TB-Profiler result

Run: ERR266120
Summary

Run ID: ERR266120

Sample name:

Date: 2024-10-05T05:49:34.518425

Number of reads: 4643475

Percentage reads mapped: 96.79

Median coverage: 104.0

Strain: M.canetti

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
M.canetti M.canetti None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5452 c.213G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6454 c.1215C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6721 c.1482C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7093 c.1854T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7763 c.462T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7937 c.636A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7970 c.669T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7988 c.687G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8039 c.738T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8054 c.753T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8219 c.918T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8756 c.1455A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8810 c.1509A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8966 c.1665C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9089 c.1788G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9101 c.1800A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9182 c.1881T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9200 c.1899A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9377 c.2076A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9716 c.2415T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9740 c.2439G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9776 c.2475T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 490666 c.-117G>T upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 490678 c.-105_-104insG upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 490687 c.-96T>C upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 490734 c.-49A>T upstream_gene_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491406 p.Met208Ile missense_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575216 c.-132C>A upstream_gene_variant 1.0 isoniazid Uncertain significance
ethionamide Uncertain significance
mshA 575665 c.318G>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 576757 c.1410C>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ccsA 620256 c.366C>G synonymous_variant 1.0 kanamycin
capreomycin
amikacin
ccsA 620257 p.Ile123Ala missense_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
ccsA 620415 c.525T>C synonymous_variant 1.0 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620490 c.600A>C synonymous_variant 1.0 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620808 c.918T>C synonymous_variant 1.0 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv0565c 657309 c.162C>G synonymous_variant 1.0 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657695 c.-225C>A upstream_gene_variant 1.0 ethionamide
hadA 731852 c.-78A>G upstream_gene_variant 1.0 isoniazid
hadA 732379 c.450A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
nusG 733883 c.-370_-368delGCG upstream_gene_variant 1.0 rifampicin
mmaA3 737397 c.753G>C synonymous_variant 1.0 isoniazid
mmaA3 738177 c.-28G>T upstream_gene_variant 1.0 isoniazid
rpoB 759741 c.-66C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763259 c.-111G>C upstream_gene_variant 1.0 rifampicin
rpoC 763660 c.291T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764107 c.738C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764134 c.765C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764152 c.783C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764159 c.790C>T synonymous_variant 1.0 rifampicin
rpoC 764195 p.Ser276Ala missense_variant 1.0 rifampicin
rpoC 764198 c.829C>T synonymous_variant 1.0 rifampicin
rpoC 764203 c.834G>T synonymous_variant 1.0 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 1.0 rifampicin
rpoC 764245 c.876C>T synonymous_variant 0.99 rifampicin
rpoC 764257 c.888G>C synonymous_variant 1.0 rifampicin
rpoC 764278 c.909A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>A synonymous_variant 1.0 rifampicin
rpoC 764341 c.972G>A synonymous_variant 1.0 rifampicin
rpoC 764365 c.996C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764437 c.1068G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764440 c.1071G>T synonymous_variant 1.0 rifampicin
rpoC 764447 c.1078_1080delCTGinsTTA synonymous_variant 1.0 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 1.0 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 1.0 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 1.0 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 1.0 rifampicin
rpoC 764536 c.1167G>C synonymous_variant 1.0 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>T synonymous_variant 1.0 rifampicin
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 1.0 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 1.0 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 1.0 rifampicin
rpoC 764650 c.1281G>C synonymous_variant 1.0 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 1.0 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 1.0 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>A synonymous_variant 1.0 rifampicin
rpoC 765149 p.Gly594Arg missense_variant 1.0 rifampicin Uncertain significance
rpoC 765177 p.Ser603Asn missense_variant 1.0 rifampicin
rpoC 765186 p.His606Arg missense_variant 1.0 rifampicin
rpoC 765189 p.Pro607Leu missense_variant 1.0 rifampicin
rpoC 765194 p.Thr609Ala missense_variant 1.0 rifampicin
rpoC 765199 c.1830T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765202 c.1833C>G synonymous_variant 1.0 rifampicin
rpoC 765298 c.1929G>T synonymous_variant 1.0 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766186 c.2817G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766189 c.2820T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766594 c.3225G>C synonymous_variant 1.0 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 1.0 rifampicin
rpoC 766621 c.3252G>A synonymous_variant 1.0 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 1.0 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 1.0 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 1.0 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 1.0 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 1.0 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 1.0 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766900 c.3531T>C synonymous_variant 1.0 rifampicin
rpoC 766924 c.3555G>A synonymous_variant 1.0 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766969 c.3600C>G synonymous_variant 1.0 rifampicin
rpoC 767062 c.3693C>A synonymous_variant 1.0 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 779283 c.-803G>A upstream_gene_variant 1.0 bedaquiline
clofazimine
mmpL5 779295 c.-815A>G upstream_gene_variant 1.0 bedaquiline
clofazimine
mmpR5 779431 p.Asn148Gln missense_variant 1.0 bedaquiline
clofazimine
mmpL5 779472 c.-992G>A upstream_gene_variant 1.0 bedaquiline
clofazimine
mmpS5 779523 c.-618T>A upstream_gene_variant 1.0 bedaquiline
clofazimine
mmpS5 779538 c.-633A>C upstream_gene_variant 1.0 bedaquiline
clofazimine
mmpS5 779539 c.-634C>A upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781456 c.-104A>G upstream_gene_variant 1.0 streptomycin Uncertain significance
rplC 800111 c.-698C>T upstream_gene_variant 1.0 linezolid
rplC 800155 c.-654_-653insG upstream_gene_variant 1.0 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid
rplC 800970 c.162T>C synonymous_variant 0.99 linezolid Not assoc w R - Interim
rplC 801003 c.195G>A synonymous_variant 1.0 linezolid Not assoc w R - Interim
rplC 801267 c.459A>G synonymous_variant 1.0 linezolid Not assoc w R - Interim
Rv1129c 1253216 p.Glu440Ala missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
Rv1129c 1253323 c.1212G>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
Rv1129c 1253904 p.Asn211Asp missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254602 c.-68C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
Rv1129c 1254654 c.-120A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
Rv1129c 1254678 c.-144A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
fbiC 1302694 c.-237C>T upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1302810 c.-121C>T upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1302860 c.-71G>A upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1304598 c.1668C>T synonymous_variant 1.0 pretomanid
delamanid
clofazimine
Rv1258c 1406466 p.Ser292Leu missense_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
Rv1258c 1406492 c.849C>A synonymous_variant 1.0 streptomycin Not assoc w R - Interim
pyrazinamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv1258c 1407559 c.-219C>T upstream_gene_variant 1.0 streptomycin
pyrazinamide
isoniazid
embR 1417294 c.54A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embR 1417454 c.-107C>A upstream_gene_variant 1.0 ethambutol
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417925 c.-578C>T upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471850 n.5_6delGTinsTGG non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1474438 n.781A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673257 c.-945C>G upstream_gene_variant 1.0 isoniazid
ethionamide
inhA 1674816 c.615T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
rpsA 1833381 c.-161T>C upstream_gene_variant 1.0 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834912 c.1371A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917606 c.-334G>C upstream_gene_variant 1.0 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2061040 c.1898_*1768del frameshift_variant&stop_lost&splice_region_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
bacA 2064378 c.351C>T synonymous_variant 1.0 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ndh 2101777 c.1266C>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
delamanid
ethionamide Not assoc w R - Interim
ndh 2101852 c.1191G>A synonymous_variant 1.0 isoniazid
delamanid
ethionamide
ndh 2101876 c.1167C>G synonymous_variant 1.0 isoniazid
delamanid
ethionamide
ndh 2101990 c.1053G>T synonymous_variant 1.0 isoniazid
delamanid
ethionamide
ndh 2102005 c.1038G>C synonymous_variant 1.0 isoniazid
delamanid
ethionamide
ndh 2102164 c.879A>G synonymous_variant 1.0 isoniazid
delamanid
ethionamide
ndh 2102353 p.Gln230His missense_variant 1.0 isoniazid Uncertain significance
delamanid
ethionamide Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2156055 c.57C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2156658 c.-547A>G upstream_gene_variant 1.0 isoniazid
PPE35 2167855 p.Phe920Leu missense_variant 1.0 pyrazinamide
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169686 c.927T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2169717 p.Asn299Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170232 c.381T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170394 c.219G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170485 p.Val43Ala missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170694 c.-82T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170720 c.-108A>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170847 c.-235T>C upstream_gene_variant 0.99 pyrazinamide
PPE35 2170858 c.-246A>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170860 c.-248A>C upstream_gene_variant 1.0 pyrazinamide
PPE35 2170868 c.-256T>A upstream_gene_variant 1.0 pyrazinamide
PPE35 2170871 c.-259A>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170890 c.-278G>A upstream_gene_variant 1.0 pyrazinamide
PPE35 2170895 c.-283C>G upstream_gene_variant 1.0 pyrazinamide
PPE35 2170924 c.-312T>C upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2222357 p.Thr270Ala missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223318 c.-154A>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
pncA 2288720 p.Glu174Asp missense_variant 1.0 pyrazinamide Uncertain significance
pncA 2288735 p.Val169Ala missense_variant 1.0 pyrazinamide
pncA 2288791 p.Leu151Met missense_variant 1.0 pyrazinamide
pncA 2288855 c.387T>C synonymous_variant 1.0 pyrazinamide
pncA 2288893 c.349C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
pncA 2288969 p.Glu91Asp missense_variant 1.0 pyrazinamide
pncA 2288981 c.261G>C synonymous_variant 1.0 pyrazinamide
pncA 2289055 p.Asp63Asn missense_variant 1.0 pyrazinamide
pncA 2289104 c.138A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
pncA 2289132 p.Glu37Ala missense_variant 1.0 pyrazinamide Uncertain significance
pncA 2289200 c.42C>T synonymous_variant 1.0 pyrazinamide
pncA 2289267 c.-26C>T upstream_gene_variant 1.0 pyrazinamide
pncA 2289311 c.-70A>G upstream_gene_variant 1.0 pyrazinamide
pncA 2289622 c.-381C>T upstream_gene_variant 1.0 pyrazinamide
pncA 2289643 c.-402C>T upstream_gene_variant 1.0 pyrazinamide
pncA 2289663 c.-422A>G upstream_gene_variant 1.0 pyrazinamide
pncA 2289820 c.-579T>C upstream_gene_variant 1.0 pyrazinamide
pncA 2289823 c.-582T>C upstream_gene_variant 1.0 pyrazinamide
pncA 2289913 c.-672T>C upstream_gene_variant 1.0 pyrazinamide
pncA 2290015 c.-774A>G upstream_gene_variant 1.0 pyrazinamide
pncA 2290072 c.-831T>C upstream_gene_variant 1.0 pyrazinamide
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518252 c.138C>T synonymous_variant 1.0 isoniazid
kasA 2519287 c.1173T>C synonymous_variant 1.0 isoniazid
eis 2714274 c.1059G>A synonymous_variant 1.0 kanamycin
amikacin
eis 2714714 p.Ala207Thr missense_variant 1.0 kanamycin Uncertain significance
amikacin Uncertain significance
eis 2714994 c.339T>C synonymous_variant 1.0 kanamycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ahpC 2725905 c.-288C>A upstream_gene_variant 1.0 isoniazid
folC 2747204 p.Ala132Gln missense_variant 1.0 para-aminosalicylic_acid
folC 2747572 c.27T>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747575 c.24G>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747628 c.-30G>C upstream_gene_variant 1.0 para-aminosalicylic_acid
folC 2747631 c.-33C>G upstream_gene_variant 1.0 para-aminosalicylic_acid
folC 2747691 c.-93A>G upstream_gene_variant 1.0 para-aminosalicylic_acid
Rv2477c 2783425 c.618C>T synonymous_variant 0.99 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2784328 c.-286C>T upstream_gene_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784432 c.-390A>G upstream_gene_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859490 p.Val310Ala missense_variant 1.0 bedaquiline
clofazimine
ribD 2986929 p.Leu31Phe missense_variant 1.0 para-aminosalicylic_acid
Rv2680 2995798 c.-307T>C upstream_gene_variant 1.0 capreomycin
Rv2680 2996009 c.-96T>C upstream_gene_variant 0.86 capreomycin Uncertain significance
Rv2680 2996010 c.-95C>A upstream_gene_variant 0.85 capreomycin Uncertain significance
Rv2680 2996440 c.336G>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2680 2996578 c.474C>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2680 2996737 c.633A>G stop_lost&splice_region_variant 1.0 capreomycin
Rv2681 2997054 p.Ser106Gly missense_variant 0.99 capreomycin Uncertain significance
Rv2681 2997059 c.321C>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997122 c.384A>G synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997293 c.555G>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2752c 3064627 p.Asn522Ser missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065499 c.693A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066354 c.-163G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066905 c.-714T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067239 p.Ala236Asp missense_variant 1.0 para-aminosalicylic_acid
thyX 3067444 p.Arg168Cys missense_variant 0.99 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074238 c.234C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074247 c.225C>T synonymous_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087122 c.303T>C synonymous_variant 1.0 cycloserine
ald 3087140 c.321G>A synonymous_variant 1.0 cycloserine
fbiD 3339049 c.-69C>T upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
fbiD 3339402 c.285C>T synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiD 3339568 c.451C>T synonymous_variant 1.0 pretomanid
delamanid
clofazimine
Rv3083 3448325 c.-179G>A upstream_gene_variant 1.0 ethionamide
Rv3083 3448474 c.-30G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448611 c.108A>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3448972 p.His157Asp missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3449109 c.606C>T synonymous_variant 1.0 ethionamide
