TB-Profiler result

Run: ERR4799171
Summary

Run ID: ERR4799171

Sample name:

Date: 2025-09-15T14:26:31.462327

Number of reads: 1936870

Percentage reads mapped: 84.54

Median coverage: 53.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 100.0
lineage4.8 Euro-American (mainly T) RD219 94.32
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.His1002Arg Uncertain significance Mutation from literature
pyrazinamide pncA c.391dupG Assoc w R
streptomycin
fluoroquinolones
moxifloxacin gyrA p.Asp94His Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94His Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethA c.550_551dupGG Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7581 p.Asp94His missense_variant 0.91 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
rpoB 761155 p.Ser450Leu missense_variant 0.73 rifampicin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 0.93 isoniazid Assoc w R High-level resistance
pncA 2288850 c.391dupG frameshift_variant 0.98 pyrazinamide Assoc w R
embB 4249518 p.His1002Arg missense_variant 0.93 ethambutol Uncertain significance Mutation from literature
ethA 4326922 c.550_551dupGG frameshift_variant 1.0 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7694 c.393A>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7697 c.396C>G synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8177 c.876A>C synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8711 c.1410A>C synonymous_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8717 c.1416C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8719 p.Glu473Gly missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8729 c.1428T>C synonymous_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8740 p.Arg480His missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8747 c.1446A>G synonymous_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8751 p.Ala484Ser missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8762 c.1461G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8796 p.Ile499Val missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8801 c.1500G>C synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8810 c.1509A>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8818 p.Ser506Asn missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8903 c.1602T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8946 c.1645T>C synonymous_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8966 c.1665C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8984 c.1683C>T synonymous_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8990 c.1689C>G synonymous_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8996 c.1695T>C synonymous_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8998 p.Leu566Trp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9032 c.1731T>C synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9035 c.1734G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
gyrA 9056 c.1755C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9065 c.1764C>T synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9068 c.1767G>A synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
fgd1 491144 p.Ala121Asp missense_variant 0.13 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491166 c.384G>C synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491181 c.399T>C synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491191 p.Gly137Arg missense_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
mshA 575617 c.270C>G synonymous_variant 0.16 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575623 c.276C>G synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575680 c.333C>T synonymous_variant 0.16 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575713 c.366G>A synonymous_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575728 c.381C>G synonymous_variant 0.23 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575734 c.387T>G synonymous_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575737 c.390T>C synonymous_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575746 c.399C>G synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575752 c.405G>C synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575756 c.409C>T synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575770 c.423G>C synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575771 p.Val142Ser missense_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575779 c.432A>G synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575785 c.438T>C synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575812 c.465C>T synonymous_variant 0.16 ethionamide Uncertain significance
isoniazid Uncertain significance
ccsA 619618 c.-273C>A upstream_gene_variant 0.26 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620226 c.336G>A synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620238 c.348G>C synonymous_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620245 c.355T>C synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620249 p.Ser120Cys missense_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620256 c.366C>G synonymous_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620265 c.375C>G synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620275 c.385C>T synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620283 c.393T>C synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620284 p.Ala132Pro missense_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620288 p.Arg133Gln missense_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620295 c.405G>C synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620310 c.420C>T synonymous_variant 0.22 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620319 c.429C>G synonymous_variant 0.21 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620649 c.759A>G synonymous_variant 0.3 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620659 c.769_771delCGCinsAGG synonymous_variant 0.29 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620664 c.774C>T synonymous_variant 0.28 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620682 c.792G>A synonymous_variant 0.26 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620688 c.798G>C synonymous_variant 0.26 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620710 p.Val274Ile missense_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620718 c.828G>C synonymous_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620721 c.831G>C synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620724 c.834C>T synonymous_variant 0.17 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620733 c.843G>C synonymous_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620734 c.844C>A synonymous_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620745 c.855G>C synonymous_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620748 c.858T>A synonymous_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620760 c.870C>G synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620763 c.873G>A synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.14 ethionamide Uncertain significance
nusG 734451 c.198G>C synonymous_variant 0.18 rifampicin Uncertain significance
nusG 734457 c.204C>G synonymous_variant 0.17 rifampicin Uncertain significance
nusG 734472 c.219T>C synonymous_variant 0.2 rifampicin Uncertain significance
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>C synonymous_variant 0.18 rifampicin Uncertain significance
nusG 734532 c.279A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.17 rifampicin Uncertain significance
nusG 734596 c.343T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.17 rifampicin Uncertain significance
rpoB 760595 c.789C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760611 c.805T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 761492 c.1686G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoB 761510 c.1704T>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoB 761858 c.2052G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 761867 c.2061C>T synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 761873 c.2067A>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 761885 c.2079T>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoB 761891 c.2085G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 761903 c.2097T>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 761912 c.2106T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 761915 p.Asp703Glu missense_variant 0.15 rifampicin Uncertain significance
rpoB 761916 p.Asp704Asn missense_variant 0.15 rifampicin Uncertain significance
rpoB 761942 c.2136C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762185 c.2379G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762224 c.2418C>G synonymous_variant 0.34 rifampicin Uncertain significance
rpoB 762233 c.2427G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762249 c.2443C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.3 rifampicin Uncertain significance
rpoB 762266 c.2460T>C synonymous_variant 0.29 rifampicin Uncertain significance
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 762380 c.-990T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoB 762857 c.3051C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762957 c.3151C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoB 762995 c.3189G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoB 763028 c.3222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.21 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763049 c.-321G>A upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoC 763414 c.45T>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 763441 c.72C>T synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 763444 c.75T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 763594 c.225C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 763711 c.342G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 763717 c.348T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 763732 c.363C>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 763765 c.396T>C synonymous_variant 0.2 rifampicin Uncertain significance
rpoC 763771 c.402C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763780 c.411C>G synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 763792 p.Glu141Asp missense_variant 0.22 rifampicin Uncertain significance
rpoC 763807 c.438T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>T synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 763816 c.447C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 763853 p.Val162Ile missense_variant 0.18 rifampicin Uncertain significance
rpoC 763858 c.489A>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.18 rifampicin Uncertain significance
rpoC 764195 p.Ser276Thr missense_variant 0.18 rifampicin Uncertain significance
rpoC 764203 c.834G>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 764206 c.837T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 764266 c.897T>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 764269 c.900G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 764272 c.903G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.26 rifampicin Uncertain significance
rpoC 764539 c.1170C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.28 rifampicin Uncertain significance
rpoC 764560 c.1191T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.27 rifampicin Uncertain significance
rpoC 764611 c.1242G>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 764626 c.1257C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764669 p.Pro434Thr missense_variant 0.74 rifampicin Uncertain significance
rpoC 764716 c.1347G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764719 c.1350G>A synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 764746 c.1377G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.3 rifampicin Uncertain significance
rpoC 764809 c.1440C>T synonymous_variant 0.25 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 765553 c.2184C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 765811 c.2442T>G synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 765826 c.2457T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.25 rifampicin Uncertain significance
rpoC 765877 c.2508C>G synonymous_variant 0.25 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 765892 c.2523T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.28 rifampicin Uncertain significance
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766594 c.3225G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 766597 c.3228C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.15 rifampicin Uncertain significance
rpoC 766645 c.3276A>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766651 c.3282T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766861 c.3492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 766895 c.3526T>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 766972 c.3603G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 766996 c.3627C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775909 p.Leu858Phe missense_variant 0.19 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 775913 c.2568C>G synonymous_variant 0.18 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 775916 c.2565T>G synonymous_variant 0.18 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 775937 c.2544G>C synonymous_variant 0.19 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 775940 c.2541C>T synonymous_variant 0.19 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 775951 c.2530C>T synonymous_variant 0.21 bedaquiline Uncertain significance
clofazimine Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.19 streptomycin Uncertain significance
rpsL 781649 c.90T>C synonymous_variant 0.19 streptomycin Uncertain significance
rpsL 781655 c.96T>C synonymous_variant 0.19 streptomycin Uncertain significance
rpsL 781658 c.99A>G synonymous_variant 0.18 streptomycin Uncertain significance
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin Uncertain significance
rpsL 781715 c.156T>C synonymous_variant 0.22 streptomycin Uncertain significance
rpsL 781728 c.169T>C synonymous_variant 0.21 streptomycin Uncertain significance
rpsL 781733 c.174G>C synonymous_variant 0.21 streptomycin Uncertain significance
rpsL 781736 c.177T>C synonymous_variant 0.2 streptomycin Uncertain significance
rpsL 781754 c.195G>C synonymous_variant 0.21 streptomycin Uncertain significance
rpsL 781760 c.201T>C synonymous_variant 0.21 streptomycin Uncertain significance
rpsL 781841 c.282C>G synonymous_variant 0.23 streptomycin Uncertain significance
rpsL 781877 c.318T>C synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781929 p.Gly124Ser missense_variant 0.14 streptomycin Uncertain significance
rplC 800844 c.36T>C synonymous_variant 0.17 linezolid Uncertain significance
rplC 800865 c.57A>G synonymous_variant 0.16 linezolid Uncertain significance
