TB-Profiler result

Run: ERR8975532
Summary

Run ID: ERR8975532

Sample name:

Date: 2024-04-15T00:13:46.575493

Number of reads: 2204251

Percentage reads mapped: 86.76

Median coverage: 69.0

Strain: lineage4.3.2.1

Spoligotype:

Drug-resistance: HR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.99
lineage4.3.2 Euro-American (LAM) None 0.98
lineage4.3.2.1 Euro-American (LAM) RD761 0.99
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5520 p.Pro94Leu missense_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 7222 c.1983C>T synonymous_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8174 c.873C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8189 c.888G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8217 p.Ser306Gly missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8225 p.Asp308Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsGG frameshift_variant&missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 575713 c.366G>A synonymous_variant 0.16 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.15 ethionamide
isoniazid
ccsA 620325 c.435G>T synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620337 c.447C>G synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620358 c.468C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620397 c.507C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620404 c.514C>T synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.19 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620418 c.528G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657678 c.-208A>C upstream_gene_variant 0.17 ethionamide
Rv0565c 657686 c.-216C>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.17 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.18 ethionamide
hadA 732346 c.417T>C synonymous_variant 0.16 isoniazid
hadA 732361 c.432C>T synonymous_variant 0.15 isoniazid
hadA 732376 c.447T>C synonymous_variant 0.15 isoniazid
hadA 732381 p.Glu151Val missense_variant 0.15 isoniazid
hadA 732391 c.462T>A synonymous_variant 0.15 isoniazid
nusG 734475 c.222T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.18 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.17 rifampicin
nusG 734733 c.480T>A synonymous_variant 0.14 rifampicin
nusG 734769 c.516G>A synonymous_variant 0.15 rifampicin
nusG 734790 c.537G>C synonymous_variant 0.15 rifampicin
nusG 734793 c.540C>T synonymous_variant 0.16 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 760577 c.771G>A synonymous_variant 0.17 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760971 c.1165C>A synonymous_variant 0.15 rifampicin
rpoB 760994 c.1188G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.17 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>A synonymous_variant 0.16 rifampicin
rpoB 761037 c.1231T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761876 c.2070C>A synonymous_variant 0.15 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.14 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Asp missense_variant 0.15 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.15 rifampicin
rpoC 762518 c.-852C>G upstream_gene_variant 0.15 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.18 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763505 c.136C>T synonymous_variant 0.23 rifampicin
rpoC 763561 c.192G>A synonymous_variant 0.2 rifampicin
rpoC 763600 c.231C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.19 rifampicin
rpoC 763618 c.249C>A synonymous_variant 0.18 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.16 rifampicin
rpoC 763639 c.270G>A synonymous_variant 0.16 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.16 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.16 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.17 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.17 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.18 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.18 rifampicin
rpoC 764576 p.Ser403Thr missense_variant 0.14 rifampicin
rpoC 764587 c.1218C>G synonymous_variant 0.16 rifampicin
rpoC 764648 c.1279C>A synonymous_variant 0.18 rifampicin
rpoC 764653 c.1284G>C synonymous_variant 0.17 rifampicin
rpoC 764656 c.1287C>T synonymous_variant 0.18 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764674 c.1305G>A synonymous_variant 0.17 rifampicin
rpoC 764681 c.1312C>T synonymous_variant 0.16 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.99 rifampicin Not assoc w R
rpoC 765622 p.Glu751Asp missense_variant 0.16 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765676 c.2307G>A synonymous_variant 0.19 rifampicin
rpoC 765688 c.2319G>C synonymous_variant 0.19 rifampicin
rpoC 765689 c.2320C>T synonymous_variant 0.18 rifampicin
rpoC 765694 c.2325G>C synonymous_variant 0.17 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765727 c.2358T>C synonymous_variant 0.17 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765748 c.2379C>T synonymous_variant 0.21 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 0.21 rifampicin
rpoC 765757 c.2388C>T synonymous_variant 0.21 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.16 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>A synonymous_variant 0.14 rifampicin
rpoC 765850 c.2481G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766360 c.2991C>T synonymous_variant 0.16 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.2 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.2 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.2 rifampicin
rpoC 766397 c.3028C>T synonymous_variant 0.18 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766417 c.3048C>T synonymous_variant 0.17 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.18 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.17 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.15 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766519 c.3150C>A synonymous_variant 0.15 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.15 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.16 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.15 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.18 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.16 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.17 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.17 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.19 rifampicin
rpoC 766907 c.3538C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766918 c.3549C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.21 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.18 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.15 rifampicin
rpoC 766975 c.3606C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781880 c.321C>G synonymous_variant 0.15 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.15 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.19 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.17 streptomycin Uncertain significance
fbiC 1303632 c.702T>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303768 p.Ser280Ala missense_variant 0.14 clofazimine
pretomanid
delamanid
atpE 1461161 c.117C>T synonymous_variant 0.14 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471935 n.90T>C non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471984 n.139T>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.89 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrl 1473981 n.324delGinsTC non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474034 n.377G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474950 n.1293G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474967 n.1311_1315delGGGTG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833718 c.177C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834186 c.645C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.15 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.14 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518672 c.558G>C synonymous_variant 0.16 isoniazid
kasA 2518681 c.567C>T synonymous_variant 0.16 isoniazid
kasA 2518684 c.570C>A synonymous_variant 0.16 isoniazid
Rv2477c 2783194 c.849A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783419 c.624G>T synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783432 p.Ser204Thr missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyA 3073868 p.Thr202Ala missense_variant 0.97 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.15 para-aminosalicylic_acid
thyA 3074061 p.Glu137Asp missense_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624389 c.522C>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625663 c.-753G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625684 c.-774G>A upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625989 p.Thr209Ala missense_variant 0.16 bedaquiline
rifampicin
mtrB 3625993 c.621G>C synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3625999 c.615A>G synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3626006 p.Ser203Asn missense_variant 0.17 bedaquiline
rifampicin
mtrB 3626008 c.606G>T synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626029 c.585A>G synonymous_variant 0.15 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3627227 c.123T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.16 rifampicin
rpoA 3877950 c.558C>T synonymous_variant 0.16 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.15 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.15 rifampicin
rpoA 3878172 c.336G>C synonymous_variant 0.15 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.21 rifampicin
rpoA 3878211 c.297G>A synonymous_variant 0.18 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878376 c.132G>A synonymous_variant 0.16 rifampicin
rpoA 3878381 c.127C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878391 c.117T>A synonymous_variant 0.19 rifampicin
rpoA 3878403 c.105C>T synonymous_variant 0.19 rifampicin
rpoA 3878406 c.102G>T synonymous_variant 0.2 rifampicin
rpoA 3878412 c.96C>T synonymous_variant 0.22 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.19 rifampicin
rpoA 3878442 p.Val22Thr missense_variant 0.18 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.19 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.17 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.18 rifampicin
rpoA 3878483 c.25C>T synonymous_variant 0.17 rifampicin
rpoA 3878490 c.18C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878496 c.12A>T synonymous_variant 0.17 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.14 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878962 c.-455G>C upstream_gene_variant 0.15 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878977 c.-470C>G upstream_gene_variant 0.16 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.86 pyrazinamide Not assoc w R
clpC1 4038302 c.2403C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038314 c.2391T>G synonymous_variant 0.16 pyrazinamide
clpC1 4038335 c.2370C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038344 c.2361G>A synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038350 c.2355C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038383 c.2322G>A synonymous_variant 0.18 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038436 p.Ala757Ser missense_variant 0.16 pyrazinamide
clpC1 4038445 p.Ala754Thr missense_variant 0.15 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.14 pyrazinamide
clpC1 4038508 c.2197C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.18 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.17 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038838 c.1867C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038902 c.1803C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038995 c.1710G>A synonymous_variant 0.16 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.19 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039337 c.1368A>C synonymous_variant 0.19 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.17 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
embC 4240795 c.933C>G synonymous_variant 0.15 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.14 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.16 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.16 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.16 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4241161 c.1299C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241167 c.1305C>G synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4245803 c.-711C>T upstream_gene_variant 0.15 ethambutol
embB 4245806 c.-708G>A upstream_gene_variant 0.15 ethambutol
embB 4245809 c.-705A>G upstream_gene_variant 0.16 ethambutol
embB 4245812 c.-702G>T upstream_gene_variant 0.16 ethambutol
embA 4245813 p.Pro861Ala missense_variant 0.16 ethambutol
embA 4245822 p.Pro864Ala missense_variant 0.15 ethambutol
embB 4245839 c.-675G>C upstream_gene_variant 0.14 ethambutol
embB 4245875 c.-639G>A upstream_gene_variant 0.16 ethambutol
embA 4246254 p.Leu1008Met missense_variant 0.15 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.16 ethambutol
embA 4246279 p.Ala1016Val missense_variant 0.15 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.15 ethambutol
embB 4247743 c.1230C>G synonymous_variant 0.15 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.14 ethambutol
embB 4248094 c.1581C>T synonymous_variant 0.15 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.17 ethambutol
embB 4248154 c.1641G>T synonymous_variant 0.17 ethambutol
embB 4248157 c.1644A>T synonymous_variant 0.18 ethambutol
embB 4248163 c.1650G>A synonymous_variant 0.17 ethambutol
embB 4248169 c.1656C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248175 c.1662G>A synonymous_variant 0.16 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.16 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.15 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.17 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.2 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.19 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.17 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.18 ethambutol
aftB 4267580 c.1257G>A synonymous_variant 0.15 ethambutol
aftB 4267592 c.1245C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
aftB 4267867 p.Leu324Val missense_variant 0.94 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407598 p.Val202Ala missense_variant 1.0 streptomycin Uncertain significance
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R