TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472644	n.799C>T	non_coding_transcript_exon_variant	0.23	streptomycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
rrs	1472119	n.274G>A	non_coding_transcript_exon_variant	0.74	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.94	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472251	n.406G>A	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472282	n.437T>G	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472284	n.439C>T	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472286	n.441C>G	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472293	n.448C>A	non_coding_transcript_exon_variant	0.84	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472297	n.453_465delGTCCGGGTTCTCT	non_coding_transcript_exon_variant	0.97	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472313	n.468_470delGATinsAAAG	non_coding_transcript_exon_variant	0.97	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472328	n.483G>C	non_coding_transcript_exon_variant	0.9	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472332	n.487A>G	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472333	n.488G>A	non_coding_transcript_exon_variant	0.76	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472338	n.493A>G	non_coding_transcript_exon_variant	0.84	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472379	n.534T>C	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472400	n.555C>T	non_coding_transcript_exon_variant	0.62	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472412	n.567A>G	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472416	n.571C>T	non_coding_transcript_exon_variant	0.45	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472422	n.577T>C	non_coding_transcript_exon_variant	0.44	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Uncertain significance
rrs	1472427	n.582T>G	non_coding_transcript_exon_variant	0.32	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472435	n.590T>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472436	n.591G>T	non_coding_transcript_exon_variant	0.35	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472437	n.592T>G	non_coding_transcript_exon_variant	0.35	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472438	n.593T>C	non_coding_transcript_exon_variant	0.98	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472439	n.594C>T	non_coding_transcript_exon_variant	0.65	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472447	n.602C>T	non_coding_transcript_exon_variant	0.64	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472448	n.603T>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472449	n.604C>T	non_coding_transcript_exon_variant	0.35	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472450	n.605A>G	non_coding_transcript_exon_variant	0.98	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472451	n.606C>G	non_coding_transcript_exon_variant	0.98	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472461	n.616G>C	non_coding_transcript_exon_variant	0.64	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472462	n.617T>C	non_coding_transcript_exon_variant	0.64	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472462	n.617T>G	non_coding_transcript_exon_variant	0.35	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472464	n.619A>G	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472471	n.626G>A	non_coding_transcript_exon_variant	0.65	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472473	n.628G>T	non_coding_transcript_exon_variant	0.34	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472474	n.629C>G	non_coding_transcript_exon_variant	0.34	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472476	n.631A>G	non_coding_transcript_exon_variant	0.38	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472485	n.640delGinsTA	non_coding_transcript_exon_variant	0.59	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472489	n.644A>T	non_coding_transcript_exon_variant	0.63	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472494	n.649A>G	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472496	n.651T>A	non_coding_transcript_exon_variant	0.45	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472498	n.653C>T	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472513	n.668T>C	non_coding_transcript_exon_variant	0.21	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472569	n.724G>A	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472597	n.752G>A	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472607	n.762G>A	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472655	n.810G>T	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472660	n.815T>C	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472687	n.842delAinsTCT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472692	n.847T>C	non_coding_transcript_exon_variant	0.96	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472714	n.869A>G	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472790	n.945T>C	non_coding_transcript_exon_variant	0.94	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472824	n.979T>A	non_coding_transcript_exon_variant	0.9	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472825	n.980G>A	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472954	n.1109T>C	non_coding_transcript_exon_variant	0.33	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472956	n.1111T>C	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	0.4	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472958	n.1113A>G	non_coding_transcript_exon_variant	0.31	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472973	n.1128A>G	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.39	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472974	n.1129A>G	non_coding_transcript_exon_variant	0.29	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472988	n.1143T>C	non_coding_transcript_exon_variant	0.35	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472990	n.1145A>G	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472992	n.1147A>G	non_coding_transcript_exon_variant	0.26	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473005	n.1160C>T	non_coding_transcript_exon_variant	0.3	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.8	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473055	n.1210C>T	non_coding_transcript_exon_variant	0.72	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473066	n.1221A>G	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.76	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>T	non_coding_transcript_exon_variant	0.26	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>A	non_coding_transcript_exon_variant	0.73	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.74	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.7	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.72	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.8	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473123	n.1278A>T	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473130	n.1285G>A	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.45	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473172	n.1327T>G	non_coding_transcript_exon_variant	0.41	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473173	n.1328C>T	non_coding_transcript_exon_variant	0.54	streptomycin	Not assoc w R