fbiC 1304868 c.1938G>C synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304869 c.1939C>T synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.14 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472753 n.908A>C non_coding_transcript_exon_variant 0.82 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673799 c.-403T>G upstream_gene_variant 0.22 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673901 c.-301A>G upstream_gene_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673905 c.-297T>G upstream_gene_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673916 c.-286A>C upstream_gene_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673917 c.-285G>C upstream_gene_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673922 c.-280T>C upstream_gene_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673976 c.-226T>C upstream_gene_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673985 c.-217C>G upstream_gene_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674006 c.-196T>G upstream_gene_variant 0.14 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674555 c.354G>A synonymous_variant 0.15 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674589 p.Met130Leu missense_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674597 p.Lys132Asn missense_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674636 c.435C>G synonymous_variant 0.15 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674738 c.537C>G synonymous_variant 0.31 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674746 p.Tyr182Phe missense_variant 0.3 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674753 c.552G>C synonymous_variant 0.32 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674756 c.555T>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.32 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674774 c.573A>G synonymous_variant 0.28 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674777 c.576C>A synonymous_variant 0.26 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674780 c.579T>G synonymous_variant 0.27 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674846 p.Ile215Met missense_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674870 c.669T>C synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1833637 c.96C>T synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833649 c.108C>T synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833667 c.126C>G synonymous_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833724 c.183C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833727 c.186G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1833730 c.189C>T synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1833733 c.192C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833745 c.204G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833748 c.207C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833940 c.399C>G synonymous_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833971 c.430C>T synonymous_variant 0.22 pyrazinamide Uncertain significance
rpsA 1833976 c.435C>G synonymous_variant 0.25 pyrazinamide Uncertain significance
rpsA 1833979 c.438T>C synonymous_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834000 c.459G>C synonymous_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834240 c.699T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834259 c.718_720delCTAinsTTG synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834262 c.721_723delTCGinsAGT synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834279 c.738C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834303 c.762T>C synonymous_variant 0.26 pyrazinamide Uncertain significance
rpsA 1834396 c.855G>T synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834411 c.870T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834414 c.873C>T synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834417 c.876G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834423 c.882G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834435 c.894G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834609 c.1068T>C synonymous_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.2 pyrazinamide Uncertain significance
rpsA 1834633 c.1092A>G synonymous_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834639 c.1098T>C synonymous_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834654 c.1113G>A synonymous_variant 0.26 pyrazinamide Uncertain significance
rpsA 1834690 c.1149T>C synonymous_variant 0.26 pyrazinamide Uncertain significance
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223491 c.-327C>A upstream_gene_variant 0.96 bedaquiline Uncertain significance
clofazimine Not assoc w R
pncA 2289969 c.-728G>C upstream_gene_variant 0.91 pyrazinamide Uncertain significance
kasA 2517923 c.-192C>G upstream_gene_variant 0.32 isoniazid Uncertain significance
kasA 2517926 c.-189G>A upstream_gene_variant 0.32 isoniazid Uncertain significance
kasA 2517968 c.-147T>C upstream_gene_variant 0.24 isoniazid Uncertain significance
kasA 2517974 c.-141T>G upstream_gene_variant 0.24 isoniazid Uncertain significance
kasA 2518843 c.729T>G synonymous_variant 0.16 isoniazid Uncertain significance
kasA 2518864 c.750G>C synonymous_variant 0.15 isoniazid Uncertain significance
kasA 2518879 c.765A>G synonymous_variant 0.16 isoniazid Uncertain significance
kasA 2518882 c.768C>T synonymous_variant 0.15 isoniazid Uncertain significance
kasA 2518885 c.771T>C synonymous_variant 0.15 isoniazid Uncertain significance
kasA 2518898 c.784T>C synonymous_variant 0.15 isoniazid Uncertain significance
folC 2746353 p.Ala416Ser missense_variant 0.14 para-aminosalicylic_acid Uncertain significance
Rv2477c 2783095 c.948C>G synonymous_variant 0.14 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
Rv2477c 2783101 c.942G>T synonymous_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783104 c.939C>T synonymous_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783116 c.927T>C synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783140 c.903C>G synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783146 c.897G>A synonymous_variant 0.17 amikacin Not assoc w R - Interim
ethambutol Uncertain significance
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783149 c.894G>C synonymous_variant 0.2 amikacin Not assoc w R - Interim
ethambutol Uncertain significance
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
Rv2477c 2783158 c.885A>C synonymous_variant 0.2 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
Rv2477c 2783185 c.858G>C synonymous_variant 0.22 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783593 c.450T>C synonymous_variant 0.21 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783605 c.438T>C synonymous_variant 0.22 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783626 p.Ala139Ser missense_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783641 c.402G>C synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
thyA 3073983 c.489C>G synonymous_variant 0.13 para-aminosalicylic_acid Uncertain significance
ald 3087647 c.830dupG frameshift_variant 1.0 cycloserine Uncertain significance
Rv3083 3448507 c.5_*1407del frameshift_variant&stop_lost&splice_region_variant 0.93 ethionamide Uncertain significance
mtrB 3625267 c.1347T>C synonymous_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625291 c.-381A>G upstream_gene_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625612 c.-702G>C upstream_gene_variant 0.23 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625616 p.Arg333Ala missense_variant 0.22 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625624 c.-714C>G upstream_gene_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625645 c.969C>T synonymous_variant 0.22 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3625648 c.-738T>C upstream_gene_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.22 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625669 c.-759G>C upstream_gene_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625687 c.-777G>C upstream_gene_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625690 c.-780T>C upstream_gene_variant 0.19 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625696 c.-786A>G upstream_gene_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625705 c.909C>G synonymous_variant 0.19 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>A upstream_gene_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625720 c.894G>C synonymous_variant 0.18 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3625741 c.-831G>A upstream_gene_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625755 p.Ala287Thr missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.16 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.14 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrA 3627221 c.129C>T synonymous_variant 0.13 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.13 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878025 c.483C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878040 c.468T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878055 c.453A>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878061 c.447G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878067 c.441C>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878070 c.438T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878076 c.432C>T synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878094 c.414C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878103 c.405A>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878106 c.402G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3878118 c.390T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3879033 c.-526C>G upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3879073 c.-566A>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879121 c.-614T>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3879127 c.-620T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879130 c.-623A>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879136 c.-629A>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879154 c.-647T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3879160 c.-653A>G upstream_gene_variant 0.16 rifampicin Uncertain significance
clpC1 4038740 c.1965G>C synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4038755 c.1950G>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038773 c.1932T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038782 c.1923G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038812 c.1893T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038965 c.1740T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4038971 c.1734T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4038974 c.1731T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039097 c.1608G>C synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039103 c.1602T>C synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039106 c.1599G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039112 c.1593C>A synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039121 c.1584T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039292 c.1413C>G synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039295 c.1410A>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039298 c.1407T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039319 c.1386T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>C synonymous_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039337 c.1368A>C synonymous_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039349 c.1356C>T synonymous_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039352 c.1353C>G synonymous_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039364 c.1341C>G synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039391 c.1314T>G synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039409 c.1296T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039412 c.1293T>G synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039415 p.Glu430Asp missense_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039556 c.1149G>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039562 c.1143C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039565 c.1140G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039570 p.Met379Leu missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Pro missense_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039601 c.1104G>C synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039610 c.1095G>C synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039991 c.714G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039996 p.Glu237Gln missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4040021 c.684A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4040057 c.648C>T synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4040090 c.615T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.18 pyrazinamide Uncertain significance
embC 4240615 c.753G>C synonymous_variant 0.16 ethambutol Uncertain significance
embC 4240630 c.768C>G synonymous_variant 0.19 ethambutol Uncertain significance
embC 4240632 p.Met257Thr missense_variant 0.19 ethambutol Uncertain significance
embC 4240642 c.780G>C synonymous_variant 0.21 ethambutol Uncertain significance
embC 4240645 c.783G>C synonymous_variant 0.22 ethambutol Uncertain significance
embC 4240670 p.Thr270Val missense_variant 0.21 ethambutol Uncertain significance
embC 4240678 c.816T>C synonymous_variant 0.21 ethambutol Uncertain significance
embC 4240685 p.Thr275Ala missense_variant 0.2 ethambutol Uncertain significance
embC 4240693 c.831T>C synonymous_variant 0.19 ethambutol Uncertain significance
embC 4240726 c.864G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4240819 c.957A>G synonymous_variant 0.15 ethambutol Uncertain significance
embC 4240828 c.966G>C synonymous_variant 0.16 ethambutol Uncertain significance
embC 4240831 c.969T>C synonymous_variant 0.17 ethambutol Uncertain significance
embC 4240837 c.975C>G synonymous_variant 0.15 ethambutol Uncertain significance
embC 4241107 c.1245G>C synonymous_variant 0.14 ethambutol Uncertain significance
embC 4241140 c.1278A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.15 ethambutol Uncertain significance
embB 4248157 c.1644A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248205 c.1692C>G synonymous_variant 0.21 ethambutol Uncertain significance
embB 4248206 p.Ser565Gly missense_variant 0.21 ethambutol Uncertain significance
embB 4248211 c.1698G>A synonymous_variant 0.2 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248304 c.1791G>C synonymous_variant 0.15 ethambutol Uncertain significance
ubiA 4269124 p.Ala237Val missense_variant 0.94 ethambutol Uncertain significance
ethA 4326844 c.630C>G synonymous_variant 0.99 ethionamide Not assoc w R - Interim
whiB6 4338362 p.Arg54Gly missense_variant 0.95 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
gid 4408061 p.His48Asn missense_variant 1.0 streptomycin Uncertain significance