TB-Profiler result

Run: ERR4816745
Summary

Run ID: ERR4816745

Sample name:

Date: 01-04-2023 14:36:25

Number of reads: 1682369

Percentage reads mapped: 65.34

Strain: lineage2.2.1

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7581 p.Asp94Asn missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761127 p.Ser441Ala missense_variant 0.22 rifampicin
rpoB 761155 p.Ser450Leu missense_variant 0.82 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.95 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.36 streptomycin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.15 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5612 p.Val125Met missense_variant 0.13
gyrB 5863 c.624G>T synonymous_variant 0.11
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620553 c.663T>C synonymous_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 761030 c.1224G>C synonymous_variant 0.15
rpoB 761037 c.1231T>C synonymous_variant 0.17
rpoB 761051 c.1245G>C synonymous_variant 0.19
rpoB 761054 c.1248G>C synonymous_variant 0.2
rpoB 761057 c.1251G>C synonymous_variant 0.2
rpoB 761060 c.1254C>G synonymous_variant 0.21
rpoB 761084 c.1278C>A synonymous_variant 0.23
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.24
rpoB 761096 c.1290G>C synonymous_variant 0.25
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.23
rpoB 761102 c.1296A>G synonymous_variant 0.25
rpoB 761132 c.1326G>C synonymous_variant 0.16
rpoB 761133 c.1327T>C synonymous_variant 0.17
rpoB 761150 c.1344A>C synonymous_variant 0.22
rpoB 761159 c.1353G>C synonymous_variant 0.18
rpoB 761165 c.1359G>C synonymous_variant 0.17
rpoB 761534 c.1728G>C synonymous_variant 0.13
rpoB 761537 c.1731C>G synonymous_variant 0.13
rpoB 761567 p.Met587Ile missense_variant 0.14
rpoB 761612 c.1806G>C synonymous_variant 0.14
rpoB 762185 c.2379G>C synonymous_variant 0.12
rpoB 762194 c.2388G>C synonymous_variant 0.21
rpoB 762200 c.2394C>T synonymous_variant 0.2
rpoB 762218 c.2412T>C synonymous_variant 0.1
rpoB 762233 c.2427G>C synonymous_variant 0.2
rpoB 762234 p.Pro810Ser missense_variant 0.18
rpoB 762239 c.2433G>A synonymous_variant 0.21
rpoB 762245 c.2439G>C synonymous_variant 0.21
rpoB 762254 c.2448T>C synonymous_variant 0.22
rpoB 762266 c.2460T>C synonymous_variant 0.16
rpoB 762858 p.Thr1018Ser missense_variant 0.11
rpoC 762863 c.-507T>C upstream_gene_variant 0.11
rpoB 762879 p.Met1025Leu missense_variant 0.16
rpoC 762887 c.-483G>C upstream_gene_variant 0.13
rpoC 762899 c.-471G>C upstream_gene_variant 0.1
rpoC 762920 c.-450C>T upstream_gene_variant 0.17
rpoC 762929 c.-441G>C upstream_gene_variant 0.21
rpoC 762956 c.-414G>C upstream_gene_variant 0.11
rpoC 762971 c.-399G>C upstream_gene_variant 0.12
rpoC 762980 c.-390T>C upstream_gene_variant 0.1
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoB 763038 p.Thr1078Ala missense_variant 0.24
rpoC 763043 c.-327G>C upstream_gene_variant 0.32
rpoC 763053 c.-317T>C upstream_gene_variant 0.32
rpoC 763070 c.-300T>C upstream_gene_variant 0.28
rpoB 763077 p.Val1091Thr missense_variant 0.28
rpoC 763103 c.-267G>C upstream_gene_variant 0.26
rpoC 763115 c.-255T>C upstream_gene_variant 0.25
rpoB 763119 p.Asn1105Asp missense_variant 0.27
rpoC 763127 c.-243G>C upstream_gene_variant 0.17
rpoC 763133 c.-237G>C upstream_gene_variant 0.15
rpoC 763511 p.Cys48Gly missense_variant 0.12
rpoC 763517 p.Lys50Gln missense_variant 0.11
rpoC 763528 c.159G>C synonymous_variant 0.12
rpoC 763531 c.162G>C synonymous_variant 0.19
rpoC 763534 c.165T>C synonymous_variant 0.15
rpoC 763546 c.177A>G synonymous_variant 0.19
rpoC 763550 p.Tyr61Ala missense_variant 0.19
rpoC 763570 c.201G>C synonymous_variant 0.12
rpoC 763666 c.297G>C synonymous_variant 0.12
rpoC 763699 c.330G>T synonymous_variant 0.26
rpoC 763708 c.339G>C synonymous_variant 0.25
rpoC 763714 c.345G>C synonymous_variant 0.26
rpoC 763717 c.348T>C synonymous_variant 0.26
rpoC 763718 p.Leu117Val missense_variant 0.24
rpoC 763723 c.354G>C synonymous_variant 0.21
rpoC 763724 p.Asp119Asn missense_variant 0.21
rpoC 763729 c.360G>C synonymous_variant 0.24
rpoC 763732 c.363C>G synonymous_variant 0.24
rpoC 763735 c.366G>C synonymous_variant 0.24
rpoC 763744 c.375G>C synonymous_variant 0.22
rpoC 763751 p.Ile128Val missense_variant 0.24
rpoC 763765 c.396T>C synonymous_variant 0.13
rpoC 763772 p.Val135Met missense_variant 0.17
rpoC 764461 c.1092A>G synonymous_variant 0.14
rpoC 764503 c.1134G>T synonymous_variant 0.15
rpoC 764509 c.1140G>C synonymous_variant 0.22
rpoC 764512 c.1143G>C synonymous_variant 0.2
rpoC 764530 c.1161C>T synonymous_variant 0.22
rpoC 764536 c.1167G>C synonymous_variant 0.23
rpoC 764543 p.Thr392Ala missense_variant 0.19
rpoC 764548 c.1179G>C synonymous_variant 0.2
rpoC 764551 c.1182G>C synonymous_variant 0.19
rpoC 764573 p.Leu402Ile missense_variant 0.35
rpoC 764578 c.1209C>G synonymous_variant 0.36
rpoC 764581 c.1212T>C synonymous_variant 0.38
rpoC 764582 p.Leu405Met missense_variant 0.38
rpoC 764602 c.1233C>T synonymous_variant 0.35
rpoC 764605 c.1236G>T synonymous_variant 0.29
rpoC 764611 c.1242G>T synonymous_variant 0.32
rpoC 764616 p.Asn416Thr missense_variant 0.66
rpoC 764632 c.1263T>A synonymous_variant 0.17
rpoC 764647 c.1278C>T synonymous_variant 0.14
rpoC 764650 c.1281G>T synonymous_variant 0.16
rpoC 764653 c.1284G>C synonymous_variant 0.12
rpoC 764656 c.1287C>T synonymous_variant 0.12
rpoC 764662 c.1293G>C synonymous_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781796 p.Met79Ile missense_variant 0.15
rpsL 781802 c.243G>C synonymous_variant 0.11
rpsL 781811 c.252C>T synonymous_variant 0.13
rpsL 781814 c.255C>T synonymous_variant 0.13
rpsL 781817 c.258G>T synonymous_variant 0.13
rpsL 781832 c.273T>C synonymous_variant 0.12
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.67
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.75
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.87
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.78
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.8
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.8
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.97
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.77
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.75
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.24
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.53
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.99
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.52
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.71
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 1.0
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.4
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.67
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.43
rrs 1472396 n.551A>T non_coding_transcript_exon_variant 0.25
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.57
rrs 1472412 n.567A>G non_coding_transcript_exon_variant 0.43
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.43
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.5
rrs 1472426 n.581T>G non_coding_transcript_exon_variant 0.4
rrs 1472427 n.582T>G non_coding_transcript_exon_variant 0.4
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.67
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.67
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.67
rrs 1472447 n.602C>T non_coding_transcript_exon_variant 0.67
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.67
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.67
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.67
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.5
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 1.0
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.67
rrs 1472484 n.639_640insC non_coding_transcript_exon_variant 0.67
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.75
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.62
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.43
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.33
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.29
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.29
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.45
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.46
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.45
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.45
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.3
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.47
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.55
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.32
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.22
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.9
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.92
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.42
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.49
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.48
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.34
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.56
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.75
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.81
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.24
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.57
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.17
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.4
rrs 1472678 n.833T>C non_coding_transcript_exon_variant 0.33
rrs 1472679 n.834T>C non_coding_transcript_exon_variant 0.33
rrs 1472681 n.838_843delTGGGAT non_coding_transcript_exon_variant 0.67
rrs 1472690 n.845C>G non_coding_transcript_exon_variant 0.29
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.25
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.34
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.42
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.27
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.64
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.34
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.35
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.38
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.34
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.62
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.37
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.43
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.97
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.44
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.18
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.94
rrs 1472840 n.995A>G non_coding_transcript_exon_variant 0.75
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.96
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.22
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.59
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.22
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.92
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.87
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.11
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.69
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.11
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.22
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.14
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.2
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.95
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.55
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.54
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.96
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.88
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.94
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.91
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.45
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.4
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.84
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.82
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.84
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.69
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.85
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.85
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.83
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.24
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.76
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.75
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.64
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.86
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.14
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.13
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.88
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.79
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.84
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.12
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.83
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.85
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.88
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.87
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.68
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.5
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.69
rrs 1473305 n.1460G>T non_coding_transcript_exon_variant 0.14
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.79
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.11
rrl 1473573 n.-85G>T upstream_gene_variant 0.25
