TB-Profiler

Lineage	Family	RDs	Frequency
La1.8	M.bovis	None	1.0
La1.8.1	M.bovis	None	1.0
La1	M.bovis	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance	Mutation from literature
pncA	2289073	p.His57Asp	missense_variant	1.0	pyrazinamide	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	467	p.His156Arg	missense_variant	1.0	isoniazid	Not assoc w R
gyrB	5752	c.513G>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	5752	c.513G>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	0.99	levofloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	0.99	moxifloxacin	Not assoc w R - Interim
gyrB	6446	p.Ala403Ser	missense_variant	1.0	levofloxacin	Not assoc w R
gyrB	6446	p.Ala403Ser	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	8285	c.984C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8285	c.984C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8471	c.1170T>C	synonymous_variant	0.15	levofloxacin
gyrA	8471	c.1170T>C	synonymous_variant	0.15	moxifloxacin
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9217	p.Asp639Ala	missense_variant	0.97	levofloxacin	Uncertain significance
gyrA	9217	p.Asp639Ala	missense_variant	0.97	moxifloxacin	Uncertain significance
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0010c	13197	p.Thr121Ser	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13228	c.330delG	frameshift_variant	1.0	isoniazid	Uncertain significance
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
fgd1	491742	c.960T>C	synonymous_variant	1.0	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
rpoB	762101	c.2295C>G	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.16	rifampicin	Uncertain significance
rpoB	762122	c.2316C>T	synonymous_variant	0.17	rifampicin
rpoB	762131	c.2325C>G	synonymous_variant	0.18	rifampicin
rpoB	762134	c.2328C>A	synonymous_variant	0.18	rifampicin
rpoB	762140	c.2334G>C	synonymous_variant	0.19	rifampicin
rpoB	762143	c.2337T>C	synonymous_variant	0.19	rifampicin
rpoB	762149	c.2343G>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	762158	c.2352G>C	synonymous_variant	0.18	rifampicin	Not assoc w R - Interim
rpoB	762167	c.2361T>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	762176	c.2370T>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>T	synonymous_variant	0.18	rifampicin
rpoB	762209	c.2403C>T	synonymous_variant	0.2	rifampicin
rpoB	762212	c.2406G>C	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoB	762233	c.2427G>C	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoB	762236	c.2430G>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	762254	c.2448T>C	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoB	762257	c.2451C>G	synonymous_variant	0.2	rifampicin
rpoB	762281	c.2475G>A	synonymous_variant	0.19	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	0.18	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	762296	c.2490G>A	synonymous_variant	0.18	rifampicin
rpoB	762317	c.2511A>G	synonymous_variant	0.17	rifampicin	Not assoc w R - Interim
rpoB	762329	c.2523G>C	synonymous_variant	0.18	rifampicin	Not assoc w R - Interim
rpoB	762338	c.2532T>C	synonymous_variant	0.17	rifampicin
rpoB	762347	c.2541T>C	synonymous_variant	0.19	rifampicin
rpoB	762362	p.Glu852Asp	missense_variant	0.17	rifampicin
rpoB	762369	c.2563T>C	synonymous_variant	0.15	rifampicin
rpoC	762374	c.-996G>C	upstream_gene_variant	0.15	rifampicin
rpoC	762380	c.-990T>G	upstream_gene_variant	0.15	rifampicin
rpoC	762398	c.-972T>C	upstream_gene_variant	0.15	rifampicin
rpoC	762401	c.-969G>C	upstream_gene_variant	0.14	rifampicin
rpoC	762407	c.-963G>C	upstream_gene_variant	0.15	rifampicin
rpoB	762410	c.2604T>G	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoB	762416	c.2610A>G	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoB	762857	c.3051C>G	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoB	762860	c.3054G>C	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoB	762863	c.3057T>C	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.13	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>C	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoC	764116	c.747C>T	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	764365	c.996C>T	synonymous_variant	0.13	rifampicin	Not assoc w R - Interim
rpoC	764539	c.1170C>G	synonymous_variant	0.15	rifampicin	Not assoc w R - Interim
rpoC	764548	c.1179G>C	synonymous_variant	0.16	rifampicin
rpoC	764566	c.1197C>G	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	1.0	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					rifampicin	Not assoc w R
Rv1129c	1254582	c.-48A>G	upstream_gene_variant	1.0	levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					isoniazid	Not assoc w R
					rifampicin	Not assoc w R
fbiC	1302899	c.-32A>G	upstream_gene_variant	1.0	pretomanid
					delamanid	Uncertain significance
					clofazimine	Uncertain significance
Rv1258c	1406243	c.1098G>A	synonymous_variant	0.99	streptomycin
					pyrazinamide
					isoniazid
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471923	n.78T>C	non_coding_transcript_exon_variant	0.15	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471925	n.80T>C	non_coding_transcript_exon_variant	0.15	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1471932	n.87A>G	non_coding_transcript_exon_variant	0.16	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	0.16	kanamycin
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471936	n.91A>G	non_coding_transcript_exon_variant	0.16	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471985	n.140T>C	non_coding_transcript_exon_variant	0.21	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471986	n.141C>T	non_coding_transcript_exon_variant	0.21	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471996	n.151C>T	non_coding_transcript_exon_variant	0.21	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472029	n.184C>T	non_coding_transcript_exon_variant	0.24	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472041	n.196C>T	non_coding_transcript_exon_variant	0.25	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472042	n.197T>C	non_coding_transcript_exon_variant	0.25	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472053	n.211_212delGC	non_coding_transcript_exon_variant	0.27	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	0.27	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472075	n.230A>G	non_coding_transcript_exon_variant	0.28	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.27	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472286	n.441C>G	non_coding_transcript_exon_variant	0.18	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472287	n.442C>T	non_coding_transcript_exon_variant	0.18	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472292	n.447A>G	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472298	n.453G>C	non_coding_transcript_exon_variant	0.17	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472302	n.457_458insT	non_coding_transcript_exon_variant	0.17	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472310	n.465_466insG	non_coding_transcript_exon_variant	0.17	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472314	n.469A>G	non_coding_transcript_exon_variant	0.17	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472315	n.470T>G	non_coding_transcript_exon_variant	0.17	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472327	n.482G>A	non_coding_transcript_exon_variant	0.19	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472328	n.483G>C	non_coding_transcript_exon_variant	0.2	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472438	n.593T>C	non_coding_transcript_exon_variant	0.21	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472446	n.601T>A	non_coding_transcript_exon_variant	0.21	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472452	n.607G>A	non_coding_transcript_exon_variant	0.21	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472456	n.611T>C	non_coding_transcript_exon_variant	0.21	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472464	n.619A>G	non_coding_transcript_exon_variant	0.23	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472489	n.644A>G	non_coding_transcript_exon_variant	0.21	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472498	n.653C>T	non_coding_transcript_exon_variant	0.2	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472847	n.1002G>C	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472848	n.1003T>G	non_coding_transcript_exon_variant	0.18	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472849	n.1004C>G	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472858	n.1013G>T	non_coding_transcript_exon_variant	0.19	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472859	n.1014G>C	non_coding_transcript_exon_variant	0.19	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472860	n.1015C>G	non_coding_transcript_exon_variant	0.19	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.26	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.15	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>T	non_coding_transcript_exon_variant	0.15	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473123	n.1278A>T	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1475573	n.1916G>A	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1475573	n.1916G>A	non_coding_transcript_exon_variant	0.15	linezolid
rrl	1475602	n.1945G>C	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1475602	n.1945G>C	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475603	n.1946G>T	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1475603	n.1946G>T	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475604	n.1947A>C	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1475604	n.1947A>C	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.13	linezolid
