TB-Profiler result

Run: ERR266126
Summary

Run ID: ERR266126

Sample name:

Date: 2024-03-24T15:45:32.611370

Number of reads: 4653139

Percentage reads mapped: 93.55

Median coverage: 81.0

Strain: La2;M.canetti

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
M.canetti M.canetti None 1.0
La2 M.caprae None 0.22
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine mmpR5 c.442_444delAACinsCA Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
para-aminosalicylic_acid
delamanid
bedaquiline mmpR5 c.442_444delAACinsCA Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
mmpR5 779431 c.442_444delAACinsCA frameshift_variant&missense_variant 1.0 clofazimine Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
bedaquiline Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 72 c.72T>C synonymous_variant 1.0 isoniazid
dnaA 264 c.264C>G synonymous_variant 1.0 isoniazid
dnaA 343 p.Pro115Ser missense_variant 1.0 isoniazid
dnaA 549 c.549C>T synonymous_variant 1.0 isoniazid
dnaA 708 c.708T>C synonymous_variant 1.0 isoniazid
dnaA 747 c.747G>A synonymous_variant 1.0 isoniazid
dnaA 942 c.942C>A synonymous_variant 1.0 isoniazid
dnaA 954 c.954G>C synonymous_variant 1.0 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 1.0 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 1.0 isoniazid
gyrB 5025 c.-215T>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 5440 c.201A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 5452 c.213G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5605 c.366C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5671 c.432C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 5770 c.531C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6001 c.762G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6004 c.765T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6370 c.1131C>T synonymous_variant 0.99 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6433 c.-869C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6436 c.-866C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 7256 c.2017C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8288 c.987T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9074 c.1773G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9218 c.1917C>T synonymous_variant 0.99 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9716 c.2415T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9740 c.2439G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9776 c.2475T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13189 p.Val124Leu missense_variant 1.0 isoniazid Uncertain significance
Rv0010c 13220 c.339T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
Rv0010c 13259 c.300C>G synonymous_variant 1.0 isoniazid
Rv0010c 13290 p.Asp90Ala missense_variant 1.0 isoniazid
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13802 c.-244A>C upstream_gene_variant 1.0 isoniazid
fgd1 490666 c.-117G>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490678 c.-105_-104insG upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490687 c.-96T>C upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490734 c.-49A>T upstream_gene_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 490744 c.-39T>C upstream_gene_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491406 p.Met208Ile missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574568 c.-780G>C upstream_gene_variant 1.0 ethionamide
isoniazid
mshA 575060 c.-288G>C upstream_gene_variant 1.0 ethionamide
isoniazid
mshA 575133 c.-215C>T upstream_gene_variant 1.0 ethionamide
isoniazid Uncertain significance
mshA 575665 c.318G>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575971 c.624C>T synonymous_variant 1.0 ethionamide
isoniazid
mshA 576285 p.Val313Ala missense_variant 1.0 ethionamide
isoniazid
mshA 576757 c.1410C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ccsA 620256 c.366C>G synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Ala missense_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
ccsA 620415 c.525T>C synonymous_variant 1.0 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620490 c.600A>C synonymous_variant 1.0 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620808 c.918T>C synonymous_variant 1.0 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
Rv0565c 656502 c.969C>T synonymous_variant 1.0 ethionamide
Rv0565c 656547 c.924C>A synonymous_variant 1.0 ethionamide
Rv0565c 656800 p.Thr224Met missense_variant 1.0 ethionamide
Rv0565c 656838 c.633A>G synonymous_variant 1.0 ethionamide
Rv0565c 656973 c.498A>C synonymous_variant 1.0 ethionamide
Rv0565c 656985 c.486T>C synonymous_variant 1.0 ethionamide
Rv0565c 656989 p.Lys161Thr missense_variant 1.0 ethionamide
Rv0565c 657309 c.162C>G synonymous_variant 1.0 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657695 c.-225C>A upstream_gene_variant 1.0 ethionamide
hadA 731852 c.-78A>G upstream_gene_variant 1.0 isoniazid
hadA 732379 c.450A>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
nusG 733883 c.-370_-368delGCG upstream_gene_variant 1.0 rifampicin
rpoB 759351 c.-456G>C upstream_gene_variant 1.0 rifampicin
rpoB 759911 c.105C>T synonymous_variant 1.0 rifampicin
rpoB 760715 c.909C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 1.0 rifampicin
rpoB 761573 c.1767C>A synonymous_variant 1.0 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763259 c.-111G>C upstream_gene_variant 1.0 rifampicin
rpoC 763660 c.291T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764107 c.738C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764134 c.765C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764152 c.783C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764159 c.790C>T synonymous_variant 1.0 rifampicin
rpoC 764195 p.Ser276Ala missense_variant 1.0 rifampicin
rpoC 764198 c.829C>T synonymous_variant 1.0 rifampicin
rpoC 764203 c.834G>T synonymous_variant 1.0 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 1.0 rifampicin
rpoC 764245 c.876C>T synonymous_variant 1.0 rifampicin
rpoC 764257 c.888G>C synonymous_variant 1.0 rifampicin
rpoC 764278 c.909A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>A synonymous_variant 1.0 rifampicin
rpoC 764341 c.972G>A synonymous_variant 1.0 rifampicin
rpoC 764365 c.996C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764437 c.1068G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764440 c.1071G>T synonymous_variant 1.0 rifampicin
rpoC 764447 c.1078_1080delCTGinsTA frameshift_variant&stop_gained 1.0 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 1.0 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 1.0 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 1.0 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 1.0 rifampicin
rpoC 764536 c.1167G>C synonymous_variant 1.0 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>T synonymous_variant 1.0 rifampicin
rpoC 764573 c.1204_1206delCTTinsTG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 1.0 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 1.0 rifampicin
rpoC 764650 c.1281G>C synonymous_variant 1.0 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 1.0 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 1.0 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>A synonymous_variant 1.0 rifampicin
rpoC 765149 p.Gly594Arg missense_variant 1.0 rifampicin Uncertain significance
rpoC 765177 p.Ser603Asn missense_variant 1.0 rifampicin
rpoC 765186 p.His606Arg missense_variant 1.0 rifampicin
rpoC 765189 p.Pro607Leu missense_variant 1.0 rifampicin
rpoC 765194 c.1825_1827delACTinsGG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 765199 c.1830T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765202 c.1833C>G synonymous_variant 1.0 rifampicin
rpoC 765298 c.1929G>T synonymous_variant 1.0 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766186 c.2817G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766189 c.2820T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766594 c.3225G>C synonymous_variant 1.0 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 1.0 rifampicin
rpoC 766621 c.3252G>A synonymous_variant 1.0 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 1.0 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 1.0 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.99 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 1.0 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 1.0 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 1.0 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766900 c.3531T>C synonymous_variant 1.0 rifampicin
rpoC 766924 c.3555G>A synonymous_variant 1.0 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766969 c.3600C>G synonymous_variant 1.0 rifampicin
rpoC 767062 c.3693C>A synonymous_variant 1.0 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 778057 p.Ser142Gly missense_variant 1.0 clofazimine
bedaquiline
mmpL5 778573 c.-93C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpL5 779283 c.-803G>A upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpL5 779295 c.-815A>G upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpL5 779472 c.-992G>A upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpS5 779523 c.-618T>A upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpS5 779538 c.-633A>C upstream_gene_variant 1.0 clofazimine
bedaquiline
mmpS5 779539 c.-634C>A upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781456 c.-104A>G upstream_gene_variant 1.0 streptomycin Uncertain significance
rplC 800111 c.-698C>T upstream_gene_variant 1.0 linezolid
rplC 800155 c.-654_-653insG upstream_gene_variant 1.0 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid
rplC 800970 c.162T>C synonymous_variant 1.0 linezolid Not assoc w R - Interim
rplC 801003 c.195G>A synonymous_variant 1.0 linezolid Not assoc w R - Interim
rplC 801267 c.459A>G synonymous_variant 1.0 linezolid Not assoc w R - Interim
Rv1129c 1253216 p.Glu440Ala missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1253323 c.1212G>T synonymous_variant 0.98 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv1129c 1253408 p.Glu376Gly missense_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253653 c.882T>G synonymous_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253692 c.843C>T synonymous_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1253904 p.Asn211Asp missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254316 c.219G>A synonymous_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254434 p.Val34Ala missense_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254576 c.-42C>T upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254602 c.-68C>T upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254610 c.-76A>C upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254654 c.-120A>G upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254678 c.-144A>G upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv1129c 1254690 c.-156T>G upstream_gene_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
fbiC 1302694 c.-237C>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1302810 c.-121C>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1302860 c.-71G>A upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1302948 c.18T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303288 p.Ser120Gly missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303750 c.820T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304141 p.Ala404Gly missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304330 p.Ala467Asp missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305060 c.2130C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
Rv1258c 1406466 p.Ser292Leu missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
Rv1258c 1406492 c.849C>A synonymous_variant 1.0 streptomycin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
pyrazinamide Not assoc w R - Interim
Rv1258c 1407559 c.-219C>T upstream_gene_variant 1.0 streptomycin
isoniazid
pyrazinamide
embR 1417294 c.54A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embR 1417454 c.-107C>A upstream_gene_variant 1.0 ethambutol
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417925 c.-578C>T upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471845 n.4dupT non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473420 n.-238A>T upstream_gene_variant 1.0 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
fabG1 1673318 c.-122C>A upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673499 c.-703T>C upstream_gene_variant 1.0 ethionamide
isoniazid Uncertain significance
fabG1 1673659 p.Ala74Thr missense_variant 1.0 ethionamide
isoniazid
rpsA 1833381 c.-161T>C upstream_gene_variant 1.0 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1833596 c.55_56delAGinsTC synonymous_variant 1.0 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833907 c.366G>A synonymous_variant 1.0 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834648 c.1107C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834912 c.1371A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1853623 c.18G>C synonymous_variant 1.0 linezolid Not assoc w R - Interim
tsnR 1853636 p.Thr11Ala missense_variant 1.0 linezolid Uncertain significance
tsnR 1853838 p.Ala78Val missense_variant 1.0 linezolid
tsnR 1854005 p.Ala134Ser missense_variant 1.0 linezolid
tsnR 1854134 c.529C>T synonymous_variant 1.0 linezolid
tsnR 1854295 c.690C>T synonymous_variant 1.0 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917606 c.-334G>C upstream_gene_variant 1.0 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2061041 c.1898_*1767del frameshift_variant&stop_lost&splice_region_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
bacA 2062890 c.1839G>A synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063040 c.1689C>T synonymous_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063275 p.His485Arg missense_variant 1.0 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin
bacA 2063788 p.Gln314Arg missense_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064210 c.519A>G synonymous_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064269 c.460A>C synonymous_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064320 p.Thr137Ala missense_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064468 c.261A>G synonymous_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064696 c.33T>C synonymous_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101676 p.Ala456Gly missense_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2101696 c.1347C>T synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2101777 c.1266C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2101804 c.1239T>C synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2101909 c.1134G>C synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2101984 c.1059C>T synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102164 c.879A>G synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102186 p.Gly286Ala missense_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102254 c.789C>T synonymous_variant 0.98 ethionamide
delamanid
isoniazid
ndh 2102302 c.741G>C synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102366 p.Ala226Glu missense_variant 1.0 ethionamide
delamanid
isoniazid Uncertain significance
ndh 2102389 c.654G>C synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102419 c.624G>A synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2102560 c.483C>T synonymous_variant 0.99 ethionamide
delamanid
isoniazid
ndh 2102791 c.252A>G synonymous_variant 0.99 ethionamide
delamanid
isoniazid
ndh 2102815 c.228G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2103001 c.42G>A synonymous_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2103012 p.Pro11Ser missense_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2103060 c.-18C>T upstream_gene_variant 1.0 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2103173 c.-132_-131insG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2103239 c.-197T>A upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2103324 c.-282G>A upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2156055 c.57C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2156658 c.-547A>G upstream_gene_variant 1.0 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169717 p.Asn299Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170232 c.381T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
PPE35 2170694 c.-82T>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170720 c.-108A>G upstream_gene_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170847 c.-235T>C upstream_gene_variant 1.0 pyrazinamide
PPE35 2170860 c.-248A>C upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2221723 p.Arg481His missense_variant 1.0 clofazimine
bedaquiline
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2222357 p.Thr270Ala missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2222504 p.Met221Leu missense_variant 1.0 clofazimine
bedaquiline
Rv1979c 2222598 c.567C>T synonymous_variant 1.0 clofazimine
bedaquiline
Rv1979c 2222778 c.387C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
Rv1979c 2222961 c.204G>A synonymous_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223146 p.Arg7Gly missense_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223255 c.-91A>G upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2288720 p.Glu174Asp missense_variant 1.0 pyrazinamide Uncertain significance
pncA 2288735 p.Val169Ala missense_variant 1.0 pyrazinamide
pncA 2288791 p.Leu151Met missense_variant 1.0 pyrazinamide
pncA 2288855 c.387T>C synonymous_variant 1.0 pyrazinamide
pncA 2288893 c.349C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
pncA 2288969 p.Glu91Asp missense_variant 1.0 pyrazinamide
pncA 2288981 c.261G>C synonymous_variant 1.0 pyrazinamide
pncA 2289055 p.Asp63Asn missense_variant 1.0 pyrazinamide
pncA 2289104 c.138A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
pncA 2289132 p.Glu37Ala missense_variant 1.0 pyrazinamide Uncertain significance
pncA 2289200 c.42C>T synonymous_variant 1.0 pyrazinamide
pncA 2289267 c.-26C>T upstream_gene_variant 1.0 pyrazinamide
pncA 2289311 c.-70A>G upstream_gene_variant 1.0 pyrazinamide
pncA 2289622 c.-381C>T upstream_gene_variant 1.0 pyrazinamide
pncA 2289643 c.-402C>T upstream_gene_variant 1.0 pyrazinamide
pncA 2289663 c.-422A>G upstream_gene_variant 1.0 pyrazinamide
pncA 2289820 c.-579T>C upstream_gene_variant 1.0 pyrazinamide
