Run ID: ERR266126
Sample name:
Date: 2024-10-03T15:20:44.546989
Number of reads: 4653139
Percentage reads mapped: 93.55
Median coverage: 81.0
Strain: La2;M.canetti
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| M.canetti | M.canetti | None | 1.0 |
| La2 | M.caprae | None | 0.22 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| dnaA | 72 | c.72T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 264 | c.264C>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 343 | p.Pro115Ser | missense_variant | 1.0 | isoniazid | |
| dnaA | 549 | c.549C>T | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 708 | c.708T>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 747 | c.747G>A | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 942 | c.942C>A | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 954 | c.954G>C | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 1161 | c.1161A>G | synonymous_variant | 1.0 | isoniazid | |
| dnaA | 1413 | c.1413A>C | synonymous_variant | 1.0 | isoniazid | |
| gyrB | 5025 | c.-215T>A | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5440 | c.201A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5452 | c.213G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 5605 | c.366C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 5671 | c.432C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 5770 | c.531C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrB | 6001 | c.762G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6004 | c.765T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6286 | c.1047T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 6370 | c.1131C>T | synonymous_variant | 0.99 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 6433 | c.-869C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 6436 | c.-866C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrB | 7256 | c.2017C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 8288 | c.987T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9074 | c.1773G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9218 | c.1917C>T | synonymous_variant | 0.99 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| gyrA | 9716 | c.2415T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9740 | c.2439G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 9776 | c.2475T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| Rv0010c | 13189 | p.Val124Leu | missense_variant | 1.0 | isoniazid | Uncertain significance |
| Rv0010c | 13220 | c.339T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| Rv0010c | 13259 | c.300C>G | synonymous_variant | 1.0 | isoniazid | |
| Rv0010c | 13290 | p.Asp90Ala | missense_variant | 1.0 | isoniazid | |
| Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
| Rv0010c | 13802 | c.-244A>C | upstream_gene_variant | 1.0 | isoniazid | |
| fgd1 | 490666 | c.-117G>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 490678 | c.-105_-104insG | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 490687 | c.-96T>C | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 490734 | c.-49A>T | upstream_gene_variant | 0.3 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 490744 | c.-39T>C | upstream_gene_variant | 0.17 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491406 | p.Met208Ile | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | Not assoc w R - Interim | |||||
| clofazimine | Not assoc w R | |||||
| mshA | 574568 | c.-780G>C | upstream_gene_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575060 | c.-288G>C | upstream_gene_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575133 | c.-215C>T | upstream_gene_variant | 1.0 | isoniazid | Uncertain significance |
| ethionamide | ||||||
| mshA | 575665 | c.318G>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | Not assoc w R - Interim | |||||
| mshA | 575971 | c.624C>T | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 576285 | p.Val313Ala | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 576757 | c.1410C>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | Not assoc w R - Interim | |||||
| ccsA | 620256 | c.366C>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| ccsA | 620257 | p.Ile123Ala | missense_variant | 1.0 | kanamycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| ccsA | 620490 | c.600A>C | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| ccsA | 620808 | c.918T>C | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| capreomycin | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| Rv0565c | 656502 | c.969C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656547 | c.924C>A | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656800 | p.Thr224Met | missense_variant | 1.0 | ethionamide | |
| Rv0565c | 656838 | c.633A>G | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656973 | c.498A>C | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656985 | c.486T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 656989 | p.Lys161Thr | missense_variant | 1.0 | ethionamide | |
| Rv0565c | 657309 | c.162C>G | synonymous_variant | 1.0 | ethionamide | |
| Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | |
| Rv0565c | 657695 | c.-225C>A | upstream_gene_variant | 1.0 | ethionamide | |
| hadA | 731852 | c.-78A>G | upstream_gene_variant | 1.0 | isoniazid | |
| hadA | 732379 | c.450A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| nusG | 733883 | c.-370_-368delGCG | upstream_gene_variant | 1.0 | rifampicin | |
| mmaA3 | 737397 | c.753G>C | synonymous_variant | 1.0 | isoniazid | |
| mmaA3 | 738177 | c.-28G>T | upstream_gene_variant | 1.0 | isoniazid | |
| rpoB | 759351 | c.-456G>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoB | 759911 | c.105C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 760715 | c.909C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761510 | c.1704T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761573 | c.1767C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
| rpoC | 763259 | c.-111G>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoC | 763660 | c.291T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764107 | c.738C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764134 | c.765C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764152 | c.783C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764159 | c.790C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764195 | p.Ser276Ala | missense_variant | 1.0 | rifampicin | |
| rpoC | 764198 | c.829C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764203 | c.834G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764206 | p.Asp279Glu | missense_variant | 1.0 | rifampicin | |
