TB-Profiler result

Run: ERR11081257
Summary

Run ID: ERR11081257

Sample name:

Date: 2025-02-11T10:53:19.463322

Number of reads: 1850124

Percentage reads mapped: 87.72

Median coverage: 38.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 371 p.Pro124Leu missense_variant 1.0 isoniazid Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
hadA 732337 c.408G>A synonymous_variant 0.13 isoniazid
rpoB 760112 c.306T>C synonymous_variant 0.17 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.18 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.25 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.41 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.4 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.43 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.42 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.27 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.34 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.36 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.3 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.42 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.35 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.33 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.36 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.29 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.14 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.15 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.16 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.14 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.17 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.16 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.19 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.3 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.16 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.21 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.25 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.32 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.3 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.3 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.3 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.21 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.15 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.18 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.24 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.26 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.26 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.26 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.24 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.34 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.31 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.15 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.19 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.25 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.32 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.27 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764059 c.690G>T synonymous_variant 0.24 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.24 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.26 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.3 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.32 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.26 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.33 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.33 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.32 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.35 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.33 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.27 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.3 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.24 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.23 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.26 rifampicin
rpoC 765835 c.2466C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.24 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.22 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.19 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.26 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.29 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.31 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.29 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.31 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.29 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.32 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.3 rifampicin
rpoC 766085 p.Pro906Ala missense_variant 0.68 rifampicin Not assoc w R
rpoC 766096 c.2727G>C synonymous_variant 0.26 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.19 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.22 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.27 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.29 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.43 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.45 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.36 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.36 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.39 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.37 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.32 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.24 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.24 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.27 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.3 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.32 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.23 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.24 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.25 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.25 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.3 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.37 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.37 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.25 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.26 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.27 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.27 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.28 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.3 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.32 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.34 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.38 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.38 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.35 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.34 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.27 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.26 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.29 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.29 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.33 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.38 streptomycin Uncertain significance
rplC 800693 c.-116A>G upstream_gene_variant 0.38 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.35 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.37 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.36 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.33 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.25 linezolid
rplC 800814 c.6A>G synonymous_variant 0.21 linezolid
rplC 800817 c.9A>T synonymous_variant 0.21 linezolid
rplC 800844 c.36T>C synonymous_variant 0.28 linezolid
rplC 800865 c.57A>G synonymous_variant 0.24 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.24 linezolid
rplC 800874 c.66A>G synonymous_variant 0.23 linezolid
rplC 800875 p.Val23Ile missense_variant 0.21 linezolid
rplC 800880 c.72A>G synonymous_variant 0.22 linezolid
rplC 800889 c.81C>G synonymous_variant 0.24 linezolid
rplC 800892 c.84G>C synonymous_variant 0.24 linezolid
rplC 800907 c.99C>G synonymous_variant 0.27 linezolid
rplC 800916 c.108A>G synonymous_variant 0.24 linezolid
fbiC 1303761 c.831T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303791 p.Ile287Met missense_variant 0.13 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
atpE 1460816 c.-229T>C upstream_gene_variant 0.23 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.2 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.18 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.19 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.17 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.17 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.17 bedaquiline
atpE 1460992 c.-53A>C upstream_gene_variant 1.0 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471935 n.90T>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.17 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.24 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.26 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.29 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2101988 p.Ala352Asp missense_variant 0.15 isoniazid
delamanid
ethionamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223492 c.-328G>C upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
kasA 2517950 c.-165C>G upstream_gene_variant 0.24 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.23 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.24 isoniazid
Rv2477c 2783718 c.325T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.17 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3064673 p.Ala507Ser missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067718 c.228C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.17 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.17 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074163 p.Ala103Thr missense_variant 0.15 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.16 para-aminosalicylic_acid
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
mtrA 3626759 c.591T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.3 rifampicin
bedaquiline
alr 3840764 c.657G>C synonymous_variant 1.0 cycloserine
rpoA 3877553 p.Glu319Gln missense_variant 0.31 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.33 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.35 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.26 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.22 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3879121 c.-614T>G upstream_gene_variant 0.31 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.45 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.3 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.21 pretomanid
delamanid
clpC1 4038530 p.Glu725Asp missense_variant 0.19 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.17 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.16 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.15 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.2 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.23 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
glpK 4139601 p.Arg52Gln missense_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
glpK 4139651 p.His35Glu missense_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240178 c.316T>C synonymous_variant 0.25 ethambutol
embC 4240183 c.321A>G synonymous_variant 0.31 ethambutol
embC 4240204 c.342T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.21 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.21 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.18 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.22 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245222 p.Tyr664Gln missense_variant 0.18 ethambutol
embA 4245248 c.2016G>C synonymous_variant 0.18 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.18 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.16 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.15 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.17 ethambutol
ubiA 4269027 c.807C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R