Rv3083 3449139 c.636A>G synonymous_variant 1.0 ethionamide
Rv3083 3449237 p.Arg245Lys missense_variant 1.0 ethionamide
Rv3083 3449253 c.750C>T synonymous_variant 1.0 ethionamide
Rv3083 3449263 p.Leu254Val missense_variant 1.0 ethionamide
Rv3083 3449290 p.Lys263Gln missense_variant 1.0 ethionamide
Rv3083 3449305 c.802T>C synonymous_variant 1.0 ethionamide
Rv3083 3449323 c.820_822delCGAinsAGG synonymous_variant 1.0 ethionamide
Rv3083 3449375 p.Leu291Arg missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3449400 c.897C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449412 c.909C>T synonymous_variant 0.99 ethionamide
Rv3083 3449421 c.918T>C synonymous_variant 1.0 ethionamide
Rv3083 3449545 c.1042C>T synonymous_variant 1.0 ethionamide
Rv3083 3449622 c.1119T>C synonymous_variant 1.0 ethionamide
Rv3083 3449652 c.1149T>C synonymous_variant 1.0 ethionamide
Rv3083 3449767 p.Thr422Val missense_variant 1.0 ethionamide
Rv3083 3449778 c.1275T>C synonymous_variant 1.0 ethionamide
Rv3083 3449802 c.1299T>C synonymous_variant 1.0 ethionamide
Rv3083 3449820 c.1317G>C synonymous_variant 1.0 ethionamide
Rv3083 3449832 c.1329T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449835 c.1332G>C synonymous_variant 1.0 ethionamide
Rv3083 3449854 p.Met451Leu missense_variant 1.0 ethionamide
Rv3083 3449917 p.Ile472Val missense_variant 1.0 ethionamide
Rv3083 3449940 c.1437T>C synonymous_variant 1.0 ethionamide
whiB7 3568687 c.-8A>T upstream_gene_variant 1.0 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
Rv3236c 3611968 c.1149T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612211 c.906A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612250 c.867A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612301 c.816G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612541 c.576G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612561 p.Thr186Ala missense_variant 1.0 pyrazinamide Uncertain significance
Rv3236c 3612577 c.540G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612580 c.537C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3612709 c.408G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv3236c 3613056 c.61C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625006 c.1608A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626461 c.153A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626999 c.351G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627190 c.160T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627715 c.-366G>A upstream_gene_variant 1.0 rifampicin Uncertain significance
bedaquiline
mtrA 3627734 c.-385A>G upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrA 3627802 c.-453T>C upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrA 3627831 c.-482T>C upstream_gene_variant 1.0 rifampicin
bedaquiline
mtrA 3627839 c.-490T>C upstream_gene_variant 1.0 rifampicin
bedaquiline
fbiA 3640799 p.Trp86Leu missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiB 3641840 c.306T>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiB 3642254 c.720G>A synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiB 3642467 c.933T>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fbiB 3642852 p.Pro440Ser missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fbiB 3642870 p.Ile446Val missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiB 3642874 p.Leu447Arg missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
alr 3840527 c.894A>C synonymous_variant 1.0 cycloserine
alr 3840620 c.801T>C synonymous_variant 1.0 cycloserine
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
alr 3840796 p.Asp209Asn missense_variant 1.0 cycloserine
alr 3840914 c.507G>C synonymous_variant 1.0 cycloserine
alr 3840994 p.His143Asp missense_variant 1.0 cycloserine
alr 3841112 c.309T>C synonymous_variant 1.0 cycloserine
alr 3841116 p.Ala102Gly missense_variant 1.0 cycloserine
alr 3841172 c.249A>C synonymous_variant 1.0 cycloserine
alr 3841199 c.222T>C synonymous_variant 1.0 cycloserine
alr 3841419 p.Val1Ala missense_variant 1.0 cycloserine
rpoA 3877527 c.981C>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877740 c.768G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>T synonymous_variant 1.0 rifampicin
rpoA 3877886 c.622C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878049 c.459G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878623 c.-116C>T upstream_gene_variant 1.0 rifampicin
rpoA 3878637 c.-130G>A upstream_gene_variant 1.0 rifampicin
rpoA 3878665 c.-158A>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878722 c.-215C>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878746 c.-239A>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878848 c.-341C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878914 c.-407T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878947 c.-440G>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878961 c.-454C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3879193 c.-686G>A upstream_gene_variant 1.0 rifampicin
ddn 3986910 c.67C>A synonymous_variant 1.0 pretomanid
delamanid
ddn 3987050 c.207C>T synonymous_variant 1.0 pretomanid
delamanid
ddn 3987287 c.444T>C synonymous_variant 1.0 pretomanid
delamanid
clpC1 4038227 c.2478G>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038443 c.2262G>A synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