| rpoC | 764245 | c.876C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764257 | c.888G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764278 | c.909A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764293 | c.924G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764341 | c.972G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764365 | c.996C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764405 | c.1036A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764431 | c.1062G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764434 | c.1065A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764437 | c.1068G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764440 | c.1071G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764447 | c.1078_1080delCTGinsTTA | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764455 | c.1086G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764461 | c.1092A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764497 | c.1128A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764506 | c.1137C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764510 | c.1141C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764521 | c.1152T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764524 | c.1155C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764527 | c.1158C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764533 | c.1164C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764536 | c.1167G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764539 | c.1170C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764572 | c.1203G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764573 | c.1204_1206delCTTinsTTG | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764578 | c.1209C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764581 | c.1212T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764650 | c.1281G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764651 | c.1282_1284delTCGinsAGC | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764716 | c.1347G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764749 | c.1380G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764752 | c.1383G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764858 | c.1489T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764948 | c.1579T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 764968 | c.1599T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765034 | c.1665T>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765073 | c.1704G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765082 | c.1713G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765149 | p.Gly594Arg | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765177 | p.Ser603Asn | missense_variant | 1.0 | rifampicin | |
| rpoC | 765186 | p.His606Arg | missense_variant | 1.0 | rifampicin | |
| rpoC | 765189 | p.Pro607Leu | missense_variant | 1.0 | rifampicin | |
| rpoC | 765194 | p.Thr609Ala | missense_variant | 1.0 | rifampicin | |
| rpoC | 765199 | c.1830T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765202 | c.1833C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765298 | c.1929G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765409 | c.2040T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765478 | c.2109T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766186 | c.2817G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766189 | c.2820T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766594 | c.3225G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766607 | p.Ile1080Leu | missense_variant | 1.0 | rifampicin | |
| rpoC | 766621 | c.3252G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766657 | c.3288A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766672 | c.3303T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766675 | c.3306C>T | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 766693 | c.3324C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766726 | c.3357T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766750 | c.3381C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766765 | c.3396A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766900 | c.3531T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766924 | c.3555G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766945 | c.3576A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766969 | c.3600C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 767062 | c.3693C>A | synonymous_variant | 1.0 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| mmpL5 | 778057 | p.Ser142Gly | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 778573 | c.-93C>G | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 779283 | c.-803G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 779295 | c.-815A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpR5 | 779431 | p.Asn148Gln | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpL5 | 779472 | c.-992G>A | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpS5 | 779523 | c.-618T>A | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpS5 | 779538 | c.-633A>C | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| mmpS5 | 779539 | c.-634C>A | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
| rpsL | 781456 | c.-104A>G | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| rplC | 800111 | c.-698C>T | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800155 | c.-654_-653insG | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
| rplC | 800970 | c.162T>C | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| rplC | 801003 | c.195G>A | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| rplC | 801267 | c.459A>G | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| Rv1129c | 1253216 | p.Glu440Ala | missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| Rv1129c | 1253323 | c.1212G>T | synonymous_variant | 0.98 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| Rv1129c | 1253408 | p.Glu376Gly | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1253653 | c.882T>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1253692 | c.843C>T | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1253904 | p.Asn211Asp | missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| Rv1129c | 1254316 | c.219G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254434 | p.Val34Ala | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| Rv1129c | 1254576 | c.-42C>T | upstream_gene_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| Rv1129c | 1254602 | c.