TB-Profiler result

Run: ERR4815079
Summary

Run ID: ERR4815079

Sample name:

Date: 01-04-2023 13:39:30

Number of reads: 583149

Percentage reads mapped: 46.7

Strain: lineage3

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.26 rifampicin
rpoB 761196 p.Leu464Met missense_variant 0.21 rifampicin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.7 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.84 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.7 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6316 c.-986G>C upstream_gene_variant 0.24
gyrB 6323 p.Val362Leu missense_variant 0.21
gyrA 6326 c.-976_-975delAGinsTC upstream_gene_variant 0.21
gyrA 6331 c.-971A>G upstream_gene_variant 0.24
gyrB 6364 p.Leu375Phe missense_variant 0.12
gyrB 6371 p.Thr378Ser missense_variant 0.12
gyrB 6416 c.1180delC frameshift_variant 0.17
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7430 p.Glu43Asp missense_variant 0.14
gyrA 7457 c.156T>C synonymous_variant 0.12
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9135 p.Ile612Phe missense_variant 0.12
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491027 p.Asn82Thr missense_variant 0.23
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 576784 c.1437C>T synonymous_variant 0.22
ccsA 620748 c.858T>G synonymous_variant 0.18
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 760692 p.Lys296Glu missense_variant 0.17
rpoB 760916 c.1110C>T synonymous_variant 0.22
rpoB 760920 p.Leu372Ile missense_variant 0.22
rpoB 760926 p.Thr374Ala missense_variant 0.18
rpoB 760931 c.1125C>G synonymous_variant 0.15
rpoB 760973 c.1167G>C synonymous_variant 0.14
rpoB 760982 c.1176G>C synonymous_variant 0.13
rpoB 760985 c.1179G>C synonymous_variant 0.14
rpoB 760988 c.1182C>G synonymous_variant 0.14
rpoB 760991 c.1185G>C synonymous_variant 0.13
rpoB 760997 c.1191G>C synonymous_variant 0.13
rpoB 761015 c.1209G>C synonymous_variant 0.17
rpoB 761027 c.1221A>C synonymous_variant 0.22
rpoB 761036 c.1230G>C synonymous_variant 0.24
rpoB 761037 c.1231T>C synonymous_variant 0.24
rpoB 761051 c.1245G>C synonymous_variant 0.19
rpoB 761054 c.1248G>C synonymous_variant 0.19
rpoB 761060 c.1254C>G synonymous_variant 0.19
rpoB 761063 c.1257C>G synonymous_variant 0.19
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.27
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.26
rpoB 761102 c.1296A>G synonymous_variant 0.26
rpoB 761132 c.1326G>C synonymous_variant 0.26
rpoB 761133 c.1327T>C synonymous_variant 0.26
rpoB 761138 c.1332C>G synonymous_variant 0.26
rpoB 761150 c.1344A>C synonymous_variant 0.31
rpoB 761156 c.1350G>C synonymous_variant 0.28
rpoB 761162 c.1356G>C synonymous_variant 0.27
rpoB 761165 c.1359G>C synonymous_variant 0.23
rpoB 761168 c.1362C>G synonymous_variant 0.24
rpoB 761174 c.1368T>C synonymous_variant 0.24
rpoB 761180 c.1374A>C synonymous_variant 0.2
rpoB 761183 c.1377T>C synonymous_variant 0.2
rpoB 761186 p.Glu460Asp missense_variant 0.24
rpoB 761195 c.1389G>C synonymous_variant 0.21
rpoB 761207 c.1401C>T synonymous_variant 0.24
rpoB 761213 c.1407G>C synonymous_variant 0.19
rpoB 761963 c.2157G>C synonymous_variant 0.18
rpoB 761974 p.His723Leu missense_variant 0.18
rpoB 762003 p.Asn733Gln missense_variant 0.33
rpoB 762009 p.Leu735Met missense_variant 0.35
rpoB 762015 p.Glu737Ser missense_variant 0.32
rpoB 762026 c.2220G>C synonymous_variant 0.42
rpoB 762053 c.2247T>C synonymous_variant 0.41
rpoB 762057 p.Ile751Val missense_variant 0.39
rpoB 762062 c.2256T>C synonymous_variant 0.44
rpoB 762065 c.2259T>C synonymous_variant 0.43
rpoB 762083 c.2277T>C synonymous_variant 0.32
rpoB 762086 c.2280G>C synonymous_variant 0.34
rpoB 762110 c.2304G>C synonymous_variant 0.14
rpoB 762114 p.Ile770Val missense_variant 0.13
rpoB 762122 p.Asp772Glu missense_variant 0.13
rpoB 762426 p.Ser874Thr missense_variant 0.15
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoB 762441 p.Leu879Met missense_variant 0.23
rpoC 762452 c.-918G>C upstream_gene_variant 0.23
rpoC 762470 c.-900G>C upstream_gene_variant 0.18
rpoB 762474 p.Gly890Ser missense_variant 0.18
rpoB 762489 p.Val895Leu missense_variant 0.15
rpoC 762509 c.-861T>G upstream_gene_variant 0.17
