Run ID: SRR9613550
Sample name:
Date: 2024-10-05T01:12:01.379678
Number of reads: 8542681
Percentage reads mapped: 99.99
Median coverage: 144.0
Strain: lineage4.1.2.1
Spoligotype:
Drug-resistance: HR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.1 | Euro-American | None | 1.0 |
lineage4.1.2 | Euro-American | None | 1.0 |
lineage4.1.2.1 | Euro-American (Haarlem) | RD182 | 1.0 |
lineage4 | Euro-American | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T |
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
inhA | 1673425 | c.-777C>T | upstream_gene_variant | 0.98 | ethionamide | Assoc w R | Alias fabG1_c.-15C>T |
isoniazid | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8156 | c.855T>C | synonymous_variant | 0.11 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8168 | c.867A>G | synonymous_variant | 0.12 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8324 | c.1023T>C | synonymous_variant | 0.1 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
fgd1 | 491591 | p.Lys270Met | missense_variant | 1.0 | pretomanid | |
delamanid | Uncertain significance | |||||
clofazimine | Not assoc w R | |||||
mshA | 575679 | p.Asn111Ser | missense_variant | 0.95 | isoniazid | Not assoc w R |
ethionamide | Not assoc w R | |||||
Rv0565c | 657269 | p.Ser68Pro | missense_variant | 1.0 | ethionamide | Uncertain significance |
rpoB | 760115 | c.309C>T | synonymous_variant | 0.98 | rifampicin | Not assoc w R |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 760298 | c.492G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 760316 | c.510C>G | synonymous_variant | 0.11 | rifampicin | |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.12 | rifampicin | Uncertain significance |
rpoB | 760407 | p.Ser201Gly | missense_variant | 0.13 | rifampicin | Uncertain significance |
rpoB | 761606 | c.1800C>G | synonymous_variant | 0.14 | rifampicin | |
rpoB | 761615 | c.1809A>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 761645 | c.1839C>G | synonymous_variant | 0.11 | rifampicin | Not assoc w R - Interim |
rpoB | 761999 | c.2193G>C | synonymous_variant | 0.13 | rifampicin | |
rpoB | 762002 | c.2196C>G | synonymous_variant | 0.12 | rifampicin | |
rpoB | 762233 | c.2427G>T | synonymous_variant | 0.14 | rifampicin | |
rpoB | 762239 | c.2433G>A | synonymous_variant | 0.18 | rifampicin | |
rpoB | 762245 | c.2439G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 762284 | c.2478G>T | synonymous_variant | 0.16 | rifampicin | |
rpoB | 762293 | c.2487T>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 762308 | c.2502G>C | synonymous_variant | 0.12 | rifampicin | |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoB | 762959 | c.3153G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 762962 | c.3156C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 762983 | c.-387C>T | upstream_gene_variant | 0.14 | rifampicin | |
rpoB | 762989 | c.3183G>A | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 763004 | c.3198G>A | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 763007 | c.3201C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 763022 | c.-348C>G | upstream_gene_variant | 0.12 | rifampicin | |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 763053 | c.3247T>C | synonymous_variant | 0.11 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.11 | rifampicin | Not assoc w R - Interim |
rpoC | 763621 | c.252C>T | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764320 | c.951C>G | synonymous_variant | 0.1 | rifampicin | |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764605 | c.1236G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764626 | c.1257C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764713 | c.1344G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764746 | c.1377G>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764758 | c.1389C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764800 | c.1431G>A | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R |
rpoC | 764935 | c.1566T>C | synonymous_variant | 0.13 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.11 | rifampicin | Not assoc w R - Interim |
rpoC | 765150 | p.Gly594Glu | missense_variant | 0.99 | rifampicin | Not assoc w R |
rpoC | 767020 | c.3651C>G | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoC | 767023 | c.3654C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 767068 | c.3699G>T | synonymous_variant | 0.15 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoC | 767104 | c.3735C>G | synonymous_variant | 0.1 | rifampicin | Not assoc w R - Interim |
rpoC | 767105 | p.Asn1246His | missense_variant | 0.1 | rifampicin | |
rpoC | 767221 | c.3852C>G | synonymous_variant | 0.11 | rifampicin | Not assoc w R - Interim |
rpoC | 767233 | c.3864T>C | synonymous_variant | 0.11 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 0.99 | streptomycin | Not assoc w R |
rpsL | 781682 | c.123T>C | synonymous_variant | 0.12 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.12 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.14 | streptomycin | Uncertain significance |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471922 | n.78delT | non_coding_transcript_exon_variant | 0.18 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471925 | n.80T>C | non_coding_transcript_exon_variant | 0.18 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1471931 | n.87delA | non_coding_transcript_exon_variant | 0.18 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.19 | kanamycin | |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471986 | n.141C>T | non_coding_transcript_exon_variant | 0.22 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472019 | n.174G>A | non_coding_transcript_exon_variant | 0.16 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472106 | n.261G>A | non_coding_transcript_exon_variant | 0.19 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.2 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 0.25 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472251 | n.406G>A | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472380 | n.535G>C | non_coding_transcript_exon_variant | 0.26 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472446 | n.601T>A | non_coding_transcript_exon_variant | 0.32 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472452 | n.607G>A | non_coding_transcript_exon_variant | 0.3 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472464 | n.619A>G | non_coding_transcript_exon_variant | 0.32 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472755 | n.910G>A | non_coding_transcript_exon_variant | 0.29 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472847 | n.1002G>C | non_coding_transcript_exon_variant | 0.11 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472860 | n.1015C>G | non_coding_transcript_exon_variant | 0.12 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472953 | n.1108G>A | non_coding_transcript_exon_variant | 0.25 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472957 | n.1112C>T | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.24 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.26 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.24 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473110 | n.1265T>G | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>G | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTC | non_coding_transcript_exon_variant | 0.19 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 