TB-Profiler result

Run: ERR9786515
Summary

Run ID: ERR9786515

Sample name:

Date: 2024-10-05T04:49:21.694327

Number of reads: 704965

Percentage reads mapped: 82.34

Median coverage: 31.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.64
lineage4.1.2 Euro-American None 0.65
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.69
lineage4 Euro-American None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin gid c.102delG Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethA c.1457delC Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
ethA 4326016 c.1457delC frameshift_variant 0.65 ethionamide Assoc w R
gid 4408100 c.102delG frameshift_variant 0.84 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 371 p.Pro124Leu missense_variant 0.57 isoniazid Not assoc w R
dnaA 1152 c.1152A>G synonymous_variant 0.16 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.15 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7033 c.-269G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.66 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9080 c.1779G>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 0.62 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13404 p.Ser52Thr missense_variant 0.49 isoniazid Uncertain significance
fgd1 490887 c.105G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490890 c.108C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 490896 c.114C>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490929 c.147C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490935 c.153C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490948 p.Ser56Ala missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491591 p.Lys270Met missense_variant 0.96 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
mshA 575679 p.Asn111Ser missense_variant 0.44 isoniazid Not assoc w R
ethionamide Not assoc w R
Rv0565c 657259 p.Tyr71Phe missense_variant 0.26 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.26 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.27 ethionamide
Rv0565c 657267 p.Ser68Pro missense_variant 0.28 ethionamide Uncertain significance
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.17 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.19 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.19 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.23 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.16 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.15 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.17 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.18 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.18 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.25 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.26 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.26 isoniazid
nusG 734556 c.303C>T synonymous_variant 0.23 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.28 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.55 rifampicin Not assoc w R
rpoB 760235 c.429T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.34 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.38 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.28 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.29 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.25 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.24 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.2 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.29 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.23 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.29 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.31 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764116 c.747C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.26 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.24 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.23 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.22 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.18 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.24 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.25 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.27 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.23 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.22 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.21 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.2 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.22 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.19 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.64 rifampicin Not assoc w R
rpoC 765409 c.2040T>C synonymous_variant 0.16 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765613 p.His748Gln missense_variant 0.19 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.27 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.23 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.22 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.21 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.21 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.18 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.16 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.2 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.21 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.21 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776656 p.Gly609Arg missense_variant 0.42 bedaquiline Uncertain significance
clofazimine Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781736 c.177T>C synonymous_variant 0.26 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.25 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.23 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.24 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.3 streptomycin Uncertain significance
rplC 800715 c.-94A>C upstream_gene_variant 0.2 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.23 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.23 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.22 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.19 linezolid
rplC 800814 c.6A>G synonymous_variant 0.2 linezolid
rplC 800817 c.9A>T synonymous_variant 0.2 linezolid
rplC 800844 c.36T>C synonymous_variant 0.17 linezolid
rplC 800874 c.66A>G synonymous_variant 0.16 linezolid
rplC 800875 p.Val23Ile missense_variant 0.16 linezolid
rplC 800889 c.81C>G synonymous_variant 0.18 linezolid
rplC 800892 c.84G>C synonymous_variant 0.17 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.18 linezolid
rplC 801402 c.594T>C synonymous_variant 0.22 linezolid
rplC 801405 c.597T>C synonymous_variant 0.22 linezolid
fbiC 1303854 c.924T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.14 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476108 n.2451T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833254 c.-288G>T upstream_gene_variant 0.59 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.14 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.18 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.25 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.31 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.27 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.29 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.25 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 0.65 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518076 c.-39C>T upstream_gene_variant 0.68 isoniazid
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ribD 2986827 c.-12G>A upstream_gene_variant 0.91 para-aminosalicylic_acid
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.24 capreomycin Uncertain significance
Rv2752c 3065018 p.Asn392His missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067556 p.His130Gln missense_variant 0.25 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.26 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.28 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.28 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074440 p.Val11Ala missense_variant 0.22 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 0.58 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 0.58 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625729 c.885A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.19 rifampicin
bedaquiline
mtrA 3627756 c.-407A>T upstream_gene_variant 0.5 rifampicin
bedaquiline
alr 3840764 c.657G>C synonymous_variant 0.3 cycloserine
rpoA 3877613 p.Ile299Val missense_variant 0.19 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.23 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.23 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.25 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.3 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.23 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.23 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.27 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.26 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.26 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.26 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.25 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.25 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.28 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.24 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.23 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.22 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.21 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.21 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.24 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.28 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.28 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.26 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.28 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.3 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.33 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.33 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.36 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.38 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.43 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.44 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.54 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.52 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.52 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.52 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.55 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.55 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.53 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.32 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.34 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.32 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.32 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.3 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.26 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.3 rifampicin
clpC1 4039226 c.1479T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.17 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.17 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
embC 4239298 c.-565C>T upstream_gene_variant 0.65 ethambutol Not assoc w R
embC 4241023 c.1161T>G synonymous_variant 0.18 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.16 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.21 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.24 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.26 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.26 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.26 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.25 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.24 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.55 ethambutol Not assoc w R
embB 4247603 c.1090C>T synonymous_variant 0.2 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.69 kanamycin
capreomycin
amikacin
gid 4407650 p.Asp185Asn missense_variant 0.48 streptomycin Uncertain significance