Run ID: ERR266125
Sample name:
Date: 2024-04-16T04:46:52.403797
Number of reads: 12469819
Percentage reads mapped: 93.95
Median coverage: 280.0
Strain: La3;M.canetti
Spoligotype:
Drug-resistance: Other
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| La3 | M.orygis | None | 0.4 |
| M.canetti | M.canetti | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | embB | p.Tyr384Asn | Mutation from literature | |
| pyrazinamide | pncA | p.Glu174Gly | Mutation from literature | |
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | mmpR5 | c.442_444delAACinsCA | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| para-aminosalicylic_acid | ||||
| delamanid | fbiC | c.682_684delCTCinsTT | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| c.817_819delACGinsGC | Assoc w R - Interim | Confers DLM-PMD cross-resistance | ||
| c.2251_2253delTTGinsCA | Assoc w R - Interim | Confers DLM-PMD cross-resistance | ||
| c.2377_2379delGTGinsAA | Assoc w R - Interim | Confers DLM-PMD cross-resistance | ||
| bedaquiline | mmpR5 | c.442_444delAACinsCA | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| mmpR5 | 779431 | c.442_444delAACinsCA | frameshift_variant&missense_variant | 1.0 | clofazimine | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 |
| bedaquiline | Assoc w R | Can only confer resistance if genetically linked to a functional MmpL5 | |||||
| fbiC | 1303612 | c.682_684delCTCinsTT | frameshift_variant&missense_variant | 1.0 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
| fbiC | 1303747 | c.817_819delACGinsGC | frameshift_variant&missense_variant | 1.0 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
| fbiC | 1305181 | c.2251_2253delTTGinsCA | frameshift_variant&missense_variant | 1.0 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
| fbiC | 1305307 | c.2377_2379delGTGinsAA | frameshift_variant&missense_variant | 1.0 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
| pncA | 2288720 | p.Glu174Gly | missense_variant | 1.0 | pyrazinamide | Mutation from literature | |
| embB | 4247663 | p.Tyr384Asn | missense_variant | 1.0 | ethambutol | Mutation from literature |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| dnaA | 72 | c.72T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 264 | c.264C>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 343 | p.Pro115Ser | missense_variant | 1.0 | isoniazid | |
| dnaA | 549 | c.549C>T | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 708 | c.708T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 720 | c.720G>A | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 747 | c.747G>A | synonymous_variant | 1.0 | isoniazid | |
| gyrB | 5025 | c.-215T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5207 | c.-33A>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5440 | c.201A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5452 | c.213G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 5770 | c.531C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6001 | c.762G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6004 | c.765T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6286 | c.1047T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6433 | c.-869C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6436 | c.-866C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7256 | c.2017C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 8288 | c.987T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9074 | c.1773G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9218 | c.1917C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9377 | c.2076A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9716 | c.2415T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9740 | c.2439G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9776 | c.2475T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
| fgd1 | 490666 | c.-117G>T | upstream_gene_variant | 0.89 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490678 | c.-105_-104insG | upstream_gene_variant | 0.76 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490687 | c.-96T>C | upstream_gene_variant | 0.68 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 490720 | c.-63T>G | upstream_gene_variant | 0.31 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491137 | p.Glu119Gln | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491310 | c.528C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| mshA | 575216 | c.-132C>A | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| mshA | 575665 | c.318G>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| mshA | 576757 | c.1410C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| isoniazid | Not assoc w R - Interim | |||||
| ccsA | 620256 | c.366C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620257 | p.Ile123Ala | missense_variant | 1.0 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620490 | c.600A>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620808 | c.918T>C | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| Rv0565c | 656511 | p.His320Gln | missense_variant | 1.0 | ethionamide | |
| Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv0565c | 657273 | c.198G>A | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | |
| hadA | 731692 | c.-238A>G | upstream_gene_variant | 1.0 | isoniazid | |
| hadA | 731747 | c.-183T>C | upstream_gene_variant | 1.0 | isoniazid | |
| hadA | 731852 | c.-78A>G | upstream_gene_variant | 1.0 | isoniazid | |
| nusG | 733883 | c.-370_-368delGCG | upstream_gene_variant | 1.0 | rifampicin | |
| rpoB | 759741 | c.-66C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoB | 760715 | c.909C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761510 | c.1704T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761573 | c.1767C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
| rpoC | 763259 | c.-111G>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoC | 763660 | c.291T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764107 | c.738C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764134 | c.765C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764152 | c.783C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764159 | c.790C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764195 | p.Ser276Ala | missense_variant | 1.0 | rifampicin | |
| rpoC | 764198 | c.829C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764203 | c.834G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764206 | p.Asp279Glu | missense_variant | 1.0 | rifampicin | |
