Run ID: SRR13861381
Sample name:
Date: 2024-10-04T00:30:38.664439
Number of reads: 1438144
Percentage reads mapped: 47.98
Median coverage: 49.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: HR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 0.98 |
lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | katG | c.926_927insA | Assoc w R | High-level resistance |
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
katG | 2155185 | c.926_927insA | frameshift_variant | 1.0 | isoniazid | Assoc w R | High-level resistance |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6209 | c.970C>T | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6242 | p.Arg335Lys | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6250 | c.1011A>G | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6253 | c.1014G>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6280 | c.1041T>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6319 | c.1080G>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrB | 6745 | c.1506T>G | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6760 | c.-542G>C | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6793 | c.1554T>C | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6797 | p.Gly520Thr | missense_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6824 | c.1585C>T | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6878 | c.1639T>C | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6881 | c.1642T>C | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6904 | c.-398C>G | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6910 | c.-392G>A | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6911 | p.Asn558His | missense_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6919 | c.1680T>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 7093 | c.1854T>C | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7099 | c.-203G>A | upstream_gene_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7124 | p.Ser629Thr | missense_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7541 | c.240C>G | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7649 | c.348C>T | synonymous_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7652 | c.351C>T | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7658 | c.357A>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7664 | c.363T>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7670 | c.369A>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7676 | c.375G>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7683 | c.382A>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7760 | c.459C>T | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7763 | c.462T>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8396 | p.Tyr365* | stop_gained | 0.89 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8504 | c.1203G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8516 | c.1215T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8519 | c.1218A>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8537 | c.1236G>A | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8546 | c.1245T>C | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8552 | c.1251C>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8556 | p.Ala419Gln | missense_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8561 | c.1260A>C | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8562 | c.1261C>T | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8597 | c.1296C>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8603 | c.1302A>G | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
Rv0010c | 13610 | c.-52A>C | upstream_gene_variant | 1.0 | isoniazid | |
fgd1 | 490821 | p.Glu13Asp | missense_variant | 0.98 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491217 | c.435T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491232 | c.450T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491241 | p.Asp153Glu | missense_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491244 | c.462T>C | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491259 | c.477T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
mshA | 575959 | p.Gln204His | missense_variant | 0.96 | isoniazid | |
ethionamide | ||||||
ccsA | 620433 | c.543C>G | synonymous_variant | 0.15 | kanamycin | Not assoc w R - Interim |
capreomycin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv0565c | 657649 | c.-179G>A | upstream_gene_variant | 0.17 | ethionamide | |
Rv0565c | 657678 | c.-209_-208delAAinsGG | upstream_gene_variant | 0.19 | ethionamide | |
Rv0565c | 657689 | c.-220_-219delCAinsAG | upstream_gene_variant | 0.19 | ethionamide | |
Rv0565c | 657701 | c.-231C>G | upstream_gene_variant | 0.2 | ethionamide | |
Rv0565c | 657719 | c.-249C>G | upstream_gene_variant | 0.2 | ethionamide | |
Rv0565c | 657723 | c.-253A>G | upstream_gene_variant | 0.22 | ethionamide | |
Rv0565c | 657734 | c.-264T>C | upstream_gene_variant | 0.21 | ethionamide | |
rpoB | 760130 | p.Asp108Glu | missense_variant | 0.17 | rifampicin | Uncertain significance |
rpoB | 760139 | c.333A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760142 | c.336C>G | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760181 | c.375T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760223 | c.417T>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760307 | c.501T>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760406 | c.600G>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760481 | c.675G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760514 | c.708C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760522 | p.Ser239Asn | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoB | 760532 | c.726T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760533 | p.Val243Thr | missense_variant | 0.19 | rifampicin | |
rpoB | 760547 | c.741G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760563 | p.Arg253Met | missense_variant | 0.19 | rifampicin | Uncertain significance |
rpoB | 760611 | c.805T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760634 | c.828T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 760970 | c.1164G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760982 | c.1176G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760985 | c.1179G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760991 | c.1185G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761573 | c.1767C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 761579 | c.1773G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761606 | c.1800C>G | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761612 | c.1806G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761615 | c.1809A>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761636 | c.1830G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761645 | c.1839C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761648 | c.1842T>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761657 | c.1851C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761675 | c.1869G>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 761690 | c.1884G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761765 | c.1959T>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 761847 | p.Cys681Ser | missense_variant | 0.14 | rifampicin | |
rpoB | 761852 | c.2046C>G | synonymous_variant | 0.13 | rifampicin | |
rpoB | 761864 | c.2058G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.15 | rifampicin | |
rpoC | 763441 | c.72C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763444 | c.75T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763468 | c.99G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763894 | c.525A>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763933 | c.564C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763945 | c.576T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 763960 | c.591T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763967 | p.Gly200Ser | missense_variant | 0.18 | rifampicin | |
rpoC | 764005 | c.636G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764011 | c.642T>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764405 | c.1036A>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764434 | c.1065A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764446 | c.1077T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764530 | c.1161C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764560 | c.1191T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764566 | c.1197C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764573 | c.1204_1206delCTTinsTTG | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764576 | c.1207_1208delTCinsAG | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764581 | c.1212T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764626 | c.1257C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764632 | c.1263T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764644 | c.1275G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764714 | c.1345C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764720 | c.1351C>T | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764791 | c.1422C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R |
rpoC | 764812 | c.1443C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765772 | c.2403C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765784 | c.2415C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765883 | c.2514C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765994 | c.2625A>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 766364 | p.Ala999Ser | missense_variant | 0.89 | rifampicin | |
rpoC | 766522 | c.3153C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766528 | c.3159T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766531 | c.3162G>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766543 | c.3174C>T | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766549 | c.3180G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766573 | c.3204T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766583 | p.Gly1072Ser | missense_variant | 0.16 | rifampicin | |
rpoC | 766588 | c.3219G>A | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766591 | c.3222A>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766594 | c.3225G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.19 | rifampicin | |
rpoC | 766645 | c.3276A>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766651 | c.3282T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766657 | c.3288A>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766672 | c.3303T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 766945 | c.3576A>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775945 | p.Val846Leu | missense_variant | 0.85 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 775981 | p.Leu834Met | missense_variant | 0.15 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 778345 | p.Leu46Ile | missense_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 778992 | c.-512C>T | upstream_gene_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
mmpR5 | 779231 | p.Glu81Val | missense_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
rpsL | 781682 | c.123T>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781715 | c.156T>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781751 | c.192G>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781793 | c.234G>C | synonymous_variant | 0.23 | streptomycin | |
rplC | 800526 | c.-283G>T | upstream_gene_variant | 0.89 | linezolid | |
rplC | 800537 | c.-272C>T | upstream_gene_variant | 0.13 | linezolid | |
rplC | 800540 | c.-269T>C | upstream_gene_variant | 0.15 | linezolid | |
rplC | 800567 | c.-242A>G | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800582 | c.-227C>G | upstream_gene_variant | 0.18 | linezolid | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.22 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.22 | linezolid | |
rplC | 800648 | c.-161A>C | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800703 | c.-106T>C | upstream_gene_variant | 0.15 | linezolid | |
rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800720 | c.-89T>C | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800723 | c.-86C>G | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800738 | c.-71T>C | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800747 | c.-62C>G | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800771 | c.-38C>T | upstream_gene_variant | 0.17 | linezolid | |
rplC | 800844 | c.36T>C | synonymous_variant | 0.19 | linezolid | |
rplC | 800865 | c.57A>G | synonymous_variant | 0.18 | linezolid | |
rplC | 800867 | p.Ser20Asn | missense_variant | 0.18 | linezolid | |
rplC | 800874 | c.66A>G | synonymous_variant | 0.18 | linezolid | |
rplC | 800877 | c.69A>C | synonymous_variant | 0.17 | linezolid | |
rplC | 800880 | c.72A>G | synonymous_variant | 0.19 | linezolid | |
rplC | 800889 | c.81C>G | synonymous_variant | 0.19 | linezolid | |
rplC | 800907 | c.99C>G | synonymous_variant | 0.19 | linezolid | |
rplC | 800916 | c.108A>G | synonymous_variant | 0.19 | linezolid | |
rplC | 800937 | c.129A>G | synonymous_variant | 0.16 | linezolid | |
rplC | 800939 | p.Arg44Gln | missense_variant | 0.16 | linezolid | |
rplC | 800946 | c.138T>C | synonymous_variant | 0.18 | linezolid | |
rplC | 800949 | c.141T>C | synonymous_variant | 0.16 | linezolid | |
rplC | 800955 | c.147C>G | synonymous_variant | 0.18 | linezolid | |
rplC | 800967 | c.159C>G | synonymous_variant | 0.18 | linezolid | |
rplC | 800970 | c.162T>C | synonymous_variant | 0.18 | linezolid | Not assoc w R - Interim |
fbiC | 1303186 | p.Tyr86His | missense_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
atpE | 1461113 | c.69C>T | synonymous_variant | 0.14 | bedaquiline | |
atpE | 1461132 | p.Val30Ile | missense_variant | 0.15 | bedaquiline | |
atpE | 1461149 | c.105T>G | synonymous_variant | 0.15 | bedaquiline | |
atpE | 1461150 | p.Ile36Val | missense_variant | 0.15 | bedaquiline | |
atpE | 1461159 | p.Val39Ile | missense_variant | 0.16 | bedaquiline | Uncertain significance |
rrs | 1472044 | n.199G>C | non_coding_transcript_exon_variant | 0.17 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472053 | n.211_212delGC | non_coding_transcript_exon_variant | 0.17 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472061 | n.216A>T | non_coding_transcript_exon_variant | 0.19 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 0.15 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473899 | n.242A>C | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473937 | n.280C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473944 | n.287G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1473945 | n.288T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Not assoc w R |
linezolid | Not assoc w R | |||||
rrl | 1474009 | n.352A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1474012 | n.355C>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1474103 | n.446A>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1474104 | n.447G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474111 | n.454T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1474112 | n.455T>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474310 | n.653T>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474356 | n.699T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474362 | n.705A>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1474991 | n.1334T>C | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1475006 | n.1349A>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1475015 | n.1358C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475199 | n.1542G>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1475206 | n.1549C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475209 | n.1552G>C | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475213 | n.1556C>T | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475659 | n.2002G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1475763 | n.2106C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476336 | n.2679C>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | |
linezolid | ||||||
rrl | 1476356 | n.2699C>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1476357 | n.2700T>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1476358 | n.2701T>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476359 | n.2702C>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476369 | n.2712C>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476381 | n.2724G>C | non_coding_transcript_exon_variant | 0.38 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476382 | n.2725A>G | non_coding_transcript_exon_variant | 0.38 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476383 | n.2726T>G | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1476384 | n.2727G>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1476408 | n.2751G>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476411 | n.2754G>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1476425 | n.2768G>A | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476429 | n.2772A>C | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476442 | n.2785T>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1476443 | n.2786G>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1476455 | n.2798C>A | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1476456 | n.2799A>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1476463 | n.2806C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1476466 | n.2809C>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
inhA | 1674654 | c.453G>C | synonymous_variant | 0.15 | isoniazid | |
ethionamide | ||||||
inhA | 1674693 | c.492C>G | synonymous_variant | 0.15 | isoniazid | |
ethionamide | ||||||
rpsA | 1833595 | c.54T>C | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1833619 | c.78A>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833724 | c.183C>G | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833940 | c.399C>G | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834264 | c.723G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834297 | c.756C>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834303 | c.762T>G | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834375 | c.834G>A | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834465 | c.924T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834474 | c.933C>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834498 | c.957C>T | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834555 | c.1014T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834558 | c.1017C>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834666 | c.1125G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834669 | c.1128G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834688 | c.1147_1149delAGTinsTCC | synonymous_variant | 0.16 | pyrazinamide | |
tsnR | 1853361 | c.-245T>C | upstream_gene_variant | 0.16 | linezolid | |
bacA | 2063272 | c.1456delC | frameshift_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
ndh | 2101749 | p.Thr432Ser | missense_variant | 1.0 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
katG | 2155982 | p.Asn44His | missense_variant | 1.0 | isoniazid | |
PPE35 | 2168042 | c.2571G>C | synonymous_variant | 1.0 | pyrazinamide | |
PPE35 | 2169365 | c.1248C>T | synonymous_variant | 1.0 | pyrazinamide | |
kasA | 2518621 | c.507G>A | synonymous_variant | 0.15 | isoniazid | |
kasA | 2518642 | c.528A>G | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518663 | c.549T>C | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518672 | c.558G>C | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518687 | c.573C>T | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518696 | c.582C>G | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518702 | c.588C>T | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518711 | c.597A>G | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518714 | c.600A>C | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518717 | c.603C>T | synonymous_variant | 0.2 | isoniazid | |
kasA | 2518723 | p.Glu203Asp | missense_variant | 0.21 | isoniazid | |
kasA | 2518732 | c.618C>G | synonymous_variant | 0.26 | isoniazid | |
kasA | 2518741 | c.627G>C | synonymous_variant | 0.26 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.24 | isoniazid | |
kasA | 2518768 | c.654C>G | synonymous_variant | 0.24 | isoniazid | |
kasA | 2518783 | c.669T>C | synonymous_variant | 0.24 | isoniazid | |