rpoC 762512 c.-858C>G upstream_gene_variant 0.17
rpoC 762827 c.-543G>C upstream_gene_variant 0.17
rpoB 762832 p.Ser1009Thr missense_variant 0.25
rpoB 762849 p.Tyr1015Asp missense_variant 0.24
rpoC 762857 c.-513C>G upstream_gene_variant 0.21
rpoB 762858 p.Thr1018Ser missense_variant 0.21
rpoC 762863 c.-507T>G upstream_gene_variant 0.21
rpoB 762878 p.Ile1024Met missense_variant 0.25
rpoB 762879 p.Met1025Leu missense_variant 0.25
rpoC 762920 c.-450C>T upstream_gene_variant 0.29
rpoC 762926 c.-444C>G upstream_gene_variant 0.26
rpoC 762929 c.-441G>C upstream_gene_variant 0.23
rpoC 762947 c.-423C>G upstream_gene_variant 0.16
rpoC 762971 c.-399G>C upstream_gene_variant 0.12
rpoC 762980 c.-390T>C upstream_gene_variant 0.12
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763483 c.114G>C synonymous_variant 0.12
rpoC 763486 c.117T>G synonymous_variant 0.12
rpoC 763504 c.135C>A synonymous_variant 0.18
rpoC 763507 c.138G>C synonymous_variant 0.26
rpoC 763528 c.159G>C synonymous_variant 0.26
rpoC 763531 c.162G>C synonymous_variant 0.26
rpoC 763534 c.165T>C synonymous_variant 0.26
rpoC 763537 c.168C>T synonymous_variant 0.25
rpoC 763546 c.177A>G synonymous_variant 0.26
rpoC 763550 p.Tyr61Ala missense_variant 0.26
rpoC 763570 c.201G>C synonymous_variant 0.35
rpoC 763622 p.Ala85Ser missense_variant 0.41
rpoC 763633 c.264T>C synonymous_variant 0.41
rpoC 763636 c.267T>C synonymous_variant 0.41
rpoC 763639 p.Glu90Asp missense_variant 0.42
rpoC 763642 c.273G>C synonymous_variant 0.44
rpoC 763660 c.291T>G synonymous_variant 0.5
rpoC 763663 c.294C>T synonymous_variant 0.5
rpoC 763669 c.300C>G synonymous_variant 0.46
rpoC 763696 c.327T>C synonymous_variant 0.44
rpoC 763708 c.339G>C synonymous_variant 0.4
rpoC 763714 c.345G>C synonymous_variant 0.36
rpoC 763717 c.348T>C synonymous_variant 0.35
rpoC 763732 c.363C>G synonymous_variant 0.29
rpoC 763744 c.375G>C synonymous_variant 0.24
rpoC 763751 p.Ile128Val missense_variant 0.23
rpoC 763765 c.396T>G synonymous_variant 0.23
rpoC 763768 c.399C>G synonymous_variant 0.21
rpoC 763772 p.Val135Met missense_variant 0.19
rpoC 764308 c.939G>C synonymous_variant 0.13
rpoC 764344 c.975C>T synonymous_variant 0.29
rpoC 764359 c.990C>G synonymous_variant 0.35
rpoC 764371 c.1002G>C synonymous_variant 0.38
rpoC 764377 c.1008C>G synonymous_variant 0.38
rpoC 764380 c.1011G>C synonymous_variant 0.43
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.46
rpoC 764404 c.1035C>T synonymous_variant 0.46
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.48
rpoC 764419 c.1050C>T synonymous_variant 0.64
rpoC 764428 c.1059G>C synonymous_variant 0.64
rpoC 764434 c.1065A>G synonymous_variant 0.63
rpoC 764435 c.1066A>C synonymous_variant 0.65
rpoC 764441 p.Ile358Leu missense_variant 0.72
rpoC 764446 c.1077T>C synonymous_variant 0.58
rpoC 764449 c.1080G>C synonymous_variant 0.58
rpoC 764452 c.1083T>C synonymous_variant 0.56
rpoC 764458 c.1089G>C synonymous_variant 0.57
rpoC 764461 c.1092A>G synonymous_variant 0.58
rpoC 764485 c.1116G>C synonymous_variant 0.62
rpoC 764497 c.1128A>G synonymous_variant 0.62
rpoC 764498 p.Ser377Ala missense_variant 0.67
rpoC 764507 p.Ala380Ser missense_variant 0.69
rpoC 764521 c.1152T>C synonymous_variant 0.66
rpoC 764539 c.1170C>G synonymous_variant 0.69
rpoC 764542 c.1173C>G synonymous_variant 0.69
rpoC 764548 c.1179G>C synonymous_variant 0.76
rpoC 764560 c.1191T>C synonymous_variant 0.72
rpoC 764575 c.1206T>C synonymous_variant 0.68
rpoC 764581 c.1212T>C synonymous_variant 0.71
rpoC 764582 p.Leu405Met missense_variant 0.72
rpoC 764611 c.1242G>T synonymous_variant 0.74
rpoC 764632 c.1263T>C synonymous_variant 0.65
rpoC 764635 c.1266C>G synonymous_variant 0.64
rpoC 764650 c.1281G>C synonymous_variant 0.63
rpoC 764665 c.1296C>G synonymous_variant 0.58
rpoC 764668 c.1299C>T synonymous_variant 0.55
rpoC 764671 c.1302G>C synonymous_variant 0.57
rpoC 764695 c.1326T>C synonymous_variant 0.52
rpoC 764701 c.1332C>G synonymous_variant 0.51
rpoC 764706 p.Leu446Gln missense_variant 0.5
rpoC 764746 c.1377G>T synonymous_variant 0.4
rpoC 764749 c.1380G>C synonymous_variant 0.4
rpoC 764758 c.1389C>G synonymous_variant 0.38
rpoC 764764 c.1395T>C synonymous_variant 0.36
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.41
rpoC 764804 p.Gln479Phe missense_variant 0.3
rpoC 764809 c.1440C>T synonymous_variant 0.26
rpoC 764812 c.1443C>G synonymous_variant 0.26
rpoC 764815 c.1446A>G synonymous_variant 0.26
rpoC 764818 c.1449G>C synonymous_variant 0.26
rpoC 764824 c.1455T>C synonymous_variant 0.26
rpoC 764833 c.1464A>G synonymous_variant 0.26
rpoC 764843 p.Ala492Thr missense_variant 0.29
rpoC 764857 c.1488G>C synonymous_variant 0.28
rpoC 764858 c.1489T>C synonymous_variant 0.26
rpoC 764872 c.1503A>C synonymous_variant 0.3
rpoC 764887 c.1518G>T synonymous_variant 0.32
rpoC 764888 c.1519T>C synonymous_variant 0.25
rpoC 764893 c.1524T>C synonymous_variant 0.29
rpoC 766877 p.Ser1170Thr missense_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 777136 p.Met449Leu missense_variant 0.2
mmpL5 777142 p.Val447Met missense_variant 0.2
mmpL5 777159 c.1321delG frameshift_variant 0.25
mmpL5 777166 p.Ser439Ala missense_variant 0.25
mmpL5 777167 p.Phe438Leu missense_variant 0.25
mmpL5 777170 c.1310_1311insC frameshift_variant 0.25
mmpL5 777173 c.1308C>G synonymous_variant 0.25
mmpL5 777176 p.Glu435Asp missense_variant 0.25
mmpL5 777179 c.1302G>C synonymous_variant 0.25
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781754 c.195G>C synonymous_variant 0.15
rpsL 781760 c.201T>C synonymous_variant 0.15
rpsL 781796 p.Met79Ile missense_variant 0.15
rpsL 781802 c.243G>C synonymous_variant 0.13
rpsL 781805 c.246G>C synonymous_variant 0.14
Rv1258c 1407084 p.Val86Gly missense_variant 0.2
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471967 n.122G>A non_coding_transcript_exon_variant 0.12
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.12
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.12
rrs 1471980 n.135G>T non_coding_transcript_exon_variant 0.12
rrs 1471981 n.136C>A non_coding_transcript_exon_variant 0.12
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.36
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.36
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.36
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.36
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.36
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.66
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.76
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.47
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.64
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.33
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.45
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.43
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.43
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.75
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.8
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.71
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.71
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.7
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.7
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.44
rrs 1472674 n.829T>A non_coding_transcript_exon_variant 0.44
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.44
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.44
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.44
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.44
rrs 1472686 n.841G>T non_coding_transcript_exon_variant 0.4
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.4
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.4
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.4
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.46
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.25
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.46
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.5
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.5
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.5
rrs 1472973 n.1128A>C non_coding_transcript_exon_variant 0.48
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.48
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.47