| rpoC | 764245 | c.876C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764257 | c.888G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764278 | c.909A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764293 | c.924G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764341 | c.972G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764365 | c.996C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764405 | c.1036A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764497 | c.1128A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764506 | c.1137C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764510 | c.1141C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764521 | c.1152T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764524 | c.1155C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764527 | c.1158C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764533 | c.1164C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764536 | c.1167G>C | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764539 | c.1170C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764554 | c.1185C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764575 | c.1206T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764578 | c.1209C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764632 | c.1263T>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764650 | c.1281G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764651 | c.1282_1284delTCGinsAGC | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765001 | c.1632C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765082 | c.1713G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765152 | p.Asp595Asn | missense_variant | 1.0 | rifampicin | |
| rpoC | 765409 | c.2040T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765478 | c.2109T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766152 | p.Asp928Gly | missense_variant | 1.0 | rifampicin | |
| rpoC | 766675 | c.3306C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766870 | c.3501C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766900 | c.3531T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766945 | c.3576A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767062 | c.3693C>A | synonymous_variant | 1.0 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| mmpL5 | 778057 | p.Ser142Gly | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778573 | c.-93C>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779283 | c.-803G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779295 | c.-815A>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779472 | c.-992G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779523 | c.-618T>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779538 | c.-633A>C | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779539 | c.-634C>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| rpsL | 781269 | c.-291C>A | upstream_gene_variant | 1.0 | streptomycin | |
| rpsL | 781291 | c.-269G>C | upstream_gene_variant | 1.0 | streptomycin | |
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| Rv1129c | 1253093 | p.Ser481Leu | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253216 | p.Glu440Ala | missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253408 | p.Glu376Gly | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253603 | p.Gly311Glu | missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253617 | c.918G>A | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1253620 | p.Leu305Arg | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253653 | c.882T>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253746 | p.Asp263Glu | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253779 | c.756A>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253806 | c.729C>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253888 | p.Ala216Val | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1253902 | c.631_633delAATinsGC | frameshift_variant&missense_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1129c | 1253924 | p.Ile204Thr | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254004 | c.531G>A | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254086 | p.Ala150Glu | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254141 | p.Glu132Gln | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254160 | c.375C>G | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254235 | c.300G>C | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254253 | c.282C>T | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1254310 | c.225T>C | synonymous_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254403 | c.132A>G | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1129c | 1254434 | p.Val34Ala | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| Rv1129c | 1254582 | c.-48A>G | upstream_gene_variant | 1.0 | moxifloxacin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| Rv1129c | 1254589 | c.-55C>T | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254602 | c.-68C>T | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254610 | c.-76A>C | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254654 | c.-120A>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254678 | c.-144A>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv1129c | 1254690 | c.-156T>G | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| fbiC | 1302622 | c.-309A>G | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302694 | c.-237C>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302777 | c.-154T>C | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302810 | c.-121C>T | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302860 | c.-71G>A | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302911 | c.-20T>C | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1302957 | c.27C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303066 | p.Ile46Val | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303116 | c.186C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303167 | p.Ser79Arg | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303194 | c.264C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303242 | c.312T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303257 | c.327C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303288 | p.Ser120Gly | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303292 | p.Thr121Met | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303404 | c.474A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303419 | c.489C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303480 | p.Gln184Glu | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303492 | c.562T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303617 | c.687C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303722 | c.792C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303743 | c.813C>T | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| fbiC | 1303750 | c.820T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303788 | c.858T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303860 | c.930A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303998 | c.1068T>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304001 | c.1071C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304092 | p.Met388Leu | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304166 | c.1236A>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304262 | p.Trp444Cys | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304301 | c.1371C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304315 | p.Val462Ala | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304330 | p.Ala467Asp | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304343 | c.1413T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304439 | c.1509G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304442 | c.1512T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304465 | p.Gly512Asp | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304469 | c.1539G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304472 | c.1542T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304481 | c.1551T>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304487 | c.1557C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304496 | c.1566T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304505 | c.1575G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304511 | c.1581C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304526 | c.1596T>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304538 | c.1608C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304546 | p.Val539Ala | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304559 | p.Glu543Asp | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304676 | c.1746A>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304677 | p.Glu583Gln | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304796 | c.1866G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304911 | c.1981C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305045 | c.2115A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305069 | c.2139G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305093 | c.2163C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305195 | c.2265T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305207 | c.2277C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305231 | c.2301C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305234 | c.2304G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305237 | c.2307A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305243 | c.2313T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305244 | c.2314T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305252 | c.2322G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305276 | c.2346G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305300 | c.2370A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305306 | c.2376A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305311 | p.Arg794Gln | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305318 | c.2388C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305330 | c.2400C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305332 | p.Glu801Gly | missense_variant | 1.0 | clofazimine | Uncertain significance |
| pretomanid | ||||||
| delamanid | Uncertain significance | |||||
| fbiC | 1305343 | p.Asn805Asp | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305405 | c.2475A>G | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| pretomanid | ||||||
| delamanid | ||||||
| sigE | 1364258 | c.-155C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| Rv1258c | 1406114 | c.1227G>C | synonymous_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| Rv1258c | 1406466 | p.Ser292Leu | missense_variant | 1.0 | streptomycin | Uncertain significance |
| isoniazid | Uncertain significance | |||||
| pyrazinamide | Uncertain significance | |||||
| Rv1258c | 1406492 | p.Ile283Met | missense_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| Rv1258c | 1407008 | c.333C>A | synonymous_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| Rv1258c | 1407459 | c.-119T>C | upstream_gene_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| Rv1258c | 1407532 | c.-192G>C | upstream_gene_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| Rv1258c | 1407602 | c.-262G>A | upstream_gene_variant | 1.0 | streptomycin | |
| isoniazid | ||||||
| pyrazinamide | ||||||
| embR | 1416226 | c.1122T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embR | 1416283 | c.1065G>A | synonymous_variant | 1.0 | ethambutol | |
| embR | 1416289 | c.1059G>A | synonymous_variant | 1.0 | ethambutol | |
| embR | 1416313 | c.1035A>C | synonymous_variant | 1.0 | ethambutol | |
| embR | 1416538 | c.810T>C | synonymous_variant | 1.0 | ethambutol | |
| embR | 1416616 | c.732T>C | synonymous_variant | 1.0 | ethambutol | |
| embR | 1416688 | c.660G>C | synonymous_variant | 1.0 | ethambutol | |
| embR | 1416717 | c.631C>T | synonymous_variant | 1.0 | ethambutol | |
| embR | 1416847 | c.501A>C | synonymous_variant | 1.0 | ethambutol | |
| embR | 1417259 | p.Ser30Leu | missense_variant | 1.0 | ethambutol | |
| embR | 1417294 | c.54A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417954 | c.-607A>G | upstream_gene_variant | 1.0 | ethambutol | |
| atpE | 1460897 | c.-148A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rrs | 1471616 | n.-230T>A | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 0.99 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471811 | n.-35A>G | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrs | 1471839 | n.-6delT | upstream_gene_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| rrl | 1473470 | n.-188A>G | upstream_gene_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1474275 | n.618T>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1474362 | n.705A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1474383 | n.726G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1474552 | n.895C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rrl | 1475416 | n.1759T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| inhA | 1673499 | c.-703T>C | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | Uncertain significance | |||||
| fabG1 | 1674079 | p.Pro214Ala | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674384 | c.183C>T | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674405 | c.204G>A | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674471 | c.270G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674480 | c.279T>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674483 | c.282G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674486 | c.285T>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674603 | c.402G>A | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674620 | p.Pro140Gln | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674780 | c.579T>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| rpsA | 1833283 | c.-259C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833367 | c.-175G>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833381 | c.-161T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833444 | c.-98A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833451 | c.-91A>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833452 | c.-90C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833454 | c.-87delA | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833471 | c.-71_-70insC | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833499 | c.-43A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833554 | p.Thr5Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1833568 | c.27G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1833596 | c.55_56delAGinsTC | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833806 | c.265C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833928 | c.387G>A | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834411 | c.870T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834414 | c.873C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834451 | c.910T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834855 | c.1314C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834912 | c.1371A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834916 | p.Thr459Ser | missense_variant | 1.0 | pyrazinamide | |
