
fbiB 3640899 c.-636G>A upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3640980 c.-555C>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3641909 c.375T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642467 c.933T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642599 c.1065C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
alr 3840226 p.Thr399Ala missense_variant 1.0 cycloserine
alr 3840527 c.894A>C synonymous_variant 1.0 cycloserine
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
alr 3840791 c.630T>C synonymous_variant 1.0 cycloserine
alr 3840796 p.Asp209Asn missense_variant 1.0 cycloserine
alr 3840914 c.507G>C synonymous_variant 1.0 cycloserine
alr 3840994 p.His143Asp missense_variant 1.0 cycloserine
alr 3841112 p.Asp103Gly missense_variant 1.0 cycloserine
alr 3841116 p.Ala102Gly missense_variant 1.0 cycloserine
alr 3841172 c.249A>C synonymous_variant 1.0 cycloserine
alr 3841199 c.222T>C synonymous_variant 1.0 cycloserine
alr 3841362 p.Thr20Lys missense_variant 1.0 cycloserine
alr 3841419 p.Val1Ala missense_variant 1.0 cycloserine
alr 3841428 c.-8A>G upstream_gene_variant 1.0 cycloserine
alr 3841531 c.-111A>G upstream_gene_variant 1.0 cycloserine
alr 3841532 c.-112A>G upstream_gene_variant 1.0 cycloserine
alr 3841539 c.-119C>T upstream_gene_variant 1.0 cycloserine
alr 3841546 c.-126C>G upstream_gene_variant 1.0 cycloserine
alr 3841568 c.-148G>A upstream_gene_variant 1.0 cycloserine
alr 3841595 c.-175T>G upstream_gene_variant 1.0 cycloserine
alr 3841600 c.-180G>A upstream_gene_variant 1.0 cycloserine
rpoA 3877886 c.622C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>T synonymous_variant 1.0 rifampicin
rpoA 3878124 c.384G>A synonymous_variant 1.0 rifampicin
rpoA 3878619 c.-113delC upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878630 c.-124_-123insCC upstream_gene_variant 1.0 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3879193 c.-686G>A upstream_gene_variant 1.0 rifampicin
ddn 3986805 c.-39G>C upstream_gene_variant 1.0 delamanid
pretomanid
ddn 3987050 c.207C>T synonymous_variant 1.0 delamanid
pretomanid
ddn 3987287 c.444T>C synonymous_variant 1.0 delamanid
pretomanid
clpC1 4038227 c.2478G>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038443 c.2262G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038683 c.2022T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038746 c.1959C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038779 c.1926C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038848 c.1857C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039046 c.1659C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039058 c.1647C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039094 c.1611C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039100 c.1605C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039336 c.1369C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039352 c.1353C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039448 c.1257A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039502 c.1203C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039682 c.1023C>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039700 c.1005C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039718 c.987C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040045 c.660C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040063 c.642G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.615T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040147 c.558A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040159 c.546G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040213 c.492T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.429C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040363 c.342A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040393 c.312G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040450 c.255A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040471 c.234T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040534 c.171A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040551 c.154T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040573 c.132T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040657 c.48T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040879 c.-177_-175delTGGinsCGGT upstream_gene_variant 1.0 pyrazinamide
panD 4043932 p.Met117Thr missense_variant 1.0 pyrazinamide Uncertain significance
panD 4044243 c.39C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
panD 4044533 c.-252T>C upstream_gene_variant 1.0 pyrazinamide
panD 4044569 c.-289_-288delCGinsGC upstream_gene_variant 1.0 pyrazinamide