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.47
rrs 1473022 n.1177G>A non_coding_transcript_exon_variant 0.55
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.59
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.56
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.57
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.59
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.67
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.57
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.57
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.55
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.55
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.55
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.55
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.55
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.57
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.57
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.57
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.62
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.62
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.85
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.85
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.79
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.74
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.68
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.71
rrs 1473317 n.1472G>A non_coding_transcript_exon_variant 0.71
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.29
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.25
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.33
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.43
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.5
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.5
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.5
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.5
rrl 1474124 n.467G>C non_coding_transcript_exon_variant 0.67
rrl 1474125 n.468C>G non_coding_transcript_exon_variant 0.67
rrl 1474133 n.476T>A non_coding_transcript_exon_variant 0.67
rrl 1474141 n.484G>C non_coding_transcript_exon_variant 0.67
rrl 1474142 n.485C>G non_coding_transcript_exon_variant 0.67
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.67
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.8
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.57
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.57
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.57
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.57
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.57
rrl 1474186 n.529A>T non_coding_transcript_exon_variant 0.57
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.62
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.62
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.57
rrl 1474275 n.618T>A non_coding_transcript_exon_variant 0.6
rrl 1474280 n.623C>T non_coding_transcript_exon_variant 0.6
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.6
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.6
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.6
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.6
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.6
rrl 1474317 n.660G>A non_coding_transcript_exon_variant 0.6
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.67
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.67
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.5
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.67
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.67
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.67
rrl 1474381 n.724T>A non_coding_transcript_exon_variant 0.67
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 1.0
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 1.0
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 1.0
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 1.0
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 1.0
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 1.0
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 1.0
