Run ID: ERR3797085
Sample name:
Date: 2024-05-17T14:17:32.141125
Number of reads: 176045
Percentage reads mapped: 25.44
Median coverage: 4.5
Strain: lineage4.9
Spoligotype:
Drug-resistance: Other
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 0.95 |
| lineage4.9 | Euro-American (H37Rv-like) | None | 0.99 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | fbiA | c.772_774delACGinsGC | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| c.781_783delTCGinsAC | Assoc w R - Interim | Confers DLM-PMD cross-resistance | ||
| c.838_840delTGCinsAT | Assoc w R - Interim | Confers DLM-PMD cross-resistance | ||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|---|---|---|---|---|---|---|
| fbiA | 3641314 | c.772_774delACGinsGC | frameshift_variant&missense_variant | 0.91 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
| fbiA | 3641323 | c.781_783delTCGinsAC | frameshift_variant&missense_variant | 0.91 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
| fbiA | 3641380 | c.838_840delTGCinsAT | frameshift_variant&missense_variant | 0.92 | pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 6775 | c.1536G>C | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| gyrA | 6778 | c.-524C>T | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| gyrB | 6793 | c.1554T>C | synonymous_variant | 1.0 | moxifloxacin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| gyrB | 6797 | p.Gly520Ser | missense_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| gyrA | 6803 | c.-499C>T | upstream_gene_variant | 1.0 | moxifloxacin | |
| levofloxacin | ||||||
| gyrA | 8121 | c.820T>C | synonymous_variant | 0.92 | moxifloxacin | |
| levofloxacin | ||||||
| gyrA | 8129 | c.828T>C | synonymous_variant | 0.93 | moxifloxacin | |
| levofloxacin | ||||||
| gyrA | 8156 | c.855T>C | synonymous_variant | 0.93 | moxifloxacin | |
| levofloxacin | ||||||
| gyrA | 8165 | c.864C>G | synonymous_variant | 0.91 | moxifloxacin | |
| levofloxacin | ||||||
| gyrA | 8168 | c.867A>G | synonymous_variant | 0.91 | moxifloxacin | |
| levofloxacin | ||||||
| mshA | 574731 | c.-617A>G | upstream_gene_variant | 0.91 | ethionamide | |
| isoniazid | ||||||
| mshA | 574739 | c.-609T>C | upstream_gene_variant | 0.91 | ethionamide | |
| isoniazid | ||||||
| mshA | 575842 | c.495G>T | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 575864 | c.517T>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| mshA | 575893 | c.546C>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| ccsA | 619507 | c.-384A>G | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620652 | c.762C>A | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620661 | c.771C>T | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620679 | c.789C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | Not assoc w R - Interim | |||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620685 | c.795G>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| amikacin | ||||||
| kanamycin | Not assoc w R - Interim | |||||
| ccsA | 620688 | c.798G>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620691 | c.801G>T | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620694 | c.804C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620698 | p.Val270Ile | missense_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620703 | c.813G>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620712 | c.822G>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620718 | c.828G>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620721 | c.831G>A | synonymous_variant | 0.93 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620730 | c.840C>T | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620733 | c.843G>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620734 | c.844C>A | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| ccsA | 620766 | c.876C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| kanamycin | ||||||
| nusG | 734475 | c.222T>C | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoB | 760181 | c.375T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760184 | c.378A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760196 | c.390C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 760223 | c.417T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760235 | c.429T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761150 | c.1344A>C | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoB | 761160 | c.1354C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761165 | c.1359G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761168 | c.1362C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761171 | c.1365C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761180 | c.1374A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761234 | c.1428G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761249 | c.1443A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761255 | c.1449T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761264 | c.1458C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761306 | c.1500C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761318 | c.1512G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761327 | c.1521A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761345 | c.1539G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761504 | c.1698C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761510 | c.1704T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761537 | c.1731C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761561 | c.1755C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761564 | c.1758G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761573 | c.1767C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761579 | c.1773G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761600 | c.1794T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761606 | c.1800C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761612 | c.1806G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761615 | c.1809A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761636 | c.1830G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761864 | c.2058G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761873 | c.2067A>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761885 | c.2079T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761891 | c.2085G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761969 | c.2163G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 762114 | p.Ile770Val | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 763468 | c.99G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763486 | c.117T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 763658 | c.289_291delCTTinsTG | frameshift_variant&missense_variant | 1.0 | rifampicin | |