| rpsA | 1834924 | c.1383T>G | synonymous_variant | 1.0 | pyrazinamide | |
| tsnR | 1853394 | c.-212C>G | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853429 | c.-177G>A | upstream_gene_variant | 1.0 | linezolid | |
| tsnR | 1853636 | p.Thr11Ala | missense_variant | 1.0 | linezolid | Uncertain significance |
| tsnR | 1853768 | p.Arg55Trp | missense_variant | 1.0 | linezolid | |
| tsnR | 1853802 | p.Ala66Val | missense_variant | 1.0 | linezolid | |
| tsnR | 1853804 | p.Ser67Pro | missense_variant | 0.99 | linezolid | |
| tsnR | 1853902 | c.297T>C | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1853926 | c.321T>C | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1853954 | p.Arg117Gly | missense_variant | 1.0 | linezolid | |
| tsnR | 1853968 | c.363C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854028 | c.423G>C | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854064 | c.459C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854070 | c.465C>T | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| tsnR | 1854073 | c.468C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854076 | c.471T>C | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854105 | p.Ala167Val | missense_variant | 1.0 | linezolid | |
| tsnR | 1854112 | p.Asp169Glu | missense_variant | 1.0 | linezolid | |
| tsnR | 1854114 | p.Val170Ala | missense_variant | 1.0 | linezolid | |
| tsnR | 1854116 | p.Gly171Pro | missense_variant | 1.0 | linezolid | |
| tsnR | 1854125 | p.Ile174Val | missense_variant | 1.0 | linezolid | |
| tsnR | 1854134 | c.529C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854289 | c.684C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854292 | c.687A>G | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
| tsnR | 1854359 | p.Glu252Gln | missense_variant | 1.0 | linezolid | |
| tlyA | 1917519 | c.-421C>T | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917606 | c.-334G>C | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917653 | c.-287A>G | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917807 | c.-133T>G | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917849 | c.-91G>A | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
| tlyA | 1918149 | c.210A>C | synonymous_variant | 1.0 | capreomycin | |
| tlyA | 1918150 | p.Val71Leu | missense_variant | 1.0 | capreomycin | |
| tlyA | 1918242 | c.303G>C | synonymous_variant | 1.0 | capreomycin | |
| tlyA | 1918587 | p.Gln216His | missense_variant | 1.0 | capreomycin | |
| tlyA | 1918604 | p.Ser222Thr | missense_variant | 1.0 | capreomycin | |
| bacA | 2061039 | c.1899_*1769del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | streptomycin | Uncertain significance |
| kanamycin | Uncertain significance | |||||
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | streptomycin | Not assoc w R |
| kanamycin | Not assoc w R | |||||
| capreomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| bacA | 2063040 | c.1689C>T | synonymous_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| bacA | 2063391 | c.1338C>G | synonymous_variant | 1.0 | streptomycin | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| ndh | 2101777 | c.1266C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| delamanid | ||||||
| isoniazid | Not assoc w R - Interim | |||||
| ndh | 2101795 | c.1248G>C | synonymous_variant | 1.0 | ethionamide | |
| delamanid | ||||||
| isoniazid | ||||||
| ndh | 2101945 | c.1098C>T | synonymous_variant | 1.0 | ethionamide | |
| delamanid | ||||||
| isoniazid | ||||||
| ndh | 2103182 | c.-140C>G | upstream_gene_variant | 1.0 | ethionamide | |
| delamanid | ||||||
| isoniazid | ||||||
| katG | 2153989 | p.Val708Ala | missense_variant | 1.0 | isoniazid | |
| katG | 2154055 | p.Lys686Thr | missense_variant | 1.0 | isoniazid | |
| katG | 2154060 | c.2052T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2154190 | p.Leu641Ser | missense_variant | 1.0 | isoniazid | |
| katG | 2154252 | c.1860T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2154435 | c.1677T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2154531 | c.1581A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2154594 | c.1518G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2154678 | c.1434G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
| katG | 2154870 | c.1242G>A | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155062 | c.1050T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155065 | c.1047C>G | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155068 | c.1044T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155071 | c.1041T>G | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155074 | c.1038C>T | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155080 | c.1032G>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155085 | c.1027C>T | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155092 | c.1020G>A | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155104 | c.1008G>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155119 | c.993T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155137 | c.975G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2155190 | p.Thr308Ala | missense_variant | 1.0 | isoniazid | |
| katG | 2155205 | p.Ser303Thr | missense_variant | 1.0 | isoniazid | |
| katG | 2155233 | c.879G>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155236 | c.876G>A | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155326 | c.786A>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155491 | c.621T>C | synonymous_variant | 1.0 | isoniazid | |
| katG | 2155508 | p.Ala202Ser | missense_variant | 1.0 | isoniazid | Uncertain significance |
| katG | 2155971 | c.141A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2156055 | c.57C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2156661 | c.-550C>G | upstream_gene_variant | 1.0 | isoniazid | |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
| PPE35 | 2167934 | c.2679G>A | synonymous_variant | 0.99 | pyrazinamide | |