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 1.0
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.67
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.67
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.67
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.67
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.67
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.71
rrl 1474662 n.1005C>A non_coding_transcript_exon_variant 0.8
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.8
rrl 1474688 n.1031G>T non_coding_transcript_exon_variant 0.73
rrl 1474710 n.1053T>G non_coding_transcript_exon_variant 0.67
rrl 1474711 n.1054_1055insAA non_coding_transcript_exon_variant 0.67
rrl 1474714 n.1058delT non_coding_transcript_exon_variant 0.67
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.67
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.67
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.67
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.67
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.67
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.67
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.67
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.78
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.78
rrl 1474784 n.1127C>T non_coding_transcript_exon_variant 0.78
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.78
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.6
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.5
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.6
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.75
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.75
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.75
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.75
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.75
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 1.0
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 1.0
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 1.0
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.5
rrl 1475757 n.2101_2104delACCC non_coding_transcript_exon_variant 1.0
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 1.0
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 1.0
rrl 1475766 n.2109G>C non_coding_transcript_exon_variant 1.0
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 1.0
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 1.0
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 1.0
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 1.0
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 1.0
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 1.0
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 1.0
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 1.0
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 1.0
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.6
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.6
rrl 1476186 n.2529T>G non_coding_transcript_exon_variant 0.33
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.83
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.8
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.8
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.83
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.83
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.83
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.57
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.33
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.33
rrl 1476253 n.2596A>G non_coding_transcript_exon_variant 0.33
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.33
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.33
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.33
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.29
rrl 1476308 n.2651G>C non_coding_transcript_exon_variant 0.44
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.44
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.44
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.58
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.7
