TB-Profiler result

Run: ERR4818615
Summary

Run ID: ERR4818615

Sample name:

Date: 2024-10-04T05:25:19.495787

Number of reads: 488582

Percentage reads mapped: 49.35

Median coverage: 10.0

Strain:

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6238 c.999G>A synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.6 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6655 c.-647T>C upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8588 c.1287G>A synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.62 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
fgd1 490998 c.216T>C synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fgd1 491001 c.219G>C synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.58 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.58 pretomanid
delamanid
clofazimine
mshA 575674 c.327G>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.41 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.39 isoniazid
ethionamide
mshA 575809 c.462C>T synonymous_variant 0.5 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.51 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.5 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.56 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.52 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.53 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.5 isoniazid Not assoc w R - Interim
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.52 isoniazid
ethionamide
ccsA 620254 c.364_366delCTCinsTTG synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620268 c.378G>C synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.3 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620424 c.534G>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620646 c.756G>A synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620659 c.769_771delCGCinsAGG synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620664 c.774C>T synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.44 kanamycin
capreomycin
amikacin
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.6 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.53 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.58 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.57 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.59 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.54 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.47 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.5 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.47 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.55 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.55 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.6 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.62 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.59 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.57 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.58 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.79 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.71 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.5 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.58 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.67 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.67 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.65 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.57 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.44 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.41 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761885 c.2079T>C synonymous_variant 0.37 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.46 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.5 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.5 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.5 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.5 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.54 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.54 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.5 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.4 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.43 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.43 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.5 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.5 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.5 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.65 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.62 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.5 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.58 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.62 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.65 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.7 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.71 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.5 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.7 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.73 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764206 c.837T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.62 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.4 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.43 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.5 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.54 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.58 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.62 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.47 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.5 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.6 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.6 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.48 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.45 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766462 c.3093G>C synonymous_variant 0.8 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.7 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.7 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.7 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.67 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.7 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.7 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.71 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.64 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.61 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.44 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.47 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.4 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.48 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.45 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.73 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
mmpL5 776672 c.1809G>C synonymous_variant 0.5 bedaquiline
clofazimine
mmpL5 776675 c.1806G>A synonymous_variant 0.54 bedaquiline
clofazimine
mmpL5 776684 c.1797G>A synonymous_variant 0.54 bedaquiline
clofazimine
mmpL5 776687 p.Trp598Phe missense_variant 0.54 bedaquiline
clofazimine
mmpL5 776695 p.Val596Ile missense_variant 0.54 bedaquiline
clofazimine
mmpL5 776738 c.1743C>T synonymous_variant 0.5 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.55 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.5 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.5 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.47 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.42 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.43 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.46 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.55 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.55 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.6 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.6 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.58 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.61 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.63 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.58 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.56 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.47 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.38 streptomycin Uncertain significance
rplC 800627 c.-182C>T upstream_gene_variant 0.58 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.62 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.64 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.62 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.6 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.56 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.5 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.47 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.44 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.5 linezolid
rplC 800814 c.6A>G synonymous_variant 0.43 linezolid
rplC 800817 c.9A>T synonymous_variant 0.43 linezolid
rplC 800844 c.36T>C synonymous_variant 0.57 linezolid
rplC 801321 c.513C>T synonymous_variant 0.32 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.35 linezolid
rplC 801339 c.531T>C synonymous_variant 0.36 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.4 linezolid
rplC 801348 c.540T>G synonymous_variant 0.4 linezolid
rplC 801357 c.549T>C synonymous_variant 0.45 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.44 linezolid
rplC 801402 c.594T>C synonymous_variant 0.43 linezolid
fbiC 1303695 c.765T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.38 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.67 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304869 c.1939C>T synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
inhA 1673685 c.-517C>T upstream_gene_variant 0.54 isoniazid
ethionamide
inhA 1673710 c.-492C>A upstream_gene_variant 0.44 isoniazid
ethionamide
inhA 1673716 c.-486_-485delGCinsAA upstream_gene_variant 0.44 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.39 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.35 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.5 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.55 isoniazid
ethionamide
rpsA 1833532 c.-10A>C upstream_gene_variant 0.45 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.41 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.52 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.54 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.63 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.65 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.67 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.65 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.59 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.59 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.47 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.64 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.64 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.53 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.57 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.57 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.57 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.6 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.58 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.58 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.6 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064978 c.-250G>C upstream_gene_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.56 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.42 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.42 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.38 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.5 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.5 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.62 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.7 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.38 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.37 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.3 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.43 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.4 isoniazid
kasA 2518993 c.879C>G synonymous_variant 0.4 isoniazid
kasA 2518999 c.885G>A synonymous_variant 0.4 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.44 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.44 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.47 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.47 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
ahpC 2726638 p.Ala149Val missense_variant 0.53 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.59 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.57 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.62 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.62 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.62 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.73 isoniazid Not assoc w R - Interim
Rv2477c 2782498 c.1545C>T synonymous_variant 0.43 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2782948 c.1095A>G synonymous_variant 0.64 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.55 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783140 c.903C>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.44 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.41 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.44 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783593 c.450T>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.57 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.67 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.64 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.73 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.73 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.75 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
thyX 3067652 c.294T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.65 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.68 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.7 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.7 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.74 para-aminosalicylic_acid
thyA 3073815 c.657G>A synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3073824 c.648A>G synonymous_variant 0.53 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.53 para-aminosalicylic_acid
thyA 3073836 c.636C>T synonymous_variant 0.69 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.75 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.65 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.59 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.59 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.62 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.6 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.6 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.4 para-aminosalicylic_acid
lpqB 3624701 c.210T>C synonymous_variant 0.7 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.77 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.75 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624755 c.154_156delTTAinsCTG synonymous_variant 0.73 rifampicin
bedaquiline
lpqB 3624770 c.141T>C synonymous_variant 0.57 rifampicin
bedaquiline
lpqB 3624776 c.135T>C synonymous_variant 0.57 rifampicin
bedaquiline
lpqB 3624783 p.Ser43Thr missense_variant 0.54 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625225 c.-315G>C upstream_gene_variant 0.62 rifampicin
bedaquiline
lpqB 3625240 c.-330T>C upstream_gene_variant 0.75 rifampicin
bedaquiline
lpqB 3625243 c.-333T>G upstream_gene_variant 0.75 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.46 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.71 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.71 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.65 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.65 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.6 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.55 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.59 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.61 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.64 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.6 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.54 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.54 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.48 rifampicin
bedaquiline
alr 3841473 c.-53G>A upstream_gene_variant 1.0 cycloserine
rpoA 3877656 c.852T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.67 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.73 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.67 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.5 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.35 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.45 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.48 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.5 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.61 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.58 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.58 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.56 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.53 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.56 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.53 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.5 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.5 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.53 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.56 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.47 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.38 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.45 rifampicin
rpoA 3878986 c.-479G>C upstream_gene_variant 0.47 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.64 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.67 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.37 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.35 rifampicin
clpC1 4038320 c.2385G>C synonymous_variant 0.37 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.47 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.44 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.44 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.5 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.37 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.44 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.7 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.71 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.69 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.8 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.35 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.48 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.83 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.83 pyrazinamide
clpC1 4040501 c.204C>T synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
panD 4044791 c.-510G>C upstream_gene_variant 0.5 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.47 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.46 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.65 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.65 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.68 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.68 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.65 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.57 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.55 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.55 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.43 pyrazinamide
glpK 4138643 c.1113A>C synonymous_variant 0.41 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.6 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.6 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.85 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138730 c.1026C>G synonymous_variant 0.85 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139611 p.Ile49Val missense_variant 0.64 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
embC 4240726 c.864G>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.52 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.52 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.54 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.48 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.44 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.48 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.4 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.38 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.35 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.38 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.41 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.48 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.42 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.5 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.54 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.62 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.5 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.47 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.5 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.53 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.53 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245053 c.1821G>C synonymous_variant 0.36 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.38 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.38 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.36 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.38 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.4 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.41 ethambutol
embA 4245248 c.2016G>C synonymous_variant 0.5 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.47 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4245701 c.-813G>C upstream_gene_variant 0.3 ethambutol
embB 4245704 c.-810G>C upstream_gene_variant 0.29 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.28 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.28 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.32 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.33 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.38 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.43 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.54 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.47 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.44 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.39 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.31 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.32 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.38 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.37 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.37 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.38 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.37 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.36 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.32 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.35 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.35 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.32 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.32 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.33 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.35 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.35 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.35 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.44 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.5 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.38 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.39 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.43 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.43 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.45 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.5 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.47 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.36 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.41 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.42 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.42 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.41 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.41 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.47 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.57 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.5 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.46 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338831 c.-310T>C upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin