Run ID: SRR29096203
Sample name:
Date: 2024-10-04T04:51:42.633800
Number of reads: 68868
Percentage reads mapped: 52.04
Median coverage: 0.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 0.95 |
| lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrA | 9227 | c.1926C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9230 | c.1929T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9233 | c.1932C>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9236 | c.1935G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9242 | c.1941A>C | synonymous_variant | 0.79 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9248 | c.1947G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9252 | p.Val651Ile | missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 9257 | c.1956C>T | synonymous_variant | 0.83 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9267 | p.Asn656Gly | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9281 | c.1980C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9284 | c.1983T>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9296 | c.1995T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9299 | c.1998G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9304 | p.Gly668Glu | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9323 | c.2022C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9335 | c.2034G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9356 | c.2055G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9362 | c.2061C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9377 | c.2076A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9383 | c.2082T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9386 | c.2085T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9395 | c.2094G>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9413 | c.2112G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| fgd1 | 491191 | p.Gly137Arg | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491196 | c.414A>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491202 | c.420G>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491203 | p.Gln141Glu | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491212 | p.Ser144Arg | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491223 | c.441C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491226 | c.444C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491232 | c.450T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491244 | c.462T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491248 | p.Arg156Lys | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491259 | c.477T>C | synonymous_variant | 0.94 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491280 | c.498C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491283 | p.Asp167Glu | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491284 | p.Gly168Ser | missense_variant | 0.94 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491292 | c.510G>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491310 | c.528C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491316 | c.534C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| ccsA | 620547 | c.657C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620559 | c.669A>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620569 | p.Gly227Arg | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620604 | c.714C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620607 | c.717T>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620613 | c.723C>A | synonymous_variant | 0.82 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620625 | c.735A>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620631 | c.741T>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620634 | c.744C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620648 | p.Glu253Gly | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620652 | c.762C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620676 | c.786C>T | synonymous_variant | 0.82 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620694 | c.804C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620698 | p.Val270Ile | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| rpoB | 761249 | c.1443A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761255 | c.1449T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761258 | c.1452G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761261 | c.1455G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761282 | c.1476C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761318 | c.1512G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761327 | c.1521A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761330 | c.1524G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761333 | c.1527G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761345 | c.1539G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761346 | p.Val514Asn | missense_variant | 1.0 | rifampicin | |
| rpoB | 761354 | c.1548C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761360 | c.1554T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761369 | p.Glu521Asp | missense_variant | 1.0 | rifampicin | |
| rpoB | 761374 | p.Val523Glu | missense_variant | 1.0 | rifampicin | |
| rpoB | 761561 | c.1755C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761564 | c.1758G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761573 | c.1767C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761579 | c.1773G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761606 | c.1800C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761612 | c.1806G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761615 | c.1809A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761636 | c.1830G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761645 | c.1839C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761648 | c.1842T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761657 | c.1851C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761669 | c.1863C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761675 | c.1869G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761690 | c.1884G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761711 | c.1905C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761712 | p.Val636Ile | missense_variant | 1.0 | rifampicin | |
| rpoB | 761723 | p.Glu639Asp | missense_variant | 1.0 | rifampicin | Not assoc w R |
| rpoB | 761724 | p.Glu640Lys | missense_variant | 1.0 | rifampicin | |
| rpoB | 761728 | p.Ser641Thr | missense_variant | 1.0 | rifampicin | |
| rpoB | 761732 | c.1926C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761744 | c.1938G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761747 | c.1941G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761750 | c.1944G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761760 | p.Ile652Val | missense_variant | 1.0 | rifampicin | |
| rpoB | 761765 | c.1959T>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761772 | p.His656Ala | missense_variant | 1.0 | rifampicin | |
| rpoB | 761778 | p.Asn658Asp | missense_variant | 1.0 | rifampicin | |
| rpoC | 765611 | p.His748Ser | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765625 | c.2256C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765628 | c.2259G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765700 | c.2331T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765871 | c.2502T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765875 | p.Val836Ile | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765904 | c.2535C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765934 | c.2565C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765967 | c.2598C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765973 | c.2604C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765979 | c.2610C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765982 | c.2613C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765991 | c.2622C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765994 | c.2625A>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766000 | c.2631G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766003 | c.2634G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766009 | c.2640G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766043 | p.Gln892Gly | missense_variant | 1.0 | rifampicin | |
| fbiC | 1305126 | c.2196T>C | synonymous_variant | 0.82 | pretomanid | |
| delamanid | Not assoc w R - Interim | |||||
| clofazimine | Not assoc w R - Interim | |||||
| fbiC | 1305132 | c.2202C>T | synonymous_variant | 0.82 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305135 | c.2205C>T | synonymous_variant | 0.82 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305147 | c.2217C>T | synonymous_variant | 0.82 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305150 | c.2220C>G | synonymous_variant | 0.82 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305173 | p.Asn748Ser | missense_variant | 0.82 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305177 | c.2247A>G | synonymous_variant | 0.82 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305181 | c.2251T>C | synonymous_variant | 0.82 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305195 | c.2265T>C | synonymous_variant | 0.9 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305197 | p.Ala756Gly | missense_variant | 0.9 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305201 | c.2271G>C | synonymous_variant | 0.9 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305231 | c.2301C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305237 | c.2307A>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305243 | c.2313T>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | Not assoc w R - Interim | |||||
| fbiC | 1305259 | c.2329T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305270 | c.2340C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1474174 | n.517A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| inhA | 1674353 | p.Thr51Ile | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674368 | p.Ala56Glu | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674370 | p.Lys57Pro | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674375 | c.174C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674399 | c.198A>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674403 | p.Glu68Asn | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674414 | c.213G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674416 | p.Ala72Asp | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674419 | p.Ser73Thr | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674421 | c.220T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674428 | p.Gly76Asp | missense_variant | 1.0 | isoniazid | Uncertain significance |
| ethionamide | Uncertain significance | |||||
| inhA | 1674435 | c.234G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674443 | p.Ala81Val | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674450 | c.249G>T | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674452 | p.Ala84Glu | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674471 | c.270G>T | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674480 | c.279T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674483 | c.282G>C | synonymous_variant | 0.95 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674486 | c.285T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674489 | c.288G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674507 | c.306G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674534 | c.333G>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | ||||||
| inhA | 1674539 | p.Tyr113Phe | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674542 | p.Ala114Glu | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674546 | c.345T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674550 | p.Ser117Ala | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674573 | c.372G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674576 | c.375T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674579 | c.378G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674585 | c.384T>C | synonymous_variant | 0.96 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674589 | p.Met130Leu | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674597 | c.396G>A | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674600 | c.399G>C | synonymous_variant | 0.97 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674618 | c.417C>T | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674624 | c.423A>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674627 | c.426T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674628 | p.Ser143Gly | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674654 | c.453G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674656 | p.Ser152Thr | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674690 | c.489C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674702 | c.501G>A | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674703 | c.502T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674714 | c.513C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674718 | c.517A>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674729 | c.528G>A | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674745 | p.Tyr182Val | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674756 | c.555T>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674765 | c.564C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674774 | c.573A>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674777 | c.576C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1674780 | c.579T>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| rpsA | 1834423 | c.882G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834432 | c.891G>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834451 | c.910T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834456 | c.915T>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834468 | c.927A>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834477 | c.936C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834489 | c.948T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834498 | c.957C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834522 | c.981C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834527 | p.Arg329His | missense_variant | 1.0 | pyrazinamide | |
| rpsA | 1834540 | c.999G>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834543 | c.1002C>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834546 | c.1005T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834555 | c.1014T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834558 | c.1017C>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834573 | c.1032G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834603 | p.Glu354Asp | missense_variant | 1.0 | pyrazinamide | |
| rpsA | 1834606 | c.1065C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834609 | c.1068T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834666 | c.1125G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834667 | p.Ala376Ser | missense_variant | 1.0 | pyrazinamide | |
| rpsA | 1834690 | c.1149T>C | synonymous_variant | 0.97 | pyrazinamide | |
| rpsA | 1834732 | c.1191T>C | synonymous_variant | 0.97 | pyrazinamide | |
| rpsA | 1834738 | c.1197A>G | synonymous_variant | 0.97 | pyrazinamide | |
| rpsA | 1834741 | c.1200C>A | synonymous_variant | 0.97 | pyrazinamide | |
| rpsA | 1834747 | c.1206A>G | synonymous_variant | 0.97 | pyrazinamide | |
| rpsA | 1834751 | p.Leu404Ile | missense_variant | 0.97 | pyrazinamide | |
| rpsA | 1834756 | c.1215G>A | synonymous_variant | 0.97 | pyrazinamide | |
| rpsA | 1834759 | c.1218A>T | synonymous_variant | 0.94 | pyrazinamide | |
| rpsA | 1834765 | p.Glu408Asp | missense_variant | 0.97 | pyrazinamide | |