-68C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254610 | c.-76A>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254654 | c.-120A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254678 | c.-144A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| Rv1129c | 1254690 | c.-156T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| fbiC | 1302694 | c.-237C>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1302810 | c.-121C>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1302860 | c.-71G>A | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1302948 | c.18T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1303288 | p.Ser120Gly | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1303750 | c.820T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1303860 | c.930A>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304141 | p.Ala404Gly | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304330 | p.Ala467Asp | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1305060 | c.2130C>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | Not assoc w R - Interim | |||||
| clofazimine | Not assoc w R - Interim | |||||
| Rv1258c | 1406466 | p.Ser292Leu | missense_variant | 1.0 | streptomycin | Uncertain significance |
| pyrazinamide | Uncertain significance | |||||
| isoniazid | Uncertain significance | |||||
| Rv1258c | 1406492 | c.849C>A | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| pyrazinamide | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| Rv1258c | 1407559 | c.-219C>T | upstream_gene_variant | 1.0 | streptomycin | |
| pyrazinamide | ||||||
| isoniazid | ||||||
| embR | 1417294 | c.54A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embR | 1417454 | c.-107C>A | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | |
| embR | 1417925 | c.-578C>T | upstream_gene_variant | 1.0 | ethambutol | |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| rrs | 1471845 | n.4dupT | non_coding_transcript_exon_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| rrl | 1473420 | n.-238A>T | upstream_gene_variant | 1.0 | capreomycin | |
| linezolid | ||||||
| rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| inhA | 1673318 | c.-884C>A | upstream_gene_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| inhA | 1673499 | c.-703T>C | upstream_gene_variant | 1.0 | isoniazid | Uncertain significance |
| ethionamide | ||||||
| inhA | 1673659 | c.-543G>A | upstream_gene_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| rpsA | 1833381 | c.-161T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1833554 | p.Thr5Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| rpsA | 1833568 | c.27G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1833596 | c.55_56delAGinsTC | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833790 | c.249T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833907 | c.366G>A | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834639 | c.1098T>C | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834648 | c.1107C>T | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1834912 | c.1371A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| tsnR | 1853623 | c.18G>C | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
| tsnR | 1853636 | p.Thr11Ala | missense_variant | 1.0 | linezolid | Uncertain significance |
| tsnR | 1853838 | p.Ala78Val | missense_variant | 1.0 | linezolid | |
| tsnR | 1854005 | p.Ala134Ser | missense_variant | 1.0 | linezolid | |
| tsnR | 1854134 | c.529C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854295 | c.690C>T | synonymous_variant | 1.0 | linezolid | |
| tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
| tlyA | 1917606 | c.-334G>C | upstream_gene_variant | 1.0 | capreomycin | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
| bacA | 2061041 | c.1898_*1767del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | kanamycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| bacA | 2062890 | c.1839G>A | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| capreomycin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| amikacin | ||||||
| bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | kanamycin | Not assoc w R |
| capreomycin | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| bacA | 2063040 | c.1689C>T | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| bacA | 2063275 | p.His485Arg | missense_variant | 1.0 | kanamycin | |
| capreomycin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| amikacin | ||||||
| bacA | 2063788 | p.Gln314Arg | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| bacA | 2064210 | c.519A>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| bacA | 2064269 | c.460A>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| bacA | 2064320 | p.Thr137Ala | missense_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| bacA | 2064468 | c.261A>G | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| bacA | 2064696 | c.33T>C | synonymous_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| ndh | 2101676 | p.Ala456Gly | missense_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2101696 | c.1347C>T | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2101777 | c.1266C>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| delamanid | ||||||
| ethionamide | Not assoc w R - Interim | |||||
| ndh | 2101804 | c.1239T>C | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2101909 | c.1134G>C | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2101984 | c.1059C>T | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102164 | c.879A>G | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102186 | p.Gly286Ala | missense_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102254 | c.789C>T | synonymous_variant | 0.98 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102302 | c.741G>C | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102366 | p.Ala226Glu | missense_variant | 1.0 | isoniazid | Uncertain significance |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102389 | c.654G>C | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102419 | c.624G>A | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102560 | c.483C>T | synonymous_variant | 0.99 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102791 | c.252A>G | synonymous_variant | 0.99 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2102815 | c.228G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| delamanid | Not assoc w R - Interim | |||||
| ethionamide | Not assoc w R - Interim | |||||
| ndh | 2103001 | c.42G>A | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2103012 | p.Pro11Ser | missense_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2103060 | c.-18C>T | upstream_gene_variant | 1.0 | isoniazid | Uncertain significance |