| PPE35 | 2168269 | p.Gly782Ser | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168342 | c.2271T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168567 | c.2046A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168612 | c.2001C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2168882 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169263 | c.1350C>T | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169304 | p.Met437Leu | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169686 | c.927T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2169717 | p.Asn299Ile | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170178 | c.435T>A | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170232 | c.381T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170394 | c.219G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170440 | p.Gln58Arg | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170452 | p.Gly54Asp | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170485 | p.Val43Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170499 | c.114A>G | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170764 | c.-152C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| Rv1979c | 2221723 | p.Arg481His | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2222357 | p.Thr270Ala | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| Rv1979c | 2222504 | p.Met221Leu | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2222598 | c.567C>T | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2222844 | c.321G>C | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2222897 | p.Ile90Val | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2223146 | p.Arg7Gly | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2223255 | c.-91A>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
| bedaquiline | Not assoc w R - Interim | |||||
| Rv1979c | 2223691 | c.-527G>C | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| pncA | 2288725 | p.Glu173Lys | missense_variant | 1.0 | pyrazinamide | |
| pncA | 2288855 | c.387T>C | synonymous_variant | 1.0 | pyrazinamide | |
| pncA | 2289104 | c.138A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| pncA | 2289820 | c.-579T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| kasA | 2517969 | c.-146C>T | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518265 | p.Val51Ile | missense_variant | 1.0 | isoniazid | |
| kasA | 2518279 | c.165T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518282 | c.168A>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518283 | c.169_171delGCGinsCC | frameshift_variant&missense_variant | 1.0 | isoniazid | |
| kasA | 2518297 | c.183C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518300 | c.186T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519041 | c.927C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519077 | c.963G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519140 | c.1026G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519287 | c.1173T>C | synonymous_variant | 1.0 | isoniazid | |
| eis | 2714202 | c.1131C>T | synonymous_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2714421 | c.912A>G | synonymous_variant | 1.0 | amikacin | Not assoc w R - Interim |
| kanamycin | Not assoc w R - Interim | |||||
| eis | 2714964 | c.369C>T | synonymous_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2715590 | c.-258A>T | upstream_gene_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| eis | 2715607 | c.-275G>A | upstream_gene_variant | 1.0 | amikacin | |
| kanamycin | ||||||
| ahpC | 2725905 | c.-288C>A | upstream_gene_variant | 1.0 | isoniazid | |
| ahpC | 2726226 | p.Ala12Thr | missense_variant | 1.0 | isoniazid | |
| folC | 2746174 | c.1425A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747204 | p.Ala132Gln | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747572 | c.27T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747575 | c.24G>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747628 | c.-30G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747631 | c.-33C>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747691 | c.-93A>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2477c | 2782483 | c.1560G>A | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2782714 | c.1329A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2782768 | c.1275C>T | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | ||||||
| levofloxacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| rifampicin | ||||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2782774 | c.1269G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2782777 | c.1266A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2782792 | c.1251A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2783992 | c.51T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2784083 | c.-41T>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| kanamycin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| amikacin | ||||||
| Rv2477c | 2784098 | c.-56G>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784101 | c.-60delC | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784108 | c.-66C>T | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784111 | c.-69A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784112 | c.-70G>A | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784116 | c.-74C>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784132 | c.-90A>T | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784140 | c.-98C>T | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784256 | c.-214G>A | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784396 | c.-354A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784399 | c.-357G>A | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| Rv2477c | 2784432 | c.-390A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| kanamycin | ||||||
| rifampicin | ||||||
| amikacin | ||||||
| pepQ | 2859490 | p.Val310Ala | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| ribD | 2987614 | c.766delA | frameshift_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2680 | 2996009 | c.-96T>C | upstream_gene_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2680 | 2996010 | c.-95C>A | upstream_gene_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2680 | 2996040 | c.-65A>T | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2680 | 2996142 | p.Glu13Val | missense_variant | 1.0 | capreomycin | |
| Rv2681 | 2996356 | c.-383G>A | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2681 | 2996404 | c.-335T>A | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2681 | 2996885 | c.147C>T | synonymous_variant | 1.0 | capreomycin | |
| Rv2681 | 2996891 | c.153C>G | synonymous_variant | 1.0 | capreomycin | |
| Rv2681 | 2997008 | c.270C>T | synonymous_variant | 1.0 | capreomycin | |
| Rv2681 | 2997054 | p.Ser106Gly | missense_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2681 | 2997059 | c.321C>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997668 | c.930G>T | synonymous_variant | 1.0 | capreomycin | |
| Rv2752c | 3064637 | p.Val519Met | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3065131 | p.Ala354Val | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066158 | p.Thr12Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv2752c | 3066367 | c.-176G>T | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066417 | c.-226C>T | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066905 | c.-714T>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| Rv2752c | 3066996 | c.-805T>C | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| thyX | 3067355 | c.591A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067439 | c.507A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067980 | c.-35T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074160 | c.312A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074529 | c.-58G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074580 | c.-109T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| ald | 3086623 | c.-197A>G | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086671 | c.-149T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086707 | c.-113G>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086733 | c.-87G>A | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086737 | c.-83_-81delTCGinsCTA | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086744 | c.-76A>T | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086753 | c.-67A>G | upstream_gene_variant | 0.99 | cycloserine | |
