TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.8	Euro-American (mainly T)	RD219	0.99

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance	Mutation from literature
amikacin	Uncertain significance	Mutation from literature
kanamycin	Uncertain significance	Mutation from literature
rrs	1473329	n.1484G>T	non_coding_transcript_exon_variant	0.5	kanamycin	Assoc w R
amikacin	Assoc w R
capreomycin	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrA	7362	p.Glu21Gln	missense_variant	0.94	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	0.94	moxifloxacin	Not assoc w R
rpoB	762233	c.2427G>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	762236	c.2430G>T	synonymous_variant	0.26	rifampicin
rpoB	762245	c.2439G>T	synonymous_variant	0.23	rifampicin
rpoB	762254	c.2448T>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	762257	c.2451C>G	synonymous_variant	0.27	rifampicin
rpoC	762899	c.-471G>T	upstream_gene_variant	0.27	rifampicin
rpoB	762920	c.3114C>T	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	762959	c.-411G>T	upstream_gene_variant	0.24	rifampicin
rpoC	762971	c.-399G>C	upstream_gene_variant	0.25	rifampicin
rpoC	763534	c.165T>C	synonymous_variant	0.38	rifampicin
rpoC	763537	c.168C>G	synonymous_variant	0.36	rifampicin
rpoC	763546	c.177A>G	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoC	763573	c.204G>C	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoC	763622	p.Ala85Ser	missense_variant	0.38	rifampicin	Uncertain significance
rpoC	763627	p.Lys86Asn	missense_variant	0.33	rifampicin	Uncertain significance
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472107	n.262A>G	non_coding_transcript_exon_variant	0.3	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472112	n.267C>T	non_coding_transcript_exon_variant	0.3	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472122	n.277G>T	non_coding_transcript_exon_variant	0.33	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472123	n.278A>T	non_coding_transcript_exon_variant	0.33	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472124	n.279C>T	non_coding_transcript_exon_variant	0.33	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.54	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>G	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472240	n.395G>A	non_coding_transcript_exon_variant	0.6	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472251	n.406G>C	non_coding_transcript_exon_variant	0.57	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	0.49	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472368	n.523A>G	non_coding_transcript_exon_variant	0.62	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472396	n.551A>T	non_coding_transcript_exon_variant	0.62	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472400	n.555C>T	non_coding_transcript_exon_variant	0.63	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472412	n.567A>G	non_coding_transcript_exon_variant	0.5	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472507	n.662C>A	non_coding_transcript_exon_variant	0.52	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472522	n.677T>G	non_coding_transcript_exon_variant	0.67	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.72	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>T	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.71	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472582	n.737G>T	non_coding_transcript_exon_variant	0.68	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.68	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472585	n.740A>C	non_coding_transcript_exon_variant	0.67	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472623	n.778A>C	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472675	n.830T>C	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472677	n.832C>A	non_coding_transcript_exon_variant	0.74	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472682	n.837T>A	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472683	n.838T>C	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472687	n.842A>T	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472707	n.862A>T	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472767	n.922G>C	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472790	n.945T>C	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472812	n.967A>T	non_coding_transcript_exon_variant	0.67	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472954	n.1110delC	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472958	n.1113_1114insC	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472986	n.1141_1142insA	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472989	n.1145delA	non_coding_transcript_exon_variant	0.77	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472996	n.1151T>C	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473081	n.1236C>T	non_coding_transcript_exon_variant	0.68	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.46	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.64	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473226	n.1381C>G	non_coding_transcript_exon_variant	0.64	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.58	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.55	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473288	n.1443C>G	non_coding_transcript_exon_variant	0.45	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.46	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473292	n.1447G>T	non_coding_transcript_exon_variant	0.46	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473294	n.1449A>G	non_coding_transcript_exon_variant	0.46	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.47	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473315	n.1470T>C	non_coding_transcript_exon_variant	0.47	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473316	n.1471C>T	non_coding_transcript_exon_variant	0.46	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473319	n.1474C>T	non_coding_transcript_exon_variant	0.44	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473324	n.1479G>A	non_coding_transcript_exon_variant	0.47	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin
rrl	1473862	n.205C>T	non_coding_transcript_exon_variant	0.38	capreomycin
rrl	1473862	n.205C>T	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1473876	n.219G>A	non_coding_transcript_exon_variant	0.39	capreomycin	Uncertain significance