pncA 2289823 c.-582T>C upstream_gene_variant 1.0 pyrazinamide
pncA 2289913 c.-672T>C upstream_gene_variant 1.0 pyrazinamide
pncA 2290015 c.-774A>G upstream_gene_variant 1.0 pyrazinamide
pncA 2290072 c.-831T>C upstream_gene_variant 1.0 pyrazinamide
kasA 2518019 c.-96A>G upstream_gene_variant 1.0 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518240 c.126C>A synonymous_variant 1.0 isoniazid
kasA 2518246 c.132C>T synonymous_variant 1.0 isoniazid
kasA 2518265 p.Val51Ile missense_variant 1.0 isoniazid
kasA 2518279 c.165T>C synonymous_variant 1.0 isoniazid
kasA 2518282 c.168A>G synonymous_variant 1.0 isoniazid
kasA 2518283 c.169_171delGCGinsCC frameshift_variant&missense_variant 1.0 isoniazid
kasA 2518297 c.183C>T synonymous_variant 1.0 isoniazid
kasA 2518300 c.186T>C synonymous_variant 1.0 isoniazid
kasA 2518819 c.705C>T synonymous_variant 1.0 isoniazid
kasA 2518822 c.708C>G synonymous_variant 1.0 isoniazid
kasA 2518843 c.729T>G synonymous_variant 1.0 isoniazid
kasA 2518864 c.750G>C synonymous_variant 1.0 isoniazid
kasA 2518873 c.759C>T synonymous_variant 1.0 isoniazid
kasA 2519062 c.948T>G synonymous_variant 1.0 isoniazid
kasA 2519089 c.975C>G synonymous_variant 1.0 isoniazid
kasA 2519095 c.981C>G synonymous_variant 1.0 isoniazid
kasA 2519104 c.990T>C synonymous_variant 1.0 isoniazid
kasA 2519260 c.1146T>C synonymous_variant 1.0 isoniazid
kasA 2519266 c.1152C>T synonymous_variant 1.0 isoniazid
kasA 2519281 c.1167G>C synonymous_variant 1.0 isoniazid
kasA 2519287 c.1173T>C synonymous_variant 1.0 isoniazid
kasA 2519295 p.Tyr394Phe missense_variant 1.0 isoniazid
kasA 2519299 c.1185C>T synonymous_variant 1.0 isoniazid
kasA 2519302 c.1188C>T synonymous_variant 1.0 isoniazid
kasA 2519305 c.1191A>G synonymous_variant 1.0 isoniazid
kasA 2519311 c.1197C>T synonymous_variant 1.0 isoniazid
kasA 2519329 c.1215C>T synonymous_variant 1.0 isoniazid
kasA 2519332 c.1218C>T synonymous_variant 1.0 isoniazid
kasA 2519344 c.1230G>A synonymous_variant 1.0 isoniazid
kasA 2519347 c.1233T>C synonymous_variant 1.0 isoniazid
kasA 2519359 c.1245T>C synonymous_variant 1.0 isoniazid
kasA 2519364 c.1250G>A splice_region_variant&stop_retained_variant 1.0 isoniazid
eis 2714202 c.1131C>T synonymous_variant 1.0 amikacin
kanamycin
eis 2714421 c.912A>G synonymous_variant 1.0 amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
eis 2714774 p.Pro187Ser missense_variant 1.0 amikacin
kanamycin
eis 2714964 c.369C>T synonymous_variant 1.0 amikacin
kanamycin
eis 2715590 c.-258A>T upstream_gene_variant 1.0 amikacin
kanamycin
eis 2715607 c.-275G>A upstream_gene_variant 1.0 amikacin
kanamycin
ahpC 2725905 c.-288C>A upstream_gene_variant 1.0 isoniazid
ahpC 2726226 p.Ala12Thr missense_variant 1.0 isoniazid
folC 2746174 c.1425A>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747204 p.Ala132Gln missense_variant 1.0 para-aminosalicylic_acid
folC 2747572 c.27T>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747575 c.24G>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747628 c.-30G>C upstream_gene_variant 1.0 para-aminosalicylic_acid
folC 2747631 c.-33C>G upstream_gene_variant 1.0 para-aminosalicylic_acid
folC 2747691 c.-93A>G upstream_gene_variant 1.0 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782714 c.1329A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782768 c.1275C>T synonymous_variant 1.0 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2782774 c.1269G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782777 c.1266A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782792 c.1251A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783989 c.54G>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784342 c.-300G>A upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>G upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784569 c.-527G>T upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859490 p.Val310Ala missense_variant 1.0 clofazimine
bedaquiline
ribD 2987614 c.766delA frameshift_variant 1.0 para-aminosalicylic_acid
Rv2680 2995798 c.-307T>C upstream_gene_variant 1.0 capreomycin
Rv2680 2996009 c.-96T>C upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2680 2996010 c.-95C>A upstream_gene_variant 1.0 capreomycin Uncertain significance
Rv2681 2996356 c.-383G>A upstream_gene_variant 1.0 capreomycin
Rv2681 2996404 c.-335T>A upstream_gene_variant 1.0 capreomycin
Rv2681 2996885 c.147C>T synonymous_variant 1.0 capreomycin
Rv2681 2996891 c.153C>G synonymous_variant 1.0 capreomycin
Rv2681 2997008 c.270C>T synonymous_variant 1.0 capreomycin
Rv2681 2997054 p.Ser106Gly missense_variant 1.0 capreomycin Uncertain significance