| ald | 3086758 | c.-62C>T | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086760 | c.-60A>T | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086771 | c.-49T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086773 | c.-47A>G | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086788 | c.-32T>A | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086797 | c.-23G>A | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086803 | c.-17T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086929 | p.Ala37Gly | missense_variant | 1.0 | cycloserine | |
| ald | 3087020 | c.201C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087065 | c.246C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087070 | p.Arg84Leu | missense_variant | 0.99 | cycloserine | |
| ald | 3087074 | c.255G>A | synonymous_variant | 0.99 | cycloserine | |
| ald | 3087077 | c.258A>C | synonymous_variant | 0.99 | cycloserine | |
| ald | 3087079 | p.His87Arg | missense_variant | 0.99 | cycloserine | |
| ald | 3087140 | c.321G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087149 | c.330C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087152 | c.333C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087155 | c.336C>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087158 | c.339G>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087164 | c.345T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087293 | c.474G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087316 | p.Val166Ala | missense_variant | 1.0 | cycloserine | |
| ald | 3087344 | c.525C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087380 | c.561C>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087381 | p.Asn188Gly | missense_variant | 1.0 | cycloserine | |
| ald | 3087401 | c.582T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087500 | c.681T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087512 | c.693T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087527 | c.708T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087533 | c.714C>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087560 | c.741C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087644 | c.825C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087653 | c.834A>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087743 | c.924G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087758 | c.939G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087800 | p.His327Gln | missense_variant | 1.0 | cycloserine | |
| ald | 3087833 | c.1014A>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087857 | c.1038C>T | synonymous_variant | 1.0 | cycloserine | |
| fbiD | 3339134 | p.Asp6Gly | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiD | 3339411 | c.294T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiD | 3339518 | p.His134Arg | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiD | 3339549 | c.432T>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| Rv3083 | 3448282 | c.-222G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448474 | c.-30G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448495 | c.-9G>T | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448611 | c.108A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3448972 | p.His157Asp | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449028 | c.525T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449029 | p.Ser176Ala | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449305 | c.802T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449400 | c.897C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449454 | c.951G>A | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449868 | c.1365C>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449877 | c.1374T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449885 | p.Arg461Lys | missense_variant | 1.0 | ethionamide | Uncertain significance |
| whiB7 | 3568557 | c.123A>G | synonymous_variant | 1.0 | streptomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB7 | 3568568 | p.Val38Ile | missense_variant | 1.0 | streptomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB7 | 3569103 | c.-424G>C | upstream_gene_variant | 1.0 | streptomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| lpqB | 3624486 | p.Asp142Gly | missense_variant | 0.99 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3625006 | c.1608A>C | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| rifampicin | Not assoc w R | |||||
| mtrB | 3626461 | c.153A>G | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3626999 | c.351G>A | synonymous_variant | 1.0 | bedaquiline | |
| rifampicin | Not assoc w R - Interim | |||||
| mtrA | 3627437 | c.-88T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | Uncertain significance | |||||
| mtrA | 3627734 | c.-385A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627802 | c.-453T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627831 | c.-482T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| mtrA | 3627839 | c.-490T>C | upstream_gene_variant | 1.0 | bedaquiline | |
| rifampicin | ||||||
| fbiB | 3641840 | c.306T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642254 | c.720G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642467 | c.933T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642599 | c.1065C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| alr | 3840207 | p.Ala405Asp | missense_variant | 1.0 | cycloserine | |
| alr | 3840527 | c.894A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840719 | c.702A>G | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840791 | c.630T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840796 | p.Asp209Asn | missense_variant | 1.0 | cycloserine | |
| alr | 3840914 | c.507G>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840994 | p.His143Asp | missense_variant | 1.0 | cycloserine | |
| alr | 3841112 | p.Asp103Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841116 | p.Ala102Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841172 | c.249A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841199 | c.222T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841362 | p.Thr20Lys | missense_variant | 1.0 | cycloserine | |
| alr | 3841419 | p.Val1Ala | missense_variant | 1.0 | cycloserine | |
| alr | 3841428 | c.-8A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841531 | c.-111A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841532 | c.-112A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841539 | c.-119C>T | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841546 | c.-126C>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841568 | c.-148G>A | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841595 | c.-175T>G | upstream_gene_variant | 0.98 | cycloserine | |
| alr | 3841600 | c.-180G>A | upstream_gene_variant | 0.98 | cycloserine | |
| rpoA | 3877886 | c.622C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878001 | c.507A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878043 | c.465G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878124 | c.384G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878619 | c.-113delC | upstream_gene_variant | 0.97 | rifampicin | Uncertain significance |
| rpoA | 3878630 | c.-124_-123insC | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878968 | c.-461T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3879193 | c.-686G>A | upstream_gene_variant | 1.0 | rifampicin | |
| ddn | 3987179 | c.336G>T | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| ddn | 3987257 | c.414C>G | synonymous_variant | 1.0 | delamanid | |
| pretomanid | ||||||
| clpC1 | 4038216 | p.Pro830Leu | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038278 | c.2427T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038683 | c.2022T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038746 | c.1959C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038779 | c.1926C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038848 | c.1857C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038860 | c.1845G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038878 | c.1827A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038974 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039046 | c.1659C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039094 | c.1611C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039100 | c.1605C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039190 | c.1515C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039274 | c.1431G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039298 | c.1407T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039448 | c.1257A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039502 | c.1203C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039610 | c.1095G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4039820 | c.885T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040045 | c.660C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040048 | c.657C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040063 | c.642G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040090 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040093 | c.612C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040147 | c.558A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040363 | c.342A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040423 | c.282A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040450 | c.255A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040471 | c.234T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040504 | c.201C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040534 | c.171A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040551 | c.154T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040600 | c.105A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040657 | c.48T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040879 | c.-177_-175delTGGinsCGGT | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4043992 | p.Arg97Gln | missense_variant | 1.0 | pyrazinamide | |
| panD | 4044050 | c.232T>C | synonymous_variant | 1.0 | pyrazinamide | |
| panD | 4044084 | c.198T>C | synonymous_variant | 1.0 | pyrazinamide | |
| panD | 4044232 | p.Cys17His | missense_variant | 1.0 | pyrazinamide | |
| panD | 4044447 | c.-167_-166delATinsGC | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044452 | c.-171C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044470 | c.-189C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044479 | c.-198C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044533 | c.-252T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044568 | c.-287G>A | upstream_gene_variant | 0.99 | pyrazinamide | |
| panD | 4044569 | c.-289_-288delCGinsGC | upstream_gene_variant | 0.99 | pyrazinamide | |
| panD | 4044682 | c.-401C>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044926 | c.-645C>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4045063 | c.-782T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4045150 | c.-869G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| glpK | 4138259 | c.1497T>C | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| levofloxacin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| glpK | 4139096 | p.Leu220Phe | missense_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4139321 | c.435T>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139420 | c.336T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| glpK | 4139477 | c.279A>G | synonymous_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4139813 | c.-58T>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| glpK | 4139934 | c.-179A>G | upstream_gene_variant | 1.0 | ethambutol | |
| moxifloxacin | ||||||
| streptomycin | ||||||
| levofloxacin | ||||||
| rifampicin | ||||||
| isoniazid | ||||||
| embC | 4239032 | c.-831T>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239110 | c.-753C>T | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239142 | c.-721C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4239146 | c.-717A>G | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239158 | c.-705C>T | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239215 | c.-648T>C | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4239284 | c.-579C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4239377 | c.-486C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4239575 | c.-288C>T | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239600 | c.-263A>G | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4239648 | c.-215A>G | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4240237 | c.375G>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4240587 | p.Gly242Ala | missense_variant | 1.0 | ethambutol | |
| embC | 4240590 | p.Ala243Val | missense_variant | 1.0 | ethambutol | |
| embC | 4240604 | c.742C>T | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4240732 | c.870C>T | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240786 | c.924C>T | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240831 | c.969T>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240867 | c.1005T>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240870 | c.1008T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240871 | p.Val337Ile | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4240879 | c.1017G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240880 | p.Ala340Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4240886 | p.Ile342Val | missense_variant | 1.0 | ethambutol | |