rrl	1475612	n.1955G>C	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1475612	n.1955G>C	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475615	n.1958C>G	non_coding_transcript_exon_variant	0.14	capreomycin
rrl	1475615	n.1958C>G	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475616	n.1959A>G	non_coding_transcript_exon_variant	0.14	capreomycin
rrl	1475616	n.1959A>G	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475619	n.1962C>T	non_coding_transcript_exon_variant	0.14	capreomycin
rrl	1475619	n.1962C>T	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475621	n.1964T>C	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1475621	n.1964T>C	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475626	n.1969delTinsCC	non_coding_transcript_exon_variant	0.15	capreomycin
rrl	1475626	n.1969delTinsCC	non_coding_transcript_exon_variant	0.15	linezolid
rrl	1475629	n.1972G>C	non_coding_transcript_exon_variant	0.15	capreomycin
rrl	1475629	n.1972G>C	non_coding_transcript_exon_variant	0.15	linezolid
rrl	1475637	n.1980T>G	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1475637	n.1980T>G	non_coding_transcript_exon_variant	0.15	linezolid
rrl	1475638	n.1981C>G	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1475638	n.1981C>G	non_coding_transcript_exon_variant	0.15	linezolid
rrl	1475639	n.1982C>G	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1475639	n.1982C>G	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1475659	n.2002G>A	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1475659	n.2002G>A	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1475753	n.2096C>G	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1475753	n.2096C>G	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1475762	n.2105G>T	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1475762	n.2105G>T	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1475763	n.2106C>T	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1475764	n.2107A>C	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1475764	n.2107A>C	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1475765	n.2108A>G	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1475765	n.2108A>G	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1475775	n.2118G>T	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1475775	n.2118G>T	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1475995	n.2338G>A	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1475995	n.2338G>A	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1475997	n.2340A>G	non_coding_transcript_exon_variant	0.34	capreomycin
rrl	1475997	n.2340A>G	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1476034	n.2377C>G	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476034	n.2377C>G	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1476035	n.2378G>C	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476035	n.2378G>C	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1476088	n.2431A>C	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1476088	n.2431A>C	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476103	n.2446C>A	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1476103	n.2446C>A	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1476108	n.2451T>G	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476108	n.2451T>G	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1476110	n.2453G>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476110	n.2453G>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.29	linezolid	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1476256	n.2599A>C	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1476256	n.2599A>C	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1476262	n.2605G>A	non_coding_transcript_exon_variant	0.25	capreomycin
rrl	1476262	n.2605G>A	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476529	n.2872A>T	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476529	n.2872A>T	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.16	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	0.17	capreomycin	Not assoc w R
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476616	n.2959A>G	non_coding_transcript_exon_variant	0.16	capreomycin
rrl	1476616	n.2959A>G	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rpsA	1833979	c.438T>C	synonymous_variant	0.13	pyrazinamide
rpsA	1834222	c.681T>C	synonymous_variant	0.14	pyrazinamide
rpsA	1834225	c.684C>G	synonymous_variant	0.14	pyrazinamide
rpsA	1834231	c.690T>G	synonymous_variant	0.13	pyrazinamide
rpsA	1834240	c.699T>C	synonymous_variant	0.14	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.16	pyrazinamide
rpsA	1834261	c.720A>G	synonymous_variant	0.14	pyrazinamide	Not assoc w R - Interim
rpsA	1834264	c.723G>C	synonymous_variant	0.14	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	0.14	pyrazinamide
rpsA	1834423	c.882G>T	synonymous_variant	0.16	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.16	pyrazinamide
rpsA	1834456	c.915T>G	synonymous_variant	0.16	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	0.17	pyrazinamide
rpsA	1834489	c.948T>C	synonymous_variant	0.15	pyrazinamide
rpsA	1834522	c.981C>T	synonymous_variant	0.15	pyrazinamide
rpsA	1834527	p.Arg329Gln	missense_variant	0.15	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	0.16	pyrazinamide
rpsA	1834555	c.1014T>C	synonymous_variant	0.17	pyrazinamide
rpsA	1834558	c.1017C>G	synonymous_variant	0.18	pyrazinamide
rpsA	1834603	p.Glu354Asp	missense_variant	0.14	pyrazinamide
rpsA	1834859	p.Ala440Thr	missense_variant	1.0	pyrazinamide	Uncertain significance
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2062922	p.Ile603Val	missense_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					streptomycin	Not assoc w R
					amikacin	Not assoc w R
ndh	2102193	p.Arg284Trp	missense_variant	1.0	isoniazid	Uncertain significance
					delamanid	Uncertain significance
					ethionamide	Uncertain significance
ndh	2103173	c.-132delG	upstream_gene_variant	1.0	isoniazid
					delamanid
					ethionamide
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
katG	2155503	c.609C>T	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156025	c.87C>A	synonymous_variant	1.0	isoniazid	Not assoc w R
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
PPE35	2168011	p.Ser868Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168319	p.Thr765Ile	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168814	c.1798dupA	frameshift_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
eis	2715125	p.Thr70Ala	missense_variant	1.0	kanamycin	Uncertain significance
eis	2715125	p.Thr70Ala	missense_variant	1.0	amikacin	Uncertain significance
Rv2477c	2782927	c.1116A>G	synonymous_variant	1.0	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2681	2997325	p.Ala196Val	missense_variant	1.0	capreomycin	Uncertain significance
ald	3086728	c.-92C>T	upstream_gene_variant	1.0	cycloserine
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
ald	3087084	c.266delA	frameshift_variant	1.0	cycloserine
Rv3083	3448783	p.Val94Ile	missense_variant	1.0	ethionamide	Uncertain significance
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624350	c.561G>T	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624350	c.561G>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624593	c.318G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624593	c.318G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624710	c.201G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624710	c.201G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
mtrB	3626995	c.-382C>A	upstream_gene_variant	0.12	rifampicin
mtrB	3626995	c.-382C>A	upstream_gene_variant	0.12	bedaquiline
rpoA	3877968	c.540C>G	synonymous_variant	0.13	rifampicin
rpoA	3877971	p.Asp179Glu	missense_variant	0.13	rifampicin	Uncertain significance
rpoA	3877974	c.534G>C	synonymous_variant	0.13	rifampicin
rpoA	3878842	c.-335G>T	upstream_gene_variant	0.14	rifampicin
rpoA	3878853	c.-346G>A	upstream_gene_variant	0.14	rifampicin
rpoA	3878873	c.-366G>A	upstream_gene_variant	0.13	rifampicin
rpoA	3878878	c.-371T>C	upstream_gene_variant	0.13	rifampicin	Uncertain significance
rpoA	3878938	c.-431T>C	upstream_gene_variant	0.13	rifampicin
rpoA	3878947	c.-440G>T	upstream_gene_variant	0.14	rifampicin
rpoA	3879154	c.-647T>C	upstream_gene_variant	1.0	rifampicin
clpC1	4038403	c.2302T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4038896	c.1809C>T	synonymous_variant	0.14	pyrazinamide
clpC1	4038908	c.1797C>G	synonymous_variant	0.14	pyrazinamide
clpC1	4038911	c.1794G>T	synonymous_variant	0.12	pyrazinamide
clpC1	4038917	c.1788C>T	synonymous_variant	0.12	pyrazinamide
clpC1	4038923	c.1782A>G	synonymous_variant	0.13	pyrazinamide
clpC1	4038926	c.1779G>A	synonymous_variant	0.13	pyrazinamide
clpC1	4040480	c.225T>C	synonymous_variant	0.13	pyrazinamide	Not assoc w R - Interim
glpK	4138377	p.Val460Ala	missense_variant	1.0	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					streptomycin	Not assoc w R
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
glpK	4138977	p.Gly260Ala	missense_variant	1.0	levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					isoniazid	Uncertain significance
					streptomycin	Uncertain significance
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embC	4242970	c.3108C>T	synonymous_variant	0.98	ethambutol	Not assoc w R
embA	4244220	c.988C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4246551	p.Asn13Ser	missense_variant	1.0	ethambutol	Not assoc w R
embB	4246864	c.351C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
aftB	4267858	p.Ile327Val	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269351	c.483C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					amikacin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result