rrl	1473876	n.219G>A	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474197	n.540C>T	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1474202	n.545T>G	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1474218	n.561T>G	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1474253	n.596A>T	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.46	capreomycin
rrl	1474529	n.872A>C	non_coding_transcript_exon_variant	0.46	linezolid
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.42	capreomycin
rrl	1474530	n.873G>A	non_coding_transcript_exon_variant	0.42	linezolid
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.44	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	0.44	linezolid	Uncertain significance
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.44	capreomycin
rrl	1474539	n.882C>T	non_coding_transcript_exon_variant	0.44	linezolid
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.48	capreomycin
rrl	1474540	n.883T>G	non_coding_transcript_exon_variant	0.48	linezolid
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1474552	n.895C>T	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.54	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.54	linezolid
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.69	capreomycin
rrl	1474582	n.925T>A	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.33	capreomycin
rrl	1474752	n.1096delA	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.44	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.44	linezolid	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.38	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.38	linezolid	Uncertain significance
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.38	capreomycin	Not assoc w R
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.38	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1474799	n.1143delT	non_coding_transcript_exon_variant	0.35	capreomycin
rrl	1474799	n.1143delT	non_coding_transcript_exon_variant	0.35	linezolid
rrl	1474803	n.1146_1147insA	non_coding_transcript_exon_variant	0.31	capreomycin
rrl	1474803	n.1146_1147insA	non_coding_transcript_exon_variant	0.31	linezolid
rrl	1474806	n.1149A>C	non_coding_transcript_exon_variant	0.45	capreomycin
rrl	1474806	n.1149A>C	non_coding_transcript_exon_variant	0.45	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.47	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.47	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.54	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.54	linezolid	Uncertain significance
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1474853	n.1196A>G	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.55	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.41	capreomycin	Uncertain significance
rrl	1475699	n.2042C>T	non_coding_transcript_exon_variant	0.41	linezolid	Uncertain significance
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.52	capreomycin
rrl	1475722	n.2065G>T	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1475781	n.2124T>C	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1475869	n.2212C>A	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1475877	n.2220C>T	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.71	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1475883	n.2226A>T	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1475892	n.2235A>C	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1475898	n.2241A>G	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1475899	n.2242G>A	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1475906	n.2249C>T	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1476141	n.2484A>G	non_coding_transcript_exon_variant	0.39	capreomycin	Uncertain significance
rrl	1476141	n.2484A>G	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
rrl	1476153	n.2496T>C	non_coding_transcript_exon_variant	0.44	capreomycin	Uncertain significance
rrl	1476153	n.2496T>C	non_coding_transcript_exon_variant	0.44	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.64	capreomycin	Not assoc w R
rrl	1476165	n.2508T>G	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.56	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.51	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.51	capreomycin	Not assoc w R
rrl	1476201	n.2544C>T	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.51	capreomycin
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.51	linezolid
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.49	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.49	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.49	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.49	linezolid	Uncertain significance
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.44	capreomycin
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.44	linezolid
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.39	capreomycin	Uncertain significance
rrl	1476245	n.2588C>T	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.43	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.43	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.47	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.47	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.43	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.43	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.4	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.4	linezolid	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476363	n.2706A>G	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1476363	n.2706A>G	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1476366	n.2709A>C	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1476366	n.2709A>C	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476374	n.2717T>G	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1476374	n.2717T>G	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.78	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.76	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.54	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.54	linezolid	Uncertain significance
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
PPE35	2168728	p.Gly629Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
Rv3083	3448507	c.5_*1408del	frameshift_variant&stop_lost&splice_region_variant	1.0	ethionamide	Uncertain significance
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
amikacin	rrs	n.1484G>T	Assoc w R
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1484G>T	Assoc w R
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1484G>T	Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result