Run ID: ERR4829530
Sample name:
Date: 2024-04-15T11:45:39.196527
Number of reads: 3221175
Percentage reads mapped: 81.45
Median coverage: 101.0
Strain: lineage4.8
Spoligotype:
Drug-resistance: Pre-XDR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.8 | Euro-American (mainly T) | RD219 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Ser450Leu | Assoc w R | |
isoniazid | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
katG | p.Ser315Thr | Assoc w R | High-level resistance | |
ethambutol | embB | p.Met306Ile | Assoc w R | |
pyrazinamide | pncA | p.Ala146Val | Assoc w R | |
streptomycin | gid | p.Gln125* | Assoc w R | |
fluoroquinolones | ||||
moxifloxacin | gyrA | p.Asp94Tyr | Assoc w R | High-level resistance |
ofloxacin | ||||
levofloxacin | gyrA | p.Asp94Tyr | Assoc w R | |
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T |
ethA | c.1391dupA | Assoc w R | ||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
gyrA | 7581 | p.Asp94Tyr | missense_variant | 0.96 | moxifloxacin | Assoc w R | High-level resistance |
levofloxacin | Assoc w R | ||||||
rpoB | 761155 | p.Ser450Leu | missense_variant | 0.91 | rifampicin | Assoc w R | |
inhA | 1673425 | c.-777C>T | upstream_gene_variant | 1.0 | ethionamide | Assoc w R | Alias fabG1_c.-15C>T |
isoniazid | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) | |||||
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid | Assoc w R | High-level resistance |
pncA | 2288805 | p.Ala146Val | missense_variant | 1.0 | pyrazinamide | Assoc w R | |
embB | 4247431 | p.Met306Ile | missense_variant | 0.95 | ethambutol | Assoc w R | |
ethA | 4326082 | c.1391dupA | frameshift_variant | 1.0 | ethionamide | Assoc w R | |
gid | 4407830 | p.Gln125* | stop_gained | 1.0 | streptomycin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 371 | p.Pro124Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
Rv0010c | 13543 | p.Trp6Arg | missense_variant | 1.0 | isoniazid | Uncertain significance |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760244 | c.438G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760298 | c.492G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760310 | c.504G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760316 | c.510C>G | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760331 | c.525G>T | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760334 | c.528G>A | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760340 | c.534G>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760357 | p.Thr184Asn | missense_variant | 0.16 | rifampicin | |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoB | 760406 | c.600G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760407 | p.Ser201Gly | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoB | 760422 | c.616_618delCTCinsTG | frameshift_variant&missense_variant | 0.18 | rifampicin | |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760457 | c.651C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 760463 | c.657C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 762176 | c.2370T>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoB | 762218 | c.2412T>C | synonymous_variant | 0.13 | rifampicin | |
rpoB | 762245 | c.2439G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 762989 | c.3183G>A | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 763007 | c.3201C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R |
rpoB | 763053 | c.3247T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763531 | c.162G>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763621 | c.252C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763699 | c.330G>T | synonymous_variant | 0.12 | rifampicin | |
rpoC | 763705 | c.336G>C | synonymous_variant | 0.12 | rifampicin | |
rpoC | 764344 | c.975C>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764353 | c.984G>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764363 | c.994_996delGGCinsCT | frameshift_variant&missense_variant | 0.8 | rifampicin | |
rpoC | 764371 | c.1002G>T | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764380 | c.1011G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764387 | c.1018T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764405 | c.1036_1038delAGGinsCC | frameshift_variant&missense_variant | 0.14 | rifampicin | |
rpoC | 764485 | c.1116G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764491 | c.1122G>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764500 | c.1131C>G | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764605 | c.1236G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764621 | c.1252_1254delCTCinsTG | frameshift_variant&missense_variant | 0.15 | rifampicin | |
rpoC | 764626 | c.1257C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764632 | c.1263T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 764713 | c.1344G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764719 | c.1350G>A | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764746 | c.1377G>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764758 | c.1389C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764791 | c.1422C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764869 | c.1500C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764875 | c.1506C>T | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764878 | c.1509C>G | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764887 | c.1518G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764912 | p.Met515Gln | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoC | 764935 | c.1566T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 765008 | p.Leu547Val | missense_variant | 1.0 | rifampicin | Uncertain significance |
rpoC | 766085 | p.Pro906Ala | missense_variant | 1.0 | rifampicin | Not assoc w R |
rpoC | 766909 | c.3540G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 766911 | p.Ile1181Thr | missense_variant | 0.14 | rifampicin | |
rpoC | 766915 | p.Asp1182Glu | missense_variant | 0.15 | rifampicin | |
rpoC | 766921 | c.3552G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766931 | c.3562_3564delGCAinsAC | frameshift_variant&missense_variant | 0.17 | rifampicin | |
rpoC | 766942 | c.3573C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 766945 | c.3576A>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 766948 | c.3579G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766960 | c.3591C>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766963 | c.3594T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766978 | c.3609C>T | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766981 | c.3612T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 767002 | c.3633G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 767008 | c.3639G>A | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 767020 | c.3651C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 767023 | c.3654C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpR5 | 779062 | p.Gly25Cys | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
atpE | 1460992 | c.-53A>C | upstream_gene_variant | 1.0 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1471922 | n.78delT | non_coding_transcript_exon_variant | 0.14 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.15 | streptomycin | Uncertain significance |
kanamycin | ||||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472042 | n.197T>G | non_coding_transcript_exon_variant | 0.12 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472053 | n.211_212delGC | non_coding_transcript_exon_variant | 0.14 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472061 | n.216A>T | non_coding_transcript_exon_variant | 0.14 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 0.18 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472106 | n.261G>A | non_coding_transcript_exon_variant | 0.2 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.2 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 0.2 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1472446 | n.601T>A | non_coding_transcript_exon_variant | 0.15 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472452 | n.607G>A | non_coding_transcript_exon_variant | 0.15 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472464 | n.619A>G | non_coding_transcript_exon_variant | 0.12 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472755 | n.910G>A | non_coding_transcript_exon_variant | 0.19 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472847 | n.1002G>C | non_coding_transcript_exon_variant | 0.13 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472849 | n.1004C>G | non_coding_transcript_exon_variant | 0.13 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472850 | n.1005T>C | non_coding_transcript_exon_variant | 0.13 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472857 | n.1012A>G | non_coding_transcript_exon_variant | 0.14 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472858 | n.1013G>T | non_coding_transcript_exon_variant | 0.14 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472859 | n.1014G>C | non_coding_transcript_exon_variant | 0.14 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472860 | n.1015C>G | non_coding_transcript_exon_variant | 0.14 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.3 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473110 | n.1265T>G | non_coding_transcript_exon_variant | 0.26 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>G | non_coding_transcript_exon_variant | 0.26 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTC | non_coding_transcript_exon_variant | 0.28 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 0.16 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473876 | n.219G>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473887 | n.230T>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1473888 | n.231T>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473922 | n.265A>G | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Not assoc w R |