| rpoC | 763666 | c.297G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763696 | c.327T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764044 | c.675T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764059 | c.690G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764077 | c.708C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764083 | c.714A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764101 | c.732C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764102 | p.Val245Gln | missense_variant | 1.0 | rifampicin | |
| rpoC | 764131 | c.762T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764284 | c.915G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764359 | c.990C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764365 | c.996C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764428 | c.1059G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764431 | c.1062G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764434 | c.1065A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764438 | c.1069C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764446 | c.1077T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764461 | c.1092A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764489 | c.1120C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764497 | c.1128A>G | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 764500 | c.1131C>G | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 764521 | c.1152T>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 764527 | c.1158C>T | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 764602 | c.1233C>T | synonymous_variant | 0.9 | rifampicin | |
| rpoC | 764611 | c.1242G>T | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoC | 764692 | c.1323C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764746 | c.1377G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764749 | c.1380G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764752 | c.1383G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764764 | c.1395T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764782 | c.1413C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764809 | c.1440C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
| rpoC | 764812 | c.1443C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764815 | c.1446A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764824 | c.1455T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764842 | c.1473C>T | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 764854 | c.1485G>C | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 764858 | c.1489T>C | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| rpoC | 764888 | c.1519T>C | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoC | 764968 | c.1599T>C | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
| rpoC | 765007 | c.1638T>G | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 765008 | c.1639T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765019 | c.1650A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765040 | c.1671T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765041 | c.1672T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765047 | c.1678T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765700 | c.2331T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765724 | c.2355C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765727 | c.2358T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765787 | c.2418C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765793 | c.2424C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765796 | c.2427C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765811 | c.2442T>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765826 | c.2457T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765886 | c.2517C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765904 | c.2535C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765908 | c.2539C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765934 | c.2565C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765994 | c.2625A>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766012 | c.2643C>G | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
| rpoC | 766021 | c.2652G>C | synonymous_variant | 0.94 | rifampicin | |
| rpoC | 766027 | c.2658G>C | synonymous_variant | 0.95 | rifampicin | |
| rpoC | 766069 | c.2700G>A | synonymous_variant | 0.94 | rifampicin | |
| rpoC | 766082 | p.Ala905Gln | missense_variant | 0.94 | rifampicin | |
| rpoC | 766087 | c.2718C>G | synonymous_variant | 0.94 | rifampicin | |
| rpoC | 766096 | c.2727G>C | synonymous_variant | 0.94 | rifampicin | |
| rpoC | 766105 | c.2736C>T | synonymous_variant | 0.94 | rifampicin | |
| rpoC | 766129 | c.2760C>G | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 766141 | c.2772C>T | synonymous_variant | 0.9 | rifampicin | |
| rpoC | 766142 | c.2773C>T | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoC | 766408 | c.3039C>T | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoC | 766426 | c.3057C>T | synonymous_variant | 0.9 | rifampicin | |
| rpoC | 766429 | c.3060C>G | synonymous_variant | 0.9 | rifampicin | |
| rpoC | 766447 | c.3078T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766456 | c.3087C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766459 | c.3090G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766462 | c.3093G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766483 | c.3114G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766486 | c.3117A>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766504 | c.3135G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766541 | p.Gly1058Asn | missense_variant | 1.0 | rifampicin | |
| rpoC | 766546 | p.Glu1059Asp | missense_variant | 1.0 | rifampicin | |
| rpoC | 766568 | p.Val1067Ile | missense_variant | 1.0 | rifampicin | |
| rpoC | 766573 | c.3204T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766583 | c.3214_3216delGGTinsAC | frameshift_variant&missense_variant | 1.0 | rifampicin | |
| rpoC | 766594 | c.3225G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766597 | c.3228C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766765 | c.3396A>C | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| rpoC | 766774 | c.3405T>C | synonymous_variant | 0.9 | rifampicin | |
| rpsL | 781682 | c.123T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781697 | c.138C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781718 | c.159C>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781721 | c.162C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781728 | c.169T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781736 | c.177T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781805 | c.246G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781808 | c.249C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781929 | p.Gly124Ser | missense_variant | 1.0 | streptomycin | Uncertain significance |
| rpsL | 781933 | c.374G>A | splice_region_variant&stop_retained_variant | 1.0 | streptomycin | |