clpC1 4038683 c.2022T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038746 c.1959C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038779 c.1926C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038848 c.1857C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039046 c.1659C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039058 c.1647C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039094 c.1611C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039100 c.1605C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039336 c.1369C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039352 c.1353C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039448 c.1257A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039502 c.1203C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039682 c.1023C>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039700 c.1005C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039718 c.987C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040045 c.660C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040063 c.642G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.615T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040147 c.558A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040159 c.546G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040213 c.492T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.429C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040363 c.342A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040393 c.312G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040450 c.255A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040471 c.234T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040534 c.171A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040551 c.154T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040573 c.132T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040657 c.48T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040879 c.-177_-175delTGGinsCGGT upstream_gene_variant 1.0 pyrazinamide
panD 4043932 p.Met117Thr missense_variant 1.0 pyrazinamide Uncertain significance
panD 4044243 c.39C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
panD 4044533 c.-252T>C upstream_gene_variant 1.0 pyrazinamide
panD 4044569 c.-289_-288delCGinsGC upstream_gene_variant 1.0 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138883 c.873C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139321 c.435T>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139420 c.336T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139813 c.-58T>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139934 c.-179A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239032 c.-831T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239110 c.-753C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239764 c.-99G>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240237 c.375G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243377 p.Ser49Arg missense_variant 1.0 ethambutol Uncertain significance
embA 4243690 p.Met153Thr missense_variant 1.0 ethambutol Uncertain significance
embA 4243919 c.687G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4244127 p.Thr299Ala missense_variant 1.0 ethambutol
embA 4244154 p.Thr308Pro missense_variant 1.0 ethambutol Uncertain significance
embA 4244312 c.1080T>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4245023 c.1791A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4245701 c.2469G>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247590 c.1077A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247815 c.1302C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248195 p.Lys561Met missense_variant 1.0 ethambutol Uncertain significance
embB 4248206 p.Ser565Gly missense_variant 1.0 ethambutol Uncertain significance
embB 4248439 c.1926C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248664 c.2151G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248721 c.2208C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248744 p.Val744Ala missense_variant 1.0 ethambutol Uncertain significance
embB 4248853 c.2340G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4249069 c.2556A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
aftB 4268331 p.Gln169Pro missense_variant 1.0 ethambutol Uncertain significance
aftB 4268810 c.27G>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269588 c.246G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269811 p.Gln8Arg missense_variant 1.0 ethambutol Uncertain significance
ethA 4326403 c.1071C>T synonymous_variant 0.99 ethionamide
ethA 4326409 c.1065T>C synonymous_variant 1.0 ethionamide
ethA 4326487 c.987A>T synonymous_variant 1.0 ethionamide
ethA 4326678 p.Ser266Gly missense_variant 1.0 ethionamide
ethR 4326760 c.-789T>C upstream_gene_variant 1.0 ethionamide
ethA 4327092 p.Ala128Thr missense_variant 1.0 ethionamide
ethA 4327474 c.-1C>T upstream_gene_variant 1.0 ethionamide
ethA 4327532 c.-59G>T upstream_gene_variant 1.0 ethionamide
ethA 4327546 c.-74_-73insC upstream_gene_variant 1.0 ethionamide
ethA 4328308 c.-835G>C upstream_gene_variant 1.0 ethionamide
ethA 4328358 c.-885C>T upstream_gene_variant 1.0 ethionamide
ethA 4328425 c.-952C>G upstream_gene_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
whiB6 4338741 c.-220A>G upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
whiB6 4338785 c.-266_-264delGGCinsAG upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
whiB6 4338878 c.-357C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408185 c.18C>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim