TB-Profiler result

Run: ERR7821123
Summary

Run ID: ERR7821123

Sample name:

Date: 2024-04-16T00:21:16.166845

Number of reads: 3068100

Percentage reads mapped: 85.41

Median coverage: 81.0

Strain: lineage1.1.3.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1.3 Indo-Oceanic RD239 0.99
lineage1.1.3.2 Indo-Oceanic RD239 0.96
lineage1.1 Indo-Oceanic RD239 0.99
lineage1 Indo-Oceanic RD239 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6112 p.Met291Ile missense_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8188 p.Leu296Pro missense_variant 0.96 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8452 p.Ala384Val missense_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 0.98 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491043 c.261T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 619695 c.-196G>A upstream_gene_variant 0.95 capreomycin
amikacin
kanamycin
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
hadA 732396 p.Gly156Ala missense_variant 0.16 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.16 isoniazid
nusG 734116 c.-138T>C upstream_gene_variant 1.0 rifampicin Not assoc w R
nusG 734442 c.189G>A synonymous_variant 0.17 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.18 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.18 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.16 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.15 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.17 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.17 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.16 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.15 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.16 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760532 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.15 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.14 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.16 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.21 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.28 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.28 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.22 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.23 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.17 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.19 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.22 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>T synonymous_variant 0.16 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761727 p.Ser641Gly missense_variant 0.15 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.15 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.15 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.16 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.18 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.14 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.15 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.15 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.18 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.15 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.23 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.17 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.16 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.17 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.15 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.15 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.16 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.15 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.15 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.17 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.17 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.17 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.21 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.16 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.14 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.18 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.2 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.18 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.19 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.19 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.19 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.19 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763835 p.Ala156Thr missense_variant 0.14 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.13 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.86 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.86 rifampicin Not assoc w R
rpoC 764196 p.Ser276Leu missense_variant 0.13 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.18 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.17 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.19 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.19 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.17 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.17 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765171 p.Pro601Leu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765230 p.Ala621Thr missense_variant 0.99 rifampicin Not assoc w R
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.26 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.28 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.22 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.16 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.22 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.25 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.19 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.21 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.2 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.22 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.21 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.21 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.19 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.22 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.22 rifampicin
rpoC 765814 c.2445A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.18 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.23 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.16 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766027 c.2658G>C synonymous_variant 0.17 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.18 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.16 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.15 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.16 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.17 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.21 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.16 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.18 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.15 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.16 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.18 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.2 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.25 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.24 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.25 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.29 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.28 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.25 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.24 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.25 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.22 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781700 c.141G>C synonymous_variant 0.16 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.15 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.16 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.17 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.16 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.15 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.14 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.2 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.2 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.19 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.24 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.24 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.27 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.27 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.24 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.21 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.22 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.22 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.2 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.23 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 0.99 linezolid Not assoc w R
rplC 801166 p.Gly120Ser missense_variant 0.95 linezolid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303860 c.930A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Asp missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304727 c.1797A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.13 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674480 c.279T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.15 ethionamide
isoniazid
inhA 1674561 c.360C>T synonymous_variant 0.14 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.9 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1833721 c.180A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.17 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.17 pyrazinamide
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2064420 c.309C>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
bacA 2064978 c.-250G>C upstream_gene_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 0.99 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.14 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.16 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.16 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.17 isoniazid
kasA 2518528 c.414C>A synonymous_variant 0.16 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.16 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.14 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.16 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.22 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.21 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.21 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.25 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.26 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.2 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.17 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.19 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.17 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
Rv2477c 2782869 p.Ala392Thr missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783586 p.Ala153Pro missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064632 c.1560C>T synonymous_variant 0.99 ethambutol Not assoc w R
moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
thyX 3067515 p.Ser144Thr missense_variant 0.16 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.14 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.18 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.16 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.15 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.17 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625696 c.-786A>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.13 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.17 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
fbiB 3642173 c.639G>A synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.19 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.18 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.18 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.16 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878143 p.Gly122Asp missense_variant 0.14 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.16 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.18 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.22 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.26 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.22 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.25 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.22 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.23 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.22 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.22 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.22 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.2 rifampicin
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.25 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039930 p.Ser259Cys missense_variant 0.14 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.94 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139086 p.Pro224Ser missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4238874 c.-989A>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240685 p.Thr275Ala missense_variant 0.16 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.14 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.18 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.18 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.17 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.95 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243848 p.Val206Met missense_variant 1.0 ethambutol Not assoc w R
embA 4245092 c.1860C>G synonymous_variant 0.14 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.14 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.23 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.23 ethambutol
embA 4245149 c.1917C>T synonymous_variant 0.23 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.22 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.23 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.22 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.21 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.2 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.2 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
embA 4245784 p.Thr851Met missense_variant 0.95 ethambutol
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247951 p.Ser480Ala missense_variant 0.2 ethambutol
embB 4247974 c.1461C>G synonymous_variant 0.15 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.17 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.15 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.14 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.14 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.14 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.15 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407780 c.423G>A synonymous_variant 1.0 streptomycin Not assoc w R - Interim
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R