linezolid | Not assoc w R | |||||
rrl | 1475762 | n.2105G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475763 | n.2106C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475764 | n.2107A>C | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475765 | n.2108A>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.31 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475991 | n.2334T>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475995 | n.2338G>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476044 | n.2387T>G | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476045 | n.2388G>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476049 | n.2392C>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476056 | n.2399G>A | non_coding_transcript_exon_variant | 0.22 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476088 | n.2431A>C | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476099 | n.2442A>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476103 | n.2446C>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476105 | n.2448G>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476106 | n.2449A>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476110 | n.2453G>C | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476115 | n.2458T>C | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476131 | n.2474C>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476251 | n.2594T>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476256 | n.2599A>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476260 | n.2603A>G | non_coding_transcript_exon_variant | 0.22 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476299 | n.2642C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476529 | n.2872A>G | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476540 | n.2883C>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476594 | n.2937C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476603 | n.2946G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1833664 | c.123C>G | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1833676 | c.135A>G | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1833694 | c.153G>T | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1833991 | c.450C>A | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1834345 | c.804C>T | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834361 | c.820T>C | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834387 | c.846C>T | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834408 | c.867C>T | synonymous_variant | 0.12 | pyrazinamide | |
tlyA | 1917972 | c.33A>G | synonymous_variant | 0.99 | capreomycin | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
Rv3083 | 3448507 | c.5_*1408del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | ethionamide | Uncertain significance |
alr | 3840764 | c.657G>C | synonymous_variant | 1.0 | cycloserine | |
rpoA | 3878143 | p.Gly122Asp | missense_variant | 0.13 | rifampicin | Uncertain significance |
rpoA | 3878145 | c.363C>G | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3878160 | c.348C>G | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoA | 3878169 | c.339G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoA | 3878175 | c.333G>C | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3878184 | c.324C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3878193 | c.315T>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoA | 3878196 | p.Glu104Ala | missense_variant | 0.12 | rifampicin | Uncertain significance |
rpoA | 3878205 | c.303T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3878247 | c.261G>C | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3878256 | c.252G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878264 | p.Ser82Gly | missense_variant | 0.14 | rifampicin | |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3878283 | p.Glu75Asp | missense_variant | 0.13 | rifampicin | Uncertain significance |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>A | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038890 | c.1815G>A | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038905 | c.1800A>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038911 | c.1794G>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038917 | c.1788C>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038923 | c.1782A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038941 | c.1764G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038980 | c.1725C>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039064 | c.1641C>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039067 | c.1638G>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039085 | c.1620A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039090 | c.1615C>T | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039100 | c.1605C>T | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039106 | c.1599G>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039118 | c.1587C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039169 | p.Glu512Asp | missense_variant | 0.2 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039187 | c.1518G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039190 | c.1515C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039208 | c.1497C>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039622 | c.1083C>T | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039649 | c.1056G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039664 | c.1041G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039670 | c.1035G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039682 | c.1023C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039694 | c.1011G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039733 | c.972G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039742 | c.963C>T | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039748 | c.957G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039751 | c.954A>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039757 | c.948A>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039763 | c.942C>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039766 | c.939T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039769 | c.936C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039778 | c.927A>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039787 | c.916_918delTCGinsAGC | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039823 | c.882T>A | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039829 | c.874_876delTTGinsCC | frameshift_variant&missense_variant | 0.21 | pyrazinamide | |
clpC1 | 4039850 | c.855T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039865 | c.840T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039904 | c.801A>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039913 | c.792C>T | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039934 | c.771G>A | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039937 | c.768G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039946 | c.759A>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4040411 | c.294T>C | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040423 | c.282A>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040431 | c.274T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040433 | c.271_272delAGinsTC | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040450 | c.255A>G | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040456 | c.249C>T | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R |