| delamanid | ||||||
| ethionamide | Uncertain significance | |||||
| ndh | 2103173 | c.-132_-131insG | upstream_gene_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2103239 | c.-197T>A | upstream_gene_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| ndh | 2103324 | c.-282G>A | upstream_gene_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
| katG | 2156055 | c.57C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| katG | 2156658 | c.-547A>G | upstream_gene_variant | 1.0 | isoniazid | |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
| PPE35 | 2169717 | p.Asn299Ile | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170232 | c.381T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| PPE35 | 2170694 | c.-82T>C | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170720 | c.-108A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2170847 | c.-235T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170860 | c.-248A>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| Rv1979c | 2221723 | p.Arg481His | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| Rv1979c | 2222357 | p.Thr270Ala | missense_variant | 1.0 | bedaquiline | Uncertain significance |
| clofazimine | Uncertain significance | |||||
| Rv1979c | 2222504 | p.Met221Leu | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2222598 | c.567C>T | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2222778 | c.387C>T | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R - Interim | |||||
| Rv1979c | 2222961 | c.204G>A | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223146 | p.Arg7Gly | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223255 | c.-91A>G | upstream_gene_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
| clofazimine | Not assoc w R | |||||
| pncA | 2288720 | p.Glu174Asp | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| pncA | 2288735 | p.Val169Ala | missense_variant | 1.0 | pyrazinamide | |
| pncA | 2288791 | p.Leu151Met | missense_variant | 1.0 | pyrazinamide | |
| pncA | 2288855 | c.387T>C | synonymous_variant | 1.0 | pyrazinamide | |
| pncA | 2288893 | c.349C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| pncA | 2288969 | p.Glu91Asp | missense_variant | 1.0 | pyrazinamide | |
| pncA | 2288981 | c.261G>C | synonymous_variant | 1.0 | pyrazinamide | |
| pncA | 2289055 | p.Asp63Asn | missense_variant | 1.0 | pyrazinamide | |
| pncA | 2289104 | c.138A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| pncA | 2289132 | p.Glu37Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| pncA | 2289200 | c.42C>T | synonymous_variant | 1.0 | pyrazinamide | |
| pncA | 2289267 | c.-26C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289311 | c.-70A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289622 | c.-381C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289643 | c.-402C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289663 | c.-422A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289820 | c.-579T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289823 | c.-582T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2289913 | c.-672T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2290015 | c.-774A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| pncA | 2290072 | c.-831T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| kasA | 2518019 | c.-96A>G | upstream_gene_variant | 1.0 | isoniazid | |
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518240 | c.126C>A | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518246 | c.132C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518265 | p.Val51Ile | missense_variant | 1.0 | isoniazid | |
| kasA | 2518279 | c.165T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518282 | c.168A>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518283 | p.Ala57Pro | missense_variant | 1.0 | isoniazid | |
| kasA | 2518297 | c.183C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518300 | c.186T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518819 | c.705C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518822 | c.708C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518843 | c.729T>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518864 | c.750G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2518873 | c.759C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519062 | c.948T>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519089 | c.975C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519095 | c.981C>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519104 | c.990T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519260 | c.1146T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519266 | c.1152C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519281 | c.1167G>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519287 | c.1173T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519295 | p.Tyr394Phe | missense_variant | 1.0 | isoniazid | |
| kasA | 2519299 | c.1185C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519302 | c.1188C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519305 | c.1191A>G | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519311 | c.1197C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519329 | c.1215C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519332 | c.1218C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519344 | c.1230G>A | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519347 | c.1233T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519359 | c.1245T>C | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519364 | c.1250G>A | splice_region_variant&stop_retained_variant | 1.0 | isoniazid | |
| eis | 2714202 | c.1131C>T | synonymous_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| eis | 2714421 | c.912A>G | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| amikacin | Not assoc w R - Interim | |||||
| eis | 2714774 | p.Pro187Ser | missense_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| eis | 2714964 | c.369C>T | synonymous_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| eis | 2715590 | c.-258A>T | upstream_gene_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| eis | 2715607 | c.-275G>A | upstream_gene_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| ahpC | 2725905 | c.-288C>A | upstream_gene_variant | 1.0 | isoniazid | |
| ahpC | 2726226 | p.Ala12Thr | missense_variant | 1.0 | isoniazid | |