| rpsA | 1834775 | p.Ala412Thr | missense_variant | 0.97 | pyrazinamide | |
| rpsA | 1834780 | c.1239A>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834786 | c.1245A>G | synonymous_variant | 0.97 | pyrazinamide | |
| rpsA | 1834789 | c.1248T>C | synonymous_variant | 0.94 | pyrazinamide | |
| rpsA | 1834792 | c.1251G>C | synonymous_variant | 0.97 | pyrazinamide | |
| tsnR | 1853361 | c.-245T>C | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853370 | c.-236_-234delGCAinsTCC | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853375 | c.-231G>C | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853387 | c.-219T>G | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853390 | c.-216G>C | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853394 | c.-212_-211delCTinsGC | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853420 | c.-186T>G | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853429 | c.-177G>C | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853432 | c.-174G>C | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853444 | c.-162C>T | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853453 | c.-153G>C | upstream_gene_variant | 1.0 | linezolid | |
| kasA | 2517917 | c.-198G>T | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2517926 | c.-189G>A | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2517941 | c.-174C>G | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2517950 | c.-165C>G | upstream_gene_variant | 1.0 | isoniazid | |
| Rv2477c | 2783593 | c.450T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783602 | c.441G>A | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| lpqB | 3625054 | c.-144C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
| bedaquiline | Uncertain significance | |||||
| lpqB | 3625069 | c.-159T>G | upstream_gene_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625072 | c.-162G>C | upstream_gene_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625075 | c.-165G>C | upstream_gene_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625078 | c.-168G>C | upstream_gene_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625087 | c.-177C>A | upstream_gene_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625094 | p.Glu507Arg | missense_variant | 0.85 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625099 | c.-189C>G | upstream_gene_variant | 0.85 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625111 | c.-201G>C | upstream_gene_variant | 0.85 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625117 | c.-207T>G | upstream_gene_variant | 0.85 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625123 | c.-213T>C | upstream_gene_variant | 0.85 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625134 | c.-224T>C | upstream_gene_variant | 0.85 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625135 | c.1479A>G | synonymous_variant | 0.85 | rifampicin | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| lpqB | 3625141 | c.-231T>C | upstream_gene_variant | 0.85 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625147 | c.-237C>G | upstream_gene_variant | 0.85 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625161 | c.-251T>C | upstream_gene_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625162 | c.1452T>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| lpqB | 3625167 | c.-257C>T | upstream_gene_variant | 0.83 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625656 | c.958T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| lpqB | 3625663 | c.-753G>T | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625678 | c.-768C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625683 | c.-773C>T | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625687 | c.-777G>T | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625690 | c.-780T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625720 | c.-810G>A | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625723 | c.-813C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625729 | c.885A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625747 | c.867G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625755 | p.Ala287Thr | missense_variant | 1.0 | rifampicin | Uncertain significance |
| bedaquiline | ||||||
| mtrB | 3625762 | c.852A>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625765 | c.849C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625768 | c.-858G>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625774 | c.840G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625806 | c.808A>C | synonymous_variant | 0.95 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625819 | c.795G>A | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625822 | c.-912C>T | upstream_gene_variant | 0.93 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625837 | c.777C>G | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625852 | c.-942A>C | upstream_gene_variant | 0.93 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625864 | c.-954T>A | upstream_gene_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625867 | c.747A>G | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| rpoA | 3877656 | c.852T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877662 | c.846C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877668 | c.840A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877677 | c.831G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877680 | c.828G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877686 | c.822A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| glpK | 4138565 | c.1191G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138568 | c.1188A>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138571 | c.1185C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138574 | c.1182G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138580 | c.1176C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138598 | c.1158G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138601 | c.1155G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138606 | c.1150T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138631 | c.1125C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138634 | c.1122G>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138643 | c.1113A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | Not assoc w R - Interim | |||||
| streptomycin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| glpK | 4138654 | c.1102C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| glpK | 4138655 | c.1101G>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138661 | c.1095T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138676 | c.1080T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138682 | c.1074C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138696 | p.Pro354Ser | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | Uncertain significance | |||||
| streptomycin | ||||||
| rifampicin | Uncertain significance | |||||
| ethambutol | Uncertain significance | |||||
| embC | 4240945 | c.1083T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240951 | c.1089C>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240954 | c.1092T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240960 | c.1098G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240966 | c.1104G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240979 | p.Thr373Gln | missense_variant | 1.0 | ethambutol | |
| embC | 4240990 | c.1128A>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240996 | c.1134G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241002 | c.1140G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241017 | c.1155T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241023 | c.1161T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241024 | p.Val388Phe | missense_variant | 1.0 | ethambutol | |
| embC | 4241039 | p.Asp393Asn | missense_variant | 1.0 | ethambutol |
