TB-Profiler result

Run: ERR2514390
Summary

Run ID: ERR2514390

Sample name:

Date: 2024-10-03T17:42:15.449564

Number of reads: 2134244

Percentage reads mapped: 80.83

Median coverage: 70.0

Strain: lineage3.1.2.1;lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.89
lineage3.1.2 East-African-Indian RD750 0.09
lineage4 Euro-American None 0.09
lineage4.9 Euro-American (H37Rv-like) None 0.06
lineage3.1.2.1 East-African-Indian RD750 0.13
lineage3.1 East-African-Indian RD750 0.16
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.14 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.15 isoniazid
gyrA 6670 c.-632G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 0.88 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7451 c.150C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.94 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7637 c.336C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCGC synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8772 p.Gly491Ser missense_variant 0.79 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 0.84 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.9 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575283 c.-65C>G upstream_gene_variant 0.78 isoniazid Uncertain significance
ethionamide Uncertain significance
mshA 575659 c.312A>G synonymous_variant 0.14 isoniazid
ethionamide
mshA 575662 c.315C>G synonymous_variant 0.14 isoniazid
ethionamide
mshA 575665 c.318G>A synonymous_variant 0.15 isoniazid
ethionamide
mshA 575674 c.327G>C synonymous_variant 0.14 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.15 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.16 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ethionamide
ccsA 620362 p.Ala158Thr missense_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620763 c.873G>A synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620769 c.879C>G synonymous_variant 0.2 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620784 c.894C>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 0.91 ethionamide Not assoc w R - Interim
hadA 732398 p.Ala157Thr missense_variant 0.14 isoniazid
nusG 734556 c.303C>T synonymous_variant 0.14 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.15 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 0.97 rifampicin Not assoc w R
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.19 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.15 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.15 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.15 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.17 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.15 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.17 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.17 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.85 rifampicin Not assoc w R
rpoB 762926 c.3120C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.95 rifampicin Not assoc w R
rpoB 763115 c.3309T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.14 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.14 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.18 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.18 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.17 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.14 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.21 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.19 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.18 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.15 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.16 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.16 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.2 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.16 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765053 p.Ser562Thr missense_variant 0.13 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.17 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.22 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.23 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.23 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.21 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.19 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.19 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.17 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766027 c.2658G>C synonymous_variant 0.15 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.15 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.14 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.17 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.17 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.17 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.17 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.16 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.15 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.19 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.19 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.18 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.22 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.22 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.21 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.2 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.22 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.22 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.21 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.17 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.17 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 0.93 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.91 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 0.96 streptomycin Not assoc w R
rpsL 781700 c.141G>C synonymous_variant 0.16 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.15 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.15 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.15 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.14 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.14 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.15 streptomycin
rplC 800693 c.-116A>G upstream_gene_variant 0.16 linezolid
Rv1129c 1253566 c.969A>G synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303695 c.765T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.15 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304661 c.1731C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.21 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304739 c.1809C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.75 pretomanid
delamanid
clofazimine
fbiC 1304862 c.1932G>A synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305030 c.2100G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
embR 1416814 c.534G>A synonymous_variant 0.72 ethambutol Not assoc w R
atpE 1461132 p.Val30Ile missense_variant 0.16 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.15 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.16 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.16 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.16 bedaquiline Uncertain significance
atpE 1461185 c.141G>T synonymous_variant 0.15 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rpsA 1833667 c.126C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.17 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.17 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.16 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.16 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.15 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.15 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.17 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.15 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.15 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.15 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 0.81 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 0.87 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 0.87 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.91 pyrazinamide Not assoc w R
PPE35 2168604 p.Pro670Leu missense_variant 0.17 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.91 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 0.79 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 0.92 pyrazinamide
kasA 2518624 c.510C>G synonymous_variant 0.19 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.21 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.19 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.2 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.19 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 0.94 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 0.78 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2782912 p.Ser377Thr missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.19 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.14 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783620 c.423C>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.14 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
thyX 3067274 c.672C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067281 p.Val222Ala missense_variant 0.16 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.16 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067292 c.654G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067295 c.651C>T synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067376 c.570G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.21 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.13 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.18 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 0.92 cycloserine
whiB7 3568857 c.-178C>T upstream_gene_variant 0.74 kanamycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
streptomycin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 0.92 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625569 c.1045T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.18 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.25 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.22 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.22 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
rpoA 3877791 c.717C>G synonymous_variant 0.15 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.14 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.13 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.18 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.16 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.16 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.15 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.15 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.15 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.15 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.16 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.15 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.15 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.17 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.18 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.18 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.17 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.16 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.14 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.17 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.25 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.3 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.31 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.3 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.29 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.22 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.23 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.17 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.15 rifampicin
clpC1 4038356 c.2349T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.17 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.14 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.14 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.18 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.13 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.14 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.21 pyrazinamide
panD 4044023 c.259C>T synonymous_variant 0.7 pyrazinamide Not assoc w R
panD 4044872 c.-591C>T upstream_gene_variant 0.97 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 0.91 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240693 c.831T>G synonymous_variant 0.16 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241089 c.1227C>G synonymous_variant 0.16 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.2 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.21 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.19 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.19 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.19 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.19 ethambutol
embC 4242075 p.Arg738Gln missense_variant 0.9 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.19 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.2 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.19 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.2 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.17 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.16 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.16 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 0.92 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.89 kanamycin
capreomycin
amikacin
whiB6 4338799 c.-278T>G upstream_gene_variant 0.64 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 0.9 streptomycin Not assoc w R