kasA | 2518792 | c.678C>G | synonymous_variant | 0.22 | isoniazid | |
kasA | 2518795 | c.681C>G | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518822 | c.708C>G | synonymous_variant | 0.19 | isoniazid | |
kasA | 2518825 | c.711T>C | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518843 | c.729T>C | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518855 | c.741C>G | synonymous_variant | 0.16 | isoniazid | |
Rv2477c | 2782537 | c.1506T>G | synonymous_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782540 | c.1503T>C | synonymous_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782549 | c.1494T>C | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2782558 | c.1485T>C | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782561 | c.1482G>C | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782567 | c.1476C>G | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782576 | c.1467C>G | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782582 | c.1461C>T | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782587 | p.Leu486Val | missense_variant | 0.14 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782594 | c.1449T>C | synonymous_variant | 0.14 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783563 | c.480A>G | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783569 | c.474C>G | synonymous_variant | 0.15 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783578 | p.Glu155Asp | missense_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783586 | p.Ala153Pro | missense_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783593 | c.450T>C | synonymous_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783596 | c.447C>T | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783605 | c.438T>C | synonymous_variant | 0.2 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783611 | c.432C>G | synonymous_variant | 0.2 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783700 | p.Thr115Ser | missense_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783719 | c.324A>G | synonymous_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783860 | p.Asp61Glu | missense_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2784596 | c.-554A>T | upstream_gene_variant | 1.0 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
thyX | 3067277 | c.669C>G | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyX | 3067280 | c.666G>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyX | 3067284 | p.Ala221Asp | missense_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067286 | c.660C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067289 | c.657C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067293 | p.Gln218Arg | missense_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067304 | c.642A>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067316 | c.630A>G | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyX | 3067325 | c.621A>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyX | 3067355 | c.591A>C | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyX | 3067367 | c.579G>C | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyX | 3067376 | c.570G>C | synonymous_variant | 0.22 | para-aminosalicylic_acid | |
thyX | 3067391 | c.555G>C | synonymous_variant | 0.23 | para-aminosalicylic_acid | |
thyX | 3067394 | c.552G>C | synonymous_variant | 0.24 | para-aminosalicylic_acid | |
thyX | 3067412 | c.534C>G | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyX | 3067439 | c.507A>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067445 | c.501C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067451 | c.495G>A | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyX | 3067463 | c.483C>A | synonymous_variant | 0.13 | para-aminosalicylic_acid | |
thyX | 3067493 | c.453A>G | synonymous_variant | 0.14 | para-aminosalicylic_acid | |
thyX | 3067878 | p.Val23Gly | missense_variant | 0.93 | para-aminosalicylic_acid | |
thyA | 3073953 | c.519T>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyA | 3074001 | c.471C>G | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyA | 3074004 | c.468T>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyA | 3074010 | c.462C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyA | 3074031 | c.441T>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyA | 3074037 | c.435C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyA | 3074056 | p.Glu139Pro | missense_variant | 0.17 | para-aminosalicylic_acid | |
thyA | 3074061 | c.411A>G | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyA | 3074076 | c.396C>G | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyA | 3074106 | c.366T>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyA | 3074117 | c.355C>T | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyA | 3074130 | c.342G>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
fbiD | 3339188 | p.Thr24Ser | missense_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
whiB7 | 3568496 | p.Pro62Ser | missense_variant | 1.0 | kanamycin | |
amikacin | ||||||
streptomycin | ||||||
Rv3236c | 3612323 | p.Pro265Gln | missense_variant | 1.0 | pyrazinamide | |
lpqB | 3624172 | p.Val247Ile | missense_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624335 | c.576C>T | synonymous_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624339 | p.Arg191His | missense_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624346 | p.Ser189Pro | missense_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624371 | c.540T>G | synonymous_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624425 | p.Glu162Asp | missense_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
lpqB | 3624452 | c.459T>C | synonymous_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626861 | c.-248C>G | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626939 | c.411A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626942 | c.-329A>G | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627065 | c.-452G>C | upstream_gene_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
fbiA | 3641121 | c.579C>A | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | Not assoc w R - Interim | |||||
rpoA | 3877503 | c.1005G>C | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3877507 | p.Gly334Ala | missense_variant | 0.14 | rifampicin | |
rpoA | 3877515 | c.993G>C | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3877613 | p.Ile299Val | missense_variant | 0.18 | rifampicin | |