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.76
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.7
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.73
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.71
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.36
rpsA 1833668 p.Ile43Val missense_variant 0.18
rpsA 1833676 c.135A>G synonymous_variant 0.16
rpsA 1833685 c.144G>C synonymous_variant 0.2
rpsA 1833694 c.153G>C synonymous_variant 0.24
rpsA 1833697 c.156C>G synonymous_variant 0.27
rpsA 1833721 c.180A>G synonymous_variant 0.4
rpsA 1833727 c.186G>C synonymous_variant 0.35
rpsA 1833733 c.192C>G synonymous_variant 0.33
rpsA 1833734 p.Ala65Ser missense_variant 0.33
rpsA 1833742 c.201A>G synonymous_variant 0.36
rpsA 1833763 c.222C>G synonymous_variant 0.36
rpsA 1833769 c.228C>G synonymous_variant 0.29
rpsA 1833770 p.Asn77Asp missense_variant 0.29
rpsA 1833781 c.240T>G synonymous_variant 0.24
rpsA 1833782 p.Ser81Ala missense_variant 0.24
rpsA 1833787 c.246C>G synonymous_variant 0.24
rpsA 1833790 c.249T>C synonymous_variant 0.24
rpsA 1833794 p.Glu85Thr missense_variant 0.24
rpsA 1833802 c.261A>G synonymous_variant 0.25
rpsA 1833811 c.270G>C synonymous_variant 0.3
rpsA 1833829 c.288A>G synonymous_variant 0.37
rpsA 1833835 c.294C>T synonymous_variant 0.36
rpsA 1833838 c.297G>C synonymous_variant 0.34
rpsA 1833841 c.300C>G synonymous_variant 0.34
rpsA 1833850 c.309C>G synonymous_variant 0.31
rpsA 1833856 c.315A>G synonymous_variant 0.3
rpsA 1833862 c.321G>C synonymous_variant 0.27
rpsA 1833874 c.333T>C synonymous_variant 0.25
rpsA 1833884 p.Thr115Asp missense_variant 0.18
rpsA 1833893 p.Ala118Lys missense_variant 0.16
rpsA 1833896 p.Leu119Ile missense_variant 0.17
rpsA 1833905 p.Lys122Glu missense_variant 0.17
rpsA 1833912 p.Glu124Gly missense_variant 0.18
rpsA 1833915 p.Ala125Val missense_variant 0.18
rpsA 1833920 p.Lys127Glu missense_variant 0.19
rpsA 1833928 c.387G>C synonymous_variant 0.19
rpsA 1833940 c.399C>G synonymous_variant 0.17
rpsA 1833949 c.408T>C synonymous_variant 0.21
rpsA 1833955 c.414G>C synonymous_variant 0.12
rpsA 1833970 c.429G>C synonymous_variant 0.2
rpsA 1833979 c.438T>C synonymous_variant 0.18
rpsA 1833985 c.444G>C synonymous_variant 0.15
rpsA 1833988 c.447C>G synonymous_variant 0.15
rpsA 1833994 c.453G>C synonymous_variant 0.14
rpsA 1833997 c.456G>C synonymous_variant 0.13
rpsA 1834012 c.471G>C synonymous_variant 0.19
rpsA 1834025 p.Gln162Ala missense_variant 0.19
rpsA 1834040 p.Lys167Gln missense_variant 0.19
rpsA 1834043 p.Glu168Lys missense_variant 0.19
rpsA 1834046 p.Ile169Leu missense_variant 0.2
rpsA 1834054 c.513C>G synonymous_variant 0.2
rpsA 1834102 c.561T>C synonymous_variant 0.13
rpsA 1834195 c.654G>C synonymous_variant 0.13
rpsA 1834213 c.672G>C synonymous_variant 0.22
rpsA 1834219 c.678C>G synonymous_variant 0.31
rpsA 1834222 c.681T>C synonymous_variant 0.32
rpsA 1834225 c.684C>G synonymous_variant 0.32
rpsA 1834231 c.690T>C synonymous_variant 0.34
rpsA 1834240 c.699T>C synonymous_variant 0.35
rpsA 1834243 c.702G>C synonymous_variant 0.36
rpsA 1834249 c.708T>C synonymous_variant 0.5
rpsA 1834261 c.720A>G synonymous_variant 0.59
rpsA 1834264 c.723G>C synonymous_variant 0.59
rpsA 1834294 c.753G>C synonymous_variant 0.57
rpsA 1834298 p.Gln253Glu missense_variant 0.57
rpsA 1834303 c.762T>G synonymous_variant 0.52
rpsA 1834306 c.765T>C synonymous_variant 0.54
rpsA 1834307 p.Asp256Gln missense_variant 0.54
rpsA 1834327 c.786G>C synonymous_variant 0.47
rpsA 1834333 p.Asp264Glu missense_variant 0.45
rpsA 1834336 c.795C>G synonymous_variant 0.41
rpsA 1834348 c.807T>C synonymous_variant 0.26
rpsA 1834354 c.813G>T synonymous_variant 0.25
rpsA 1834357 c.816T>C synonymous_variant 0.24
rpsA 1834360 c.819G>C synonymous_variant 0.24
rpsA 1834361 c.820T>C synonymous_variant 0.22
rpsA 1834366 c.825A>G synonymous_variant 0.26
rpsA 1834369 c.828C>G synonymous_variant 0.29
rpsA 1834378 c.837T>C synonymous_variant 0.32
rpsA 1834384 c.843A>G synonymous_variant 0.33
rpsA 1834395 p.Arg285Gln missense_variant 0.29
rpsA 1834398 p.His286Leu missense_variant 0.28
rpsA 1834411 c.870T>C synonymous_variant 0.24
rpsA 1834417 c.876G>C synonymous_variant 0.26
rpsA 1834418 p.Ile293Leu missense_variant 0.25
rpsA 1834423 c.882G>C synonymous_variant 0.26
rpsA 1834427 p.Ile296Val missense_variant 0.26
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.26
rpsA 1834456 c.915T>G synonymous_variant 0.23
rpsA 1834465 c.924T>C synonymous_variant 0.22
rpsA 1834468 c.927A>G synonymous_variant 0.18
rpsA 1834486 p.Glu315Asp missense_variant 0.16
rpsA 1834489 c.948T>C synonymous_variant 0.16
rpsA 1834501 c.960G>C synonymous_variant 0.19
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155173 c.939C>T synonymous_variant 0.15
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167965 p.Ala883Gly missense_variant 0.12
PPE35 2167967 c.2646A>C synonymous_variant 0.12
PPE35 2169475 p.Gly380Ser missense_variant 0.15
PPE35 2169602 c.1011C>A synonymous_variant 0.14
PPE35 2169995 p.Ser206Arg missense_variant 0.22
PPE35 2170196 p.Ala139Glu missense_variant 0.25
PPE35 2170202 c.411A>G synonymous_variant 0.29
PPE35 2170398 p.Tyr72Cys missense_variant 0.13
Rv1979c 2222025 c.1140C>T synonymous_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
kasA 2518879 c.765A>G synonymous_variant 0.18
kasA 2518882 c.768C>A synonymous_variant 0.2
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
ahpC 2726338 p.Val49Gly missense_variant 0.29
thyA 3074648 c.-177T>G upstream_gene_variant 0.3
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086987 p.Gln56His missense_variant 1.0
Rv3083 3448873 p.Ala124Thr missense_variant 0.18
Rv3083 3449562 c.1059G>A synonymous_variant 0.14
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474143 p.Trp46Tyr missense_variant 0.17
fprA 3474165 c.159C>G synonymous_variant 0.15
fbiB 3642877 p.Lys448Arg missense_variant 1.0
rpoA 3877935 p.Lys191Arg missense_variant 0.23
rpoA 3877959 c.549C>A synonymous_variant 0.21
rpoA 3877962 c.546G>T synonymous_variant 0.21
rpoA 3877971 p.Asp179Glu missense_variant 0.22
rpoA 3877974 c.534G>C synonymous_variant 0.26
rpoA 3877981 p.Tyr176Phe missense_variant 0.23
rpoA 3877989 c.519A>G synonymous_variant 0.26
rpoA 3877995 c.513G>C synonymous_variant 0.22
rpoA 3878001 c.507A>C synonymous_variant 0.2
clpC1 4038863 c.1842G>C synonymous_variant 0.12
clpC1 4038878 c.1827A>G synonymous_variant 0.2
clpC1 4038899 c.1806C>G synonymous_variant 0.15
clpC1 4039714 p.Tyr331His missense_variant 0.14
clpC1 4039724 c.981A>G synonymous_variant 0.23
clpC1 4039730 c.975C>G synonymous_variant 0.29
clpC1 4039748 c.957G>C synonymous_variant 0.39
clpC1 4039751 c.954A>G synonymous_variant 0.38
clpC1 4039757 c.948A>G synonymous_variant 0.35
clpC1 4039766 c.939T>C synonymous_variant 0.33
clpC1 4039769 c.936C>G synonymous_variant 0.37
clpC1 4039773 p.Lys311Met missense_variant 0.37
clpC1 4039778 c.927A>G synonymous_variant 0.35
clpC1 4039781 c.924G>C synonymous_variant 0.34
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.37
clpC1 4039814 c.891C>G synonymous_variant 0.43
clpC1 4039817 c.888A>T synonymous_variant 0.39
clpC1 4039820 c.885T>G synonymous_variant 0.36
clpC1 4039823 c.882T>G synonymous_variant 0.36
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.38
clpC1 4039838 p.Leu289Ile missense_variant 0.35
clpC1 4039850 c.855T>C synonymous_variant 0.38
clpC1 4039865 c.840T>G synonymous_variant 0.48
clpC1 4039871 c.834C>G synonymous_variant 0.48
clpC1 4039875 p.Asn277Arg missense_variant 0.42
clpC1 4039898 c.807C>G synonymous_variant 0.25
clpC1 4039904 c.801A>G synonymous_variant 0.27
clpC1 4039916 c.789T>C synonymous_variant 0.12
clpC1 4040009 c.696C>G synonymous_variant 0.19
clpC1 4040015 c.690G>C synonymous_variant 0.29
clpC1 4040021 c.684A>C synonymous_variant 0.25
clpC1 4040024 c.681A>G synonymous_variant 0.31
clpC1 4040033 c.672G>C synonymous_variant 0.34
clpC1 4040063 c.642G>C synonymous_variant 0.47
clpC1 4040069 c.636G>C synonymous_variant 0.45
clpC1 4040087 c.618G>C synonymous_variant 0.38
clpC1 4040090 c.615T>C synonymous_variant 0.36
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4248781 p.Glu756Asp missense_variant 0.12
aftB 4268217 p.Trp207* stop_gained 0.17
ubiA 4269280 p.Leu185Pro missense_variant 0.22
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0