TB-Profiler result

Run: SRR13861381
Summary

Run ID: SRR13861381

Sample name:

Date: 2024-10-04T00:30:38.664439

Number of reads: 1438144

Percentage reads mapped: 47.98

Median coverage: 49.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.98
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.926_927insA Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155185 c.926_927insA frameshift_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6209 c.970C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6242 p.Arg335Lys missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7093 c.1854T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Thr missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7649 c.348C>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8396 p.Tyr365* stop_gained 0.89 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8597 c.1296C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13610 c.-52A>C upstream_gene_variant 1.0 isoniazid
fgd1 490821 p.Glu13Asp missense_variant 0.98 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
mshA 575959 p.Gln204His missense_variant 0.96 isoniazid
ethionamide
ccsA 620433 c.543C>G synonymous_variant 0.15 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.19 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.19 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.2 ethionamide
Rv0565c 657719 c.-249C>G upstream_gene_variant 0.2 ethionamide
Rv0565c 657723 c.-253A>G upstream_gene_variant 0.22 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.21 ethionamide
rpoB 760130 p.Asp108Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.2 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.16 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.15 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.15 rifampicin
rpoB 760481 c.675G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760514 c.708C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.2 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.19 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760611 c.805T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.16 rifampicin
rpoB 761573 c.1767C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.17 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.15 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.16 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.15 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.14 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.13 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.15 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.16 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763894 c.525A>G synonymous_variant 0.16 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.18 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.18 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.14 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.18 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.17 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 0.16 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.16 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.15 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.16 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.17 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.15 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.15 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 0.16 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.15 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.16 rifampicin
rpoC 765883 c.2514C>G synonymous_variant 0.17 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.17 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766364 p.Ala999Ser missense_variant 0.89 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.18 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.19 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.22 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.2 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.19 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.18 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.16 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.16 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.16 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.19 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.16 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.17 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.18 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.18 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775945 p.Val846Leu missense_variant 0.85 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.15 bedaquiline
clofazimine
mmpL5 778345 p.Leu46Ile missense_variant 1.0 bedaquiline
clofazimine
mmpL5 778992 c.-512C>T upstream_gene_variant 1.0 bedaquiline
clofazimine
mmpR5 779231 p.Glu81Val missense_variant 1.0 bedaquiline
clofazimine
rpsL 781682 c.123T>C synonymous_variant 0.18 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.17 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.17 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.17 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.19 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.23 streptomycin
rplC 800526 c.-283G>T upstream_gene_variant 0.89 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.13 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.15 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.17 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.18 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.22 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.22 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.21 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.15 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.17 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.16 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.17 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.17 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.17 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.17 linezolid
rplC 800844 c.36T>C synonymous_variant 0.19 linezolid
rplC 800865 c.57A>G synonymous_variant 0.18 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.18 linezolid
rplC 800874 c.66A>G synonymous_variant 0.18 linezolid
rplC 800877 c.69A>C synonymous_variant 0.17 linezolid
rplC 800880 c.72A>G synonymous_variant 0.19 linezolid
rplC 800889 c.81C>G synonymous_variant 0.19 linezolid
rplC 800907 c.99C>G synonymous_variant 0.19 linezolid
rplC 800916 c.108A>G synonymous_variant 0.19 linezolid
rplC 800937 c.129A>G synonymous_variant 0.16 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.16 linezolid
rplC 800946 c.138T>C synonymous_variant 0.18 linezolid
rplC 800949 c.141T>C synonymous_variant 0.16 linezolid
rplC 800955 c.147C>G synonymous_variant 0.18 linezolid
rplC 800967 c.159C>G synonymous_variant 0.18 linezolid
rplC 800970 c.162T>C synonymous_variant 0.18 linezolid Not assoc w R - Interim
fbiC 1303186 p.Tyr86His missense_variant 1.0 pretomanid
delamanid
clofazimine
atpE 1461113 c.69C>T synonymous_variant 0.14 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.15 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.15 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.15 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.16 bedaquiline Uncertain significance
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475015 n.1358C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
inhA 1674654 c.453G>C synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674693 c.492C>G synonymous_variant 0.15 isoniazid
ethionamide
rpsA 1833595 c.54T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.17 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.16 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.16 linezolid
bacA 2063272 c.1456delC frameshift_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
ndh 2101749 p.Thr432Ser missense_variant 1.0 isoniazid
delamanid
ethionamide
katG 2155982 p.Asn44His missense_variant 1.0 isoniazid
PPE35 2168042 c.2571G>C synonymous_variant 1.0 pyrazinamide
PPE35 2169365 c.1248C>T synonymous_variant 1.0 pyrazinamide
kasA 2518621 c.507G>A synonymous_variant 0.15 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.17 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.17 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.16 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.17 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.18 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.17 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.18 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.18 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.2 isoniazid
kasA 2518723 p.Glu203Asp missense_variant 0.21 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.26 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.26 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.24 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.24 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.24 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.22 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.21 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.19 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.17 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.16 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.16 isoniazid
Rv2477c 2782537 c.1506T>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782582 c.1461C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782587 p.Leu486Val missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783596 c.447C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784596 c.-554A>T upstream_gene_variant 1.0 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
thyX 3067277 c.669C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067280 c.666G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067284 p.Ala221Asp missense_variant 0.17 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067293 p.Gln218Arg missense_variant 0.17 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067463 c.483C>A synonymous_variant 0.13 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067878 p.Val23Gly missense_variant 0.93 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.17 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074117 c.355C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.15 para-aminosalicylic_acid
fbiD 3339188 p.Thr24Ser missense_variant 1.0 pretomanid
delamanid
clofazimine
whiB7 3568496 p.Pro62Ser missense_variant 1.0 kanamycin
amikacin
streptomycin
Rv3236c 3612323 p.Pro265Gln missense_variant 1.0 pyrazinamide
lpqB 3624172 p.Val247Ile missense_variant 0.13 rifampicin
bedaquiline
lpqB 3624335 c.576C>T synonymous_variant 0.14 rifampicin
bedaquiline
lpqB 3624339 p.Arg191His missense_variant 0.15 rifampicin
bedaquiline
lpqB 3624346 p.Ser189Pro missense_variant 0.15 rifampicin
bedaquiline
lpqB 3624371 c.540T>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624425 p.Glu162Asp missense_variant 0.16 rifampicin
bedaquiline
lpqB 3624452 c.459T>C synonymous_variant 0.16 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>G upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.14 rifampicin
bedaquiline
fbiA 3641121 c.579C>A synonymous_variant 1.0 pretomanid
delamanid
clofazimine Not assoc w R - Interim
rpoA 3877503 c.1005G>C synonymous_variant 0.14 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.14 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.14 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.18 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878292 c.216T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.2 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.2 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.2 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.2 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.21 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.22 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.21 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.19 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.15 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.15 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.18 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.21 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.16 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.16 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.18 rifampicin
clpC1 4038346 p.Glu787* stop_gained 0.89 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.15 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.15 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.18 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.16 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038611 c.2094C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.22 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.18 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.18 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038748 p.Arg653Cys missense_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038851 c.1854G>A synonymous_variant 0.16 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.17 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.15 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.15 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.16 pyrazinamide
glpK 4139375 p.Asp127Glu missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 p.Leu71Val missense_variant 0.91 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4238896 c.-967C>A upstream_gene_variant 0.96 ethambutol
embC 4239894 p.Ala11Gly missense_variant 1.0 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.15 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.16 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.16 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.16 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embA 4245771 p.Asn847Ser missense_variant 0.14 ethambutol Uncertain significance
embB 4247876 c.1363C>T synonymous_variant 0.19 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.17 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.17 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.19 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.16 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.16 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.15 ethambutol
ethA 4327073 p.Leu134Pro missense_variant 1.0 ethionamide Uncertain significance