rpoA | 3877638 | c.870T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3877656 | c.852T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878364 | c.144A>G | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878370 | c.138T>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878376 | c.132G>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878391 | c.117T>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878396 | c.112C>T | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3879079 | c.-572A>G | upstream_gene_variant | 0.18 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.18 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3879121 | c.-614T>G | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3879127 | c.-620T>C | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3879136 | c.-629A>G | upstream_gene_variant | 0.16 | rifampicin | |
rpoA | 3879154 | c.-647T>C | upstream_gene_variant | 0.16 | rifampicin | |
rpoA | 3879160 | c.-653A>G | upstream_gene_variant | 0.16 | rifampicin | |
rpoA | 3879178 | c.-671T>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3879190 | c.-683C>G | upstream_gene_variant | 0.18 | rifampicin | |
clpC1 | 4038346 | p.Glu787* | stop_gained | 0.89 | pyrazinamide | |
clpC1 | 4038398 | c.2307G>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038419 | c.2286T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038434 | c.2271G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038444 | p.Ala754Lys | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038446 | c.2259T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038452 | c.2253G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038461 | p.Ala748Asp | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038498 | p.Ser736Thr | missense_variant | 0.18 | pyrazinamide | |
clpC1 | 4038530 | p.Glu725Asp | missense_variant | 0.16 | pyrazinamide | |
clpC1 | 4038536 | c.2169C>T | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038596 | c.2109A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038611 | c.2094C>T | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038623 | c.2082A>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038640 | p.Asp689Asn | missense_variant | 0.22 | pyrazinamide | |
clpC1 | 4038653 | c.2052C>T | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038658 | p.Lys683Gln | missense_variant | 0.18 | pyrazinamide | |
clpC1 | 4038661 | p.Ser682Thr | missense_variant | 0.18 | pyrazinamide | |
clpC1 | 4038662 | c.2043T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038671 | c.2034T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038683 | c.2022T>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038695 | c.2010C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038701 | c.2004G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038704 | c.2001T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038707 | c.1998C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038710 | c.1995G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038748 | p.Arg653Cys | missense_variant | 0.19 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038851 | c.1854G>A | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039073 | c.1632C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039090 | c.1615C>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039103 | c.1602T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039226 | c.1479T>C | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039268 | c.1437C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039274 | c.1431G>C | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039286 | c.1419T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039289 | c.1416T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039295 | c.1410A>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039298 | c.1407T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039388 | c.1317C>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039391 | c.1314T>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039409 | c.1296T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039412 | c.1293T>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039430 | c.1275T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039442 | c.1263A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039448 | c.1257A>G | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039454 | c.1251A>G | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039463 | c.1242C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039466 | c.1239T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039469 | c.1236T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>G | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039484 | c.1221T>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039946 | c.759A>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039958 | c.747G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040237 | c.468C>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040363 | c.342A>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040411 | c.294T>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040423 | c.282A>G | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040426 | c.279T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040431 | c.274T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4040441 | c.264C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040444 | c.261C>G | synonymous_variant | 0.16 | pyrazinamide | |
glpK | 4139375 | p.Asp127Glu | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139545 | p.Leu71Val | missense_variant | 0.91 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
embC | 4238896 | c.-967C>A | upstream_gene_variant | 0.96 | ethambutol | |
embC | 4239894 | p.Ala11Gly | missense_variant | 1.0 | ethambutol | |
embC | 4240632 | p.Met257Thr | missense_variant | 0.15 | ethambutol | |
embC | 4240645 | c.783G>C | synonymous_variant | 0.16 | ethambutol | |
embC | 4240654 | c.792C>T | synonymous_variant | 0.16 | ethambutol | |
embC | 4240657 | c.795G>C | synonymous_variant | 0.16 | ethambutol | |
embC | 4240726 | c.864G>C | synonymous_variant | 0.15 | ethambutol | Not assoc w R - Interim |
embA | 4245771 | p.Asn847Ser | missense_variant | 0.14 | ethambutol | Uncertain significance |
embB | 4247876 | c.1363C>T | synonymous_variant | 0.19 | ethambutol | |
embB | 4248097 | c.1584C>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4248118 | c.1605T>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4248127 | c.1614G>C | synonymous_variant | 0.19 | ethambutol | |
embB | 4248133 | c.1620C>G | synonymous_variant | 0.2 | ethambutol | |
embB | 4248142 | c.1629T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248143 | c.1630T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248157 | c.1644A>G | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4248206 | p.Ser565Gly | missense_variant | 0.16 | ethambutol | Uncertain significance |
embB | 4248220 | c.1707A>G | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4248241 | c.1728C>T | synonymous_variant | 0.16 | ethambutol | |
embB | 4249469 | p.Leu986Met | missense_variant | 0.15 | ethambutol | |
ethA | 4327073 | p.Leu134Pro | missense_variant | 1.0 | ethionamide | Uncertain significance |