| rplC | 800576 | c.-233C>A | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800582 | c.-227C>A | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800585 | c.-224T>A | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800597 | c.-212A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800612 | c.-197A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800648 | c.-161A>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800693 | c.-116A>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800703 | c.-106T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800715 | c.-94A>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800723 | c.-86C>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800745 | c.-64_-62delCTCinsTG | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800759 | c.-50C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800771 | c.-38C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800796 | c.-13A>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800801 | c.-8A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800802 | c.-6_-5delAG | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800808 | c.-1A>G | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800814 | c.6A>G | synonymous_variant | 1.0 | linezolid | |
| rplC | 800815 | c.7C>A | synonymous_variant | 1.0 | linezolid | |
| rplC | 800820 | c.12G>A | synonymous_variant | 1.0 | linezolid | |
| rplC | 800829 | c.21C>G | synonymous_variant | 1.0 | linezolid | |
| rplC | 800844 | c.36T>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 800865 | c.57A>G | synonymous_variant | 1.0 | linezolid | |
| rplC | 800867 | p.Ser20Asn | missense_variant | 1.0 | linezolid | |
| rplC | 800872 | c.64A>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 800877 | c.69A>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 800880 | c.72A>G | synonymous_variant | 1.0 | linezolid | |
| rplC | 800889 | c.81C>G | synonymous_variant | 1.0 | linezolid | |
| rplC | 800901 | c.93C>T | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| rplC | 800907 | c.99C>G | synonymous_variant | 1.0 | linezolid | |
| rplC | 800916 | c.108A>G | synonymous_variant | 1.0 | linezolid | |
| fbiC | 1303788 | c.858T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303798 | p.Val290Met | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1303818 | c.888C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304778 | c.1848T>C | synonymous_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304784 | c.1854T>G | synonymous_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304787 | c.1857T>C | synonymous_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304790 | c.1860C>G | synonymous_variant | 0.93 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304799 | c.1869G>C | synonymous_variant | 0.93 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304808 | c.1878C>G | synonymous_variant | 0.93 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304811 | c.1881C>G | synonymous_variant | 0.93 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304817 | c.1887T>C | synonymous_variant | 0.94 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304823 | c.1893C>T | synonymous_variant | 0.94 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304829 | c.1899T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304832 | c.1902C>G | synonymous_variant | 1.0 | clofazimine | Not assoc w R - Interim |
| pretomanid | ||||||
| delamanid | Not assoc w R - Interim | |||||
| fbiC | 1304853 | c.1923C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304868 | c.1938G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304869 | c.1939C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304874 | c.1944C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304883 | c.1953G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304894 | p.Gly655Ala | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304898 | c.1968G>A | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304910 | c.1980G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304916 | c.1986T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304925 | c.1995G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304928 | c.1998T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304937 | c.2007G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304940 | c.2010A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304943 | c.2013C>T | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304946 | c.2016G>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304958 | c.2028T>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1304961 | c.2031C>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiC | 1305006 | c.2076A>G | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| inhA | 1674585 | c.384T>A | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674589 | p.Met130Leu | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674600 | c.399G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674603 | c.402G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674604 | c.403C>T | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674618 | c.417C>T | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674619 | p.Pro140Ser | missense_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674624 | c.423A>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674627 | c.426T>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674630 | c.429C>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674654 | c.453G>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| rpsA | 1833745 | c.204G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834249 | c.708T>C | synonymous_variant | 0.92 | pyrazinamide | |
| rpsA | 1834252 | c.711C>G | synonymous_variant | 0.92 | pyrazinamide | |
| rpsA | 1834261 | c.720A>G | synonymous_variant | 0.92 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834264 | c.723G>C | synonymous_variant | 0.92 | pyrazinamide | |
| rpsA | 1834288 | c.747C>G | synonymous_variant | 0.93 | pyrazinamide | |
| rpsA | 1834294 | c.753G>C | synonymous_variant | 0.92 | pyrazinamide | |
| rpsA | 1834303 | c.762T>G | synonymous_variant | 0.93 | pyrazinamide | |
| rpsA | 1834306 | c.765T>C | synonymous_variant | 0.93 | pyrazinamide | |
| rpsA | 1834327 | c.786G>C | synonymous_variant | 0.94 | pyrazinamide | |
| rpsA | 1834348 | c.807T>C | synonymous_variant | 0.94 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834361 | c.820T>C | synonymous_variant | 0.92 | pyrazinamide | |
| rpsA | 1834366 | c.825A>G | synonymous_variant | 0.92 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1834369 | c.828C>G | synonymous_variant | 0.92 | pyrazinamide | |
| rpsA | 1834375 | c.834G>A | synonymous_variant | 0.92 | pyrazinamide | |
| rpsA | 1834378 | c.837T>G | synonymous_variant | 0.92 | pyrazinamide | |
| rpsA | 1834465 | c.924T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834468 | c.927A>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834489 | c.948T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834513 | c.972C>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834519 | c.978G>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834528 | c.987T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.93 | pyrazinamide | |
| rpsA | 1834552 | c.1011G>C | synonymous_variant | 0.93 | pyrazinamide | |
| rpsA | 1834555 | c.1014T>C | synonymous_variant | 0.93 | pyrazinamide | |
| rpsA | 1834561 | c.1020C>G | synonymous_variant | 0.94 | pyrazinamide | |
| rpsA | 1834612 | c.1071G>A | synonymous_variant | 0.92 | pyrazinamide | Not assoc w R - Interim |
| kasA | 2518627 | c.513T>C | synonymous_variant | 0.92 | isoniazid | |
| kasA | 2518723 | c.609G>A | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518727 | c.613C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518747 | c.633C>G | synonymous_variant | 1.0 | isoniazid | |
| Rv2477c | 2783520 | c.523T>C | synonymous_variant | 1.0 | kanamycin | |
| moxifloxacin | ||||||
| amikacin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| streptomycin | ||||||
| ethambutol | Not assoc w R - Interim | |||||
| levofloxacin | ||||||
| Rv2477c | 2783674 | c.369T>C | synonymous_variant | 1.0 | kanamycin | |
| moxifloxacin | ||||||
| amikacin | ||||||
| rifampicin | ||||||
| streptomycin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2477c | 2783683 | c.360A>G | synonymous_variant | 1.0 | kanamycin | |
| moxifloxacin | ||||||
| amikacin | ||||||
| rifampicin | ||||||
| streptomycin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2477c | 2783700 | p.Thr115Ser | missense_variant | 1.0 | kanamycin | |
| moxifloxacin | ||||||
| amikacin | ||||||
| rifampicin | ||||||
| streptomycin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2477c | 2783751 | p.Ile98Val | missense_variant | 1.0 | kanamycin | |
| moxifloxacin | ||||||
| amikacin | ||||||
| rifampicin | ||||||
| streptomycin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064878 | c.1314C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| Rv2752c | 3064881 | c.1311T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | ||||||
| levofloxacin | Not assoc w R - Interim | |||||
| Rv2752c | 3064887 | c.1305A>G | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064905 | c.1287C>G | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064914 | c.1278T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| Rv2752c | 3064932 | c.1260T>C | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064941 | p.Gln417Pro | missense_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064947 | c.1245A>T | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064950 | c.1242C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| moxifloxacin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| levofloxacin | ||||||
| Rv2752c | 3064956 | c.1236T>C | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064962 | c.1230C>G | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064967 | c.1225C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| levofloxacin | Not assoc w R - Interim | |||||
| Rv2752c | 3064974 | c.1218T>C | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| Rv2752c | 3064986 | p.Met402His | missense_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| thyA | 3073863 | c.609T>A | synonymous_variant | 0.92 | para-aminosalicylic_acid | |
| thyA | 3073872 | c.598_600delATCinsGG | frameshift_variant&missense_variant | 0.92 | para-aminosalicylic_acid | |
| thyA | 3073884 | c.588C>A | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073887 | p.Ser195Asp | missense_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073892 | c.580T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073902 | c.570C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073917 | c.555C>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073923 | c.547_549delTTGinsCC | frameshift_variant&missense_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073929 | c.543T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073995 | c.477G>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074034 | c.438T>C | synonymous_variant | 0.92 | para-aminosalicylic_acid | |
| thyA | 3074037 | c.435C>G | synonymous_variant | 0.92 | para-aminosalicylic_acid | |
| thyA | 3074056 | p.Glu139Pro | missense_variant | 0.92 | para-aminosalicylic_acid | |
| thyA | 3074079 | c.393G>C | synonymous_variant | 0.91 | para-aminosalicylic_acid | |
| thyA | 3074082 | c.390G>C | synonymous_variant | 0.91 | para-aminosalicylic_acid | |
| thyA | 3074106 | c.366T>C | synonymous_variant | 0.9 | para-aminosalicylic_acid | |
| lpqB | 3623615 | c.1296G>C | synonymous_variant | 0.9 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623642 | c.1269G>A | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623648 | c.1263A>G | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623651 | c.1260G>C | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623654 | p.Asp419Glu | missense_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623666 | c.1245A>C | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623672 | c.1239G>C | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623676 | p.Val412Asn | missense_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623681 | c.1230C>G | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3623684 | c.1227T>C | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623687 | c.1224C>G | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623693 | c.1218G>C | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623699 | c.1212C>G | synonymous_variant | 0.92 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623720 | c.1191C>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624314 | c.597C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3624320 | c.591G>A | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624323 | c.588G>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624326 | c.585C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3624331 | c.580C>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624339 | p.Arg191His | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624341 | c.570C>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624371 | c.540T>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624383 | c.528C>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624392 | c.519C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| lpqB | 3624407 | c.504C>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624416 | c.495G>A | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624422 | c.489G>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624425 | p.Glu162Ala | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624428 | c.483A>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624452 | c.459T>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624455 | c.456G>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624464 | c.447A>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624470 | c.441T>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625669 | c.