| folC | 2746174 | c.1425A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747204 | p.Ala132Gln | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747572 | c.27T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747575 | c.24G>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747628 | c.-30G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747631 | c.-33C>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747691 | c.-93A>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2477c | 2782483 | c.1560G>A | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2782714 | c.1329A>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2782768 | c.1275C>T | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2782774 | c.1269G>A | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2782777 | c.1266A>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2782792 | c.1251A>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783989 | c.54G>A | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783992 | c.51T>C | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | ||||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | ||||||
| Rv2477c | 2784342 | c.-300G>A | upstream_gene_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2784432 | c.-390A>G | upstream_gene_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2784569 | c.-527G>T | upstream_gene_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| pepQ | 2859490 | p.Val310Ala | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| ribD | 2987614 | c.766delA | frameshift_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2680 | 2995798 | c.-307T>C | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2680 | 2996009 | c.-96T>C | upstream_gene_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2680 | 2996010 | c.-95C>A | upstream_gene_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2681 | 2996356 | c.-383G>A | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2681 | 2996404 | c.-335T>A | upstream_gene_variant | 1.0 | capreomycin | |
| Rv2681 | 2996885 | c.147C>T | synonymous_variant | 1.0 | capreomycin | |
| Rv2681 | 2996891 | c.153C>G | synonymous_variant | 1.0 | capreomycin | |
| Rv2681 | 2997008 | c.270C>T | synonymous_variant | 1.0 | capreomycin | |
| Rv2681 | 2997054 | p.Ser106Gly | missense_variant | 1.0 | capreomycin | Uncertain significance |
| Rv2681 | 2997059 | c.321C>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
| Rv2681 | 2997668 | c.930G>T | synonymous_variant | 1.0 | capreomycin | |
| Rv2752c | 3064637 | p.Val519Met | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3065131 | p.Ala354Val | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066158 | p.Thr12Ala | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| ethambutol | Uncertain significance | |||||
| Rv2752c | 3066367 | c.-176G>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066417 | c.-226C>T | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| thyX | 3067355 | c.591A>C | synonymous_variant | 0.98 | para-aminosalicylic_acid | |
| thyX | 3067439 | c.507A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067874 | c.72C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067959 | c.-14C>T | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067980 | c.-35T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074160 | c.312A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074529 | c.-58G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074580 | c.-109T>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| ald | 3086759 | c.-61A>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086760 | c.-60A>G | upstream_gene_variant | 0.99 | cycloserine | |
| ald | 3086767 | c.-53A>T | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3087070 | p.Arg84Leu | missense_variant | 1.0 | cycloserine | |
| ald | 3087074 | c.255G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087077 | c.258A>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087079 | p.His87Arg | missense_variant | 1.0 | cycloserine | |
| ald | 3087122 | c.303T>C | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087140 | c.321G>A | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087197 | c.378A>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087263 | c.444C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087380 | c.561C>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087381 | p.Asn188Gly | missense_variant | 1.0 | cycloserine | |
| ald | 3087563 | c.744A>G | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087644 | c.825C>T | synonymous_variant | 1.0 | cycloserine | |
| ald | 3087671 | c.852C>T | synonymous_variant | 1.0 | cycloserine | |
| fbiD | 3339049 | c.-69C>T | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiD | 3339402 | c.285C>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | Not assoc w R - Interim | |||||
| clofazimine | Not assoc w R - Interim | |||||
| fbiD | 3339568 | c.451C>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| Rv3083 | 3448474 | c.-30G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3448611 | c.108A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449109 | c.606C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449139 | c.636A>G | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449237 | p.Arg245Lys | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449253 | c.750C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449263 | p.Leu254Val | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449290 | p.Lys263Gln | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449305 | c.802T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449323 | c.820_822delCGAinsAGG | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449375 | p.Leu291Arg | missense_variant | 1.0 | ethionamide | Uncertain significance |
| Rv3083 | 3449400 | c.897C>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449412 | c.909C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449421 | c.918T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449545 | c.1042C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449622 | c.1119T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449652 | c.1149T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449767 | p.Thr422Val | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449778 | c.1275T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449802 | c.1299T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449820 | c.1317G>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449832 | c.1329T>C | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
| Rv3083 | 3449835 | c.1332G>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449854 | p.Met451Leu | missense_variant | 0.99 | ethionamide | |
| Rv3083 | 3449917 | p.Ile472Val | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449940 | c.1437T>C | synonymous_variant | 1.0 | ethionamide | |
| lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | rifampicin | Not assoc w R |
| bedaquiline | Uncertain significance | |||||
| mtrB | 3625006 | c.1608A>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
| bedaquiline | Uncertain significance | |||||
| mtrB | 3626461 | c.153A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrA | 3626999 | c.351G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrA | 3627190 | c.160T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| mtrA | 3627734 | c.-385A>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3627802 | c.-453T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3627831 | c.-482T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrA | 3627839 | c.-490T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| fbiB | 3641840 | c.306T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiB | 3642254 | c.720G>A | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiB | 3642467 | c.933T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| alr | 3840527 | c.894A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840620 | c.801T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840719 | c.702A>G | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840796 | p.Asp209Asn | missense_variant | 1.0 | cycloserine | |
| alr | 3840914 | c.507G>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3840994 | p.His143Asp | missense_variant | 1.0 | cycloserine | |
| alr | 3841112 | c.309T>C | synonymous_variant | 0.99 | cycloserine | |
| alr | 3841116 | p.Ala102Gly | missense_variant | 1.0 | cycloserine | |
| alr | 3841172 | c.249A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841199 | c.222T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841419 | p.Val1Ala | missense_variant | 1.0 | cycloserine | |
| rpoA | 3877740 | c.768G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877886 | c.622C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3877887 | c.621G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878001 | c.507A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878049 | c.459G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoA | 3878623 | c.-116C>T | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3878637 | c.-130G>A | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3878665 | c.-158A>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878722 | c.-215C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878746 | c.-239A>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878848 | c.-341C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878961 | c.-454C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878962 | c.-455G>A | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878968 | c.-461T>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3879193 | c.-686G>A | upstream_gene_variant | 1.0 | rifampicin | |
| ddn | 3986805 | c.-39G>C | upstream_gene_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| ddn | 3987050 | c.207C>T | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| ddn | 3987287 | c.444T>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clpC1 | 4038227 | c.2478G>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038443 | c.2262G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038683 | c.2022T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038746 | c.1959C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038779 | c.1926C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038848 | c.1857C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038860 | c.1845G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038878 | c.1827A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038974 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039046 | c.1659C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039058 | c.1647C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039094 | c.1611C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039100 | c.1605C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039274 | c.1431G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039336 | c.1369C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039352 | c.1353C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039448 | c.1257A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039454 | c.1251A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039502 | c.1203C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039682 | c.1023C>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039700 | c.1005C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039718 | c.987C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039817 | c.888A>C | synonymous_variant | 0.98 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039820 | c.885T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4039823 | c.882T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040045 | c.660C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040048 | c.657C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040063 | c.642G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040090 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040093 | c.612C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040147 | c.558A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040159 | c.546G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040162 | c.543G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040213 | c.492T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040267 | c.438A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040273 | c.432T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040276 | c.429C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040279 | c.426C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040363 | c.342A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040393 | c.312G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040411 | c.294T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040423 | c.282A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040450 | c.255A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040471 | c.234T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040480 | c.225T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040534 | c.171A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040551 | c.154T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040573 | c.132T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040657 | c.48T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040879 | c.-177_-175delTGGinsCGGT | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4043932 | p.Met117Thr | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| panD | 4044243 | c.39C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| panD | 4044533 | c.-252T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| panD | 4044569 | c.-289_-288delCGinsGC | upstream_gene_variant | 1.0 | pyrazinamide | |
| glpK | 4138259 | c.1497T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | levofloxacin | Not assoc w R |
| moxifloxacin | Not assoc w R | |||||
| isoniazid | Not assoc w R | |||||
| streptomycin | Not assoc w R | |||||
| rifampicin | Not assoc w R | |||||
| ethambutol | Not assoc w R | |||||
| glpK | 4139096 | p.Leu220Phe | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4139321 | c.435T>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| glpK | 4139420 | c.336T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| isoniazid | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| glpK | 4139477 | c.279A>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4139813 | c.-58T>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| glpK | 4139934 | c.-179A>G | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| embC | 4239032 | c.-831T>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239110 | c.-753C>T | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4239764 | c.-99G>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4240237 | c.375G>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4240587 | p.Gly242Ala | missense_variant | 1.0 | ethambutol | |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embC | 4241150 | p.Ile430Val | missense_variant | 1.0 | ethambutol | |
| embC | 4241540 | p.Thr560Ala | missense_variant | 1.0 | ethambutol | |
| embC | 4241710 | c.1848G>A | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241758 | c.1896G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4241882 | p.Leu674Met | missense_variant | 1.0 | ethambutol | |
| embC | 4241957 | c.2095C>A | synonymous_variant | 1.0 | ethambutol | |
| embC | 4242261 | p.Met800Thr | missense_variant | 0.98 | ethambutol | |
| embA | 4242325 | c.-908C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embC | 4242449 | p.Met863Val | missense_variant | 1.0 | ethambutol | |
| embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| embA | 4242655 | c.-578A>G | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4242760 | c.-473G>A | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4242946 | c.-287T>C | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4243628 | c.396A>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4243649 | c.417G>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4243690 | p.Met153Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243961 | c.729G>A | synonymous_variant | 0.98 | ethambutol | |
| embA | 4244154 | p.Thr308Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4244177 | c.945G>C | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244178 | p.Ala316Thr | missense_variant | 1.0 | ethambutol | |
| embA | 4244312 | c.1080T>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4244846 | c.1614C>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245023 | c.1791A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4245764 | c.-750G>T | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4246193 | c.2961C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embA | 4246443 | p.Asp1071Asn | missense_variant | 1.0 | ethambutol | |
| embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
| embB | 4247815 | c.1302C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4248070 | c.1557T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248226 | c.1713G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| aftB | 4267412 | c.1425T>C | synonymous_variant | 1.0 | ethambutol | |
| aftB | 4268588 | c.249G>T | synonymous_variant | 1.0 | ethambutol | |
| aftB | 4268615 | c.222C>T | synonymous_variant | 1.0 | ethambutol | |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
| ubiA | 4269811 | p.Gln8Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| ubiA | 4270065 | c.-232C>T | upstream_gene_variant | 1.0 | ethambutol | |
| ethA | 4326403 | c.1071C>T | synonymous_variant | 1.0 | ethionamide | |
| ethA | 4326409 | c.1065T>C | synonymous_variant | 1.0 | ethionamide | |
| ethA | 4326487 | c.987A>T | synonymous_variant | 1.0 | ethionamide | |
| ethA | 4326678 | p.Ser266Gly | missense_variant | 1.0 | ethionamide | |
| ethR | 4326760 | c.-789T>C | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327092 | p.Ala128Thr | missense_variant | 0.99 | ethionamide | |
| ethA | 4327474 | c.-1C>T | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327532 | c.-59G>T | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327546 | c.-74_-73insC | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4328308 | c.-835G>C | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4328358 | c.-885C>T | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4328425 | c.-952C>G | upstream_gene_variant | 1.0 | ethionamide | |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
| capreomycin | Not assoc w R | |||||
| amikacin | Not assoc w R | |||||
| whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| whiB6 | 4338741 | c.-220A>G | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| whiB6 | 4338785 | c.-266_-264delGGCinsAG | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| whiB6 | 4338878 | c.-357C>T | upstream_gene_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| amikacin | ||||||
| gid | 4407568 | p.Ala212Val | missense_variant | 1.0 | streptomycin | |
| gid | 4407572 | p.Ile211Val | missense_variant | 1.0 | streptomycin | |
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
| gid | 4407705 | c.498G>T | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407782 | p.Ala141Thr | missense_variant | 1.0 | streptomycin | Uncertain significance |
| gid | 4407822 | c.381A>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4407943 | p.Gln87Arg | missense_variant | 1.0 | streptomycin | Uncertain significance |
| gid | 4407951 | c.252G>T | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408008 | c.195C>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408110 | p.Val31Ala | missense_variant | 1.0 | streptomycin | |
| gid | 4408113 | c.90T>C | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408153 | p.Gly17Asp | missense_variant | 1.0 | streptomycin | |
| gid | 4408176 | c.27T>C | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408228 | c.-28_-27delCA | upstream_gene_variant | 0.97 | streptomycin |