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473221	n.1376C>T	non_coding_transcript_exon_variant	0.61	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473252	n.1407T>C	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473259	n.1414C>T	non_coding_transcript_exon_variant	0.48	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrl	1475937	n.2280A>T	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1475937	n.2280A>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475943	n.2286G>A	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475945	n.2288C>A	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1475945	n.2288C>A	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1475952	n.2295A>G	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1475970	n.2313C>T	non_coding_transcript_exon_variant	0.77	linezolid	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1475975	n.2318C>T	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1475977	n.2320A>G	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.72	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1475991	n.2334T>C	non_coding_transcript_exon_variant	0.58	capreomycin	Uncertain significance
rrl	1475991	n.2334T>C	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1475992	n.2335T>G	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1475992	n.2335T>G	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1475995	n.2338G>T	non_coding_transcript_exon_variant	0.58	capreomycin
rrl	1475995	n.2338G>T	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1475998	n.2341C>T	non_coding_transcript_exon_variant	0.66	capreomycin
rrl	1475998	n.2341C>T	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1475999	n.2342G>A	non_coding_transcript_exon_variant	0.57	capreomycin
rrl	1475999	n.2342G>A	non_coding_transcript_exon_variant	0.57	linezolid
rrl	1476001	n.2344T>C	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1476001	n.2344T>C	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.46	capreomycin	Uncertain significance
rrl	1476030	n.2373A>G	non_coding_transcript_exon_variant	0.46	linezolid
rrl	1476033	n.2376T>G	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1476033	n.2376T>G	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1476034	n.2377C>T	non_coding_transcript_exon_variant	0.32	capreomycin
rrl	1476034	n.2377C>T	non_coding_transcript_exon_variant	0.32	linezolid
rrl	1476035	n.2378G>T	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1476035	n.2378G>T	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1476046	n.2389G>C	non_coding_transcript_exon_variant	0.28	capreomycin
rrl	1476046	n.2389G>C	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1476058	n.2401T>C	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1476058	n.2401T>C	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1476059	n.2402G>C	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1476059	n.2402G>C	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1476110	n.2453G>C	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476110	n.2453G>C	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1476113	n.2456T>G	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1476113	n.2456T>G	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476164	n.2507A>G	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476164	n.2507A>T	non_coding_transcript_exon_variant	0.63	capreomycin
rrl	1476164	n.2507A>T	non_coding_transcript_exon_variant	0.63	linezolid
rrl	1476179	n.2522C>T	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1476179	n.2522C>T	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.3	capreomycin	Not assoc w R
rrl	1476194	n.2537A>G	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476194	n.2537A>T	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1476194	n.2537A>T	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.97	capreomycin	Not assoc w R
rrl	1476200	n.2543A>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.68	capreomycin
rrl	1476204	n.2547C>T	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1476207	n.2550T>C	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1476207	n.2550T>C	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1476235	n.2578A>G	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476256	n.2599A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476267	n.2610G>T	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1476267	n.2610G>T	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1476276	n.2619C>A	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1476276	n.2619C>A	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1476279	n.2622G>A	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1476279	n.2622G>A	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1476295	n.2638C>A	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1476295	n.2638C>A	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476299	n.2642C>G	non_coding_transcript_exon_variant	0.25	capreomycin
rrl	1476299	n.2642C>G	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1476300	n.2643G>T	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1476301	n.2644A>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476306	n.2649A>G	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1476306	n.2649A>G	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1476307	n.2650A>T	non_coding_transcript_exon_variant	0.48	capreomycin
rrl	1476307	n.2650A>T	non_coding_transcript_exon_variant	0.48	linezolid
rrl	1476308	n.2651G>C	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1476308	n.2651G>C	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1476311	n.2654G>T	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1476311	n.2654G>T	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.72	linezolid	Uncertain significance
rrl	1476337	n.2680C>T	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476337	n.2680C>T	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1476357	n.2700T>C	non_coding_transcript_exon_variant	0.52	capreomycin
rrl	1476357	n.2700T>C	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1476359	n.2702C>G	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1476381	n.2724G>C	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.69	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.69	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.68	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1476513	n.2856G>T	non_coding_transcript_exon_variant	0.63	capreomycin
rrl	1476513	n.2856G>T	non_coding_transcript_exon_variant	0.63	linezolid
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1476523	n.2866T>C	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476523	n.2866T>C	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1476539	n.2882A>G	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1476539	n.2882A>G	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin	rrs	n.799C>T	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

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