rrl 1474163 n.506C>T non_coding_transcript_exon_variant 0.8
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.89
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.93
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.93
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.88
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.84
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.93
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.92
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.43
rrl 1474271 n.614A>G non_coding_transcript_exon_variant 0.5
rrl 1474272 n.615C>T non_coding_transcript_exon_variant 0.75
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.75
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.83
rrl 1474326 n.669T>A non_coding_transcript_exon_variant 0.62
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.57
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.83
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.67
rrl 1474355 n.698A>G non_coding_transcript_exon_variant 0.83
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.83
rrl 1474381 n.724T>G non_coding_transcript_exon_variant 0.4
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.8
rrl 1474393 n.736A>G non_coding_transcript_exon_variant 0.5
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.75
rrl 1474448 n.791T>C non_coding_transcript_exon_variant 0.8
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.9
rrl 1474487 n.830G>T non_coding_transcript_exon_variant 0.12
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.81
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.88
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.13
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.82
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.82
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.18
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.93
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.81
rrl 1474517 n.860C>G non_coding_transcript_exon_variant 0.12
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.65
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.25
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.24
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.27
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.29
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.62
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.54
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.15
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.69
rrl 1474634 n.977T>G non_coding_transcript_exon_variant 0.62
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 0.9
rrl 1474637 n.980C>G non_coding_transcript_exon_variant 0.2
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.92
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.15
rrl 1474643 n.986A>G non_coding_transcript_exon_variant 0.21
rrl 1474658 n.1001A>G non_coding_transcript_exon_variant 0.36
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.7
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.67
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.83
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.86
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.8
rrl 1474706 n.1049G>A non_coding_transcript_exon_variant 0.88
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.92
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 0.93
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.11
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.89
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.93
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 1.0
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.67
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.11
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 1.0
rrl 1474879 n.1222G>A non_coding_transcript_exon_variant 0.13
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.9
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.38
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 1.0
rrl 1475109 n.1452C>T non_coding_transcript_exon_variant 0.67
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 1.0
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 1.0
rrl 1475137 n.1480A>T non_coding_transcript_exon_variant 0.86
rrl 1475171 n.1514C>T non_coding_transcript_exon_variant 1.0
rrl 1475175 n.1518G>C non_coding_transcript_exon_variant 0.8
rrl 1475188 n.1531C>G non_coding_transcript_exon_variant 0.8
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.5
rrl 1475518 n.1861A>G non_coding_transcript_exon_variant 0.75
rrl 1475521 n.1864T>C non_coding_transcript_exon_variant 0.75
rrl 1475526 n.1869C>T non_coding_transcript_exon_variant 0.5
rrl 1475529 n.1872A>G non_coding_transcript_exon_variant 0.75
rrl 1475532 n.1875A>T non_coding_transcript_exon_variant 0.67
rrl 1475538 n.1881T>C non_coding_transcript_exon_variant 0.75
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.5
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.6
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.8
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.4
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.8
rrl 1475715 n.2058G>T non_coding_transcript_exon_variant 0.3
rrl 1475743 n.2086T>C non_coding_transcript_exon_variant 0.35
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.62
rrl 1475754 n.2097G>A non_coding_transcript_exon_variant 0.23
rrl 1475774 n.2117C>T non_coding_transcript_exon_variant 0.25
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.92
rrl 1475783 n.2126T>C non_coding_transcript_exon_variant 0.19
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.19
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.94
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.83
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.76
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.42
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.36
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.82
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.82
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.27
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.4
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 1.0
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 1.0
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.62
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.89
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.67
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.88
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.5
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.5
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.83
