TB-Profiler result

Run: ERR2514390
Summary

Run ID: ERR2514390

Sample name:

Date: 2025-09-15T14:08:15.021458

Number of reads: 2134244

Percentage reads mapped: 80.83

Median coverage: 70.0

Strain: lineage3.1;lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 91.54
lineage3.1 East-African-Indian RD750 16.0
lineage4 Euro-American None 7.07
lineage4.9 Euro-American (H37Rv-like) None 6.33
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.14 isoniazid Uncertain significance
dnaA 1428 c.1428C>G synonymous_variant 0.15 isoniazid Uncertain significance
gyrA 6670 c.-632G>C upstream_gene_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6676 c.-626T>G upstream_gene_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6700 c.-602T>C upstream_gene_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6703 c.-599G>C upstream_gene_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6949 c.-353A>G upstream_gene_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 0.88 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7451 c.150C>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7457 c.156T>C synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7475 c.174A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7484 c.183T>C synonymous_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7514 c.213C>G synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7523 c.222C>A synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7547 c.246C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7571 c.270G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.94 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7637 c.336C>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7658 c.357A>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7664 c.363T>C synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7670 c.369A>G synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7676 c.375G>C synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7683 c.382_384delAGGinsCGC synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7694 c.393A>G synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7697 c.396C>A synonymous_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8543 c.1242C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8561 c.1260A>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8772 p.Gly491Ser missense_variant 0.79 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8786 c.1485T>C synonymous_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8807 c.1506C>T synonymous_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8810 c.1509A>G synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8816 c.1515C>G synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8818 p.Ser506Asn missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8829 c.1528T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8867 c.1566A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8897 c.1596T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 0.84 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.9 clofazimine Not assoc w R
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
mshA 575283 c.-65C>G upstream_gene_variant 0.78 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575659 c.312A>G synonymous_variant 0.14 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575662 c.315C>G synonymous_variant 0.14 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575665 c.318G>A synonymous_variant 0.15 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575674 c.327G>C synonymous_variant 0.14 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575830 c.483C>G synonymous_variant 0.15 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575833 c.486C>G synonymous_variant 0.16 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575845 c.498C>T synonymous_variant 0.16 ethionamide Uncertain significance
isoniazid Not assoc w R - Interim
ccsA 620362 p.Ala158Thr missense_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620682 c.792G>A synonymous_variant 0.14 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620688 c.798G>C synonymous_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620710 p.Val274Ile missense_variant 0.21 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620718 c.828G>C synonymous_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620721 c.831G>C synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620733 c.843G>C synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620734 c.844C>A synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620739 c.849A>G synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620742 c.852G>C synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620745 c.855G>C synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620748 c.858T>A synonymous_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620763 c.873G>A synonymous_variant 0.21 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620769 c.879C>G synonymous_variant 0.2 amikacin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620784 c.894C>G synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 0.91 ethionamide Not assoc w R - Interim
hadA 732398 p.Ala157Thr missense_variant 0.14 isoniazid Uncertain significance
nusG 734556 c.303C>T synonymous_variant 0.14 rifampicin Uncertain significance
nusG 734559 c.306T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 759746 c.-61C>T upstream_gene_variant 0.97 rifampicin Not assoc w R
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoB 760235 c.429T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 760310 c.504G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 760328 c.522G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 760340 c.534G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 761006 c.1200C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 761027 c.1221A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 762185 c.2379G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 762233 c.2427G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.85 rifampicin Not assoc w R
rpoB 762926 c.3120C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.95 rifampicin Not assoc w R
rpoB 763115 c.3309T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 763594 c.225C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 763765 c.396T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 763774 c.405G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 763987 c.618C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 764428 c.1059G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 764449 c.1080G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 764452 c.1083T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 764458 c.1089G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 764566 c.1197C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 764593 c.1224C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 764611 c.1242G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.2 rifampicin Uncertain significance
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.2 rifampicin Uncertain significance
rpoC 764752 c.1383G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 765040 c.1671T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765053 p.Ser562Thr missense_variant 0.13 rifampicin Uncertain significance
rpoC 765383 p.Met672Leu missense_variant 0.17 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.22 rifampicin Uncertain significance
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.23 rifampicin Uncertain significance
rpoC 765541 c.2172C>G synonymous_variant 0.23 rifampicin Uncertain significance
rpoC 765553 c.2184C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 765580 c.2211G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 765613 p.His748Gln missense_variant 0.19 rifampicin Uncertain significance
rpoC 765625 c.2256C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.17 rifampicin Uncertain significance
rpoC 765700 c.2331T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766027 c.2658G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766030 c.2661C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766390 c.3021C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 766408 c.3039C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766411 c.3042C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766426 c.3057C>T synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766447 c.3078T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766607 p.Ile1080Leu missense_variant 0.16 rifampicin Uncertain significance
rpoC 766630 c.3261G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766660 c.3291G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766673 p.Gly1102Asn missense_variant 0.18 rifampicin Uncertain significance
rpoC 766726 c.3357T>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 766738 c.3369G>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 766765 c.3396A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 766801 c.3432C>G synonymous_variant 0.2 rifampicin Uncertain significance
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.2 rifampicin Uncertain significance
rpoC 766876 c.3507C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 766895 c.3526T>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 766900 c.3531T>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 766933 c.3564A>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766945 c.3576A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766996 c.3627C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 0.93 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.91 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 0.96 streptomycin Not assoc w R
rpsL 781700 c.141G>C synonymous_variant 0.16 streptomycin Uncertain significance
rpsL 781703 c.144G>T synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781772 c.213C>A synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781808 c.249C>T synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781811 c.252C>T synonymous_variant 0.14 streptomycin Uncertain significance
rpsL 781841 c.282C>G synonymous_variant 0.14 streptomycin Uncertain significance
rpsL 781877 c.318T>C synonymous_variant 0.15 streptomycin Uncertain significance
rplC 800693 c.-116A>G upstream_gene_variant 0.16 linezolid Uncertain significance
Rv1129c 1253566 c.969A>G synonymous_variant 0.63 isoniazid Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.95 isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
fbiC 1303695 c.765T>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303704 c.774T>C synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303728 c.798G>A synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303737 c.807G>A synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303746 c.816T>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303752 c.822A>G synonymous_variant 0.15 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
fbiC 1303755 c.825T>C synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303761 c.831T>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303789 p.Ile287Val missense_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303797 c.867A>G synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303860 c.930A>C synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304613 c.1683T>C synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304634 c.1704C>G synonymous_variant 0.27 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304640 c.1710A>C synonymous_variant 0.27 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304646 c.1716T>C synonymous_variant 0.28 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304658 c.1728C>G synonymous_variant 0.27 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304661 c.1731C>T synonymous_variant 0.26 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304670 c.1740G>C synonymous_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304671 p.Val581Thr missense_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304675 p.Gly582Asp missense_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304691 c.1761G>C synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304694 c.1764A>C synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304703 c.1773C>G synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304711 p.Ala594Glu missense_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304715 c.1785G>C synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304724 c.1794A>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