Rv2681 2997059 c.321C>A synonymous_variant 1.0 capreomycin Not assoc w R - Interim
Rv2681 2997668 c.930G>T synonymous_variant 1.0 capreomycin
Rv2752c 3064637 p.Val519Met missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065131 p.Ala354Val missense_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066158 p.Thr12Ala missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066367 c.-176G>T upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066417 c.-226C>T upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067355 c.591A>C synonymous_variant 0.98 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067874 c.72C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyX 3067959 c.-14C>T upstream_gene_variant 1.0 para-aminosalicylic_acid
thyX 3067980 c.-35T>C upstream_gene_variant 1.0 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074529 c.-58G>C upstream_gene_variant 1.0 para-aminosalicylic_acid
thyA 3074580 c.-109T>C upstream_gene_variant 1.0 para-aminosalicylic_acid
ald 3086759 c.-61A>C upstream_gene_variant 1.0 cycloserine
ald 3086760 c.-60A>G upstream_gene_variant 0.99 cycloserine
ald 3086767 c.-53A>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087070 p.Arg84Leu missense_variant 1.0 cycloserine
ald 3087074 c.255G>A synonymous_variant 1.0 cycloserine
ald 3087077 c.258A>C synonymous_variant 1.0 cycloserine
ald 3087079 p.His87Arg missense_variant 1.0 cycloserine
ald 3087122 c.303T>C synonymous_variant 1.0 cycloserine
ald 3087140 c.321G>A synonymous_variant 1.0 cycloserine
ald 3087197 c.378A>G synonymous_variant 1.0 cycloserine
ald 3087263 c.444C>T synonymous_variant 1.0 cycloserine
ald 3087380 c.561C>G synonymous_variant 1.0 cycloserine
ald 3087381 p.Asn188Gly missense_variant 1.0 cycloserine
ald 3087563 c.744A>G synonymous_variant 1.0 cycloserine
ald 3087644 c.825C>T synonymous_variant 1.0 cycloserine
ald 3087671 c.852C>T synonymous_variant 1.0 cycloserine
fbiD 3339049 c.-69C>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
fbiD 3339402 c.285C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiD 3339568 c.451C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
Rv3083 3448474 c.-30G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
Rv3083 3448611 c.108A>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449109 c.606C>T synonymous_variant 1.0 ethionamide
Rv3083 3449139 c.636A>G synonymous_variant 1.0 ethionamide
Rv3083 3449237 p.Arg245Lys missense_variant 1.0 ethionamide
Rv3083 3449253 c.750C>T synonymous_variant 1.0 ethionamide
Rv3083 3449263 p.Leu254Val missense_variant 1.0 ethionamide
Rv3083 3449290 p.Lys263Gln missense_variant 1.0 ethionamide
Rv3083 3449305 c.802T>C synonymous_variant 1.0 ethionamide
Rv3083 3449323 c.820_822delCGAinsAG frameshift_variant&synonymous_variant 1.0 ethionamide Uncertain significance
Rv3083 3449375 p.Leu291Arg missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3449400 c.897C>G synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449412 c.909C>T synonymous_variant 1.0 ethionamide
Rv3083 3449421 c.918T>C synonymous_variant 1.0 ethionamide
Rv3083 3449545 c.1042C>T synonymous_variant 1.0 ethionamide
Rv3083 3449622 c.1119T>C synonymous_variant 1.0 ethionamide
Rv3083 3449652 c.1149T>C synonymous_variant 1.0 ethionamide
Rv3083 3449767 p.Thr422Val missense_variant 1.0 ethionamide
Rv3083 3449778 c.1275T>C synonymous_variant 1.0 ethionamide
Rv3083 3449802 c.1299T>C synonymous_variant 1.0 ethionamide
Rv3083 3449820 c.1317G>C synonymous_variant 1.0 ethionamide
Rv3083 3449832 c.1329T>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449835 c.1332G>C synonymous_variant 1.0 ethionamide
Rv3083 3449854 p.Met451Leu missense_variant 0.99 ethionamide
Rv3083 3449917 p.Ile472Val missense_variant 1.0 ethionamide
Rv3083 3449940 c.1437T>C synonymous_variant 1.0 ethionamide
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625006 c.1608A>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626461 c.153A>G synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626999 c.351G>A synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627190 c.160T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627734 c.-385A>G upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627802 c.-453T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627831 c.-482T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3627839 c.-490T>C upstream_gene_variant 1.0 bedaquiline
rifampicin
fbiB 3641840 c.306T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642254 c.720G>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiB 3642467 c.933T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
alr 3840527 c.894A>C synonymous_variant 1.0 cycloserine
alr 3840620 c.801T>C synonymous_variant 1.0 cycloserine
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
alr 3840796 p.Asp209Asn missense_variant 1.0 cycloserine
alr 3840914 c.507G>C synonymous_variant 1.0 cycloserine
alr 3840994 p.His143Asp missense_variant 1.0 cycloserine
alr 3841112 c.309T>C synonymous_variant 0.99 cycloserine
alr 3841116 p.Ala102Gly missense_variant 1.0 cycloserine
alr 3841172 c.249A>C synonymous_variant 1.0 cycloserine
alr 3841199 c.222T>C synonymous_variant 1.0 cycloserine
alr 3841419 p.Val1Ala missense_variant 1.0 cycloserine
rpoA 3877740 c.768G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877886 c.622C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878049 c.459G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878623 c.-116C>T upstream_gene_variant 1.0 rifampicin
rpoA 3878637 c.-130G>A upstream_gene_variant 1.0 rifampicin
rpoA 3878665 c.-158A>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878722 c.-215C>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878746 c.-239A>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878848 c.-341C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878914 c.-407T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878947 c.-440G>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878961 c.-454C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoA 3879193 c.-686G>A upstream_gene_variant 1.0 rifampicin
ddn 3986805 c.-39G>C upstream_gene_variant 1.0 delamanid
pretomanid
ddn 3987050 c.207C>T synonymous_variant 1.0 delamanid
pretomanid
ddn 3987287 c.444T>C synonymous_variant 1.0 delamanid
pretomanid
clpC1 4038227 c.2478G>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038443 c.2262G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038683 c.2022T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038746 c.1959C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038779 c.1926C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038848 c.1857C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038974 c.1731T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039046 c.1659C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039058 c.1647C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039094 c.1611C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039100 c.1605C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039336 c.1369C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039352 c.1353C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039448 c.1257A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039502 c.1203C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039682 c.1023C>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039700 c.1005C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039718 c.987C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>C synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040045 c.660C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040063 c.642G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.615T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040147 c.558A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040159 c.546G>A synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040213 c.492T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.429C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040363 c.342A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040393 c.312G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040450 c.255A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040471 c.234T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040534 c.171A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040551 c.154T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040573 c.132T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040657 c.48T>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4040879 c.-177_-175delTGGinsCGGT upstream_gene_variant 1.0 pyrazinamide
panD 4043932 p.Met117Thr missense_variant 1.0 pyrazinamide Uncertain significance
panD 4044243 c.39C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
panD 4044533 c.-252T>C upstream_gene_variant 1.0 pyrazinamide
panD 4044569 c.-289_-288delCGinsGC upstream_gene_variant 1.0 pyrazinamide
glpK 4138259 c.1497T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139096 p.Leu220Phe missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139321 c.435T>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139420 c.336T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139477 c.279A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139813 c.-58T>G upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139934 c.-179A>G upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239032 c.-831T>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239110 c.-753C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239764 c.-99G>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240237 c.375G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240587 p.Gly242Ala missense_variant 1.0 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241150 p.Ile430Val missense_variant 1.0 ethambutol
embC 4241540 p.Thr560Ala missense_variant 1.0 ethambutol
embC 4241710 c.1848G>A synonymous_variant 1.0 ethambutol
embC 4241758 c.1896G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4241882 p.Leu674Met missense_variant 1.0 ethambutol
embC 4241957 c.2095C>A synonymous_variant 1.0 ethambutol
embC 4242261 p.Met800Thr missense_variant 0.98 ethambutol
embA 4242325 c.-908C>T upstream_gene_variant 1.0 ethambutol
embC 4242449 p.Met863Val missense_variant 1.0 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242655 c.-578A>G upstream_gene_variant 1.0 ethambutol
embA 4242760 c.-473G>A upstream_gene_variant 1.0 ethambutol
embA 4242946 c.-287T>C upstream_gene_variant 1.0 ethambutol
embA 4243628 c.396A>G synonymous_variant 1.0 ethambutol
embA 4243649 c.417G>C synonymous_variant 1.0 ethambutol
embA 4243690 p.Met153Thr missense_variant 1.0 ethambutol Uncertain significance
embA 4243961 c.729G>A synonymous_variant 0.98 ethambutol
embA 4244154 p.Thr308Pro missense_variant 1.0 ethambutol Uncertain significance
embA 4244177 c.945G>C synonymous_variant 1.0 ethambutol
embA 4244178 p.Ala316Thr missense_variant 1.0 ethambutol
embA 4244312 c.1080T>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4244846 c.1614C>G synonymous_variant 1.0 ethambutol
embA 4245023 c.1791A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4245764 c.-750G>T upstream_gene_variant 1.0 ethambutol
embA 4246193 c.2961C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4246443 p.Asp1071Asn missense_variant 1.0 ethambutol
embB 4247590 c.1077A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247815 c.1302C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 1.0 ethambutol
embB 4248206 p.Ser565Gly missense_variant 1.0 ethambutol Uncertain significance
embB 4248226 c.1713G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
aftB 4267412 c.1425T>C synonymous_variant 1.0 ethambutol
aftB 4268588 c.249G>T synonymous_variant 1.0 ethambutol
aftB 4268615 c.222C>T synonymous_variant 1.0 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269811 p.Gln8Arg missense_variant 1.0 ethambutol Uncertain significance
ubiA 4270065 c.-232C>T upstream_gene_variant 1.0 ethambutol
ethA 4326403 c.1071C>T synonymous_variant 1.0 ethionamide
ethA 4326409 c.1065T>C synonymous_variant 1.0 ethionamide
ethA 4326487 c.987A>T synonymous_variant 1.0 ethionamide
ethA 4326678 p.Ser266Gly missense_variant 1.0 ethionamide
ethR 4326760 c.-789T>C upstream_gene_variant 1.0 ethionamide
ethA 4327092 p.Ala128Thr missense_variant 0.99 ethionamide
ethA 4327474 c.-1C>T upstream_gene_variant 1.0 ethionamide
ethA 4327532 c.-59G>T upstream_gene_variant 1.0 ethionamide
ethA 4327546 c.-74_-73insC upstream_gene_variant 1.0 ethionamide
ethA 4328308 c.-835G>C upstream_gene_variant 1.0 ethionamide
ethA 4328358 c.-885C>T upstream_gene_variant 1.0 ethionamide
ethA 4328425 c.-952C>G upstream_gene_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
whiB6 4338741 c.-220A>G upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
whiB6 4338785 c.-266_-264delGGCinsAG upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
whiB6 4338878 c.-357C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407568 p.Ala212Val missense_variant 1.0 streptomycin
gid 4407572 p.Ile211Val missense_variant 1.0 streptomycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407705 c.498G>T synonymous_variant 1.0 streptomycin
gid 4407782 p.Ala141Thr missense_variant 1.0 streptomycin Uncertain significance
gid 4407822 c.381A>G synonymous_variant 1.0 streptomycin
gid 4407943 p.Gln87Arg missense_variant 1.0 streptomycin Uncertain significance
gid 4407951 c.252G>T synonymous_variant 1.0 streptomycin
gid 4408008 c.195C>G synonymous_variant 1.0 streptomycin
gid 4408110 p.Val31Ala missense_variant 1.0 streptomycin
gid 4408113 c.90T>C synonymous_variant 1.0 streptomycin
gid 4408153 p.Gly17Asp missense_variant 1.0 streptomycin
gid 4408176 c.27T>C synonymous_variant 1.0 streptomycin
gid 4408228 c.-28_-27delCA upstream_gene_variant 0.97 streptomycin