| embC | 4240897 | c.1035C>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4240900 | c.1038A>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240903 | c.1041C>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4240936 | c.1074A>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241035 | c.1173G>A | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241248 | c.1386G>T | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241710 | c.1848G>A | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241758 | c.1896G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4241809 | c.1947A>G | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241882 | p.Leu674Met | missense_variant | 1.0 | ethambutol | |
| embC | 4241957 | c.2095C>A | synonymous_variant | 1.0 | ethambutol | |
| embA | 4242325 | c.-908C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4242487 | c.-746G>A | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4242499 | p.Arg879Ser | missense_variant | 1.0 | ethambutol | |
| embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4242655 | c.-578A>G | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4242779 | p.Asn973Asp | missense_variant | 1.0 | ethambutol | |
| embA | 4242946 | c.-287T>C | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4243131 | p.Pro1090Arg | missense_variant | 1.0 | ethambutol | |
| embA | 4243628 | c.396A>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4243690 | p.Met153Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243961 | c.729G>A | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244154 | p.Thr308Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4244177 | c.945G>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244178 | p.Ala316Thr | missense_variant | 1.0 | ethambutol | |
| embA | 4244312 | c.1080T>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4244456 | c.1224C>T | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244534 | c.1302T>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244778 | p.Ser516Ala | missense_variant | 1.0 | ethambutol | |
| embA | 4244846 | c.1614C>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245023 | c.1791A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245594 | p.Ser788Thr | missense_variant | 1.0 | ethambutol | |
| embB | 4246226 | c.-288C>A | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4246443 | p.Asp1071Asn | missense_variant | 1.0 | ethambutol | |
| embA | 4246485 | p.Gly1085Ser | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4246582 | c.69T>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4246682 | p.Asp57Asn | missense_variant | 1.0 | ethambutol | |
| embB | 4246969 | c.456T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247246 | c.734_787delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | disruptive_inframe_deletion | 1.0 | ethambutol | |
| embB | 4247357 | p.Val282Met | missense_variant | 1.0 | ethambutol | |
| embB | 4247584 | c.1071C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embB | 4247662 | c.1149C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247916 | p.Arg468His | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248070 | c.1557T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248226 | c.1713G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248532 | c.2019C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248676 | c.2163C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248931 | c.2418C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249009 | c.2496G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4249102 | c.2589T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249334 | p.Ala941Ser | missense_variant | 1.0 | ethambutol | |
| embB | 4249351 | c.2838C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249429 | c.2916C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249456 | c.2943G>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249786 | c.3273G>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249801 | c.3288T>C | synonymous_variant | 1.0 | ethambutol | |
| aftB | 4267412 | c.1425T>C | synonymous_variant | 1.0 | ethambutol | |
| aftB | 4268588 | c.249G>T | synonymous_variant | 1.0 | ethambutol | |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| aftB | 4269783 | c.-947G>A | upstream_gene_variant | 1.0 | ethambutol | |
| ubiA | 4269811 | p.Gln8Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| ubiA | 4269853 | c.-20C>T | upstream_gene_variant | 1.0 | ethambutol | |
| ethA | 4326016 | c.1458G>C | synonymous_variant | 0.92 | ethionamide | |
| ethA | 4326025 | c.1449G>A | synonymous_variant | 1.0 | ethionamide | |
| ethA | 4326205 | c.1269C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| ethA | 4326403 | c.1071C>T | synonymous_variant | 1.0 | ethionamide | |
| ethA | 4326409 | c.1065T>C | synonymous_variant | 1.0 | ethionamide | |
| ethA | 4326487 | c.987A>T | synonymous_variant | 1.0 | ethionamide | |
| ethA | 4326538 | c.936G>A | synonymous_variant | 1.0 | ethionamide | |
| ethA | 4326678 | p.Ser266Gly | missense_variant | 1.0 | ethionamide | |
| ethR | 4326733 | c.-816C>G | upstream_gene_variant | 1.0 | ethionamide | |
| ethR | 4326760 | c.-789T>C | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327001 | p.Val158Ala | missense_variant | 1.0 | ethionamide | |
| ethA | 4327003 | c.471C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| ethA | 4327092 | p.Ala128Thr | missense_variant | 1.0 | ethionamide | |
| ethR | 4327342 | c.-207G>T | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327546 | c.-74_-73insC | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327842 | c.-369G>A | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4328231 | c.-758G>A | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4328308 | c.-835G>C | upstream_gene_variant | 1.0 | ethionamide | |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
| amikacin | Not assoc w R | |||||
| kanamycin | Not assoc w R | |||||
| whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338741 | c.-220A>G | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338785 | c.-266_-264delGGCinsAG | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| whiB6 | 4338878 | c.-357C>T | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| gid | 4407568 | p.Ala212Val | missense_variant | 1.0 | streptomycin | |
| gid | 4407572 | p.Ile211Val | missense_variant | 1.0 | streptomycin | |
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
| gid | 4407703 | p.Ala167Val | missense_variant | 1.0 | streptomycin | |
| gid | 4407705 | c.498G>T | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407782 | p.Ala141Thr | missense_variant | 1.0 | streptomycin | Uncertain significance |
| gid | 4407822 | c.381A>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407943 | p.Gln87Arg | missense_variant | 1.0 | streptomycin | Uncertain significance |
| gid | 4407951 | c.252G>T | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408008 | c.195C>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408110 | p.Val31Ala | missense_variant | 1.0 | streptomycin | |
| gid | 4408113 | c.90T>C | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408153 | p.Gly17Asp | missense_variant | 1.0 | streptomycin | |
| gid | 4408176 | c.27T>C | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408228 | c.-28_-27delCA | upstream_gene_variant | 0.97 | streptomycin |