fbiC 1304727 c.1797A>G synonymous_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304739 c.1809C>T synonymous_variant 0.2 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304742 c.1812T>C synonymous_variant 0.2 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304856 c.1926C>G synonymous_variant 0.75 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304862 c.1932G>A synonymous_variant 0.42 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304869 c.1939C>T synonymous_variant 0.38 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304875 p.Ile649Val missense_variant 0.35 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304883 p.Glu651Asp missense_variant 0.32 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304891 p.Ile654Thr missense_variant 0.31 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304893 p.Gly655Ser missense_variant 0.32 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304907 c.1977C>G synonymous_variant 0.36 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304910 c.1980G>C synonymous_variant 0.36 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304916 c.1986T>C synonymous_variant 0.38 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304928 c.1998T>C synonymous_variant 0.34 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304937 c.2007G>C synonymous_variant 0.31 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304958 c.2028T>G synonymous_variant 0.28 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304983 c.2053C>T synonymous_variant 0.25 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304994 c.2064A>G synonymous_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304995 p.Leu689Met missense_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305006 c.2076A>G synonymous_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305012 c.2082G>C synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305015 c.2085G>C synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305021 c.2091C>G synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305030 c.2100G>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
embR 1416814 c.534G>A synonymous_variant 0.72 ethambutol Not assoc w R
atpE 1461132 p.Val30Ile missense_variant 0.16 bedaquiline Uncertain significance
atpE 1461149 c.105T>G synonymous_variant 0.15 bedaquiline Uncertain significance
atpE 1461150 p.Ile36Val missense_variant 0.16 bedaquiline Uncertain significance
atpE 1461158 c.114T>G synonymous_variant 0.16 bedaquiline Uncertain significance
atpE 1461159 p.Val39Ile missense_variant 0.16 bedaquiline Uncertain significance
atpE 1461185 c.141G>T synonymous_variant 0.15 bedaquiline Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rpsA 1833667 c.126C>G synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1833724 c.183C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833787 c.246C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833790 c.249T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833802 c.261A>G synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833811 c.270G>T synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833838 c.297G>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833886 c.345C>G synonymous_variant 0.24 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.24 pyrazinamide Uncertain significance
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide Uncertain significance
rpsA 1833971 c.430C>T synonymous_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide Uncertain significance
rpsA 1834000 c.459G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834021 c.480C>T synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834303 c.762T>C synonymous_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834306 c.765T>C synonymous_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834411 c.870T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834417 c.876G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834654 p.Glu371Asp missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834690 c.1149T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834732 c.1191T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834733 p.Ala398Ser missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834738 c.1197A>G synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834753 c.1212T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834765 p.Glu408Asp missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834775 p.Ala412Thr missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834780 c.1239A>G synonymous_variant 0.15 pyrazinamide Uncertain significance
tsnR 1853361 c.-245T>C upstream_gene_variant 0.17 linezolid Uncertain significance
tsnR 1853420 c.-186T>G upstream_gene_variant 0.15 linezolid Uncertain significance
tsnR 1853423 c.-183C>T upstream_gene_variant 0.15 linezolid Uncertain significance
tsnR 1853429 c.-177G>C upstream_gene_variant 0.15 linezolid Uncertain significance
tsnR 1853432 c.-174G>C upstream_gene_variant 0.15 linezolid Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 0.81 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 0.87 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
bacA 2064978 c.-250G>C upstream_gene_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
bacA 2064979 c.-251C>T upstream_gene_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
bacA 2064984 c.-256A>G upstream_gene_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
bacA 2064993 c.-265T>C upstream_gene_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 0.87 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.91 pyrazinamide Not assoc w R
PPE35 2168604 p.Pro670Leu missense_variant 0.17 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.91 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 0.79 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 0.92 pyrazinamide Uncertain significance
kasA 2518624 c.510C>G synonymous_variant 0.19 isoniazid Uncertain significance
kasA 2518639 c.525G>C synonymous_variant 0.21 isoniazid Uncertain significance
kasA 2518657 c.543G>C synonymous_variant 0.19 isoniazid Uncertain significance
kasA 2518744 c.630C>T synonymous_variant 0.2 isoniazid Uncertain significance
kasA 2518747 c.633C>G synonymous_variant 0.19 isoniazid Uncertain significance
ahpC 2726105 c.-88G>A upstream_gene_variant 0.94 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 0.78 amikacin Not assoc w R
ethambutol Not assoc w R
kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
Rv2477c 2782912 p.Ser377Thr missense_variant 0.18 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782927 p.Thr372Glu missense_variant 0.23 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782936 c.1107G>T synonymous_variant 0.25 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782948 c.1095A>G synonymous_variant 0.22 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782957 c.1086A>G synonymous_variant 0.24 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.23 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782969 c.1074A>C synonymous_variant 0.21 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782972 c.1071G>C synonymous_variant 0.21 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782981 c.1062G>C synonymous_variant 0.21 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782984 c.1059T>C synonymous_variant 0.2 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2782990 c.1053C>G synonymous_variant 0.21 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783002 c.1041T>C synonymous_variant 0.21 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783008 c.1035C>G synonymous_variant 0.18 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783013 c.1030T>C synonymous_variant 0.19 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.18 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783035 c.1008G>C synonymous_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783116 c.927T>C synonymous_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783140 c.903C>G synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783146 c.897G>A synonymous_variant 0.14 amikacin Not assoc w R - Interim
ethambutol Uncertain significance
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783620 c.423C>G synonymous_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783628 p.Ala139Ser missense_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783656 c.387G>C synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783665 c.378A>G synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783674 c.369T>C synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783683 c.360A>G synonymous_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783700 p.Thr115Ser missense_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783863 c.180C>T synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783914 c.129T>C synonymous_variant 0.18 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783920 c.123G>C synonymous_variant 0.19 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783929 c.114C>G synonymous_variant 0.18 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783932 c.111C>T synonymous_variant 0.18 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783938 c.105T>C synonymous_variant 0.18 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783953 c.90G>A synonymous_variant 0.14 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
Rv2477c 2783971 c.72G>C synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
thyX 3067274 c.672C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067277 c.669C>G synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067281 p.Val222Ala missense_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067284 p.Ala221Gly missense_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067286 c.660C>G synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067289 c.657C>G synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067292 c.654G>A synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067295 c.651C>T synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067325 c.621A>G synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067349 c.597G>C synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067355 c.591A>C synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067367 c.579G>C synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyX 3067373 c.573C>G synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyX 3067376 c.570G>A synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyX 3067391 c.555G>C synonymous_variant 0.21 para-aminosalicylic_acid Uncertain significance
thyX 3067394 c.552G>C synonymous_variant 0.23 para-aminosalicylic_acid Uncertain significance
thyX 3067439 c.507A>G synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyX 3067445 c.501C>G synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyX 3067457 c.489C>G synonymous_variant 0.21 para-aminosalicylic_acid Uncertain significance
thyX 3067465 p.Ile161Val missense_variant 0.21 para-aminosalicylic_acid Uncertain significance
thyX 3067475 c.471A>G synonymous_variant 0.21 para-aminosalicylic_acid Uncertain significance
thyX 3067619 c.327A>C synonymous_variant 0.13 para-aminosalicylic_acid Uncertain significance
thyA 3073892 c.580T>C synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyA 3073898 p.Ala192Ser missense_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyA 3073917 c.555C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3073920 c.552C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3073925 c.547T>C synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3073929 c.543T>C synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 0.92 cycloserine Uncertain significance
whiB7 3568857 c.-178C>T upstream_gene_variant 0.74 amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
streptomycin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 0.92 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625569 c.1045T>C synonymous_variant 0.18 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625579 c.-669A>G upstream_gene_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625594 c.-684T>C upstream_gene_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625602 c.-692T>C upstream_gene_variant 0.23 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625612 c.-702G>C upstream_gene_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625616 p.Arg333Ala missense_variant 0.25 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625624 c.-714C>G upstream_gene_variant 0.25 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625636 c.978C>G synonymous_variant 0.27 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.25 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625669 c.-759G>C upstream_gene_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625690 c.-780T>C upstream_gene_variant 0.23 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625696 c.-786A>G upstream_gene_variant 0.23 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625705 c.909C>G synonymous_variant 0.21 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625720 c.894G>C synonymous_variant 0.19 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.18 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625749 c.-839C>T upstream_gene_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625750 c.864G>A synonymous_variant 0.21 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.22 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.21 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.21 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.22 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.21 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.2 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
rpoA 3877791 c.717C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3877866 c.642G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3877900 p.Ser203Asn missense_variant 0.13 rifampicin Uncertain significance
rpoA 3877962 c.546G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878040 c.468T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878094 c.414C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878106 c.402G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878313 c.195G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878346 c.162T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878364 c.144A>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878367 c.141C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878376 c.132G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878385 c.123C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3878388 c.120C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3878391 c.117T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878415 c.93C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878442 c.66G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3878746 c.-239A>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878761 c.-254G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878764 c.-257A>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878785 c.-278T>G upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878788 c.-281G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878809 c.-302T>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878824 c.-317G>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878833 c.-326C>G upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878853 c.-346G>A upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878860 c.-353C>T upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878914 c.-407T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878947 c.-440G>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.15 rifampicin Uncertain significance
clpC1 4038356 c.2349T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038368 c.2337T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038392 c.2313C>T synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038419 c.2286T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038640 p.Asp689Asn missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4038653 c.2052C>T synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4038658 p.Lys683Gln missense_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038661 p.Ser682Thr missense_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038662 c.2043T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038671 c.2034T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038695 c.2010C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038701 c.2004G>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038704 c.2001T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038707 c.1998C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038710 c.1995G>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038713 c.1992T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038908 c.1797C>G synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4038914 c.1791G>C synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4038953 c.1752A>G synonymous_variant 0.23 pyrazinamide Uncertain significance
clpC1 4038956 c.1749T>C synonymous_variant 0.24 pyrazinamide Uncertain significance
clpC1 4038965 c.1740T>C synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4038971 c.1734T>C synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039022 c.1683A>G synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039064 c.1641C>T synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039097 c.1608G>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039103 c.1602T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039112 c.1593C>G synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039121 c.1584T>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039142 c.1563A>G synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039183 c.1522T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039517 c.1188C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039610 c.1095G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039616 c.1089G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039622 c.1083C>T synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039625 c.1080G>A synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039661 c.1044T>G synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039664 c.1041G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039694 c.1011G>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039724 c.981A>G synonymous_variant 0.27 pyrazinamide Uncertain significance
clpC1 4039751 c.954A>G synonymous_variant 0.23 pyrazinamide Uncertain significance
clpC1 4039757 c.948A>G synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039760 c.945T>C synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039766 c.939T>C synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039769 c.936C>G synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039775 c.930G>C synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039778 c.927A>G synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039781 c.924G>C synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039790 c.915C>G synonymous_variant 0.21 pyrazinamide Uncertain significance
panD 4044023 c.259C>T synonymous_variant 0.7 pyrazinamide Not assoc w R
panD 4044872 c.-591C>T upstream_gene_variant 0.97 pyrazinamide Uncertain significance
glpK 4138622 c.1134C>T synonymous_variant 0.91 ethambutol Not assoc w R
isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
embC 4240693 c.831T>G synonymous_variant 0.16 ethambutol Uncertain significance
embC 4240699 c.837C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241089 c.1227C>G synonymous_variant 0.16 ethambutol Uncertain significance
embC 4241107 c.1245G>C synonymous_variant 0.2 ethambutol Uncertain significance
embC 4241140 c.1278A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.21 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.19 ethambutol Uncertain significance
embC 4241161 c.1299C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.19 ethambutol Uncertain significance
embC 4241170 c.1308G>C synonymous_variant 0.19 ethambutol Uncertain significance
embC 4241173 c.1311C>T synonymous_variant 0.19 ethambutol Uncertain significance
embC 4242075 p.Arg738Gln missense_variant 0.9 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.19 ethambutol Uncertain significance
embA 4245146 c.1914G>A synonymous_variant 0.2 ethambutol Uncertain significance
embA 4245149 c.1917C>G synonymous_variant 0.19 ethambutol Uncertain significance
embA 4245153 p.Ile641Val missense_variant 0.2 ethambutol Uncertain significance
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol Uncertain significance
embA 4245189 c.1957C>T synonymous_variant 0.17 ethambutol Uncertain significance
embA 4245198 p.Leu656Ile missense_variant 0.16 ethambutol Uncertain significance
embA 4245207 c.1975T>C synonymous_variant 0.16 ethambutol Uncertain significance
embA 4245215 c.1983A>C synonymous_variant 0.15 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 0.92 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.89 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338799 c.-278T>G upstream_gene_variant 0.64 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 0.9 streptomycin Not assoc w R