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.33
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.83
rrl 1475995 n.2338G>C non_coding_transcript_exon_variant 0.33
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.8
rrl 1475998 n.2341C>G non_coding_transcript_exon_variant 0.4
rrl 1476000 n.2343G>A non_coding_transcript_exon_variant 0.33
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.83
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 1.0
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0
rrl 1476164 n.2507A>T non_coding_transcript_exon_variant 0.29
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.12
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.89
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.86
rrl 1476194 n.2537A>T non_coding_transcript_exon_variant 0.78
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.9
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.38
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.7
rrl 1476207 n.2550T>C non_coding_transcript_exon_variant 0.43
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.48
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.48
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.3
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.7
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.17
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.35
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.17
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.42
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.73
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.2
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.14
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.45
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.82
rrl 1476267 n.2610G>T non_coding_transcript_exon_variant 0.14
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.79
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.95
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.93
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.88
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.51
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.81
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.88
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.71
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.86
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.61
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.69
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.36
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.67
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.71
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.83
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.42
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.7
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.7
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.55
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.27
rrl 1476548 n.2891T>C non_coding_transcript_exon_variant 0.14
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.22
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.68
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.84
rrl 1476590 n.2933T>C non_coding_transcript_exon_variant 0.11
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.39
rrl 1476600 n.2943A>C non_coding_transcript_exon_variant 0.22
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.41
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.44
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.72
rrl 1476609 n.2952G>A non_coding_transcript_exon_variant 0.11
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.8
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.79
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.65
rrl 1476624 n.2967T>C non_coding_transcript_exon_variant 0.1
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.67
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.64
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.68
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.44
rrl 1476633 n.2976A>G non_coding_transcript_exon_variant 0.37
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.44
rrl 1476664 n.3007T>A non_coding_transcript_exon_variant 0.25
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.22
rrl 1476668 n.3011C>T non_coding_transcript_exon_variant 0.38
rpsA 1833679 c.138G>C synonymous_variant 0.1
rpsA 1833685 c.144G>C synonymous_variant 0.12
rpsA 1833694 c.153G>C synonymous_variant 0.15
rpsA 1833721 c.180A>G synonymous_variant 0.12
rpsA 1833724 c.183C>T synonymous_variant 0.12
rpsA 1833727 c.186G>C synonymous_variant 0.12
rpsA 1833732 p.Pro64Leu missense_variant 0.12
rpsA 1833734 p.Ala65Ser missense_variant 0.12
rpsA 1833742 c.201A>G synonymous_variant 0.12
rpsA 1833764 p.Asp75Asn missense_variant 0.12
rpsA 1834069 c.528G>C synonymous_variant 0.14
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834183 c.642T>C synonymous_variant 0.1
rpsA 1834189 c.648G>C synonymous_variant 0.16
rpsA 1834195 c.654G>C synonymous_variant 0.28
rpsA 1834228 c.687C>T synonymous_variant 0.12
rpsA 1834234 c.693G>C synonymous_variant 0.44
rpsA 1834240 c.699T>C synonymous_variant 0.4
rpsA 1834246 c.705G>T synonymous_variant 0.4
rpsA 1834249 c.708T>C synonymous_variant 0.47
rpsA 1834258 c.717G>A synonymous_variant 0.38
rpsA 1834261 c.720A>G synonymous_variant 0.53
rpsA 1834264 c.723G>C synonymous_variant 0.53
rpsA 1834294 c.753G>C synonymous_variant 0.44
rpsA 1834298 p.Gln253Glu missense_variant 0.44
rpsA 1834306 c.765T>C synonymous_variant 0.39
rpsA 1834307 p.Asp256Gln missense_variant 0.38
rpsA 1834312 c.771G>A synonymous_variant 0.38
rpsA 1834327 c.786G>T synonymous_variant 0.43
rpsA 1834345 c.804C>T synonymous_variant 0.29
rpsA 1834348 c.807T>C synonymous_variant 0.27
rpsA 1834375 c.834G>C synonymous_variant 0.17
rpsA 1834378 c.837T>C synonymous_variant 0.17
rpsA 1834411 c.870T>C synonymous_variant 0.24
rpsA 1834417 c.876G>C synonymous_variant 0.17
rpsA 1834423 c.882G>C synonymous_variant 0.16
rpsA 1834427 p.Ile296Val missense_variant 0.16
rpsA 1834435 c.894G>C synonymous_variant 0.17
rpsA 1834451 c.910T>C synonymous_variant 0.17
rpsA 1834459 c.918G>C synonymous_variant 0.15
rpsA 1834468 c.927A>G synonymous_variant 0.15
rpsA 1834474 c.933C>G synonymous_variant 0.15
rpsA 1834486 p.Glu315Asp missense_variant 0.17
rpsA 1834489 c.948T>C synonymous_variant 0.17
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289106 p.Ala46Thr missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embB 4249757 p.Thr1082Ala missense_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0
ethR 4326897 c.-651_*354del transcript_ablation 1.0