glpK 4138259 c.1497T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139096 p.Leu220Phe missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139321 c.435T>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139420 c.336T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139477 c.279A>G synonymous_variant 0.99 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139813 c.-58T>G upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139934 c.-179A>G upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239575 c.-288C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239600 c.-263A>G upstream_gene_variant 1.0 ethambutol
embC 4240060 c.198G>C synonymous_variant 1.0 ethambutol
embC 4240106 p.Leu82Met missense_variant 1.0 ethambutol
embC 4240237 c.375G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240499 p.Ser213Arg missense_variant 1.0 ethambutol
embC 4240533 p.Ser224Thr missense_variant 1.0 ethambutol
embC 4240559 p.Ala233Thr missense_variant 1.0 ethambutol Uncertain significance
embC 4240587 p.Gly242Ala missense_variant 1.0 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241698 c.1836G>C synonymous_variant 1.0 ethambutol
embC 4241710 c.1848G>A synonymous_variant 1.0 ethambutol
embC 4241758 c.1896G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241809 c.1947A>G synonymous_variant 1.0 ethambutol
embC 4241920 c.2058C>T synonymous_variant 0.99 ethambutol
embC 4241921 p.Gly687Arg missense_variant 0.99 ethambutol
embC 4242092 c.2230T>C synonymous_variant 1.0 ethambutol
embA 4242325 c.-908C>T upstream_gene_variant 1.0 ethambutol
embA 4242460 c.-773G>C upstream_gene_variant 1.0 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242655 c.-578A>G upstream_gene_variant 1.0 ethambutol
embA 4242946 c.-287T>C upstream_gene_variant 1.0 ethambutol
embC 4243131 p.Pro1090Arg missense_variant 1.0 ethambutol
embA 4243628 c.396A>G synonymous_variant 1.0 ethambutol
embA 4243690 p.Met153Thr missense_variant 0.99 ethambutol Uncertain significance
embA 4243961 c.729G>A synonymous_variant 1.0 ethambutol
embA 4244154 p.Thr308Pro missense_variant 1.0 ethambutol Uncertain significance
embA 4244177 c.945G>C synonymous_variant 1.0 ethambutol
embA 4244178 p.Ala316Thr missense_variant 1.0 ethambutol
embA 4244312 c.1080T>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4244456 c.1224C>T synonymous_variant 1.0 ethambutol
embA 4244534 c.1302T>C synonymous_variant 1.0 ethambutol
embA 4244778 p.Ser516Ala missense_variant 1.0 ethambutol
embA 4244846 c.1614C>G synonymous_variant 1.0 ethambutol
embA 4245023 c.1791A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4245594 p.Ser788Thr missense_variant 1.0 ethambutol
embB 4246226 c.-288C>A upstream_gene_variant 1.0 ethambutol
embA 4246443 p.Asp1071Asn missense_variant 1.0 ethambutol
embA 4246485 p.Gly1085Ser missense_variant 1.0 ethambutol Uncertain significance
embB 4246544 p.Thr11Pro missense_variant 1.0 ethambutol Uncertain significance
embB 4246582 c.69T>A synonymous_variant 1.0 ethambutol
embB 4246682 p.Asp57Asn missense_variant 1.0 ethambutol
embB 4247590 c.1077A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247815 c.1302C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 1.0 ethambutol
embB 4248206 p.Ser565Gly missense_variant 1.0 ethambutol Uncertain significance
embB 4248226 c.1713G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
aftB 4267412 c.1425T>C synonymous_variant 1.0 ethambutol
aftB 4268588 c.249G>T synonymous_variant 1.0 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4269783 c.-947G>A upstream_gene_variant 1.0 ethambutol
ubiA 4269811 p.Gln8Arg missense_variant 1.0 ethambutol Uncertain significance
ubiA 4269853 c.-20C>T upstream_gene_variant 1.0 ethambutol
ubiA 4269945 c.-112G>C upstream_gene_variant 1.0 ethambutol
ethA 4326463 c.1011C>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
ethA 4326740 p.Arg245His missense_variant 1.0 ethionamide Uncertain significance
ethR 4327547 c.-2_-1insA upstream_gene_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 0.54 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
whiB6 4338741 c.-220A>G upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
whiB6 4338785 c.-266_-264delGGCinsAG upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
whiB6 4338878 c.-357C>T upstream_gene_variant 0.51 capreomycin
amikacin
kanamycin
gid 4407568 p.Ala212Val missense_variant 1.0 streptomycin
gid 4407572 p.Ile211Val missense_variant 1.0 streptomycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407703 p.Ala167Val missense_variant 1.0 streptomycin
gid 4407705 c.498G>T synonymous_variant 1.0 streptomycin
gid 4407782 p.Ala141Thr missense_variant 1.0 streptomycin Uncertain significance
gid 4407822 c.381A>G synonymous_variant 1.0 streptomycin
gid 4407943 p.Gln87Arg missense_variant 1.0 streptomycin Uncertain significance
gid 4407951 c.252G>T synonymous_variant 1.0 streptomycin
gid 4408008 c.195C>G synonymous_variant 1.0 streptomycin
gid 4408110 p.Val31Ala missense_variant 1.0 streptomycin
gid 4408113 c.90T>C synonymous_variant 1.0 streptomycin
gid 4408153 p.Gly17Asp missense_variant 1.0 streptomycin
gid 4408176 c.27T>C synonymous_variant 1.0 streptomycin
gid 4408228 c.-28_-27delCA upstream_gene_variant 0.96 streptomycin