0.25 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473290 | n.1445C>T | non_coding_transcript_exon_variant | 0.22 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473291 | n.1446_1447insT | non_coding_transcript_exon_variant | 0.23 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473301 | n.1456T>C | non_coding_transcript_exon_variant | 0.23 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473717 | n.60G>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473746 | n.89T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473770 | n.113T>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474425 | n.768A>G | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1474428 | n.771C>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474803 | n.1146G>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474830 | n.1173A>G | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475061 | n.1404C>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475062 | n.1405A>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475120 | n.1463G>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475452 | n.1795C>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475479 | n.1822C>G | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475531 | n.1874C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475544 | n.1887A>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475545 | n.1888T>G | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475659 | n.2002G>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475753 | n.2096C>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475762 | n.2105G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475763 | n.2106C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475764 | n.2107A>C | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475765 | n.2108A>G | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475775 | n.2118G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.17 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475991 | n.2334T>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475995 | n.2338G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476031 | n.2374_2378delCCTCGinsTTCAC | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1476044 | n.2387T>G | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476045 | n.2388G>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476049 | n.2392C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476088 | n.2431A>C | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476099 | n.2442A>G | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476103 | n.2446C>G | non_coding_transcript_exon_variant | 0.12 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476110 | n.2453G>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476115 | n.2458T>C | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476131 | n.2474C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476160 | n.2503T>C | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476251 | n.2594T>G | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476256 | n.2599A>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476260 | n.2603A>G | non_coding_transcript_exon_variant | 0.26 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476299 | n.2642C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476529 | n.2872A>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476540 | n.2883C>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476594 | n.2937C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476603 | n.2946G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476664 | n.3007T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476665 | n.3008T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476674 | n.3017T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476679 | n.3022T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rpsA | 1833894 | p.Ala118Glu | missense_variant | 0.13 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1833949 | c.408T>C | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834361 | c.820T>C | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.1 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1834690 | c.1149T>C | synonymous_variant | 0.13 | pyrazinamide | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
PPE35 | 2170048 | p.Leu189Val | missense_variant | 0.23 | pyrazinamide | |
PPE35 | 2170053 | p.Thr187Ser | missense_variant | 0.22 | pyrazinamide | |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
kasA | 2518076 | c.-39C>T | upstream_gene_variant | 1.0 | isoniazid | |
folC | 2746564 | c.1035A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
Rv2680 | 2996085 | c.-20G>A | upstream_gene_variant | 0.37 | capreomycin | Uncertain significance |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
rpoA | 3878639 | c.-132C>G | upstream_gene_variant | 0.17 | rifampicin | Uncertain significance |
clpC1 | 4038587 | c.2118C>G | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4038596 | c.2109A>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.11 | pyrazinamide | |
clpC1 | 4038838 | c.1867C>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038842 | c.1863G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039046 | c.1659C>T | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039067 | c.1638G>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039079 | c.1626C>G | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039085 | c.1620A>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.11 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.11 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4039556 | c.1149G>C | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4039559 | c.1146C>G | synonymous_variant | 0.11 | pyrazinamide | |
clpC1 | 4039664 | c.1041G>C | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4039670 | c.1035G>C | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4039682 | c.1023C>G | synonymous_variant | 0.11 | pyrazinamide | |
clpC1 | 4039694 | c.1011G>C | synonymous_variant | 0.11 | pyrazinamide | |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.11 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039934 | c.771G>A | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039946 | c.759A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039955 | c.750G>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039958 | c.747G>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039964 | c.741C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039991 | c.714G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040021 | c.684A>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.12 | pyrazinamide | |
embC | 4239298 | c.-565C>T | upstream_gene_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242803 | p.Val981Leu | missense_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4246544 | p.Thr11Pro | missense_variant | 0.18 | ethambutol | Uncertain significance |
embB | 4246548 | p.Pro12Gln | missense_variant | 0.17 | ethambutol | Uncertain significance |
embB | 4246555 | c.42G>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4246556 | p.Ala15Pro | missense_variant | 0.17 | ethambutol | Uncertain significance |
embB | 4246563 | p.Leu17Trp | missense_variant | 0.17 | ethambutol | Uncertain significance |
embB | 4246567 | c.54G>T | synonymous_variant | 0.18 | ethambutol | Not assoc w R - Interim |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin |