TB-Profiler result

Run: 2065c619-4516-4a06-91d2-6eb04a0d2697
Summary

Run ID: 2065c619-4516-4a06-91d2-6eb04a0d2697

Sample name:

Date: 19-04-2024 07:22:45

Number of reads: 2297953

Percentage reads mapped: 84.13

Median coverage: 72

Strain: lineage4.4.1.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.4 Euro-American None 0.98
lineage4.4.1 Euro-American (S-type) None 0.99
lineage4.4.1.1 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
moxifloxacin
levofloxacin
bedaquiline
delamanid
pretomanid
linezolid
streptomycin
amikacin
kanamycin
capreomycin
clofazimine
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7132 c.-170T>G upstream_gene_variant 0.1 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7135 c.-167G>A upstream_gene_variant 0.1 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7153 c.-149G>T upstream_gene_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7159 c.-143C>T upstream_gene_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7162 c.-140C>T upstream_gene_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7165 c.-137C>T upstream_gene_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 7210 p.Asp657Glu missense_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7213 c.-89G>C upstream_gene_variant 0.1 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7499 c.198G>C synonymous_variant 0.1 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
rpoB 760244 c.438G>C synonymous_variant 0.13 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.16 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.18 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.19 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.17 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.17 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.16 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.17 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.17 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.13 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.13 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.14 rifampicin
rpoB 760406 c.600G>T synonymous_variant 0.11 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.11 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.11 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.1 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.1 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.11 rifampicin
rpoB 760585 p.Asn260Ser missense_variant 0.12 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.13 rifampicin Uncertain significance
rpoB 760595 c.789C>T synonymous_variant 0.13 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.12 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.12 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.13 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.11 rifampicin
rpoB 760841 c.1035T>C synonymous_variant 0.1 rifampicin
rpoB 760887 p.Thr361Ala missense_variant 0.1 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.12 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.12 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.12 rifampicin
rpoB 761198 c.1392G>T synonymous_variant 0.12 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.13 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 0.13 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.12 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.12 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.13 rifampicin
rpoB 761264 c.1458C>G synonymous_variant 0.15 rifampicin
rpoB 761282 c.1476C>T synonymous_variant 0.13 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.14 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.1 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.1 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.1 rifampicin
rpoB 762062 c.2256T>C synonymous_variant 0.13 rifampicin
rpoB 762065 c.2259T>C synonymous_variant 0.13 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.13 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.13 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.14 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.15 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.16 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.16 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.16 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.16 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.17 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.19 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.19 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.19 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.18 rifampicin
rpoC 762920 c.-450C>T upstream_gene_variant 0.12 rifampicin
rpoC 762929 c.-441G>C upstream_gene_variant 0.12 rifampicin
rpoC 762962 c.-408C>T upstream_gene_variant 0.15 rifampicin
rpoC 762995 c.-375G>T upstream_gene_variant 0.15 rifampicin
rpoC 763004 c.-366G>A upstream_gene_variant 0.14 rifampicin
rpoC 763007 c.-363C>T upstream_gene_variant 0.14 rifampicin
rpoC 763028 c.-342T>C upstream_gene_variant 0.15 rifampicin
rpoC 763031 c.-339T>G upstream_gene_variant 0.18 rifampicin
rpoC 763053 c.-317T>C upstream_gene_variant 0.17 rifampicin
rpoC 763070 c.-300T>C upstream_gene_variant 0.19 rifampicin
rpoC 763085 c.-285C>G upstream_gene_variant 0.2 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.15 rifampicin
rpoC 763115 c.-255T>C upstream_gene_variant 0.17 rifampicin
rpoC 763127 c.-243G>C upstream_gene_variant 0.19 rifampicin
rpoC 763130 c.-240G>A upstream_gene_variant 0.17 rifampicin
rpoC 763133 c.-237G>C upstream_gene_variant 0.17 rifampicin
rpoC 763136 c.-234C>T upstream_gene_variant 0.16 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.16 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.12 rifampicin
rpoC 763166 c.-204A>G upstream_gene_variant 0.12 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.11 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.11 rifampicin
rpoC 763411 c.42T>C synonymous_variant 0.11 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.11 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.12 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCGT synonymous_variant 0.12 rifampicin
rpoC 763433 p.Gln22Asn missense_variant 0.12 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.12 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.13 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.11 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.11 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.13 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.16 rifampicin
rpoC 763666 c.297G>A synonymous_variant 0.17 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.17 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.2 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.23 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.18 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.17 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.17 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.14 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.11 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.12 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.16 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.14 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.12 rifampicin
rpoC 763813 c.444C>G synonymous_variant 0.12 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.1 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.1 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.1 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.11 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.11 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.13 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.12 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.13 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.11 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.1 rifampicin
rpoC 764500 c.1131C>G synonymous_variant 0.11 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.11 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.12 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.11 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.12 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.11 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.13 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.11 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.13 rifampicin
rpoC 764623 c.1254C>G synonymous_variant 0.13 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.12 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.13 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.13 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.12 rifampicin
rpoC 764713 c.1344G>T synonymous_variant 0.12 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.12 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.15 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.12 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.13 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.13 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.13 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.12 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.12 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.11 rifampicin
rpoC 764827 c.1458G>C synonymous_variant 0.12 rifampicin
rpoC 767020 c.3651C>G synonymous_variant 0.1 rifampicin
rpoC 767023 c.3654C>T synonymous_variant 0.1 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.11 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781682 c.123T>C synonymous_variant 0.1 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.11 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.12 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.1 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.12 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.12 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.12 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.12 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.15 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.13 streptomycin Uncertain significance
fbiC 1304613 c.1683T>C synonymous_variant 0.12 delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.12 delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.14 delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.12 delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.1 delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.1 delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.11 delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.1 delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.1 delamanid
fbiC 1304727 c.1797A>C synonymous_variant 0.11 delamanid
fbiC 1304751 c.1821C>G synonymous_variant 0.11 delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.1 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.14 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.12 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.14 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.21 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.21 linezolid
kanamycin Uncertain significance
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.17 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.22 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.12 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.12 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.16 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.19 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.18 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.2 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.22 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.21 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.24 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.22 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.11 linezolid
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.15 linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.15 linezolid Uncertain significance
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.13 linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.15 linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.15 linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.15 linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.15 linezolid
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.15 linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.15 linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.18 linezolid
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.22 linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.21 linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.19 linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.11 linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.11 linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.11 linezolid
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.1 linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.1 linezolid
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.1 linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.12 linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.15 linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.16 linezolid
rpsA 1833832 c.291G>A synonymous_variant 0.1 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.11 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin
ndh 2102990 p.Val18Ala missense_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
PPE35 2169840 p.Gly258Asp missense_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448608 c.105G>A synonymous_variant 1.0 ethionamide
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0 capreomycin
amikacin
Rv3236c 3612665 p.Val151Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpoA 3877875 c.633T>A synonymous_variant 0.12 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.1 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.1 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.11 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.1 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.12 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.11 rifampicin
rpoA 3878187 c.321C>A synonymous_variant 0.11 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.11 rifampicin
rpoA 3878197 p.Glu104Ala missense_variant 0.11 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.12 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.13 rifampicin
rpoA 3878238 c.270C>T synonymous_variant 0.11 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.11 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.11 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.11 rifampicin
rpoA 3878630 c.-123G>C upstream_gene_variant 0.12 rifampicin
clpC1 4039046 c.1659C>T synonymous_variant 0.11 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.11 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.1 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.1 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.1 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.11 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.11 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.11 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.11 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.11 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.11 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.11 pyrazinamide
clpC1 4040390 c.315C>G synonymous_variant 0.12 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.13 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 1.0 pyrazinamide
embA 4242643 c.-590C>T upstream_gene_variant 1.0 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 streptomycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance