TB-Profiler result

Run: ERR4816151
Summary

Run ID: ERR4816151

Sample name:

Date: 2024-10-04T17:49:42.135744

Number of reads: 782952

Percentage reads mapped: 74.52

Median coverage: 20.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6760 c.-542G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6763 c.-539G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.25 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 0.28 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7715 c.414G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7748 c.447A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7850 c.549C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9467 c.2166T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9518 c.2217A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
mshA 575732 c.385_387delCTTinsTTG synonymous_variant 0.29 isoniazid
ethionamide
mshA 575740 c.393G>C synonymous_variant 0.32 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.32 isoniazid
ethionamide
mshA 575755 c.408G>A synonymous_variant 0.32 isoniazid
ethionamide
mshA 575756 c.409C>T synonymous_variant 0.32 isoniazid
ethionamide
mshA 575788 c.441C>T synonymous_variant 0.29 isoniazid
ethionamide
mshA 575809 c.462C>T synonymous_variant 0.38 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.38 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.38 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.35 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.35 isoniazid
ethionamide
mshA 575845 c.498C>G synonymous_variant 0.35 isoniazid
ethionamide
ccsA 620295 c.405G>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620307 c.417C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
rpoB 760130 p.Asp108Glu missense_variant 0.33 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.4 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.29 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.19 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760381 p.Thr192Met missense_variant 0.24 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.29 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.32 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760427 c.621G>A synonymous_variant 0.3 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.16 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.26 rifampicin
rpoB 760845 p.Thr347Ser missense_variant 0.37 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.4 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.39 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.21 rifampicin
rpoB 760920 c.1114C>T synonymous_variant 0.21 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.18 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.31 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.29 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.28 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.37 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>C synonymous_variant 0.33 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>G synonymous_variant 0.42 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>C synonymous_variant 0.33 rifampicin
rpoB 761336 c.1530C>T synonymous_variant 0.33 rifampicin
rpoB 761360 c.1554T>G synonymous_variant 0.28 rifampicin
rpoB 761594 c.1788C>G synonymous_variant 0.3 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.28 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761819 c.2013G>C synonymous_variant 0.3 rifampicin
rpoB 761859 p.Asp685Asn missense_variant 0.38 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.4 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.36 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.36 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.32 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.32 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.3 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.3 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.3 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.3 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.32 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.29 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.32 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.31 rifampicin
rpoB 762266 c.2460T>G synonymous_variant 0.3 rifampicin
rpoB 762278 c.2472C>T synonymous_variant 0.32 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>G synonymous_variant 0.32 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.18 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.22 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.22 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763480 c.111C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.21 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>C synonymous_variant 0.28 rifampicin Not assoc w R
rpoC 763546 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.24 rifampicin
rpoC 763648 c.279C>A synonymous_variant 0.31 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.17 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.29 rifampicin
rpoC 763851 p.Ala161Gly missense_variant 0.33 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.33 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.33 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.36 rifampicin
rpoC 763876 c.507A>G synonymous_variant 0.36 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.36 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.34 rifampicin
rpoC 763951 c.582G>A synonymous_variant 0.36 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.65 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.63 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.5 rifampicin
rpoC 764266 c.897T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764272 c.903G>C synonymous_variant 0.39 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>T synonymous_variant 0.24 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.39 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.22 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.23 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.35 rifampicin Uncertain significance
rpoC 765408 p.Gly680Ala missense_variant 0.37 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.43 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Ser missense_variant 0.35 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>A synonymous_variant 0.35 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.53 rifampicin
rpoC 765592 c.2223C>G synonymous_variant 0.44 rifampicin
rpoC 765595 c.2226G>A synonymous_variant 0.44 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765753 p.Asp795Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765784 c.2415C>G synonymous_variant 0.33 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.36 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.28 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765856 c.2487T>C synonymous_variant 0.29 rifampicin
rpoC 765877 c.2508C>G synonymous_variant 0.24 rifampicin
rpoC 765883 c.2514C>G synonymous_variant 0.24 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.28 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765970 c.2601C>G synonymous_variant 0.44 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.56 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.59 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.41 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.38 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.35 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.27 rifampicin
rpoC 766486 c.3117A>C synonymous_variant 0.27 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.29 rifampicin
rpoC 766501 c.3132G>C synonymous_variant 0.34 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.37 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.37 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.37 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.37 rifampicin
rpoC 766542 p.Gly1058Asp missense_variant 0.42 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.38 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.31 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.32 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.3 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.42 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.42 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.42 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.44 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.42 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.39 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.37 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.45 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.33 rifampicin
rpoC 766792 c.3423C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>A synonymous_variant 0.36 rifampicin
rpoC 766846 c.3477C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.3 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.27 rifampicin Uncertain significance
rpoC 766891 c.3522G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.33 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.35 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.39 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.36 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.29 rifampicin
rpoC 766981 c.3612T>G synonymous_variant 0.27 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.23 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.31 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.26 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.24 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.34 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781728 c.169T>C synonymous_variant 0.29 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.28 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.27 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.27 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.27 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.28 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.28 streptomycin
rpsL 781772 c.213C>G synonymous_variant 0.27 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.2 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.2 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.2 streptomycin
rpsL 781862 c.303G>C synonymous_variant 0.19 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.19 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.16 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.22 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.21 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.21 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.3 streptomycin Uncertain significance
rplC 800600 c.-209G>T upstream_gene_variant 0.19 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.19 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.18 linezolid
rplC 800624 c.-185G>A upstream_gene_variant 0.18 linezolid
rplC 800628 c.-181_-179delGTGinsATA upstream_gene_variant 0.24 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.24 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.19 linezolid
fbiC 1303489 c.559C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303509 c.579G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303554 c.624G>A synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304853 c.1923C>G synonymous_variant 0.93 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.86 pretomanid
delamanid
clofazimine
fbiC 1304868 c.1938G>C synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.56 pretomanid
delamanid
clofazimine
sigE 1364763 c.351T>C synonymous_variant 0.2 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.21 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.24 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.26 pyrazinamide
sigE 1364793 c.381C>T synonymous_variant 0.27 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.28 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.26 pyrazinamide
sigE 1364829 c.417C>T synonymous_variant 0.24 pyrazinamide
sigE 1364832 c.420C>G synonymous_variant 0.24 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.24 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.24 pyrazinamide
sigE 1364860 c.448_450delCGCinsAGG synonymous_variant 0.24 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.26 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.26 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.26 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
inhA 1673808 c.-394A>G upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1673832 c.-370A>G upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1673838 c.-364T>C upstream_gene_variant 0.35 isoniazid
ethionamide
inhA 1673841 c.-361A>G upstream_gene_variant 0.37 isoniazid
ethionamide
inhA 1673847 c.-355A>C upstream_gene_variant 0.31 isoniazid
ethionamide
inhA 1673853 c.-349A>C upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1673870 c.-332G>C upstream_gene_variant 0.41 isoniazid
ethionamide
inhA 1673901 c.-301A>G upstream_gene_variant 0.42 isoniazid
ethionamide
inhA 1673916 c.-286A>C upstream_gene_variant 0.35 isoniazid
ethionamide
inhA 1673922 c.-280T>G upstream_gene_variant 0.27 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.18 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1833771 p.Asn77Ser missense_variant 0.27 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.37 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.35 pyrazinamide
rpsA 1833805 c.264C>A synonymous_variant 0.35 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.35 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834474 c.933C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.31 pyrazinamide
tsnR 1853978 p.Val125Leu missense_variant 0.23 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102269 c.774C>G synonymous_variant 0.39 isoniazid
delamanid
ethionamide
ndh 2102296 c.747C>G synonymous_variant 0.47 isoniazid
delamanid
ethionamide
ndh 2102305 c.738T>A synonymous_variant 0.43 isoniazid
delamanid
ethionamide
ndh 2102308 c.735G>C synonymous_variant 0.46 isoniazid
delamanid
ethionamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv2477c 2783914 c.129T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783926 c.117C>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065016 c.1176C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065052 c.1140G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067718 c.228C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.21 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073874 p.Ile200Val missense_variant 0.21 para-aminosalicylic_acid
thyA 3073878 p.Glu198Asp missense_variant 0.22 para-aminosalicylic_acid
thyA 3073881 c.591C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073884 c.588C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073888 p.Ser195Glu missense_variant 0.22 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.24 para-aminosalicylic_acid
Rv3083 3448322 c.-182G>A upstream_gene_variant 1.0 ethionamide
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
mtrA 3626939 c.411A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626969 c.-356C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627016 c.-403C>T upstream_gene_variant 0.32 rifampicin
bedaquiline
fbiA 3640708 p.Leu56Val missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiB 3640713 c.-822T>G upstream_gene_variant 0.27 pretomanid
delamanid
clofazimine
fbiB 3640719 c.-816C>T upstream_gene_variant 0.28 pretomanid
delamanid
clofazimine
fbiB 3640743 c.-792T>C upstream_gene_variant 0.26 pretomanid
delamanid
clofazimine
fbiB 3640747 c.-788_-786delCTGinsTTA upstream_gene_variant 0.26 pretomanid
delamanid
clofazimine
fbiB 3640758 c.-777G>C upstream_gene_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3640761 c.-774G>C upstream_gene_variant 0.22 pretomanid
delamanid
clofazimine
fbiB 3640767 c.-768C>G upstream_gene_variant 0.19 pretomanid
delamanid
clofazimine
fbiB 3640776 c.-759C>G upstream_gene_variant 0.21 pretomanid
delamanid
clofazimine
rpoA 3877494 p.Glu338Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.24 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.23 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.15 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877731 c.777G>C synonymous_variant 0.33 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.35 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.21 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.17 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.27 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.27 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.26 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.19 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.25 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.25 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.24 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>T synonymous_variant 0.26 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.23 rifampicin
ddn 3986645 c.-199G>A upstream_gene_variant 0.35 pretomanid
delamanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.35 pretomanid
delamanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.3 pretomanid
delamanid
clpC1 4038746 c.1959C>G synonymous_variant 0.55 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.44 pyrazinamide
clpC1 4038863 c.1842G>T synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4038869 c.1836G>A synonymous_variant 0.54 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>T synonymous_variant 0.55 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.46 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.5 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.48 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.44 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038977 c.1728G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.43 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Ser missense_variant 0.43 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.2 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040180 c.525C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.32 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.3 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247437 c.924A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247455 c.942C>A synonymous_variant 0.24 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.24 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.21 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.26 ethambutol
embB 4248106 c.1593C>G synonymous_variant 0.26 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R