TB-Profiler result

Run: ERR4821276
Summary

Run ID: ERR4821276

Sample name:

Date: 2025-09-15T15:34:34.864145

Number of reads: 3003745

Percentage reads mapped: 51.03

Median coverage: 62.0

Strain: lineage3

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7386 p.Ile29Leu missense_variant 0.12 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7394 c.93T>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
gyrA 7406 c.105G>C synonymous_variant 0.11 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 0.98 ethionamide Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760263 p.Met153Leu missense_variant 0.12 rifampicin Uncertain significance
rpoB 760266 p.Met154Leu missense_variant 0.12 rifampicin Uncertain significance
rpoB 760273 p.Glu156Gly missense_variant 0.12 rifampicin Uncertain significance
rpoB 760298 c.492G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 760313 c.507G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoB 760991 c.1185G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoB 760997 c.1191G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761013 p.Val403Ile missense_variant 0.12 rifampicin Uncertain significance
rpoB 761027 c.1221A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761046 p.Ile414Val missense_variant 0.14 rifampicin Uncertain significance
rpoB 761051 c.1245G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761162 c.1356G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 761165 c.1359G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761175 c.1371_1372delGT frameshift_variant 0.16 rifampicin Uncertain significance
rpoB 761180 c.1374_1375insGC frameshift_variant 0.15 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761196 p.Leu464Val missense_variant 0.16 rifampicin Uncertain significance
rpoB 761207 c.1401C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 761213 c.1407G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761562 p.Ala586Ser missense_variant 0.27 rifampicin Uncertain significance
rpoB 761565 p.Met587Leu missense_variant 0.26 rifampicin Uncertain significance
rpoB 761570 c.1764T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.26 rifampicin Uncertain significance
rpoB 761603 c.1797C>T synonymous_variant 0.26 rifampicin Uncertain significance
rpoB 761612 c.1806G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762879 p.Met1025Leu missense_variant 0.2 rifampicin Uncertain significance
rpoC 762896 c.-474G>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoB 762929 c.3123G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762932 c.-438G>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoC 762947 c.-423C>G upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoB 762962 c.3156C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763052 c.-318G>C upstream_gene_variant 0.12 rifampicin Uncertain significance
rpoB 763053 c.3247T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoB 763070 c.3264T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763075 p.Thr1090Ile missense_variant 0.22 rifampicin Uncertain significance
rpoB 763094 c.3288G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763126 p.Pro1107Gln missense_variant 0.23 rifampicin Uncertain significance
rpoC 763148 c.-222G>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoC 763660 c.291T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.27 rifampicin Uncertain significance
rpoC 763711 c.342G>C synonymous_variant 0.27 rifampicin Uncertain significance
rpoC 763714 c.345G>A synonymous_variant 0.26 rifampicin Uncertain significance
rpoC 763717 c.348T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.29 rifampicin Uncertain significance
rpoC 763727 p.Leu120Met missense_variant 0.27 rifampicin Uncertain significance
rpoC 763732 c.363C>G synonymous_variant 0.28 rifampicin Uncertain significance
rpoC 763744 c.375G>C synonymous_variant 0.25 rifampicin Uncertain significance
rpoC 763751 p.Ile128Val missense_variant 0.2 rifampicin Uncertain significance
rpoC 763765 c.396T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 764308 c.939G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 764316 p.Ala316Val missense_variant 0.19 rifampicin Uncertain significance
rpoC 764320 c.951C>G synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 764353 c.984G>C synonymous_variant 0.29 rifampicin Uncertain significance
rpoC 764365 c.996C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.36 rifampicin Uncertain significance
rpoC 764387 c.1018T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.24 rifampicin Uncertain significance
rpoC 764503 c.1134G>C synonymous_variant 0.31 rifampicin Uncertain significance
rpoC 764509 c.1140G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.43 rifampicin Uncertain significance
rpoC 764536 c.1167G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764549 p.Pro394Thr missense_variant 0.42 rifampicin Uncertain significance
rpoC 764561 p.Pro398Ala missense_variant 0.45 rifampicin Uncertain significance
rpoC 764566 c.1197C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.43 rifampicin Uncertain significance
rpoC 764582 p.Leu405Met missense_variant 0.42 rifampicin Uncertain significance
rpoC 764611 c.1242G>C synonymous_variant 0.49 rifampicin Uncertain significance
rpoC 764632 c.1263T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.39 rifampicin Uncertain significance
rpoC 764650 c.1281G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764660 p.Val431Ile missense_variant 0.36 rifampicin Uncertain significance
rpoC 764677 c.1308C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764683 c.1314G>C synonymous_variant 0.3 rifampicin Uncertain significance
rpoC 764692 c.1323C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Ala missense_variant 0.17 rifampicin Uncertain significance
rpoC 764911 c.1542A>G synonymous_variant 0.12 rifampicin Uncertain significance
rpoC 764912 p.Met515Leu missense_variant 0.11 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 764956 c.1587T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 764958 p.Glu530Ala missense_variant 0.18 rifampicin Uncertain significance
rpoC 764968 c.1599T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766075 c.2706C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781760 c.201T>C synonymous_variant 0.13 streptomycin Uncertain significance
rpsL 781794 p.Met79Leu missense_variant 0.15 streptomycin Uncertain significance
rpsL 781802 c.243G>C synonymous_variant 0.16 streptomycin Uncertain significance
rpsL 781805 c.246G>C synonymous_variant 0.16 streptomycin Uncertain significance
rpsL 781808 c.249C>T synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781811 c.252C>A synonymous_variant 0.16 streptomycin Uncertain significance
rpsL 781817 c.258G>T synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781829 c.270G>C synonymous_variant 0.12 streptomycin Uncertain significance
rpsL 781832 c.273T>C synonymous_variant 0.13 streptomycin Uncertain significance
rpsL 781838 c.279G>C synonymous_variant 0.12 streptomycin Uncertain significance
rpsL 781841 c.282C>T synonymous_variant 0.12 streptomycin Uncertain significance
Rv1129c 1253359 c.1176C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473134 n.1289T>C non_coding_transcript_exon_variant 0.54 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.47 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.5 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.46 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.5 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.64 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473269 n.1424C>T non_coding_transcript_exon_variant 0.5 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.5 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.46 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.43 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.43 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.44 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rpsA 1833709 c.168C>G synonymous_variant 0.12 pyrazinamide Uncertain significance
rpsA 1833721 c.180A>G synonymous_variant 0.11 pyrazinamide Uncertain significance
rpsA 1833727 c.186G>C synonymous_variant 0.11 pyrazinamide Uncertain significance
rpsA 1833734 p.Ala65Ser missense_variant 0.12 pyrazinamide Uncertain significance
rpsA 1833769 c.228C>G synonymous_variant 0.12 pyrazinamide Uncertain significance
rpsA 1833790 c.249T>C synonymous_variant 0.12 pyrazinamide Uncertain significance
rpsA 1833856 c.315A>G synonymous_variant 0.12 pyrazinamide Uncertain significance
rpsA 1833859 c.318C>G synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833874 c.333T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833884 p.Thr115Asp missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833887 p.Ile116Val missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833893 p.Ala118Lys missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833896 p.Leu119Ile missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833907 p.Lys122Asn missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833912 p.Glu124Gly missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833915 p.Ala125Val missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833921 p.Lys127Thr missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834384 c.843A>G synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834395 p.Arg285Gln missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1834397 p.His286Val missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1834411 c.870T>C synonymous_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834423 c.882G>T synonymous_variant 0.37 pyrazinamide Uncertain significance
rpsA 1834427 p.Ile296Val missense_variant 0.38 pyrazinamide Uncertain significance
rpsA 1834431 p.Val297Ala missense_variant 0.37 pyrazinamide Uncertain significance
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.39 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.42 pyrazinamide Uncertain significance
rpsA 1834465 c.924T>C synonymous_variant 0.42 pyrazinamide Uncertain significance
rpsA 1834468 c.927A>G synonymous_variant 0.42 pyrazinamide Uncertain significance
rpsA 1834474 c.933C>G synonymous_variant 0.42 pyrazinamide Uncertain significance
rpsA 1834482 p.Glu314Ala missense_variant 0.36 pyrazinamide Uncertain significance
rpsA 1834486 p.Glu315Asp missense_variant 0.32 pyrazinamide Uncertain significance
rpsA 1834489 c.948T>C synonymous_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834501 c.960G>C synonymous_variant 0.22 pyrazinamide Uncertain significance
rpsA 1834513 c.972C>G synonymous_variant 0.13 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide Uncertain significance
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
folC 2746452 p.Gly383Ser missense_variant 1.0 para-aminosalicylic_acid Uncertain significance
Rv2477c 2782498 c.1545C>T synonymous_variant 0.97 amikacin Not assoc w R
ethambutol Not assoc w R
kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4040024 c.681A>G synonymous_variant 0.12 pyrazinamide Uncertain significance
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4040063 c.642G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.26 pyrazinamide Uncertain significance
clpC1 4040069 c.636G>C synonymous_variant 0.27 pyrazinamide Uncertain significance
clpC1 4040083 p.Thr208Ser missense_variant 0.3 pyrazinamide Uncertain significance
clpC1 4040090 c.615T>G synonymous_variant 0.31 pyrazinamide Uncertain significance
clpC1 4040096 p.Val203Ile missense_variant 0.28 pyrazinamide Uncertain significance
clpC1 4040117 c.588A>G synonymous_variant 0.25 pyrazinamide Uncertain significance
clpC1 4040126 c.579C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040129 c.576C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
panD 4044872 c.-591C>T upstream_gene_variant 0.99 pyrazinamide Uncertain significance
glpK 4138622 c.1134C>T synonymous_variant 0.97 ethambutol Not assoc w R
isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R