TB-Profiler result

Run: SRR8692887
Summary

Run ID: SRR8692887

Sample name:

Date: 2024-10-05T03:53:10.234223

Number of reads: 871195

Percentage reads mapped: 27.74

Median coverage: 21.0

Strain:

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.07
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid rplC p.Cys154Arg Assoc w R
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rplC 801268 p.Cys154Arg missense_variant 0.5 linezolid Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7502 c.201C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 0.46 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7585 p.Ser95Thr missense_variant 0.53 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCGC synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7700 c.399G>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7706 c.405C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7709 c.408G>A synonymous_variant 0.47 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7710 c.409T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.57 levofloxacin
moxifloxacin
nusG 734508 c.255C>G synonymous_variant 0.32 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.29 rifampicin
rpoB 760715 c.909C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.3 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.26 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.25 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.36 rifampicin Not assoc w R
rpoC 763049 c.-321G>A upstream_gene_variant 0.3 rifampicin
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.27 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.24 rifampicin
rpoC 763079 c.-291C>G upstream_gene_variant 0.24 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764800 c.1431G>A synonymous_variant 0.39 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.41 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.33 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.35 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765898 c.2529C>T synonymous_variant 0.36 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.29 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.26 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.26 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.25 rifampicin
mmpL5 775955 p.Ile842Val missense_variant 0.36 bedaquiline
clofazimine
mmpL5 775961 c.2520C>G synonymous_variant 0.42 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.35 bedaquiline
clofazimine
mmpL5 775997 c.2484T>C synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776000 c.2481G>C synonymous_variant 0.19 bedaquiline
clofazimine
rpsL 781817 c.258G>T synonymous_variant 0.28 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.27 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.3 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.31 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.32 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.31 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.33 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.32 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.28 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.28 streptomycin
Rv1258c 1406686 p.Val219Ile missense_variant 0.7 streptomycin
pyrazinamide
isoniazid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.57 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_647delTCCTTTTCCTCTCCGGAGinsCTCTCTTT non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979_982delACCGinsTTAC non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475108 n.1451C>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475343 n.1686A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475358 n.1701T>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475382 n.1725A>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475759 n.2102C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833760 c.219C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.33 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.31 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.3 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.29 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.27 pyrazinamide Uncertain significance
Rv2752c 3065120 p.Ile358Val missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065130 c.1062A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065133 c.1059T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065142 c.1050A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
mtrB 3626562 p.Pro18Ser missense_variant 0.41 rifampicin Not assoc w R
bedaquiline Uncertain significance
clpC1 4039085 c.1620A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.35 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>A synonymous_variant 0.24 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.21 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.29 pyrazinamide
whiB6 4338732 c.-211C>T upstream_gene_variant 0.32 kanamycin
capreomycin
amikacin