-759G>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625675 | c.-765G>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625683 | c.-773C>T | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625690 | c.-780T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625720 | c.894G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625726 | c.-816G>A | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625729 | c.885A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625747 | c.867G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625852 | c.762A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625864 | c.-954T>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625867 | c.747A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625927 | c.687T>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625930 | c.684C>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625936 | c.678C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625945 | c.669A>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625951 | c.663A>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3626759 | c.591T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrA | 3626774 | c.574_576delAGGinsCC | frameshift_variant&missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3626780 | c.-167T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3626783 | c.-170C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3626786 | c.564A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3626798 | c.-185T>A | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3626804 | c.546A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrA | 3626846 | c.504G>A | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3626996 | c.-383G>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3626999 | c.-386G>T | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3627011 | c.-398T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3627023 | c.-410C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3627068 | c.282T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrA | 3627098 | c.252A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3627104 | c.-491C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| fbiB | 3641274 | c.-261G>C | upstream_gene_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiA | 3641288 | p.Glu249Gly | missense_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3641310 | c.-225C>T | upstream_gene_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3641328 | c.-207T>G | upstream_gene_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiA | 3641351 | p.Ala270Glu | missense_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3641355 | c.-180T>C | upstream_gene_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3641358 | c.-177G>C | upstream_gene_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3641364 | c.-171G>A | upstream_gene_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3641373 | c.-162C>T | upstream_gene_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3641379 | c.-156G>C | upstream_gene_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiA | 3641384 | p.Ala281Gly | missense_variant | 0.92 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| fbiB | 3642684 | c.1150T>C | synonymous_variant | 1.0 | clofazimine | |
| pretomanid | ||||||
| delamanid | ||||||
| rpoA | 3877567 | p.Ser314Thr | missense_variant | 1.0 | rifampicin | |
| rpoA | 3877587 | c.921A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877593 | c.915C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877613 | p.Ile299Val | missense_variant | 1.0 | rifampicin | |
| rpoA | 3877647 | c.861C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877686 | c.822A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877692 | c.816G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877704 | c.804G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877710 | c.798C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877728 | c.780C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877737 | c.771G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877743 | c.765T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877764 | c.744C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877770 | c.738A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877776 | c.732T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877782 | c.726T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877806 | c.702C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877818 | c.690A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877830 | c.678C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877839 | c.669G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877848 | c.660C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877857 | c.651G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878247 | c.261G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878256 | c.252G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878292 | c.216T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878298 | c.210A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878313 | c.195G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878322 | c.186A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878331 | c.177A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878337 | c.171T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878346 | c.162T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878364 | c.144A>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878385 | c.123C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878406 | c.102G>T | synonymous_variant | 0.93 | rifampicin | |
| rpoA | 3878415 | c.93C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878418 | c.90C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878436 | c.72A>G | synonymous_variant | 1.0 | rifampicin | |
| clpC1 | 4038419 | c.2286T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038596 | c.2109A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038623 | c.2082A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038640 | p.Asp689Asn | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038642 | p.Asn688Ser | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038644 | p.Glu687Asp | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038653 | c.2052C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038658 | p.Lys683Gln | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038660 | c.2044_2045delTCinsAG | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038662 | c.2043T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038665 | c.2040C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038668 | c.2037G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038671 | c.2034T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038683 | c.2022T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038773 | c.1932T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038782 | c.1923G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038790 | c.1915C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038809 | c.1896G>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038812 | c.1893T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038815 | c.1890G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038827 | c.1878G>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038878 | c.1827A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038881 | c.1824C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038908 | c.1797C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038911 | c.1794G>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038917 | c.1788C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038923 | c.1780_1782delCTAinsTG | frameshift_variant&synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038953 | c.1752A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038956 | c.1749T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038965 | c.1740T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038971 | c.1734T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038974 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038989 | c.1716T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038997 | c.1708T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039037 | c.1668T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040159 | c.546G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040162 | c.543G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040168 | c.537G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040204 | c.501G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040207 | c.498T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040213 | c.492T>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040225 | c.480A>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040228 | c.477G>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040231 | c.474C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040234 | c.471C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040246 | c.459C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040258 | c.447G>A | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040267 | c.438A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040273 | c.432T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040277 | c.427_428delTCinsAG | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040279 | c.426C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040284 | c.421C>T | synonymous_variant | 1.0 | pyrazinamide | |
| glpK | 4138661 | c.1095T>C | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| streptomycin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| glpK | 4138667 | c.1089G>C | synonymous_variant | 1.0 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| streptomycin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| glpK | 4138681 | p.Met359Val | missense_variant | 0.9 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| streptomycin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| glpK | 4138696 | p.Pro354Ala | missense_variant | 0.9 | isoniazid | |
| moxifloxacin | ||||||
| rifampicin | ||||||
| streptomycin | ||||||
| ethambutol | ||||||
| levofloxacin | ||||||
| embA | 4244372 | c.1140T>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244396 | c.1164T>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244400 | c.1168C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4244408 | c.1176G>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244412 | c.1180_1182delGTGinsAC | frameshift_variant&missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4244415 | c.1183T>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244426 | c.1194G>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244438 | c.1206C>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245224 | c.1992T>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245254 | c.2022C>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245257 | c.2025A>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245263 | c.2031A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4245269 | c.2037C>T | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245278 | c.2046C>T | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245285 | c.2053T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247899 | p.Met462Ile | missense_variant | 0.9 | ethambutol | |
| embB | 4247911 | p.Leu466Phe | missense_variant | 0.9 | ethambutol | |
| embB | 4248169 | c.1656C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248172 | c.1659G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248190 | c.1677G>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248232 | c.1719G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248252 | p.Gly580Ala | missense_variant | 1.0 | ethambutol | |
| embB | 4248277 | c.1764G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248280 | c.1767C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248305 | c.1792C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248316 | c.1803C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248319 | c.1806A>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248322 | c.1809G>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248329 | p.Met606Val | missense_variant | 1.0 | ethambutol | |
| embB | 4248334 | c.1821C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248338 | c.1825C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248349 | c.1836G>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248358 | c.1845C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248445 | c.1932C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248472 | c.1959T>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249552 | c.3039C>T | synonymous_variant | 0.91 | ethambutol | Not assoc w R - Interim |
| embB | 4249558 | c.3045A>G | synonymous_variant | 1.0 | ethambutol | |
| ethA | 4327638 | c.-165G>C | upstream_gene_variant | 0.91 | ethionamide | |
| ethR | 4327651 | p.Asn35Arg | missense_variant | 0.91 | ethionamide | |
| ethA | 4327656 | c.-183A>C | upstream_gene_variant | 0.91 | ethionamide | |
| ethA | 4327674 | c.-201C>G | upstream_gene_variant | 0.91 | ethionamide | |
| ethR | 4327675 | p.Ala43Ser | missense_variant | 0.91 | ethionamide | |
| ethA | 4327680 | c.-207A>G | upstream_gene_variant | 0.91 | ethionamide | |
| ethA | 4327686 | c.-213C>G | upstream_gene_variant | 0.91 | ethionamide | |
| ethA | 4327695 | c.-222A>G | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327713 | c.-240A>G | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327716 | c.-243G>A | upstream_gene_variant | 1.0 | ethionamide | |
| ethR | 4327720 | c.172_174delAGGinsCA | frameshift_variant&missense_variant | 1.0 | ethionamide | Uncertain significance |
| ethA | 4327725 | c.-252C>G | upstream_gene_variant | 1.0 | ethionamide |
